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Docking control for probe-drogue refueling: An additive-state-decomposition-based output feedback iterative learning control method

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Chinese Journal of Aeronautics 2020年第3期33卷 1016-1025页

作者： jinrui ren Quan QUAN Cunjia LIU Kai-Yuan CAI School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100083China Department of Aeronautical and Automotive Engineering Loughborough UniversityLeicestershire LE113TUUnited Kingdom

Designing a controller for the docking maneuver in Probe-Drogue Refueling(PDR) is an important but challenging task, due to the complex system model and the high precision *** order to overcome the disadvantage of only feedback control, a feedforward control scheme known as Iterative Learning Control(ILC) is adopted in this ***, Additive State Decomposition(ASD) is used to address the tight coupling of input saturation, nonlinearity and the property of Non Minimum Phase(NMP) by separating these features into two subsystems(a primary system and a secondary system).After system decomposition, an adjoint-type ILC is applied to the Linear Time-Invariant(LTI) primary system with NMP to achieve entire output trajectory tracking, whereas state feedback is used to stabilize the secondary system with input *** two controllers designed for the two subsystems can be combined to achieve the original control goal of the PDR ***, to compensate for the receiverindependent uncertainties, a correction action is proposed by using the terminal docking error,which can lead to a smaller docking error at the docking *** tests have been carried out to demonstrate the performance of the proposed control method, which has some advantages over the traditional derivative-type ILC and adjoint-type ILC in the docking control of PDR.

关键词： Additive state decomposition Adjoint operator Docking control Iterative learning control Probe-drogue refueling Stable inversion

Aerial refueling scheduling of multi-receiver and multi-tanker under spatial-temporal constraints for forest firefighting

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Chinese Journal of Aeronautics 2024年第5期37卷 71-91,I0001页

作者： Jing HUANG Jiaqi XING jinrui ren Quan QUAN Youmin ZHANG Department of Information and Control Engineering Xi’an University of TechnologyXi’an 710048China Jiujiang Measuring Test Technology Research Institute Jiujiang 332000China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Xi’an University of Posts&TelecommunicationsShaanxiXi’an 710121China Department of Mechanical Industrial and Aerospace EngineeringConcordia UniversityMontreal H3G 1M8Canada

Forest fires pose a significant threat to human life and property,so the utilization of unmanned aircraft systems provides new ways for forest *** the constrained load capacities of these aircraft,aerial refueling becomes crucial to extend their operational time and *** order to address the complexities of firefighting missions involving multi-receiver and multi-tanker deployed from various airports,first,a fuel consumption calculation model for aerial refueling scheduling is established based on the receiver ***,two distinct methods,including an integrated one and a decomposed one,are designed to address the challenges of establishing refueling airspace and allocating tasks for *** methods aim to optimize total fuel consumption of the receivers and tankers within the aerial refueling scheduling *** optimization problem is established as nonlinear optimization models along with *** integrated method seamlessly combines refueling rendezvous point scheduling and tanker task allocation into unified *** has a complete solution space and excels in optimizing total fuel *** decomposed method,through the separation of rendezvous point scheduling and task allocation,achieves a reduced computational ***,this comes at the cost of sacrificing optimality by excluding specific feasible ***,numerical simulations are carried out to verify the feasibility and effectiveness of the proposed *** simulations yield insights crucial for the practical engineering application of both the integrated and decomposed methods in real-world *** comprehensive approach aims to enhance the efficiency of forest firefighting operations,mitigating the risks posed by forest fires to human life and property.

关键词： Aerial refueling Scheduling Planning Spatial-temporal constraint Firefighting

Additive-state-decomposition-based station-keeping control for autonomous aerial refueling

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Science China(Information Sciences) 2021年第11期64卷 240-242页

作者： jinrui ren Quan QUAN Haibiao MA Kai-Yuan CAI School of Automation Science and Electrical Engineering Beihang University

Dear editor,Aerial refueling(AR) is an effective method of increasing the endurance and range of aircraft by refueling them in flight [1, 2]. Station-keeping control is the basis of autonomous aerial refueling(AAR). The station-keeping control for AAR is a difficult task for two main reasons. First,the receiver is disturbed by the atmospheric turbulence and the wake vortex of the tanker. Secondly, owing to the fuel injection in the refueling process, the mass and the center of mass of the receiver will change.

