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Association between statin therapy and the risk of stroke in patients with moyamoya disease:a nationwide cohort study

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Stroke & Vascular Neurology 2023年第4期8卷 276-283,I0010-I0021页

作者： Joonsang Yoo Jimin Jeon Minyoul Baik jinkwon kim Department of Neurology Yongin Severance HospitalYonsei College of MedicineYongin-siKorea(the Republic of) Institute for Innovation in Digital Healthcare Yonsei UniversitySeoulKorea(the Republic of)

Background and objective Knowledge regarding the pharmacological treatment for moyamoya disease(MMD),a chronic and progressive cerebrovascular disease conferring greater stroke risk,is *** the present study,whether statin therapy is associated with a reduced risk of stroke in patients with MMD was *** This was a retrospective cohort study in which the occurrence of stroke in patients with newly diagnosed MMD was investigated using the nationwide health insurance database in Korea from January 2007 to March 2021.A multivariable Cox proportional hazards regression model was constructed for stroke,in which statin therapy after MMD diagnosis was treated as a time-dependent *** was done for sex,age,presence of comorbidities,concurrent stroke,revascularisation surgery and treatment with *** The present study included 13373 newly diagnosed patients with MMD;40.8%had a concurrent stroke at the time of MMD *** the mean follow-up of 5.1±3.3 years,631 patients(4.7%)suffered a stroke event(haemorrhagic stroke:458 patients,ischaemic stroke:173 patients).Statin therapy after MMD diagnosis was significantly associated with a reduced risk of stroke(adjusted HR 0.74;95%CI 0.60 to 0.91,p=0.004).In the secondary outcome analysis,the risk of haemorrhagic stroke(adjusted HR 0.74;95%CI 0.58 to 0.95,p=0.018)and ischaemic stroke(adjusted HR 0.75;95%CI 0.52 to 1.08,p=0.124)were reduced with the statin *** statins was also associated with a lower risk of all-cause mortality(adjusted HR 0.47;95%CI 0.33 to 0.67,p<0.001).Conclusion In patients with MMD,statin therapy was associated with a reduced risk of subsequent *** findings indicate statin treatment may be beneficial for patients with MMD,however the results should be confirmed in randomised controlled trials.

关键词： patients diagnosis nationwide

Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm:a nationwide cohort study

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Stroke & Vascular Neurology 2024年第5期9卷 560-567页

作者： Minyoul Baik Jimin Jeon jinkwon kim Joonsang Yoo Department of Neurology Yongin Severance HospitalYonsei University College of MedicineYongin-siGyeonggi-doKorea(the Republic of)

Introduction Stent-assisted coil embolisation(SACE)for the treatment of unruptured cerebral aneurysms has been increasingly ***-term advantages of antiplatelet therapy(APT)post-SACE treatment are still not well *** investigated the long-term effects of APT on clinical prognosis after *** and methods We conducted a retrospective study using nationwide health insurance claims data from South Korea,including patients with cerebral aneurysm treated with SACE from January 2009 to December *** study outcomes consisted of the occurrence of cerebral infarction and major *** evaluate the impact of APT,we employed a multivariable time-dependent Cox proportional hazards regression model for each of the three distinct periods:1–12 months,12–24 months and>24 months after *** This study included 17692 unruptured cerebral aneurysm patients treated with *** the mean follow-up of 4.2 years,there were 379(2.1%)patients with cerebral infarction and 190(1.1%)patients with major *** percentage of patients receiving APT was 79.5%at 1year,which gradually decreased to 58.3%at 2 years after *** was beneficial in preventing cerebral infarction within 12 months after SACE(adjusted HR(aHR)0.56;95%CI,0.35 to 0.89;p=0.014).After 12 months,this association was not *** increased the risk of haemorrhage after 24 months(aHR 1.76;95%CI 1.11 to 2.87;p=0.016).Discussion and conclusion Our findings suggest that in patients with unruptured cerebral aneurysm treated with SACE,the reasonable duration of APT for preventing cerebral infarction might be 1year after SACE.

关键词： cerebral aneurysm nationwide

Potentially inappropriate prescribing of cardiovascular system and antiplatelet/anticoagulant drugs among elderly patients:a Korean population-based national study

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Journal of Geriatric Cardiology 2021年第5期18卷 327-337页

作者： Jongyeon kim Euna Han Hee-Jin Hwang Hyeonseok Cho Young-Sang kim Hyejin Chun jinkwon kim Yon Chul Park Hye-Young Kang Department of Pharmaceutical Medicine and Regulatory Sciences Colleges of Medicine and PharmacyYonsei UniversityIncheonSouth Korea College of Pharmacy Yonsei Institute of Pharmaceutical SciencesYonsei UniversityIncheonSouth Korea Department of Family Medicine Catholic Kwandong University International St.Mary’s HospitalIncheonSouth Korea Department of Family Medicine CHA Bundang Medical CenterCHA UniversitySeongnamSouth Korea Department of Neurology Yongin Severance HospitalYonsei University College of MedicineYonginSouth Korea Department of Family Medicine Wonju Severance Christian HospitalWonjuSouth Korea

