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E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang Xinyi Xie Boyu Chen lina Pan Jianping li Wanbing Wang jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Shenzhen Research Institute of Xiamen University ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q Late onset

Additives strategies to improving cycling stability of li metal batteries by modifying electrode electrolyte interphases

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Progress in Natural Science:Materials International 2024年第2期34卷 338-344页

作者： Yuan li Pengfei Huang Chunyu Cui Xiaoyuan Ma li Chen Zekun li linhai li Yuhong Tian School of Biological and Chemical Engineering Guangxi University of Science and Technology School of College of Chemistry and Chemical Engineering Hunan University Isky Future Energy Institute

li metal batteries（LMBs） have attracted much attention due to the ultra-high theoretical capacity of the li metal anode（LMA）.However,the uncontrollable dendrites growth and low coulombic efficiency hinder their practical ***,we explore 3,5-difluoropyridine（2F-BD） as a novel electrolyte additive to enable highperformance *** 2F-BD additive participates in and modifies the solvation structure of li ions by reducing the coordinated number of PF6-at the electrode surface,leading to the formation of a liF and li3N-rich solid electrolyte interphase（SEI）.The liF component increases the robustness of SEI and suppresses the formation of li dendrites,while the li3N component facilitates the transportation and reaction kinetics of li *** a result,the li‖li symmetric cell presents a stable cycling performance of up to 500 h at a current density of 1 mA *** coupling with liFePO4cathode,the obtained full cell achieves high specific capacities of 106.06 mA h g-1and 84.98 mA h g-1at 2.55 mA cm-2and 5.10 mA cm-2,respectively,and maintains a high capacity retention of84.0% after 1000 cycles at 0.13 mA cm-2,with an average cycling CE of 99.58%.

关键词： Electrolyte additive li dendrites li metal batteries liF and li3N-Rich electrode-electrolyte interphase liFePO4 cathode

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一种基于短语的汉蒙统计机器翻译与调序模型

高技术通讯 2009年第5期19卷 475-479页

作者：侯宏旭刘群李锦涛内蒙古大学计算机学院呼和浩特010021 中国科学院计算技术研究所北京100190 中国科学院研究生院北京100190

根据蒙古语的一些特点,为基于短语的汉蒙统计机器翻译提出了一种适合于汉蒙统计机器翻译的调序模型,并给出了相应的训练和解码算法以及初步实验的结果。汉蒙双语语料库规模很小,数据稀疏问题严重,而在汉蒙翻译中,词序变化又非常明显,在... 详细信息

根据蒙古语的一些特点,为基于短语的汉蒙统计机器翻译提出了一种适合于汉蒙统计机器翻译的调序模型,并给出了相应的训练和解码算法以及初步实验的结果。汉蒙双语语料库规模很小,数据稀疏问题严重,而在汉蒙翻译中,词序变化又非常明显,在汉英等机器翻译中使用的调序方法难于应用到汉蒙统计机器翻译中。通过对汉蒙翻译过程中词语顺序变化的正态分布假设,建立了一种概率调序模型。实验表明,这种概率调序模型好于 Moses系统中采用的调序方法。

关键词：机器翻译统计方法蒙古语调序概率

Effects of PM_(2.5)and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

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Environment & Health 2024年第5期2卷 290-300页

作者： jintao liu Rong Song Xuanxuan li li liu Ning Wei Jiajun Yuan Weizhuo Yi Rubing Pan Jian Cheng Xulai Zhang Hong Su Department of Epidemiology and Health Statistics School of Public HealthAnhui Medical UniversityHefeiAnhui 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province HefeiAnhui 230032China Center for Big Data and Population Health of IHM HefeiAnhui 230032China Anhui Mental Health Center(Affiliated Psychological Hospital of Anhui Medical University) HefeiAnhui 230032China

Studies have indicated the different effects of PM_(2.5)components on human ***,specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain ***,a repeated measures study for schizophrenia was constructed based on Anhui Mental Health *** collected information,including demographics and thyroid hormones(TH)levels,on repeat admissions of schizophrenia patients during 2017−2020,assessing their illness severity by positive and negative symptom scales(PANSS).Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant’s exposure *** assessed the effects of PM_(2.5)components individually and in combination on schizophrenia and explored the mediating role of *** indicated that benzo[a]pyrene,sulfate,nitrate,chloride,ammonia,cadmium,chromium,lead,selenium,and thallium exposure were associated with increased PANSS scores,with more significant results observed in *** exposure to PM_(2.5)components was found to be associated with increased PANSS scores and decreased free triiodothyronine(FT3).Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM_(2.5)components and PANSS *** findings emphasize the impacts of PM_(2.5)components on schizophrenia and the potential value of focusing on changes in THs.

