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Evolution of stomatal and trichome density of the Quercus delavayi complex since the late Miocene

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Chinese Science Bulletin 2014年第3期59卷 310-319页

作者： Qian hu Yaowu Xing jinjin hu Yongjiang huang Hongjie Ma Zhekun Zhou Key Laboratory of Biogeography and Biodiversity Kunming Institute of BotanyChinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of Sciences Institute of Systematic Botany University of Zrich Faculty of Land Resource Engineering Kunming University of Science and Technology

A fossil oak species,Quercus tenuipilosa *** et ***,is reported from the upper Pliocene Ciying Formation in Kunming,Yunnan Province,southwestern *** establishment of this species is based on detailed morphologic and cuticular *** fossil leaves are elliptic,with serrate margins on the apical *** primary venation is pinnate,and the major secondary venation is *** tertiary veins are opposite or alternate-opposite percurrent with two *** stomata are anomocytic,occurring only on the abaxial *** trichome bases are unicellular or *** new fossil species shows the closest affinity with theextant *** and the late Miocene *** *** et *** from the Xiaolongtan Formation of the Yunnan *** three species share similar leaf morphology,but differ with respect to trichome base and stomatal ***,and *** can be considered to constitute the *** *** the late Miocene,a gradual reduction in trichome base density has occurred in this *** trend is the opposite of that of precipitation,indicating that increased trichome density is not an adaptation to dry *** stomatal density(SD)of the *** complex was the highest during the late Miocene,declined in the late Pliocene,and then increased during the present *** values show an inverse relationship with atmospheric CO_2 concentrations,suggesting that the SD of the *** complex may be a useful proxy for reconstruction of paleo-CO_2 concentrations.

关键词：气孔密度晚中新世二氧化碳浓度演变皮毛栎化石种云南昆明

Historical biogeography and evolutionary diversification of Lilium(Liliaceae): New insights from plastome phylogenomics

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Plant Diversity 2024年第2期46卷 219-228页

作者： Nian Zhou Ke Miao Changkun Liu Linbo Jia jinjin hu Yongjiang huang Yunheng Ji CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610065China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Population Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Here, we infer the historical biogeography and evolutionary diversification of the genus Lilium. For this purpose, we used the complete plastomes of 64 currently accepted species in the genus Lilium(14plastomes were newly sequenced) to recover the phylogenetic backbone of the genus and a timecalibrated phylogenetic framework to estimate biogeographical history scenarios and evolutionary diversification rates of Lilium. Our results suggest that ancient climatic changes and geological tectonic activities jointly shaped the distribution range and drove evolutionary radiation of Lilium, including the Middle Miocene Climate Optimum(MMCO), the late Miocene global cooling, as well as the successive uplift of the Qinghai-Tibet Plateau(QTP) and the strengthening of the monsoon climate in East Asia during the late Miocene and the Pliocene. This case study suggests that the unique geological and climatic events in the Neogene of East Asia, in particular the uplift of QTP and the enhancement of monsoonal climate, may have played an essential role in formation of uneven distribution of plant diversity in the Northern Hemisphere.

关键词： Asian monsoon Climatic changes Distribution range Evolutionary complexity Radiative diversification Species diversity Qinghai-Tibet Plateau(QTP)

A hybrid algorithm for job shop scheduling problem with consideration of work timetable

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A hybrid algorithm for job shop scheduling problem with cons...

基于C-H键活化的铜催化二苄胺氧化酰胺化反应(英文)

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作者： jinjin hu Hegen Xiong Guangcan Yang School of Machinery and Automation Wuhan University of Science and Technology

A job shop scheduling problem with consideration of work timetable(JSP-WT) is studied in this paper. A mathematical programming model is presented for JSP-WT. A hybrid algorithm combining genetic algorithm, tabu search and key block movement algorithm(GASBM) is developed to solve the problem. A comparative experiment is conducted to demonstrate the validity of the algorithm. In the experiment, fifteen cases are designed to be solved by GASBM in three different strategies: without consideration of work timetable, consideration of work timetable and operation-interruptible, and consideration of work timetable and operation-uninterruptible. The results and corresponding analyses demonstrate the effectiveness of the algorithm.