关键词： Aerial refueling station keeping two-degree-of-freedom additive state decomposition varying mass

Advances in synthetic biology-based drug delivery systems for disease treatment

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Chinese Chemical Letters 2024年第11期35卷 66-73页

作者： Yujie Li Ya-Nan Wang Yin-Gen Luo Hongcai Yang jinrui ren Xiao Li Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiology the Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

With the increasing demand for personalized and precise treatment,the rapid advancement of synthetic biology technology has inevitably led to the development of nanobiology-based drug delivery *** biology-based drug delivery systems are being increasingly used in the treatment of various *** one hand,synthetic biology technology enables the clever combination of chassis cells,bacteria,and their derivatives with nanomaterials,forming nano-artificial hybrid *** systems effectively integrate the functions of both materials,leading to further breakthroughs and optimization of biological *** the other hand,synthetic biology strategies guide the self-assembly of modular nanocomponents with biocatalytic or intelligent response functions,resulting in the mimicry of living cell features such as compartmentalization of enzymatic reactions and responsiveness to external *** provides novel design ideas for the construction of artificial *** paper aims to explore the construction and application of biogenic drug delivery systems based on whole cells,cell membrane-encapsulated nanoparticles,exosomes,bacteria,bacterial outer membrane vesicles and artificial cells,taking into account recent advances in this *** advantages and limitations of current synthetic biology-based nanodrug delivery systems for clinical translation are discussed,and the future prospects of nanotechnology for intelligent drug diagnostic and therapeutic systems are envisioned.

关键词： Drug delivery system Synthetic biology Nanotechnology Genetic engineering Nanoparticles

Safety Assessment for Autonomous Aerial Refueling Based on Reachability Analysis

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Transactions of Nanjing University of Aeronautics and Astronautics 2021年第2期38卷 216-224页

作者： ren jinrui MA Haibiao QUAN Quan HANG Bin School of Automation Northwestern Polytechnical UniversityXi’an 710072P.R.China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191P.R.China

Autonomous aerial refueling(AAR)has demonstrated significant benefits to aviation by extending the aircraft range and *** is of significance to assess system safety for autonomous aerial *** this paper,the reachability analysis method is adopted to assess system *** to system uncertainties,the aerial refueling system can be considered as a stochastic ***,probabilistic reachability is *** there is a close relationship between reachability probability and collision probability,the collision probability of the AAR system is analyzed by using reachability analysis ***,the collision probability is accessed by using the Monte-Carlo experiment ***,simulations demonstrate the effectiveness of the proposed safety assessment method.

关键词： aerial refueling safety assessment collision probability probabilistic reachability Monte-Carlo method

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畸变感知相关滤波目标跟踪算法

计算机科学与探索 2023年第11期17卷 2703-2720页

作者：姜文涛任金瑞辽宁工程技术大学软件学院辽宁葫芦岛125105 辽宁工程技术大学研究生院辽宁葫芦岛125105

针对现有相关滤波跟踪算法在目标畸变情况下应对能力不足和滤波器模型更新存在误差累积易导致跟踪失败的问题,提出畸变感知相关滤波目标跟踪算法。首先,利用粒子采样构建强化目标信息的空间参考权值,适应相邻帧间目标外观变化,使滤波器... 详细信息

针对现有相关滤波跟踪算法在目标畸变情况下应对能力不足和滤波器模型更新存在误差累积易导致跟踪失败的问题,提出畸变感知相关滤波目标跟踪算法。首先,利用粒子采样构建强化目标信息的空间参考权值,适应相邻帧间目标外观变化,使滤波器专注于学习目标可信赖部分,抑制背景干扰信息;其次,采用交替方向乘子法以较少的迭代次数求解目标最优函数值,优化算法,降低计算复杂度;最后,为进一步增强滤波器的判别能力,设计目标畸变感知策略,通过分析平均峰值相关能量和响应图峰值时序约束来衡量目标受干扰因素影响后的畸变程度,判别当前跟踪结果是否可靠。当目标跟踪定位可靠性较低时,采用粒子滤波对目标进行选择性的重检测。并依据当前跟踪目标畸变程度,自适应地更新滤波器模型。在OTB50、OTB100和DTB70数据集上与多种代表性目标跟踪算法进行对比实验,实验结果表明,该算法的跟踪成功率和精确率较优,在面对实际场景中因多个干扰因素而产生畸变的目标时具有较强鲁棒性。

