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Science China Chemistry 2013年第11期56卷 1578-1585页

作者： NING Hui SONG jinliang hou MinQiang YANG DeZhong FAN HongLei HAN BuXing Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

In this work,we synthesized tin(IV)phosphonate(SnBPMA)and zirconium phosphonate(ZrBPMA)by the reaction of SnCl4·5H2O or ZrOCl2·8H2O with N,N-bis(phosphonomethyl)aminoacetic acid,which was synthesized from a biomaterial glycine through a Mannich-type *** SnBPMA and ZrBPMA were very efficient heterogeneous catalysts for the dehydration of fructose to produce 5-hydroxymethylfurfural(HMF),and the SnBPMA had higher activity than the *** effects of solvents,temperature,reaction time,and reactant/solvent weight ratio on the reaction catalyzed by SnBPMA were *** was demonstrated that the yield of HMF could reach 86.5%with 1-ethyl-3-methylimidazolium bromide([Emim]Br)as solvent,and the SnBPMA and SnBPMA/[Emim]Br catalytic system could be reused five times without considerable reduction in catalytic *** study indicated that the SnBPMA and ZrBPMA in[Emim]Br were also effective for the dehydration of sucrose and inulin to produce HMF with satisfactory yields.

关键词： fructose inulin sucrose dehydration 5-hydroxymethylfurfural heterogeneous catalysts

一起特高压换流变压器油中总烃超标问题的分析和处理

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山东电力高等专科学校学报 2024年第1期27卷 18-21页

作者：侯全兵张金良胡鹏飞赵拓侯永涛山东电工电气集团有限公司山东济南250001 山东电力设备有限公司山东济南250001

某特高压换流变压器运行时油中总烃超标,最后被迫退出运行,返厂检修。利用油色谱分析、长时空载试验、局部放电试验、超声波定位、解体检查等手段,对故障原因进行分析,最终确定换流变压器总烃超标与三角形硅钢片、纠结线虚焊导致的两处... 详细信息

某特高压换流变压器运行时油中总烃超标,最后被迫退出运行,返厂检修。利用油色谱分析、长时空载试验、局部放电试验、超声波定位、解体检查等手段,对故障原因进行分析,最终确定换流变压器总烃超标与三角形硅钢片、纠结线虚焊导致的两处过热点有关,并进行了相应处理,处理后换流变压器顺利通过了出厂试验,为类似故障的分析和处理提供了参考。

关键词：油色谱分析总烃三角形硅钢片过热虚焊

沉香片剂小鼠口鼻吸入给药抗焦虑和催眠功效实验研究

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山东中医药大学学报 2021年第1期45卷 113-119页

作者：侯金良张媛媛张浩耿希文李自发齐冬梅邓华亮魏盛济宁市食品药品检验检测中心山东济宁272025 潍坊护理职业学院山东潍坊262500 山东中医药大学实验中心山东济南250355

目的:通过多种行为学检测,考察沉香片剂口鼻吸入给药对小鼠睡眠质量与焦虑状态的影响。方法:沉香片剂通过吸入给药模拟沉香传统给药方式,①利用焦虑三联小鼠行为模型,选择沉香片剂口鼻吸入给药评价其抗焦虑功效;②采用阈上和阈下剂量戊... 详细信息

目的:通过多种行为学检测,考察沉香片剂口鼻吸入给药对小鼠睡眠质量与焦虑状态的影响。方法:沉香片剂通过吸入给药模拟沉香传统给药方式,①利用焦虑三联小鼠行为模型,选择沉香片剂口鼻吸入给药评价其抗焦虑功效;②采用阈上和阈下剂量戊巴比妥钠协同催眠小鼠范式,选择沉香片剂口鼻吸入给药评价其催眠功效。结果:沉香片剂小剂量组能明显增加旷场实验中央区路程,沉香片剂小、中剂量组能明显延长旷场实验中央区停留时间;沉香片剂小、中、大剂量组能明显延长明暗箱明区停留时间;沉香片剂小、中、大剂量组能明显缩短阈上剂量戊巴比妥钠睡眠潜伏期、延长睡眠时间,沉香片剂中剂量组更能明显增多阈下剂量戊巴比妥钠动物睡眠只数。结论:沉香片剂口鼻吸入给药表现出明显抗焦虑活性,并能显著促进小鼠睡眠,对其自主活动无明显影响,同时证明了沉香口鼻吸入给药用于临床和亚临床抑郁症状治疗的合理性。