关键词： job-shop scheduling problem work timetable genetic algorithm tabu search

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催化学报 2013年第9期34卷 1644-1650页

作者：胡金金左秀锦黄汉民中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室甘肃兰州730000 大连大学环境与化学工程学院辽宁大连116622

基于铜催化的C-H键活化构建了一类高效的二苄胺氧化酰基化生成N-苄基苯甲酰胺的反应. 该反应使用CuBr作为催化剂,二乙酸碘苯作为氧化剂, 在温和条件下生成两种酰胺, 总产率最高可达92.0%. CuBr催化剂价廉易得, 催化活性高. 同时这也是... 详细信息

基于铜催化的C-H键活化构建了一类高效的二苄胺氧化酰基化生成N-苄基苯甲酰胺的反应. 该反应使用CuBr作为催化剂,二乙酸碘苯作为氧化剂, 在温和条件下生成两种酰胺, 总产率最高可达92.0%. CuBr催化剂价廉易得, 催化活性高. 同时这也是首次使用二乙酸碘苯作为氧化剂, 通过二苄胺的直接氧化酰基化反应合成N-苄基苯甲酰胺.

关键词： C-H键活化铜催化剂二乙酸碘苯氧化酰基化二苄胺

肺炎支原体肺炎患儿肠道菌群和粪便免疫因子分析

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中华微生物学和免疫学杂志 2024年第10期44卷 838-852页

作者：胡津津张晓英上海交通大学医学院附属第九人民医院儿科上海200011

目的探讨不同临床分型肺炎支原体肺炎(MPP)患儿肠道菌群和粪便裂解液免疫因子差异。方法选取2023年3月—2024年2月上海第九人民医院住院的3~14岁MPP患儿,依据病情严重程度分为轻症组(GMPP组)和重症组(SMPP组),根据治疗反应分为非难治组(... 详细信息

目的探讨不同临床分型肺炎支原体肺炎(MPP)患儿肠道菌群和粪便裂解液免疫因子差异。方法选取2023年3月—2024年2月上海第九人民医院住院的3~14岁MPP患儿,依据病情严重程度分为轻症组(GMPP组)和重症组(SMPP组),根据治疗反应分为非难治组(NRMPP组)和难治组(RMPP组);采用16S rRNA测序分析肠道菌群特征,采用MSD电化学发光法测定粪便裂解液免疫因子水平;分析比较MPP患儿的临床特征、肠道菌群、粪便免疫因子差异;Spearman法进行相关性分析;受试者工作特征(ROC)曲线分析肠道菌群对MPP临床分型的评估和预测价值。结果64例MPP患儿中GMPP组34例,SMPP组30例,两组在热程、有无低氧血症、C-反应蛋白(CRP)、D-二聚体、胸部CT评分等方面差异有统计学意义(t=-4.49,P0.05);两组肠道菌群Beta多样性分析差异有统计学意义(R2=0.06,P=0.001);物种差异分析显示,SMPP组双歧杆菌属(Bifidobacterium)相对丰度较GMPP组明显降低,布劳特菌属(Blautia)、活泼瘤胃球菌(Ruminococcus gnavus)相对丰度较GMPP组明显升高,差异有统计学意义(z=5.21,P0.05);两组肠道菌群Beta多样性分析差异有统计学意义(R2=0.05,P=0.001);物种差异分析显示,RMPP组双歧杆菌属、罕见小球菌属(Subdoligranulum)相对丰度较NRMPP组明显降低,布劳特菌属、活泼瘤胃球菌相对丰度较NRMPP组明显升高,差异有统计学意义(z=3.44,P=0.012,Q=0.638;z=3.64,P=0.040,Q=0.638;z=5.80,P=0.001,Q=0.338;z=5.46,P=0.015,Q=0.638)。GMPP组和SMPP组之间粪便免疫因子IL-10、IL-1β水平差异有统计学意义(z=-1.96,P=0.050;z=-2.46,P=0.014)。NRMPP组和RMPP组之间粪便免疫因子IFN-γ、IL-10、IL-1β、IL-8、TNF-α水平差异有统计学意义(z=-2.20,P=0.028;z=-2.17,P=0.030;z=-2.00,P=0.046;z=-2.14,P=0.032;z=-2.22,P=0.027)。Sperman相关分析显示,双歧杆菌属与热程、胸部CT评分呈负相关(r=-0.35,P=0.005;r=-0.30,P=0.017);布劳特菌属与D-二聚体、热程、胸部CT评分呈正相关(r=0.33,P=0.008;r=0.37,P=0.003;r=0.40,P=0.001);活泼瘤胃球菌与TNF-α、IL-10、IL-4、IL-6呈负相关(r=-0.34,P=0.001;r=-0.29,P=0.021;r=-0.28,P=0.024;r=-0.28,P=0.027)。ROC曲线分析显示,双歧杆菌属丰度对MPP严重程度评估的曲线下面积(AUC)为0.767(95%CI:0.649~0.885,P<0.001);布劳特菌属丰度对MPP严重程度评估的AUC为0.774(95%CI:0.658~0.889,P<0.001),对MPP治疗反应预测的AUC为0.787(95%CI:0.655~0.919,P=0.001)。结论不同临床分型MPP患儿粪便免疫因子水平不同;MPP患儿肠道菌群中双歧杆菌属和布劳特菌属相对丰度分析对MPP病情严重程度评估、辅助治疗和治疗反应预测可能有一定临床价值。

