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Multicenter analysis on the correlation between the anatomical characteristics of hepatic veins and hepatic venous wedge pressure

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World Journal of Gastroenterology 2025年第9期31卷 43-53页

作者： Qiu-Xia Ye Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Yi-Fan lv Shao-Li You Sa lv Hui-Guo Ding Ying Han Yong-Ping Yang Bing Zhu Fu-Quan Liu Liver Disease Minimally Invasive Diagnosis and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Liver Vascular Disease Diagnosis and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China Department of Gastroenterology and Hepatology Beijing You’an HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND Wedged hepatic venous pressure(WHVP)is a crucial variable for accurately assessing the hepatic venous pressure gradient(HVPG)and is vital for the diagnosis and prognostic evaluation of patients with portal hypertension(PH).AIM To investigate the anatomical characteristics of balloon-occluded hepatic venous angiography in patients with PH and analyze the relationship between the WHVP and portal venous pressure(PVP).METHODS This retrospective study included 877 patients with PH who met the inclusion criteria from January 2020 to June *** and innovative hepatic venous angiography was performed during transjugular intrahepatic portosystemic shunt procedures to measure hepatic venous and *** patients'angiographic images were collected for *** associations between WHVP and PVP in each group were analyzed via linear regression analysis,and a predictive model was *** The 877 patients had a mean age of 52.6±13.0 years,with 582 males and 295 *** were categorized into four groups on the basis of their anatomical *** groups showed strong correlations between WHVP and *** regression coefficient between the WHVP and PVP in the hepatic right vein-portal venous angiography group was 0.884(P<0.05);in the hepatic right vein-accessory hepatic venous angiography group,it was 0.721(P<0.05);in the hepatic right vein-middle hepatic venous angiography group,it was 0.344(P<0.05);and in the hepatic right vein-nonangiography group,it was 0.293(P<0.05).CONCLUSION The presence and anatomical classification of hepatic venous collaterals are key factors influencing the relationship between WHVP with and *** on the different anatomical classifications of hepatic veins,WHVP can be used to estimate PVP,improving the accuracy of PVP prediction.

关键词： Wedged hepatic venous pressure Portal venous pressure Portal hypertension Collateral branches of the hepatic vein Transjugular intrahepatic portosystemic shunt

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Femtosecond mode-locking and soliton molecule generation based on a GaAs saturable absorber

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Chinese Physics B 2025年第1期34卷 344-349页

作者： Chen-Yan Zhang Xin-He Dou Zhen Chen Jing-Han Zhao Wei Sun Ze-Yu Fan Tao Zhang Hao Teng Zhi-Guo lv School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

In the last few years,research on advanced ultrafast photonic devices has attracted great interest from laser *** a semiconductor material with excellent nonlinear saturation absorption characteristics,Ga As has been used in solidstate and fiber lasers as a ***,the pulse widths that have been reported in the searchable published literature are all long and the shortest is tens of *** pulse widths,desired for a variety of applications,have not yet been reported in Ga As-based pulsed *** this work,we further explore the nonlinear characteristics of Ga As that has been magnetron sputtered onto the surface of a tapered fiber and its application in the generation of femtosecond lasing via effective dispersion optimization and nonlinearity *** the enhanced interaction between evanescent waves and Ga As nanosheets,mode-locked soliton pulses as short as 830 fs are generated at repetition rates of 4.64 *** far as we know,this is the first time that femtosecond-level pulses have been generated with a Ga As-based saturable *** addition,soliton molecules,including in the dual-pulse state,are also realized under stronger *** work demonstrates that Ga As-based photonic devices have good application prospects in effective polymorphous ultrashort pulsed laser generation.

关键词： GaAs saturable absorber mode-locking soliton molecule

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基于立德树人理念的教育教学改革探索——以“空间环境探测技术”课程为例

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科教导刊 2022年第23期 115-117页

作者：郭义盼方美华全荣辉吕金鹏于丹南京航空航天大学航天学院江苏南京210016

在“立德树人作为教育的根本任务”引领下,文章以“空间环境探测技术”理论课程为例,探索了专业课程与思政教育相结合以及由传统讲授式教学向“以学生为中心”转变的教育教学模式的改革方式。同时,也探讨了教学方法与手段多样化以及线... 详细信息

在“立德树人作为教育的根本任务”引领下,文章以“空间环境探测技术”理论课程为例,探索了专业课程与思政教育相结合以及由传统讲授式教学向“以学生为中心”转变的教育教学模式的改革方式。同时,也探讨了教学方法与手段多样化以及线上多资源的利用使得课程具有多元化、多层次感。最终力求使思政教育贯穿课程内容,学生参与度和满意度增加,积极性和主动性提高,人才培养质量也随之提升。

关键词：立德树人思政教育改革线上多资源

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Chasing in virtual environment:Dynamic alignment for multi-user collaborative redirected walking

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Virtual Reality & Intelligent Hardware 2025年第1期7卷 26-46页