关键词：沉香片剂口鼻吸入抗焦虑旷场实验高架十字迷宫实验明暗箱实验戊巴比妥钠协同催眠小鼠

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银盘的径向金属丰度梯度

天文学进展 2001年第1期19卷 68-81页

作者：侯金良常瑞香中国科学院上海天文台

详细综述了银盘（包括ＨＩＩ区，早Ｂ型星，行星状星云和疏散星团）径向元素丰度梯度的观测结果，分析了丰度梯度的空间和时间变化情况，指出根据目前的观测结果，还很难确定在银盘的演化历史中径向元素丰度梯度是逐渐变平缓还是逐渐变... 详细信息

详细综述了银盘（包括ＨＩＩ区，早Ｂ型星，行星状星云和疏散星团）径向元素丰度梯度的观测结果，分析了丰度梯度的空间和时间变化情况，指出根据目前的观测结果，还很难确定在银盘的演化历史中径向元素丰度梯度是逐渐变平缓还是逐渐变陡。比较了目前各种化学演化模型对径向丰度梯度演化的预测结果，初步探讨了丰度梯度可能的产生机制及影响其演化的各种重要物理过程。

关键词：银河系丰度梯度观测模型银盘化学演化径向元素产生机制

Diagenesis and Diagenetic Evolution of Deltaic and Neritic Gas-Bearing Sandstones in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin: Implications for Depositional Environments and Sequence Stratigraphy Controls

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Acta Geologica Sinica(English Edition) 2015年第5期89卷 1625-1635页

作者： XU Fa ZHANG Penghui ZHANG jinliang LIU Jinshui hou Guowei ZHANG Ming LI Jingzhe LIU Shasha GUO Jiaqi MENG Ningning Shanghai Branch of CNOOC Ltd. Qingdao Institute of Marine Geology College of Resources Science & Technology Beijing Normal University College of Marine Geosciences Ocean University of China

Gas-bearing deposits in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin consist of shoreface sandstones of the highstand systems tract（HST） and transgressive systems tract（TST）, and deltaic sandstones of the lowstand systems tract（LST） and falling stage systems tract（FSST）.Detailed petrographic observations suggest that the diagenetic features and related evolution of these deposits cannot be simply characterized and demonstrated in the depth ***, the occurrence of diagenetic minerals systematically depends on the studied interval within the HST, TST, LST, and FSST; therefore, diagenesis in this region can be better constrained when studied in the context of the depositional environments and sequence stratigraphic *** eogenetic processes in such settings include：（1） microcrystalline siderite precipitated as concretions in almost all environments and systems tracts, which inhibited further mechanical compaction;（2） grain dissolution and kaolinitization occurred in shoreface HST sandstones and deltaic LST and FSST sandstones;（3） glaucony was locally observed, which did not clearly reflect the controls of facies or sequence stratigraphy; and（4） cementation by pyrite aggregates occurred in the shoreface HST sandstones and deltaic LST *** mesogenetic diagenesis includes：（1） partial conversion of kaolinite into dickite in deltaic LST sandstones, and minor chlorite cementation in deltaic FSST sandstones;（2） transformation of kaolinite into illite and quartz cementation in deltaic LST and FSST sandstones;（3） frequent precipitation of ankerite and ferroan calcite in shoreface TST sandstones and early HST sandstones, forming baffles and barriers for fluid flow, with common calcite in shoreface HST sandstones as a late diagenetic cement; and（4） formation of dawsonite in the deltaic LST and FSST sandstones, which is interpreted to be a product of the invasion of a CO2-rich fluid, and acts as a good indicator o

关键词： diagenetic alteration depositional environment sequence stratigraphy reservoir quality Paleogene East China Sea Shelf Basin

基于RCC-M规范建造的核电站一回路水压试验工艺优化研究

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电工技术 2024年第9期 198-200,203页

作者：程钢刘伯欢冉威侯帆叶金梁詹震宇中广核核电运营有限公司广东深圳518000

就ASME和RCC-M两种体系标准关于压力试验的技术差异开展了溯源研究,结合断裂力学计算结果与压力爆破试验数据对水压试验的目的和能力进行了分析,通过论述超声技术的发展和研究一回路边界完整性,得出泄漏试验替代水压试验对一回路完整性... 详细信息

就ASME和RCC-M两种体系标准关于压力试验的技术差异开展了溯源研究,结合断裂力学计算结果与压力爆破试验数据对水压试验的目的和能力进行了分析,通过论述超声技术的发展和研究一回路边界完整性,得出泄漏试验替代水压试验对一回路完整性不会带来负面影响的结论。

关键词： RCC-M规范一回路水压试验工艺优化

Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

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Cancer Communications 2022年第1期42卷 37-55页

