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A self-adaptive negative selection algorithm used for anomaly detection

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Progress in Natural Science:Materials International 2009年第2期19卷 261-266页

作者： jinquan zeng,Xiaojie Liu,Tao Li,Caiming Liu,Lingxi Peng,Feixian Sun Department of Computer Science,Sichuan University,Chengdu 610065,China Department of Computer Science Sichuan University Chengdu 610065 China

A novel negative selection algorithm (NSA),which is referred to as ANSA,is presented. In many actual anomaly detection systems,the training data are just partially composed of the normal elements,and the self/nonself space often varies over time. Therefore,anom-aly detection system has to build the profile of the system based on a part of self elements and adjust itself to adapt those variables. However,previous NSAs need a large number of self elements to build the profile of the system,and lack adaptability. In order to over-come these limitations,the proposed approach uses a novel technique to adjust the self radius and evolve the nonself-covering detectors to build an appropriate profile of the system. To determine the performance of the approach,the experiments with the well-known data-set were performed. Results exhibited that our proposed approach outperforms the previous techniques.

关键词： Artificial immune system Anomaly detection Negative selection algorithm

Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation

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Bioactive Materials 2018年第1期3卷 74-79页

作者： Zhengao Wang jinquan zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China Guangdong Key Laboratory of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou 510006China Guangzhou Tieyi Middle School Guangzhou 510660China Institute of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangzhou Institute of Advanced Technology Chinese Academy of SciencesGuangzhou 510006China Department of Spine Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and *** highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral *** results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body *** PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant.

关键词： Titanium Hydroxyapatite Nanowires Catechol Polypyrrole

Fight or flee,a vital choice for Clostridioides difficile

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mLife 2024年第1期3卷 14-20页

作者： Ji zeng Sshuying Fang jinquan Guo Min Dong Guo-Bao Tian Liang Tao School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhouChina Department of Brest Surgery Panyu Central Hospital.GuangzhouChina Department of Microbiology Harvard Medical SchoolBostonMassachusettsUSA Department of Urology Boston Children's HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Advanced Medical Technology Center The First Affiliated HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Key Laboratory of Tropical Diseases Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina School of Medicine Xizang Minzu UniversityXianyangChina Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineWestlake UniversityHangzhouChina Research Center for Industries of the Future School of Life SciencesWestlake UniversityHangzhouChina

Clostridioides difficile is a leading cause of healthcare-associated infections,causing billions of economic losses every *** symptoms range from mild diarrhea to life-threatening damage to the *** and recurrence of *** infection(CDl)are mediated by the metabolically dormant spores,while the virulence of *** is mainly due to the two large clostridial toxins,TcdA and *** toxins or forming spores are two different strategies for *** to cope with harsh environmental *** is of great significance to understand the molecular mechanisms for *** to skew to either of the cellular ***,we summarize the current understanding of the regulation and connections between toxin production and sporulation in *** and further discuss the potential solutions for yet-to-be-answered questions.

关键词： C.difficile sporulation TcdA TcdB toxin production

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO_2 nanostructures

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Science China Materials 2018年第4期61卷 557-564页

作者： Lei Qian Peng Yu jinquan zeng Zhifeng Shi Qiyou Wang Guoxin Tan Chengyun Ning School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China Biomedical Engineering Key Laboratory of Guangdong Province Guangzhou 510641China Guangzhou Tieyi Middle School Guangzhou 510660China Department of Spine Surgery the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Construction of functional porous titanium scaffold is drawing ever growing attention, due to its effectiveness in solving the mechanical mismatch between titanium implant and bone tissue. However, the poor water permeability as well as the problem in achieving uniform surface modification inside scaffold hinders the further biomedical application of porous titanium scaffold. In this study, largescale functional Ti O2 nanostructures（nanonetwork, nanoplate and nanowire） were constructed on three-dimensional porous titanium scaffolds surface via an effective hydrothermal treatment method. These nanostructures increase the hydrophilicity of the titanium scaffold surface, facilitating the cell culture medium to penetrate into the inner pore of the scaffold. Zeta potential analyses indicate that the surface electrical properties depend on the nanostructure, with nanowire exhibiting the lowest potential at p H 7.4. The influence of the nano-functionalized scaffold on protein adsorption and cell adhesion was examined. The results indicate that the nano-functionalized surface could modulate protein adsorption and bone marrow derived mesenchymal stem cells（BMSCs） adhesion, with the nanowire functionalized porous scaffold homogeneously promoting protein adsorption and BMSCs adhesion. Our research will facilitate future research on the development of novel functional porous scaffold.