关键词：肺炎支原体肺炎肠道菌群免疫因子布劳特菌属双歧杆菌属

Cenozoic plants from Tibet:An extraordinary decade of discovery,understanding and implications

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Science China Earth Sciences 2023年第2期66卷 205-226页

作者： Zhekun ZHOU Jia LIU Linlin CHEN Robert A.SPICER Shufeng LI Jian huANG Shitao ZHANG Yongjiang huANG Linbo JIA jinjin hu Tao SU CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla666303China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming650204China School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China State Key Laboratory of Paleobiology and Stratigraphy Nanjing Institute of Geology and PaleontologyChinese Academy of SciencesNanjing210008China

Plant fossils play an important role in understanding landscape evolution across the Tibetan Region,as well as plant diversity across wider eastern *** the last decade or so,paleobotanical investigations within the Tibet Region have led to a paradigm shift in our understanding of how the present plateau formed and how this affected the regional climate and *** is because:(1)Numerous new taxa have been *** all the Cenozoic records of new plant fossil species reported from the Tibet(Xizang)Autonomous Region 45 out of 63(70%)were documented after *** these,many represent the earliest records from Asia,or in some cases worldwide,at the genus or family level.(2)These fossils show that during the Paleogene,the region now occupied by the Tibetan Plateau was a globally significant floristic exchange *** on paleobiogeographic studies,grounded by fossil evidence,there are four models of regional floristic migration and exchange,i.e.,into Tibet,out of Tibet,out of India and into/out of Africa.(3)Plant fossils evidence the asynchronous formation histories for different parts of the Tibetan *** most of the Paleogene,there was a wide east-west trending valley with a subtropical climate in central Tibet bounded by high(>4 km)mountain systems,but that by the early Oligocene the modern high plateau had begun to form by the rise of the valley *** reconstructions using radiometrically-dated plant fossil assemblages in southeastern Tibet show that by the earliest Oligocene southeastern Tibet(including the Hengduan Mountains)had reached its present elevation.(4)The coevolution between vegetation,landform and paleoenvironment is evidenced by fossil records from what is now the central Tibetan *** the Paleocene to Pliocene,plant diversity transformed from that of tropical,to subtropical forests,through warm to cool temperate woodland and eventually to deciduous shrubland in response to landscape evolution from a seas

关键词： Tibetan Plateau Cenozoic Paleobotany Flora Central valley Biodiversity

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Bergman核、全纯函数的极小延拓以及全纯向量丛上的奇异Hermite度量

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数学进展 2022年第5期51卷 891-906页

作者：邓富声胡金金中国科学院大学数学科学学院北京100049

我们证明,具有正曲率的奇异Hermite度量的向量丛自然出现在Bergman核理论和全纯函数的L^(2)延拓中.我们此处强调的关键点是,即使最初研究的对象是光滑的且具有良好性质,但所涉及的度量的奇异性仍是不可避免的.我们也提出了一些有待进一... 详细信息

我们证明,具有正曲率的奇异Hermite度量的向量丛自然出现在Bergman核理论和全纯函数的L^(2)延拓中.我们此处强调的关键点是,即使最初研究的对象是光滑的且具有良好性质,但所涉及的度量的奇异性仍是不可避免的.我们也提出了一些有待进一步研究的相关问题.