关键词：目标跟踪粒子滤波相关滤波自适应空间正则项畸变感知

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垂体生长激素细胞肿瘤围手术期的诊疗进展

中华神经外科杂志 2024年第10期40卷 1075-1080页

作者：何源嵩郑勇广东医科大学第一临床医学院湛江524023 广东医科大学深圳宝安临床医学院神经外科深圳518101

目前,手术治疗仍是垂体生长激素(GH)细胞肿瘤的首选治疗方法。随着临床研究的深入,近年来该病在围手术期诊疗方面的研究取得了一定的进展,主要表现在术前的精准诊断和风险评估、对复发及异位肿瘤的评估、内分泌及麻醉管理、术中辅助技... 详细信息

目前,手术治疗仍是垂体生长激素(GH)细胞肿瘤的首选治疗方法。随着临床研究的深入,近年来该病在围手术期诊疗方面的研究取得了一定的进展,主要表现在术前的精准诊断和风险评估、对复发及异位肿瘤的评估、内分泌及麻醉管理、术中辅助技术的发展及手术入路的选择等。此外,在手术并发症的处理、术后疗效预测和评估、术后复发或残留肿瘤的处理、特殊人群的治疗等方面也有诸多新的研究成果。因此,本文针对垂体GH细胞肿瘤围手术期的诊疗进展进行综述,以期为临床制定个体化的治疗方案提供帮助。

关键词：麻醉管理手术入路诊疗进展垂体生长激素肿瘤围手术期特殊人群风险评估精准诊断

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Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第9期22卷 733-745页

作者： Lei JI Siliang CHEN Guangchao GU Wei WANG jinrui ren Fang XU Fangda LI Jianqiang WU Dan YANG Yuehong ZHENG Department of Vascular Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China School of Clinical Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Computational Biology and Bioinformatics Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Abdominal aortic aneurysm(AAA)and atherosclerosis(AS)have considerable similarities in clinical risk factors and molecular *** aim of our study was to investigate the differences between AAA and AS from the perspective of metabolomics,and to explore the potential mechanisms of differential metabolites via integration analysis with *** samples from 32 AAA and 32 AS patients were applied to characterize the metabolite profiles using untargeted liquid chromatography-mass spectrometry(LC-MS).A total of 18 remarkably different metabolites were identified,and a combination of seven metabolites could potentially serve as a biomarker to distinguish AAA and AS,with an area under the curve(AUC)***,we analyzed both the metabolomics and transcriptomics data and found that seven metabolites,especially 2’-deoxy-D-ribose(2 d DR),were significantly correlated with differentially expressed *** conclusion,our study presents a comprehensive landscape of plasma metabolites in AAA and AS patients,and provides a research direction for pathogenetic mechanisms in atherosclerotic AAA.

关键词： Abdominal aortic aneurysm(AAA) Atherosclerosis(AS) Untargeted metabolomics Transcriptomics

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颈动脉体瘤手术并发症的预防与处理

中华血管外科杂志 2021年第4期6卷 230-235页

作者：任金锐郑月宏中国医学科学院北京协和医院血管外科北京100730

手术切除是颈动脉体瘤(CBT)的首选治疗方式。由于CBT位置特殊,常累及颅神经、颈部血管,手术切除后一般并发症如失血、颈动脉损伤、颅神经损伤、脑缺血事件等发生率较高,特殊并发症即CBT(功能性、恶性、双侧CBT)切除后相关并发症包括血... 详细信息

手术切除是颈动脉体瘤(CBT)的首选治疗方式。由于CBT位置特殊,常累及颅神经、颈部血管,手术切除后一般并发症如失血、颈动脉损伤、颅神经损伤、脑缺血事件等发生率较高,特殊并发症即CBT(功能性、恶性、双侧CBT)切除后相关并发症包括血压波动变化、转移或复发及颈动脉窦功能损伤等也十分棘手。详细的术前评估、多学科合作、规范的围术期管理以及先进而熟练的手术操作有助于减少手术并发症的发生,术前栓塞、颈动脉重建的多种方式、脑缺血评估与监测、颅神经保护等手术并发症的预防和处理措施仍需进一步研究。

关键词：颈动脉体瘤手术并发症预防与处理