关键词： porous titanium hydrothermal nanostructure scaffold cell adhesion

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软骨下骨病变在骨关节炎发病机制中的作用

中国细胞生物学学报 2020年第7期42卷 1255-1262页

作者：曾锦全柯俊杰武汉城市职业学院职业网球学院武汉430070 成都体育学院运动医学与健康学院成都610041

骨–软骨下骨是一个由关节透明软骨、钙化软骨和软骨下骨组成的整体功能单位,其中任何一个组织的变化都会直接或间接影响该复合单位内其他组织的结构及功能。它们之间的生物力学与生物化学分子的相互作用在关节稳态维持和关节退化中起... 详细信息

骨–软骨下骨是一个由关节透明软骨、钙化软骨和软骨下骨组成的整体功能单位,其中任何一个组织的变化都会直接或间接影响该复合单位内其他组织的结构及功能。它们之间的生物力学与生物化学分子的相互作用在关节稳态维持和关节退化中起到重要的作用。在骨关节炎中,关节软骨的损伤或缺损,使传递到软骨下骨上的机械负荷明显增加,导致软骨下骨异常骨重塑,同时出现微裂纹,使其正常力学性能被破坏。软骨下骨正常力学性能的破坏反过来又使得关节软骨承受更大的应力,导致软骨的损伤和退行性病变进一步加重。此外,软骨下骨异常骨重塑导致软骨下骨板孔隙增加和血管新生,为骨–软骨单元的生物化学分子的双向交流提供可能,从而促进骨关节炎的发生发展。

关键词：骨关节炎软骨下骨血管生成微裂纹骨髓损伤

间充质干细胞来源的细胞外囊泡修复骨缺损的作用机制

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生命的化学 2023年第4期43卷 528-540页

作者：曾锦全柯俊杰武汉城市职业学院职业网球学院武汉430070 四川省骨科医院康复医学科成都610041 成都体育学院运动医学与健康学院成都610041

临界骨缺损的再生修复是骨科研究的热点之一。在骨组织工程研究中,常通过调控间充质干细胞的基因表达改变细胞外囊泡的内部活性分子表达谱,从而增强细胞外囊泡的成骨活性,促进骨缺损的再生修复。然而,目前对于间充质干细胞来源的细胞外... 详细信息

临界骨缺损的再生修复是骨科研究的热点之一。在骨组织工程研究中,常通过调控间充质干细胞的基因表达改变细胞外囊泡的内部活性分子表达谱,从而增强细胞外囊泡的成骨活性,促进骨缺损的再生修复。然而,目前对于间充质干细胞来源的细胞外囊泡(mesenchymal stem cell-derived extracellular vesicles,MSC-EVs)促进骨缺损修复的具体机制尚不清晰。因此,本文通过查阅近年来MSC-EVs在骨缺损修复中的相关研究,阐述了MSC-EVs通过其内部活性物质促进骨缺损修复的作用机制,为科学合理应用MSC-EVs进行骨缺损的临床修复提供理论依据。

关键词：骨缺损细胞外囊泡间充质干细胞外泌体骨再生

线粒体自噬调控椎间盘退变的分子机制研究进展

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中国细胞生物学学报 2023年第2期45卷 266-273页