作者： Dan Wu Yi Yang Yiran hou Zifeng Zhao Ning Liang Peng Yuan Tao Yang jinliang Xing Jibin Li Department of Physiology and Pathophysiology State Key Laboratory of Cancer BiologyFourth Military Medical UniversityXi’anShaanxi 710032P.R.China Department of Pain Treatment Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710032P.R.China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710038P.R.China Experimental Teaching Center of Basic Medicine Fourth Military Medical UniversityXi’anShaanxi 710038P.R.China

Background:Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion ***,abnormally increased mitochondrial fission has been observed in several types of ***,the functional roles of increased mitochondrial fission in lipid metabolism reprogramming in cancer cells remain *** study aimed to explore the role of increased mitochondrial fission in lipid metabolism in hepa-tocellular carcinoma(HCC)***:Lipid metabolism was determined by evaluating the changes in the expressions of core lipid metabolic enzymes and intracellular lipid *** rate of fatty acid oxidation was evaluated by[PH]-labelled oleic *** mito-chondrial morphology in HCC cells was evaluated by fluorescent *** expression of protein was determined by real-time PCR,imnmunohistochemistry and Western ***:Activation of mitochondrial fission significantly promoted de novo fatty acid synthesis in HCC cells through upregulating the expression of lipogenic genes fatty acid synthase(FASN),acetyl-CoA carboxylasel(ACCI),and elonga-tion of very long chain fatty acid protein 6(ELOVL6),while suppressed fatty acid oxidation by downregulating carnitine palmitoyl transferase 1A(CPTIA)and acyl-CoA oxidase 1(ACOX1).Consistently,suppressed mitochondrial fission exhibited the opposite ***,in vitro and in vivo studies revealed that mitochondrial fission-induced lipid metabolism reprogramming significantly promoted the proliferation and metastasis of HCC ***,mito-chondrial fission increased the acetylation level of sterol regulatory element-binding protein 1(SREBPI)and peroxisome proliferator-activated receptor coaC-tivator 1 alpha(PGC-1a)by suppressing nicotinamide adenine dinucleotide(NAD+)/Sirtuin 1(SIRTI)*** elevated SREBP1 then upregulated the expression of FASN,ACC1 and ELOVL6 in HCC cells,while PGC-1c/PPARa sup-pressed the expression of CPTIA and ACOXL Conclusi

关键词： hepatocellular carcinoma lipogenesis fatty acid oxidation metabolic reprogramming mito-chondrial fission Sirtuin 1

Progress in China's Unconventional Oil & Gas Exploration and Development and Theoretical Technologies

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Acta Geologica Sinica(English Edition) 2015年第3期89卷 938-971页

作者： ZOU Caineng YANG Zhi ZHU Rukai ZHANG Guosheng hou Lianhua WU Songtao TAO Shizhen YUAN Xuanjun DONG Dazhong WANG Yuman WANG Lan HUANG jinliang WANG Shufang PetroChina Research Institute of Petroleum Exploration & Development

The new century has witnessed a strategic breakthrough in unconventional oil ＆ *** accumulated in micro-/nano-scale pore throat shale systems has become an important domain that could replace current oil ＆ gas *** oil ＆ gas plays an increasingly important role in our energy *** gas,CBM,heavy oil and asphaltic sand have served as a key domain of exploration ＆ development,with tight oil becoming a ＇bright spot＇ domain and shale gas becoming a ＇hotspot＇ *** has made great breakthroughs in unconventional oil ＆ gas resources,such as tight gas,shale gas,tight oil and CBM,and great progress in oil shale,gas hydrate,heavy oil and oil *** has an estimated（223-263）×10~8t of unconventional oil resources and（890-1260）×l0^（12）m^3 of gas *** has made a breakthrough for progress in unconventional oil ＆ gas *** progress achieved in fine-grained sedimentary studies related to continental open lacustrine basin large-scale shallow-water delta sand bodies,lacustrine basin central sandy clastic flow sediments and marine-continental fine-grained sediments provide a theoretical basis for the formation and distribution of basin central reservoir *** breakthroughs have been made in unconventional reservoir geology in respect of research methodology ＆ technology,multi-scale data merging and physical simulation of formation *** characterization of unconventional reservoirs via multi-method and multi-scale becomes increasingly popular and facilitates the rapid development of unconventional oil ＆ gas geological theory,method and *** formation of innovative,continuous hydrocarbon accumulation theory,the establishment of the framework of the unconventional oil ＆ gas geological theory system,and the determination of the implications,geological feature,formation mechanism,distribution rule and core technology of unconventional oil＆ gas geological study lays a theoretical foundation for ext

