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Heparin-free veno-venous extracorporeal membrane oxygenation in non-trauma patients with difficult airways for surgery

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Chinese Medical Journal 2023年第10期136卷 1251-1252页

作者： Hongya Chen jinsheng Liu Lili Wu Cunliang ji Tong Li Guyan Wang Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Intensive Care Unit Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

To the Editor:For patients with critical tracheal stenosis in surgery,extracorporeal membrane oxygenation(ECMO)is probably the last,yet safest,choice to ensure definitive airway *** anticoagulation in the form of heparin is a typical ***,heparin is fraught with its own complications that include both bleeding in the patient and clotting within the circuitry.

关键词： airway surgery patients

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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Heavy Precipitation over the jing–jin–ji Region in Early October: What Controls Its Interannual Variability?

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Journal of Meteorological Research 2022年第4期36卷 586-600页

作者： jing FENG Tim LI ji WANG Linna ZHANG Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate andEnvironmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC–FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Beijing Meteorological Information Center China Meteorological AdministrationBeijing 100089China International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversity of Hawaii at ManoaHonoluluHawaii 96822USA Beijing Municipal Climate Center Beijing 100089China Beijing Meteorological Observatory Beijing 100089China

Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the jing–jin–ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by exceptionally large population during the Chinese National Day Holidays(CNDH).What causes the year-to-year variation of the HRP during early October is investigated through an observational *** is found that the HRP arises from moisture transport by southerly anomalies to the west of an anomalous low-level anticyclone over the subtropical northwestern Pacific(SNWP).Sensitivity numerical experiments reveal that the low-level anticyclonic anomaly is caused by a dipole heating pattern over tropical western and central Pacific associated with a La Niña-like SST anomaly(SSTA)pattern in the Pacific and by a negative heating anomaly over North *** latter connects the SNWP anticyclone through a Rossby wave *** ascent associated with a positive heating anomaly over the tropical western Pacific may strengthen the local Hadley Cell,contributing to maintenance of the low-level anomalous anticyclone over SNWP and extending westwards of the western Pacific subtropical high(WPSH).Therefore,both the tropical Pacific and midlatitude heating signals over North Europe may be potential predictors for HRP forecast in the JJJ region in early October.

关键词： heavy regional precipitation(HRP)in jing–jin–ji(JJJ) Beijing Tianjin and Hebei Province water vapor(WV)transport Rossby wave train diabatic heating anomalies La Niña-like SST anomaly

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浙江省高职院校现代学徒制政策执行效果评价

职业技术 2025年第1期24卷 39-46页

作者：季青媛浙江艺术职业学院杭州310053

浙江加快改造提升传统产业,大力培育战略性新兴产业与未来产业,打造新技术、新产业、新业态、新模式“四新”经济。为解决企业转型升级所引致的人才结构性供需矛盾问题,职业院校积极深化产教融合,推进现代学徒制,全面提升技术技能人才... 详细信息

浙江加快改造提升传统产业,大力培育战略性新兴产业与未来产业,打造新技术、新产业、新业态、新模式“四新”经济。为解决企业转型升级所引致的人才结构性供需矛盾问题,职业院校积极深化产教融合,推进现代学徒制,全面提升技术技能人才培养能力和水平。基于史密斯政策执行理论的四个维度,分析浙江省现代学徒制政策执行的影响因素,发现政策执行存在现代学徒制政策协同作用有待提升,企业主体地位有待充分显现,学生学徒双重身份保障不力,政策执行环境有待优化等问题。基于此,提出应加强政策顶层设计,强化执行机构能力,把控学徒培养质量,提升目标群体政策认同度,营造良好政策执行生态。

关键词：现代学徒制政策执行效果评价

Mechanism Study on the Effect of Retarder on Polyurethane Setting Time Based on Molecular Simulation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 224-231页

作者：吴宇轩徐文远 YU Tianlai ji Yongcheng School of Civil Engineering Northeast Forestry University

This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal *** mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics *** transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane *** results demonstrate that a 1% concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of *** phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component *** reduction in interaction slows the setting ***,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.

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Distributed optimal consensus control for multiagent systems based on event-triggered and prioritized experience replay strategies

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Science China(Information Sciences) 2025年第1期 306-321页

作者： Cuijuan ZHANG Lianghao ji Shasha YANG Xing GUO Huaqing LI Chongqing Key Laboratory of Image Cognition Chongqing University of Posts and Telecommunications Key Laboratory of Intelligent Perception and Computing of Anhui Province Anqing Normal University College of Electronic and Information Engineering Southwest University

This study uses event-triggered(ET) and reinforcement learning methods to investigate the optimal consensus control problem for cooperative-competitive multiagent systems. It proposes a novel distributed ET control strategy, which relies on a prioritized experience replay(PER) policy. This strategy not only conserves communication resources but also ensures acceptable system performance. To implement the proposed method, actor-critic(AC) dual-structured neural networks(NNs) are used to approximate the value function and control policy. In the AC NNs, the weight estimates for the NNs are updated at the moment of event triggering, resulting in a nonperiodic weight adjustment pattern. This approach decreases the computational cost in comparison with the traditional ET mechanism. The PER-based ET mechanism makes full use of valid historical data and effectively establishes a balance between system performance and communication resource ***, it does not require the following two conditions in most existing studies:(1) requirement of the system dynamics model to be known, and(2) persistent excitation. In addition, Zeno behavior is excluded from this study. Finally, a simulation is conducted to confirm the validity of the suggested approach.

关键词：

Self-Triggered Impulsive Control for Nonlinear Stochastic Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 264-266页

作者： Tao Zhan Yi ji Yabin Gao Hongyi Li Yuanqing Xia the School of Mathematics and Statistics Southwest University the School of Astronautics Harbin Institute of Technology IEEE the College of Electronic and Information Engineering Southwest University Zhongyuan University of Technology the School of Automation Beijing Institute of Technology

Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous state monitoring. In contrast to the existing self-triggered control method, novel self-triggered mechanism(STM) is proposed by incorporating a waiting time for stabilizing impulses. This allows for direct prediction of the next impulsive instant.

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袁大滩煤矿主斜井带式输送机提能改造设计

煤矿机械 2025年第1期46卷 143-146页

作者：姬红刚中煤科工集团北京华宇工程有限公司西安分公司西安710075

以袁大滩煤矿主斜井带式输送机为例,介绍了主斜井带式输送机提能改造的设计特点:采用低噪声节能托辊和低滚阻节能型输送带来降低运行阻力,采用工期最短的改造方案来减少矿井停产造成的经济损失。改造的思路和方案,可供相关煤矿和设计人... 详细信息

以袁大滩煤矿主斜井带式输送机为例,介绍了主斜井带式输送机提能改造的设计特点:采用低噪声节能托辊和低滚阻节能型输送带来降低运行阻力,采用工期最短的改造方案来减少矿井停产造成的经济损失。改造的思路和方案,可供相关煤矿和设计人员参考借鉴。

关键词：煤矿主斜井带式输送机提能改造节能