作者：曾锦全柯俊杰武汉城市职业学院职业网球学院武汉430070 成都体育学院运动医学与健康学院成都610041

椎间盘退变是一种常见的慢性退行性关节疾病。椎间盘退变的发病与髓核细胞的功能障碍或丧失密切相关。线粒体作为髓核细胞腺苷三磷酸(adenosine triphosphate,ATP)的主要来源,对维持髓核细胞生存和生理功能至关重要。线粒体自噬是近几... 详细信息

椎间盘退变是一种常见的慢性退行性关节疾病。椎间盘退变的发病与髓核细胞的功能障碍或丧失密切相关。线粒体作为髓核细胞腺苷三磷酸(adenosine triphosphate,ATP)的主要来源,对维持髓核细胞生存和生理功能至关重要。线粒体自噬是近几年发现的一种重要细胞生理过程,通常被认为是线粒体质量控制的一种主要机制。大量研究显示,线粒体自噬在椎间盘退变的发生和缓解过程中均发挥重要作用。因此,该文通过综述线粒体自噬与椎间盘退变的相关文献,探究sirtuins、Parkin和缺氧诱导因子1α(hypoxia-inducible factor 1-alpha,HIF-1α)等信号分子在线粒体自噬调控椎间盘退变的过程中可能起到的关键作用,总结线粒体自噬对椎间盘退变的具体调控机制,以期为椎间盘退变潜在治疗靶点的相关研究提供参考和依据。

关键词：椎间盘退变线粒体自噬髓核细胞自噬

基于GIS的闪电数据可视化监测与统计分析系统

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气象科学 2013年第2期33卷 202-207页

作者：路明月曾金全张烨方南京信息工程大学气象灾害省部共建教育部重点实验室南京210044 南京信息工程大学遥感学院南京210044 福建省防雷中心福州350001

基于ArcEngine开发平台,结合大型网络数据库sqlServer2005,设计并实现了基于GIS的闪电数据可视化监测与统计分析系统。有效地将闪电数据与GIS平台进行无缝对接,实现其相关数据管理、查询以及时空统计分析等功能,为气象部门进行有效的雷... 详细信息

基于ArcEngine开发平台,结合大型网络数据库sqlServer2005,设计并实现了基于GIS的闪电数据可视化监测与统计分析系统。有效地将闪电数据与GIS平台进行无缝对接,实现其相关数据管理、查询以及时空统计分析等功能,为气象部门进行有效的雷电灾害监测,更好地掌握雷电发生的规律提供有利的可视化平台,同时也为GIS与气象专业领域的结合进行了有益的探索。

关键词：雷电 GIS 时空分析可视化

Ka波段云雷达速度模糊质量控制及对云探测影响的评估

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国外电子测量技术 2022年第5期41卷 31-36页

作者：曾正茂曾金全黄新洲陈龙福郑佳锋福建省气象信息中心福州350001 厦门市气象局海峡气象开放实验室厦门362012 福建省灾害天气重点实验室福州350001 福建省气象灾害防御技术中心福州350001 闽侯县预警信息发布中心闽侯350100 福建省大气探测技术保障中心福州350008 成都信息工程大学大气科学学院高原大气与环境四川省重点实验室成都610225

针对Ka波段毫米波云雷达观测资料中出现的速度模糊问题,且结合雷达的实际性能特点,提出一种改进的速度退模糊算法。并利用福建平和县2018年9月~2019年10月的谱数据,定量评估雷达速度模糊对云-降水探测的具体影响。结果表明,提出的速度... 详细信息

针对Ka波段毫米波云雷达观测资料中出现的速度模糊问题,且结合雷达的实际性能特点,提出一种改进的速度退模糊算法。并利用福建平和县2018年9月~2019年10月的谱数据,定量评估雷达速度模糊对云-降水探测的具体影响。结果表明,提出的速度退模糊算法能有效纠正速度模糊问题;速度模糊发生率低,但造成的径向速度和谱宽的测量误差较大,径向速度V平均偏大1.17 m/s,谱宽σ;平均偏大2.09 m/s;福建平和县的速度模糊主要发生在融化层以下,由下沉运动导致,占99.43%。

关键词：毫米波云雷达速度退模糊评估