关键词： Bergman核 L^(2)延拓全纯向量丛奇异Hermite度量正曲率

虚拟筛选技术在黑色素生成抑制剂研发中的应用

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日用化学工业（中英文） 2024年第6期54卷 718-726页

作者：胡金金刘智禹陈小娥陈贝浙江海洋大学食品与药学学院浙江舟山316000 福建水产研究所国家海水鱼类加工技术研发中心福建省海洋生物增养殖与高值化利用重点实验室福建厦门361013

黑色素含量水平及其分布被认为是影响肤色的重要因素。在黑色素生成过程中,酪氨酸酶(TYR)是调节黑色素含量的关键限速酶。小眼畸形相关转录因子(MITF)是黑色素细胞的主要调控因子,在黑色素细胞的分化和增殖中发挥着关键作用。大量研究... 详细信息

黑色素含量水平及其分布被认为是影响肤色的重要因素。在黑色素生成过程中,酪氨酸酶(TYR)是调节黑色素含量的关键限速酶。小眼畸形相关转录因子(MITF)是黑色素细胞的主要调控因子,在黑色素细胞的分化和增殖中发挥着关键作用。大量研究表明通过降低TYR活性或稳定性,或干扰MITF正常转录,可预防或缓解黑色素生成异常而产生的各种皮肤问题。虚拟筛选具有成本低、效率高的优点,该技术应用于筛选黑色素生成抑制剂的研究具有良好的应用前景。本文总结了黑色素的合成和调控规律,综述了虚拟筛选技术在黑色素生成抑制剂研发中的应用进展,为探索黑色素生成抑制剂先导化合物提供参考。

关键词：黑色素抑制剂酪氨酸酶小眼畸形转录因子虚拟筛选

威伐光辅助药物治疗急性期带状疱疹后遗神经痛临床分析

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中国实用神经疾病杂志 2018年第2期21卷 203-205页

作者：胡瑾瑾河南省直第三人民医院皮肤科河南郑州450006

目的探讨德国威伐光联合伐昔洛韦、甲钴胺、加巴喷丁治疗急性期带状疱疹,对于减轻带状疱疹后遗神经痛的疗效及安全性。方法采用随机、双盲、平行对照临床研究,入选急性期带状疱疹患者125例,实验组63例,对照组62例。对照组口服伐昔洛韦... 详细信息

目的探讨德国威伐光联合伐昔洛韦、甲钴胺、加巴喷丁治疗急性期带状疱疹,对于减轻带状疱疹后遗神经痛的疗效及安全性。方法采用随机、双盲、平行对照临床研究,入选急性期带状疱疹患者125例,实验组63例,对照组62例。对照组口服伐昔洛韦片、甲钴胺片、加巴喷丁胶囊,实验组在对照组治疗的基础上,加用威伐光治疗系统,治疗1次/d,30 min/次,连续治疗2周。分析2组的疗效,评估其安全性。结果治疗前2组患者的疼痛强度VAS评分无差异性(P>0.05),治疗后2组疼痛评分均有所下降(P<0.05),并呈现VAS递减的趋势;组间比较,治疗组患者在治疗后几个时间点(治疗后第4、8、16、24周末)VAS评分均比对照组低(P<0.05)。2组均未见明显不良反应。结论威伐光联合伐昔洛韦、甲钴胺、加巴喷丁治疗急性期带状疱疹,对减轻患者后期的神经痛疗效显著,明显优于传统的药物治疗。

关键词：带状疱疹神经痛威伐光药物治疗伐昔洛韦甲钴胺片加巴喷丁