关键词： Unconventional oil and gas Unconventional Petroleum geology fine-grainedsedimentology unconventional reservoir geology "man-made reservoir" development micro-/nano- scalepore throat tight gas tight oil shale gas shale oil

Electrocardiogram abnormalities and higher body mass index as clinically applicable factors for predicting poor outcome in patients with coronavirus disease 2019

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Frigid Zone Medicine 2022年第4期2卷 251-256页

作者： Zhidan Sun Yan hou Zheng Zhang Benzhi Cai jinliang Li Department of Pharmacy The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Epidemiology and Biostatistics Public Health SchoolHarbin Medical UniversityHarbin 150081China Department of Critical Care Medicine Harbin Infectious Disease HospitalHarbin 150030China Department of Cardiology Harbin Infectious Disease HospitalHarbin 150030China

Background:Patients with coronavirus disease 2019(COVID-19)have high resource *** the causes of severe COVID-19 is helpful for early intervention to reduce the consumption of medical ***:We included 103 patients with COVID-19 in this single-center observational *** evaluate the incidence,predictors,and effects of COVID-19,we analyzed demographic information,laboratory results,comorbidities,and vital signs as factors for association with severe ***:The incidence of severe COVID-19 was 16.5%and the percent poor outcome(including mortality,entering in ICU or transferred to a superior hospital)was 6.8%.The majority of severe COVID-19 patients had abnormal electrocardiogram(ECG)(82.35%),hypertension(76.47%)and other cardiac diseases(58.82%).Multivariate logistic regression was used to determine the predictors of severe *** body mass index(BMI)and ECG(P<0.05)were independent predictors of severe *** abnormality was associated with increased odds of poor outcome(area under the receiver operating characteristic curves[AUC],0.793;P=0.010)and severe COVID-19(AUC,0.807;P<0.0001).Overweight was also associated with increased odds of poor outcome(AUC,0.728;P=0.045)and severe illness COVID-19(AUC,0.816;P<0.0001).Conclusion:Overweight and electrophysiological disorders on admission are important predictors of prognosis of patients with COVID-19.

关键词： electrocardiogram abnormalities overweight coronavirus disease 2019

The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation

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aBIOTECH 2022年第3期3卷 178-196页

作者： Xuezhu Liao Yuanjun Ye Xiaoni Zhang Dan Peng Mengmeng hou Gaofei Fu Jianjun Tan Jianli Zhao Rihong Jiang Yechun Xu Jinmei Liu jinliang Yang Wusheng Liu Luke RTembrock Genfa Zhu Zhiqiang Wu Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518120China Guangdong Provincial Key Lab of Ornamental Plant Germplasm Innovation and Utilization Environmental Horticulture Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou510640China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology Yunnan UniversityKunming650504China Guangxi Engineering and Technology Research Center for Woody Spices Guangxi Key Laboratory for Cultivation and Utilization of Special Non-Timber Forest CropsGuangxi Forestry Research InstituteNanning530002China Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE68583USA Department of Horticultural Science North Carolina State UniversityRaleighNC27607USA Department of Agricultural Biology Colorado State UniversityFort CollinsCO80523USA Kunpeng Institute of Modern Agriculture at Foshan Foshan528200China

Compared with most flowers where the showy part comprises specialized leaves(petals)directly subtending the reproductive structures,most Zingiberaceae species produce showy“flowers”through modifications of leaves(bracts)subtending the true flowers throughout an *** alismatifolia,belonging to the Zingiberaceae family,a plant species originating from Southeast Asia,has become increasingly popular in the flower market worldwide because of its varied and esthetically pleasing bracts produced in different ***,we present the chromosome-scale genome assembly of ***“Chiang Mai Pink”and explore the underlying mechanisms of bract *** genomic analysis revealed *** contains a residual signal of whole-genome *** genes,including pigment-related genes,exhibit functional and structural differentiation resulting in diverse bract colors among *** *** addition,we identified the key genes that produce different colored bracts in ***,such as F3′5'H,DFR,ANS and several transcription factors for anthocyanin synthesis,as well as chlH and CAO in the chlorophyll synthesis pathway by conducting transcriptomic analysis,bulked segregant analysis using both DNA and RNA data,and population genomic *** work provides data for understanding the mechanism of bract pigmentation and will accelerate breeding in developing novel cultivars with richly colored bracts in *** and related *** is also important to understand the variation in the evolution of the Zingiberaceae family.

关键词： Anthocyanin synthesis Siam tulip Floriculture Zingiberaceae Genome evolution