作者： Tianyang Dong Shuqian lv Hubin Kong Huanbo Zhang College of Computer Science and Technology Zhejiang University of Technology Hangzhou 310004 China

Background The redirected walking (RDW) method for multi-user collaboration requires maintaining the relative position between users in a virtual environment (VE) and physical environment (PE). A chasing game in a VE is a typical virtual reality game that entails multi-user collaboration. When a user approaches and interacts with a target user in the VE, the user is expected to approach and interact with the target user in the corresponding PE as well. Existing methods of multi-user RDW mainly focus on obstacle avoidance, which does not account for the relative positional relationship between the users in both VE and PE. Methods To enhance the user experience and facilitate potential interaction, this paper presents a novel dynamic alignment algorithm for multi-user collaborative redirected walking (DA-RDW) in a shared PE where the target user and other users are moving. This algorithm adopts improved artificial potential fields, where the repulsive force is a function of the relative position and velocity of the user with respect to dynamic obstacles. For the best alignment, this algorithm sets the alignment-guidance force in several cases and then converts it into a constrained optimization problem to obtain the optimal direction. Moreover, this algorithm introduces a potential interaction object selection strategy for a dynamically uncertain environment to speed up the subsequent alignment. To balance obstacle avoidance and alignment, this algorithm uses the dynamic weightings of the virtual and physical distances between users and the target to determine the resultant force vector. Results The efficacy of the proposed method was evaluated using a series of simulations and live-user experiments. The experimental results demonstrate that our novel dynamic alignment method for multi-user collaborative redirected walking can reduce the distance error in both VE and PE to improve alignment with fewer collisions.

关键词： Virtual reality Multi-user redirected walking User collisions Dynamic alignment

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A self-adaptive inorganic in-situ separator by particle crosslinking for nonflammable lithium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 469-480页

作者： Jiarui Yang Jiuzhou Liu Wenrui Cai Ziyu Zhao Shan Wang Lu He Shanshan lv Zhiwei Zhu Zhongfeng Ji Guojiang Wen Hua Li Yuanming Zhai Xuewei Fu Wei Yang Yu Wang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina

All-safe liquid-state lithium-ion batteries(ASLS-LIBs) is of great interest as they can potentially combine the safety of all-solid-state batteries with the high performance and low manufacturing cost of traditional liquid-state LIBs. However, the practical success of ASLS-LIBs is bottlenecked by the lack of advanced separator technology that can simultaneously realize high performances in puncturing-tolerability,fire-resistance, and importantly, wetting-capability with non-flammable liquid-electrolytes. Here, we propose a concept of inorganic in-situ separator(IISS) by hybrid-sol physical crosslinking directly onto the electrode surface to address the above challenges. Particularly, the hybrid-sol is designed with silica nanoparticles as the building block and poly(vinylidene difluoride) nanoparticles as the crosslinking agent. The critical factors for controlling the IISS microstructures and properties have been systematically investigated. The advantages of the IISS have been confirmed by its fast wetting with various fireresistant liquid-electrolytes, customizable thickness and porous structures, robust interface with planar or three-dimensional(3D)-structured electrodes, and importantly, unexpected self-adaptability against puncturing. Enabled by the above merits, a fire-resistant ASLS-LIB is successfully assembled and demonstrated with stable electrochemical performance. This sol-crosslinked IISS may open an avenue for the studies on the next-generation separator technology, cell assembling, solid electrolyte processing as well as non-flammable secondary batteries.

关键词： Safe liquid-state lithium-ion batteries In-situ separator technology Hybrid-sol physical crosslinking Electrode coating Inorganic nonflammable separator

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Muti-Biomarker Approach and IBR Index to Evaluate the Oxidative Stress of Nanoplastic on the Clams,Meretrix meretrix and Sinonovacula constricta

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Journal of Ocean University of China 2025年第1期24卷 249-258页

作者： lv Linlan FENG Wanjun SUN Ke ZHAO Weihong JIANG Fengjuan MOHAMED Mohsen LI Lei YANG Yue ZHANG Yingying SUI Yanming DONG Xuexing Department of Ocean Technology Key Laboratory for Aquaculture and Ecology of Coastal Pool of Jiangsu ProvinceYancheng Institute of TechnologyYancheng 224000China Department of Animal Production Faculty of AgricultureAl-Azhar UniversityNasr CityCairo 11884Egypt CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266000China East China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai 20090China

Nanoplastic(NP)contaminants are receiving increasing attention due to the harm they can cause to aquatic organisms and their accumulation in the human body through the food *** goal of this study was to evaluate the oxidative stress caused by NPs on the clams Meretrix meretrix and Sinonovacula *** were exposed to three concentrations of fluorescently labeled polystyrene NPs(PS-NPs;0,0.1,and 1 mg L^(-1))for 7 d followed by a 3 d recovery *** activities of antioxidant enzymes,such as catalase(CAT),superoxide dismutase(SOD),glutathione peroxidase(GPx)and the content of malonaldehyde(MDA)were measured in the digestive gland,gills,and mantle *** showed that the SOD activity in the gills of *** was significantly higher than that of the control at day 1,and PS-NPs exposure inhibited the CAT activity in the gills and SOD and GPx activities in the *** to low or high concentrations of PS-NPs increased the activities of both CAT and GPx in the gills of *** at day *** oxidative damage was more severe in the digestive gland of *** and in the mantle of *** based on MDA level,and it returned to normal after *** biomarker response,index version 2(IBRv2)values showed that the gills were more sensitive to PS-NPs than mantle and digestive ***,the oxidative stress by PS-NPs depended on exposure time,dose,organ,and species.