关键词： PM_(2.5)components Schizophrenia Thyroid hormones Mediation analysis

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光伏组件干式除尘刷设计及工作参数优化研究

太阳能学报 2018年第12期39卷 3399-3405页

作者：康儒龚俊宁会峰李翠明李进韬兰州理工大学机电工程学院兰州730050 兰州理工大学数字制造技术与应用省部共建教育部重点实验室兰州730050

为解决水资源匮乏地区光伏组件表面灰尘清洁的难题,提出一种集双滚刷清扫起尘、掸土机构配合外罩输尘、引风机彻底吸尘于一体的光伏组件干式除尘刷。首先对刷体结构进行设计定型,然后借助Fluent软件对刷体内部流场进行可视化分析,验证... 详细信息

为解决水资源匮乏地区光伏组件表面灰尘清洁的难题,提出一种集双滚刷清扫起尘、掸土机构配合外罩输尘、引风机彻底吸尘于一体的光伏组件干式除尘刷。首先对刷体结构进行设计定型,然后借助Fluent软件对刷体内部流场进行可视化分析,验证双滚刷结构及掸土机构的可行性。最后通过搭建实验平台,对光伏组件干式除尘刷工作参数进行优化研究,确定最佳的工作参数。该光伏组件干式除尘刷通过外界移动载体带动行走,在无水、无清洁剂的条件下实现光伏组件表面的清洁。

关键词：光伏板干式除尘流场掸土机构起尘吸尘

术前康复训练在食管癌合并2型糖尿病患者治疗中的应用价值

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中外医药研究 2024年第6期3卷 60-62页

作者：李金涛曹道白音王浩然北京大望路急诊抢救医院胸外科北京100021

目的:分析术前康复训练在食管癌合并2型糖尿病患者治疗中的应用价值。方法:选取2020年8月—2023年7月于北京大望路急诊抢救医院拟行胸腹腔镜食管癌根治术治疗的食管癌合并2型糖尿病患者90例作为研究对象,按照随机数字法分为对照组和观察... 详细信息

目的:分析术前康复训练在食管癌合并2型糖尿病患者治疗中的应用价值。方法:选取2020年8月—2023年7月于北京大望路急诊抢救医院拟行胸腹腔镜食管癌根治术治疗的食管癌合并2型糖尿病患者90例作为研究对象,按照随机数字法分为对照组和观察组,各45例。对照组行术前常规准备,观察组在对照组基础上进行术前康复训练。比较两组治疗情况、术后并发症发生情况、血糖水平。结果:两组手术时间和清扫淋巴结个数比较,差异无统计学意义(P>0.05);观察组住院时间短于对照组,差异有统计学意义(P=0.002)。观察组术后并发症总发生率低于对照组,差异有统计学意义(P=0.022)。干预前,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平比较,差异无统计学意义(P>0.05);术后2 d,观察组空腹血糖、餐后2 h血糖及糖化血红蛋白水平低于干预前及对照组,差异有统计学意义(P<0.05)。结论:术前康复训练在食管癌合并2型糖尿病患者治疗中的应用价值较高,可缩短住院时间,减少术后并发症发生风险,调节血糖。

关键词：食管癌 2型糖尿病术前康复训练胸腹腔镜根治术

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电磁组合场对镁合金凝固组织的影响

稀有金属材料与工程 2009年第12期38卷 2195-2198页

作者：许光明李金涛崔建忠东北大学材料电磁过程研究教育部重点实验室辽宁沈阳110004

研究了不同电磁组合场对AZ61镁合金凝固组织的影响。结果表明,在静磁场作用下,镁合金的凝固组织为等轴晶,晶界上的结晶相成网状分布;在静磁场与工频交流电组合场作用下,其凝固组织与只施加静磁场时类似,基本为等轴晶,但由于交流电的施... 详细信息

研究了不同电磁组合场对AZ61镁合金凝固组织的影响。结果表明,在静磁场作用下,镁合金的凝固组织为等轴晶,晶界上的结晶相成网状分布;在静磁场与工频交流电组合场作用下,其凝固组织与只施加静磁场时类似,基本为等轴晶,但由于交流电的施加晶粒明显得到细化,晶界上结晶相的网状结构也变得细小;而在镁合金凝固过程中同时施加静磁场和直流电流组合场时,由于组合场产生的熔体内部的定向力作用的结果,凝固组织主要为蔷薇状晶粒,组织得到明显的净化,其晶界上结晶相的网状结构彻底消失,以不连续的薄条状和点状形态分布。

关键词： AZ61镁合金电磁组合场结晶相

Noise-Transfer2Clean: Denoising cryo-EM images based on noise modeling and transfer

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Noise-Transfer2Clean: Denoising cryo-EM images based on nois...

Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

第七届全国冷冻电子显微学与结构生物学专题研讨会

作者：李鸿佳 Hui Zhang Xiaohua Wan Zhidong Yang Chengmin li jintao li Renmin Han Ping Zhu Fa Zhang High Performance Computer Research Center Institute of Computing Technology Chinese Academy of Sciences University of Chinese Academy of Sciences National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Research Center for Mathematics and Interdisciplinary Sciences Shandong University

＜正＞Cryo-electron microscopy （cryo-EM） has become a widely-used tool for determining threedimensional （3D） structures of protein and macromolecular complexes from two-dimensional （2D） ***,limited by the electron beam dose,the micrographs in cryo-EM generally suffer from extremely low signal-to-noise ratio （SNR）,which reduces the confidence and the efficiency of downstream ***,the noise in cryo-EM is not simple additive or multiplicative noise whose statistical characteristics are quite different from the ones in natural image,extremely shackling the performance of conventional denoising methods.

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode *** this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery *** mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this *** leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/***,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami *** interaction of Al and F is advantageous to realize the defluoridation to some *** is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics