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Importance of nutrient availability for soluble microbial products formation during a famine period of activated sludge:Evidence from multiple analyses

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Journal of Environmental Sciences 2019年第10期31卷 112-121页

作者： Tahir Maqbool jinwoo cho Jin Hur Department of Environment and Energy Sejong University

Much remains unknown about compositional variations in soluble microbial products(SMP)with the shift of the substrate condition from a feast to a famine phase in biological treatment *** study demonstrated that the formation of SMP could be suppressed by up to 75%during the famine phase with the addition of essential *** contrast,presence of electron acceptor did not play any significant role during the stress condition,showing the similar amounts of SMP(r=0.98,p0.95).The fluorescence excitation-emission matrix coupled with parallel factor analysis(EEM-PARAFAC)revealed the presence of four different fluorescent components,including two protein-like(C1 and C4),fulvic-like(C2),and humic-like(C3)components,in the SMP and bEPS formed at different *** C1 and C4 showed increasing trends(R^2>0.95)with the length of starvation in the bioreactors without essential *** availability was found to be a key factor to quench the production of large-sized *** study provides a wealth of information on operation conditions of activated sludge treatment systems to minimize large sized SMP molecules(particularly proteins),which typically exert many environmental concerns to effluent organic matter quality.

关键词： Soluble microbial products Nutrient availability EEM-PARAFAC SEC-OCD-OND Famine phase

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Design and roles of RGO-wrapping in charge transfer and surface passivation in photoelectrochemical enhancement of cascade-band photoanode

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Nano Research 2017年第7期10卷 2415-2430页

作者： Zhuo Zhang Mingi choi Minki Baek Insung Hwang Changshin cho Zexiang Deng jinwoo Lee Kijung Yong Surface Chemistry Laboratory of Electronic Materials Department of Chemical Engineering POSTECH Pohang 790-784 Republic of Korea Advanced Functional Nanomaterial Laboratory Department of Chemical Engineering POSTECH Pohang 790-784 Repubfic of Korea State Key Laboratory of Optoelectronic Materials and Technologies School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China

Fast charge transfer and anti-photocorrosion are two crucial factors for developing efficient, durable photoanodes for photoelectrochemical （PEC） cells. Reduced graphene oxide （RGO） is a promising photoanode element that can provide both of these. In this study, we elucidated the roles of RGO in the charge transfer and surface passivation of photoanodes by the precise design of a RGO-wrapped photoanode and examination of its PEC properties. Arrays of hetero-nanorods （HNRs） with three different designs were fabricated as photoanodes using RGO, CdSe nanoparticles （NPs）, and ZnO nanorods （NRs） as building blocks. CdSe@ZnO HNRs were prepared by decorating ZnO NRs with CdSe NPs. Finite-element analysis and experimental studies demonstrated that in the CdSe@ZnO HNRs, if only the ZnO NRs were wrapped by RGO, the conductivity between CdSe and ZnO was enhanced by RGO to shuttle charges. If RGO only surrounded the outside of the CdSe@ZnO HNRs, the corrosion was slowed owing to the passivation effect of RGO, which increased the electron lifetime of the photoanode. If both CdSe and ZnO were fully wrapped by RGO, the advantages of the two aforementioned cases were both obtained. RGO-wrapped CdSe@ZnO HNRs with position-controlled designs are promising photoanode materials with a high PEC efficiency, and the developed synthesis process can be applied to explore the design and fabrication of next-generation photoanodes using RGO as a buildin~ block.

关键词： photoelectrochemical reduced graphene oxide(RGO) charge transfer surface passivation CdSe ZnO

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In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria,Streptococcus mutans and Streptococcus sobrinus

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 308-314页

作者： Okhee choi Su Kyung cho Junheon Kim Chung Gyoo Park jinwoo Kim Division of Applied Life Science (BK21 Plus) Gyeongsang National University Institute of Agriculture & Life Science Gyeongsang National University

Objective:To evaluate the antibacterial activity of Cinnamomum verum(***) from32 different essential oils against cariogenic bacteria,Streptococcus mutans(***)and Streptococcus sobrinus(***).Methods:The antibacterial activities of each essential oil were individually investigated against *** and *** essential oil of *** was selected for further evaluation against *** and *** chromatography mass spectrometry was used to determine the major constituents of *** essential *** addition,the minimum inhibitory concentration(MIC) and minimum bactericidal concentration of the most effective constituent was ***:The essential oil from *** exhibited the greatest antibacterial *** chromatography mass spectrometry analysis revealed that the major components of *** essential oil were cinnamaldehyde(56.3%),cinnamyl acetate(7.1%) and bphellandrene(6.3%).The MIC of cinnamaldehyde was measured using broth dilution *** MIC of cinnamaldehyde was 0.02%(v/v) against both bacterial strains *** minimum bactericidal concentration of cinnamaldehyde against *** and *** were 0.2% and 0.1%(v/v),***:The essential oil of *** and its major component cinnamaldehyde possessed considerable in vitro antibacterial activities against cariogenic bacteria,*** and *** *** results showed that the essential oil of *** and its bioactive component,cinnamaldehyde,have potential for application as natural agents for the prevention and treatment of dental caries.