关键词： biomarker antioxidant enzyme Meretrix meretrix Sinonovacula constricta nanoplastics oxidative stress

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Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

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Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei Hu Li-Jun Xu Sheng-Xia Zhang Peng-Fei Zhai Ling lv Xiao-Yu Yan Zong-Zhen Li Yan-Rong Cao Xue-Feng Zheng Jian Zeng Yuan He Jie Liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

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Associations of multiple metals exposure with immunoglobulin levels in pregnant women:Hangzhou Birth Cohort Study

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Journal of Environmental Sciences 2025年第5期151卷 560-572页

作者： Jiena Zhou Lanfei Jin Yexinyi Zhou Kunhong Zhong Kegui Huang Qi Zhang Jun Tang Xue Zhang Lihe Peng Shuai Li Na lv Dongdong Yu Qinheng Zhu Jing Guo Qiong Luo Guangdi Chen Department of Public Health and Key Laboratory of Reproductive Genetics(Ministry of Education)Women’s HospitalZhejiang University School of MedicineHangzhou 310058China Department of Clinical Laboratory Shaw HospitalZhejiang University School of MedicineHangzhou 310018China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China Jiashan County Center for Disease Control and Prevention JiashanZhejiang 314199China Department of Clinical Laboratory Women’s HospitalZhejiang University School of MedicineHangzhou 310020China Department of Obstetrics Women’s HospitalZhejiang University School of MedicineHangzhou 310020China

Metal may affect maternal immune function,but few epidemiological studies have reported the associations between multiple-metal exposure and maternal immunoglobulin(Ig)*** on the Hangzhou Birth Cohort Study,1059 participants were included,and eleven metals in whole blood samples and serum IgA,IgG,IgE and IgM levels were *** regression,quantile-based g-computation(QGC),and Bayesian kernel machine regression(BKMR)models were used to evaluate the *** with the first tertile of metal levels,arsenic(As)was negatively associated with IgE(β=-0.25,95%confidence interval(CI)=-0.48 to-0.02).Moreover,significant associations of manganese(Mn)with IgA,IgG and IgM were demonstrated(β=0.10,95%CI=0.04 to 0.18;β=0.07,95%CI=0.03 to 0.12;β=0.10,95%CI=0.03 to 0.18,respectively).Cadmium(Cd)were associated with higher levels of *** models showed the positive association of the metalmixtures with IgA and IgG,with Mn playing amajor *** and Cd had positive contributions to IgM,while As had negative contributions to *** the BKMR models,the latent continuous outcomes of IgA and IgG showed a significant increase when all the metals were at their 60th percentile or above compared to those at their 50th ***,exposure to metals was associated with maternal Igs,and mainly showed that Mn was associated with increased levels of IgA,IgG and IgM,and As was associated with low IgE levels.

关键词： Metals Immunoglobulin Pregnant woman Quantile-based g-computation (QGC) Bayesian kernel machine regression (BKMR)

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Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway,as determined by network pharmacology

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 221-236页

作者： Zhuo-Cong Bao Ye Zhang Zhao-Dong Liu Hui-Jun Dai Fu Ren Ning Li Shang-Yu lv Yan Zhang Graduate School Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Clinical Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina International Education School International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality *** study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin(THC)on HCC and its mechanism of *** research hypothesis is that THC can inhibit the proliferation,migration,and invasion of HCC cells,and promote their apoptosis by regulating the TP53 target *** To explore the mechanism by which THC inhibits HCC cell proliferation via the TP53 signaling *** Potential targets of THC and HCC were identified from multiple *** core targets were subjected to analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,and visualization processing,using the online platform Metascape to identify the key molecules and signaling pathways involved in the action of THC against *** molecular mechanisms of action of THC against TP53 in the inhibition of HCC cells were verified using cell counting kit-8,Transwell,apoptosis,and western blotting *** Molecular docking results showed that THC had a high score for the TP53 target *** vitro experiments indicated that THC effectively inhibited the proliferation and migration of HCC cells,and affected the expression levels of TP53,MDM2,cyclin B,Bax,Bcl-2,caspase-9,and *** THC induces the apoptosis of HCC cells through the TP53 signaling pathway,thereby inhibiting their proliferation and migration.

关键词： Hepatocellular carcinoma cells Tetrahydrocurcumin TP53 Network pharmacology Molecular docking

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NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University Department of Critical Care Medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University Department of Emergency The First Affiliated Hospital of Guangxi Medical University College & Hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

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