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The construction of a lymphoma cell-based, DC-targeted vaccine, and its application in lymphoma prevention and cure

Bioactive Materials 2021年第3期6卷 697-711页

作者： Tianlin Zhou jinrong penga Ying Hao Kun Shi Kai Zhou Yun Yang Chengli Yang Xinlong He Xinmian Chen Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengdu610041PR China Personalized Drug Therapy Key Laboratory of Sichuan Province Department of pharmacySichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu610072PR China

In recent years,Non-Hodgkin lymphoma(NHL)has been one of the most fast-growing malignant tumor *** poses severe damages to physical health and a heavy burden to *** therapies(chemotherapy or radiotherapy)bring some benefit to patients,but have severe adverse effects and do not prevent *** relevance of emerging immunotherapy options(immune-checkpoint blockers or adoptive cellular methods)for NHL remains uncertain,and more intensive evaluations are *** this work,inspired by the idea of vaccination to promote an immune response to destroy tumors,we used a biomaterial-based strategy to improve a tumor cell-based vaccine and constructed a novel vaccine named Man-EG7/CH@CpG with antitumor *** this vaccine,natural tumor cells are used as a vector to load CpG-ODN,and following lethal irradiation,the formulations were decorated with *** study of the characterization of the doubleimproved vaccine evidenced the enhanced ability of DCs targeting and improved immunocompetence,which displayed an antitumor *** the lymphoma prevention model,the Man-EG7/CH@CpG vaccine restrained tumor formation with high ***,unlike the non-improved vaccine,the double-improved vaccine elicited an enhanced antitumor effect in the lymphoma treatment ***,to improve the moderate therapeutic effect of the mono-treatment method,we incorporated a chemotherapeutic drug(doxorubicin,DOX)into the process of vaccination and devised a combination ***,a tumor inhibition rate of~85%was achieved via the combination therapy,which could not be achieved by mono-chemotherapy or *** summary,the strategy presented here may provide a novel direction in the establishment of a tumor vaccine and is the basis for a prioritization scheme of immuno-chemotherapy in enhancing the therapeutic effect on NHL.

关键词： Non-hodgkin lymphoma DCs targeting Man-EG7/CH@CpG vaccine Combinational therapy

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