OBJECTIVES To investigate the prevalence of potentially inappropriate prescribing(PIP)for cardiovascular system(CVS)and antiplatelet/anticoagulant(AP/AC)drugs among Korean elderly patients,using the Screening Tool of Older Persons’Prescriptions(STOPP)criteria version 2 and to identify the risk factors related to *** The 2016 National Aged Patient Sample data,comprising National Health Insurance claim records for a random sample of 20%of patients aged≥65 years,were used to calculate PIP prevalence of outpatient *** criteria including drugdisease interactions,PIP prevalence per indication was *** Among 1,274,148 elderly patients and 27,062,307 outpatient prescription claims,100,085 patients(7.85%)and 341,664 claims(1.27%)had one or more *** most frequent PIP was“nonsteroidal antiinflammatory drug with concurrent antiplatelet agent(s)without protonpump inhibitor prophylaxis”in the claimlevel(0.97%)and patientlevel(6.33%)analyses.“Betablocker with bradycardia”(16.47%of claims)and“angiotensin receptor blockers in patients with hyperkalaemia”(23.89%of claims)showed the highest PIP prevalence per *** regression analysis revealed that,among the patient and health care provider characteristics,female,older age,more severe comorbidities,polypharmacy,higher level of healthcare organization,and specialty of prescriber were significantly associated with a higher risk of *** Our findings of a high prevalence of PIP for CVS and AP/AC drugs among the elderly suggest that an effective strategy is urgently needed to improve the prescription practices of these drugs.

关键词： drugs patients prescription

Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： jinkwon Lee Gyeonghwa kim Tae-Su Han Eunsun Jung Taesang Son Kwangho kim Kiyoon Kwon Yuna Roh Tae Young Ryu In Hwan Tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo Young Park Won Young Tak Dae-Soo kim Mi-Young Son Keun Hur Hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

Improvement of Renewable Bioenergy Production in Microbial Fuel Cells with Saponin Supplementation

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Journal of Sustainable Bioenergy Systems 2021年第2期11卷 82-93页

作者： Skylar Choi Yongjin Park Immanuel H. Anaborne Jin Sik Song Ji Woo Han So Hyun Jeon Jaewoo kim James kim jinkwon Lee Paul S. Chung Horace Greeley High School Chappaqua NY USA Deerfield Academy Deerfield MA USA Oakton High School Vienna VA USA School of Arts & Sciences University of Virginia Charlottesville VA USA School of Arts & Sciences Emory University Atlanta GA USA Bachelor of Science Villanova University Villanova PA USA College of Letters & Sciences University of California Los Angeles Los Angeles CA USA School of Arts & Sciences University of Michigan Ann Arbor MI USA Division of Biological Sciences Revelle College University of California San Diego CA USA Fuzbien Technology Institute Rockville MD USA

Microbial fuel cell (MFC) is one of renewable biofuel production technology that directly converts biomass to electricity. Cellulosic biomass is particularly attractive renewable resources for its low cost and abundance and neutral carbon balance. However, methanogenesis remains as a major factor limiting MFC performance. The current study reports that saponin addition at 0.05% w/v dose to anolyte in MFCs inhibited methanogenesis and improves power generation and cellulose fermentation. Mediator-less two chamber H-type MFCs were prepared using rumen fluid as anode inocula at 20% v/v of anolyte to convert finely ground pine tree (Avicel) at 2%, w/v to electricity. Saponin was added to the anode of MFC at 0.005% or 0.05% v/v dosage for treatment. MFC power and current across an external resistor were measured daily for 10d. On d10, collected gases from anode compartment were measured for total gas volume and analyzed for gas composition on gas chromatography. Supplementation of saponin to MFC at 0.005% did not have any effects on electricity generation or biogas production and composition. Saponin at 0.05% dose reduced 10% of methane prod

关键词： Microbial Fuel Cells Saponin Bioenergy

Bulk-Si photonics technology for DRAM interface[Invited]

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Photonics Research 2014年第3期2卷 S0025-S0033页

作者： Hyunil Byun jinkwon Bok Kwansik Cho Keunyeong Cho Hanmei Choi Jinyong Choi Sanghun Choi Sangdeuk Han Seokyong Hong Seokhun Hyun TJJeong Ho-Chul Ji In-Sung Joe Beomseok kim Donghyun kim Junghye kim Jeong-Kyoum kim Kiho kim Seong-Gu kim Duanhua Kong Bongjin Kuh Hyuckjoon Kwon Beomsuk Lee Hocheol Lee Kwanghyun Lee Shinyoung Lee Kyoungwon Na Jeongsik Nam Amir Nejadmalayeri Yongsang Park Sunil Parmar Junghyung Pyo Dongjae Shin Joonghan Shin Yong-hwack Shin Sung-Dong Suh Honggoo Yoon Yoondong Park Junghwan Choi Kyoung-Ho Ha Gitae Jeong Samsung Electronics 1 SamsungjeonjaroHwasungshiGyoung-gido445-330South Korea

We present photonics technology based on a bulk-Si substrate for cost-sensitive dynamic random-access memory(DRAM)optical interface *** summarize the progress on passive and active photonic devices using a local-crystallized Si waveguide fabricated by solid phase epitaxy or laser-induced epitaxial growth on bulk-Si *** process of integration of a photonic integrated circuit(IC)with an electronic IC is demonstrated using a 65 nm DRAM periphery process on 300 mm wafers to prove the possibility of seamless integration with various complementary metal-oxide-semiconductor *** the bulk-Si photonic devices,we show the feasibility of high-speed multidrop interface:the Mach–Zehnder interferometer modulators and commercial photodetectors are used to demonstrate four-drop link operation at 10 Gb∕s,and the transceiver chips with photonic die and electronic die work for the DDR3 DRAM interface at 1.6 Gb∕s under a 1∶4 multidrop configuration.

关键词： interferometer waveguide interface