关键词： Streptococcus mutans Streptococcus sobrinus Cariogenic bacteria Essential oil Antibacterial activity Cinnamaldehyde

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Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 411-417页

作者： Okhee choi Dong-Wan Kang Su Kyung cho Yeyeong Lee Byeongsam Kang Juyoung Bae Seunghoe Kim Jeong Hoon Lee Seung Eun Lee jinwoo Kim Institute of Agriculture & Life Science Gyeongsang National University Gyeonsangnam-do Agriculture Extension Services Department of Plant Medicine Gyeongsang National University Division of Applied Life Science Gyeongsang National University National Institute of Horticultural and Herbal Science Rural Development Administration

Objective: To investigate anti-quorum sensing(anti-QS) and anti-biofilm formation(antiBF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the antiBF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa(C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.

关键词： Plant extracts Quorum sensing Biofilm formation Cornus controversa

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Proportion and clinical features of never-smokers with non-small cell lung cancer

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Chinese Journal of Cancer 2017年第2期36卷 81-87页

作者： Jaeyoung cho Sun Mi choi jinwoo Lee Chang-Hoon Lee Sang-Min Lee Dong-Wan Kim Jae-Joon Yim Young Tae Kim Chul-Gyu Yoo Young Whan Kim Sung Koo Han Young Sik Park Department of Internal Medicine Seoul National University HospitalSeoul 110-744Republic of Korea Department of Thoracic and Cardiovascular Surgery Seoul National University HospitalSeoul 110-744Republic of Korea

Background: The proportion of never?smokers with non?small cell lung cancer(NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never?smokers with NSCLC in a large single ***: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December ***: Of the 1860 NSCLC patients, 707(38.0%) were never?smokers. The proportions of women(83.7% vs. 5.6%) and adenocarcinoma(89.8% vs. 44.9%) were higher among never?smokers than among ever?smokers. Significantly more never?smokers were diagnosed at a younger median age(65 vs. 68 years, P < 0.001) and earlier stage(stage I–II, 44.5% vs. 38.9%, P < 0.001) a= 0.015) compared with ever?smokers. Epidermal growth factor receptor mutations(57.8% vs. 24.4%, Pnd anaplastic lymphoma kinase rearrangements(7.8% vs. 2.8%, P < 0.001) were more common in never?smokers, whereas Kirsten rat sarcoma viral oncogene homolog mutations(5.8% vs. 9.6%, P ntly encountered in never?smokers than in ever?smokers. Never?smokers showed longer su= 0.021) were less frequervival after adjust?ing for the favorable effects of younger age, female sex, adenocarcinoma histology, better performance status, early stage disease, being asymptomatic at diagnosis, received antitumor treatment, and the presence of driver mutations(hazard ratio, 0.624; 95% confidence interval, 0.460–0.848; P = 0.003).Conclusions: More than one?third of the Korean patients with NSCLC were never?smokers. NSCLC in never?smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever?smokers.

关键词： Non-small cell lung carcinoma Never-smoker Epidermal growth factor receptor KRAS Prognosis

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非吸烟非小细胞肺癌患者的比例和临床特征研究

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癌症 2018年第1期37卷 26-32页

作者： Jaeyoung cho Sun Mi choi jinwoo Lee Chang-Hoon Lee Sang-Min Lee Dong-Wan Kim Jae-Joon Yim Young Tae Kim Chul-Gyu Yoo Young Whan Kim Sung Koo Han Young Sik Park Department of Internal Medicine Seoul National University Hospital Department of Thoracic and Cardiovascular Surgery Seoul National University Hospital

背景与目的非小细胞肺癌(non?small cell lung cancer, NSCLC)患者中非吸烟患者的比例正在增加,但在韩国,这个人数众多的群体并没有得到很好的治疗。本研究旨对NSCLC非吸烟患者的比例和临床特征进行一个单中心评估。方法我们分析了从201... 详细信息

背景与目的非小细胞肺癌(non?small cell lung cancer, NSCLC)患者中非吸烟患者的比例正在增加,但在韩国,这个人数众多的群体并没有得到很好的治疗。本研究旨对NSCLC非吸烟患者的比例和临床特征进行一个单中心评估。方法我们分析了从2011年6月到2014年12月所有新诊断为NSCLC的1860例患者的临床数据。结果在1860例NSCLC患者中,707例(38%)从不吸烟。非吸烟患者中女性(83.7%vs.5.6%)和腺癌(89.8%vs. 44.9%)的比例均高于吸烟患者。非吸烟患者与吸烟患者相比,中位年龄明显更低(65 vs. 68岁,P<0.001),早期肿瘤比例更高(I–II期,44.5%vs. 38.9%,P=0.015)。与吸烟患者相比,表皮生长因子受体突变(57.8%vs. 24.4%,P<0.001)和间变性淋巴瘤激酶重排(7.8%vs. 2.8%,P<0.001)在非吸烟患者中更常见,而Kirsten大鼠肉瘤病毒癌基因同源染色体的基因突变(5.8%vs. 9.6%,P=0.021)出现频率则较低。在对年龄低、女性、腺癌、体能更好、疾病早期、诊断时无症状、曾接受抗肿瘤治疗以及存在驱动基因突变等的有利影响进行校正后,非吸烟患者的生存期比吸烟患者更长(hazard ratio,0.624,95%CI:0.460–0.848; P=0.003)。结论韩国超过三分之一的NSCLC患者是非吸烟者。NSCLC非吸烟患者与吸烟患者相比,有着不同的临床特征和主要驱动基因突变,总生存期更长。

关键词：非小细胞肺癌非吸烟者表皮生长因子受体 KRAS 预后

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