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Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

Neural Regeneration Research 2024年第2期19卷 331-335页

作者： Seung-Woo Han jinhee choi Kwon-Yul Ryu Department of Life Science University of SeoulSeoulSouth Korea School of Environmental Engineering University of SeoulSeoulSouth Korea

Many types of plastic products,including polystyrene,have long been used in commercial and industrial *** and nanoplastics,plastic particles derived from these plastic products,are emerging as environmental pollutants that can pose health risks to a wide variety of living organisms,including ***,it is not well understood how microplastics and nanoplastics affect cellular functions and induce stress *** can be exposed to polystyrene-microplastics and polystyrene-nanoplastics through ingestion,inhalation,or skin *** ingested plastics are excreted from the body,but inhaled plastics may accumulate in the lungs and can even reach the brain via the nose-to-brain ***-sized polystyrene-nanoplastics can enter cells by endocytosis,accumulate in the cytoplasm,and cause various cellular stresses,such as inflammation with increased pro-inflammatory cytokine production,oxidative stress with generation of reactive oxygen species,and mitochondrial *** induce autophagy activation and autophagosome formation,but autophagic flux may be impaired due to lysosomal *** permanently exposed to polystyrene-nanoplastics,they can be removed from cells by exocytosis and subsequently restore cellular ***,neurons are very susceptible to this type of stress,thus even acute exposure can lead to neurodegeneration without *** review focuses specifically on recent advances in research on polystyrene-nanoplastic-induced cytotoxicity and ***,in this review,based on mechanistic studies of polystyrene-nanoplastics at the cellular level other than neurons,future directions for overcoming the negative effects of polystyrene-nanoplastics on neurons were suggested.

关键词： autophagy cellular stress cytotoxicity endocytosis exocytosis inflammation microplastics nanoplastics neurotoxicity oxidative stress polystyrene

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郭象对“性”的解释及其在中国哲学史上的意义

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中国哲学史 2006年第3期 15-23页

作者：崔珍皙韩国西江大学哲学系

一、序言:玄学自春秋战国时期开始的中国固有的哲学到郭象(252～312)便告一段落.①这并不是说中国思想终结了,而是说春秋战国时期由老子和孔子等诸子提出的思维方式和哲学思想经过汉代的宇宙发生论,到魏晋时期呈现出向本体论发展的倾向... 详细信息

一、序言:玄学自春秋战国时期开始的中国固有的哲学到郭象(252～312)便告一段落.①这并不是说中国思想终结了,而是说春秋战国时期由老子和孔子等诸子提出的思维方式和哲学思想经过汉代的宇宙发生论,到魏晋时期呈现出向本体论发展的倾向,并最终精炼为中国式的抽象思维.

关键词：中国哲学史郭象 “性” 春秋战国时期中国思想哲学思想思维方式魏晋时期抽象思维本体论

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Neuroprotective Effects of the Biologically Active Components From Traditional Korean Medicine on the Brain Ischemia in Rats

Neuroprotective Effects of the Biologically Active Component...

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第十五届国际药理学大会

作者： Daehee Lee Miyeon Kim jinhee Jung Seongmi choi Hocheol Kim Dep.of Herbal Pharmacology College of Oriental MedicineKyung Hee Univ.SeoulKorea. Korea Institute of Science and Technology for Eastern Medicien （KISTEM） NeuMed Co. Korea Institute of Science and Technology for Eastern Medicien （KISTEM） NeuMed Co. Korea Institute of Science and Technology for Eastern Medicien （KISTEM） NeuMed Co. Dep.of Herbal Pharmacology College of Oriental MedicineKyung Hee Univ.SeoulKorea.

＜正＞ The purpose of the study is to observe the neuroprotective components of herbs which have been used to treat stroke in traditional Korean medicine. For global cerebral ischemia,male wister rats weighing 180 ± 10 g were used and common carotid arteries and vertebral arteries were occluded for 10 min. For focal cerebral ischemia,male SD rats weighing 300 ± 10 g were used and the right middle cerebral artery were occluded for 2 hrs. As the results,decursin （10 mg/kg） showed 36.46% , gomisin A. （30 mg/kg） showed 41.18% of neurorprotection in global cerebral ischemia. Nodakenin （30 mg/kg）. wogonin （30 mg/kg） showed 61. 33% and 42.67% of neuroprotection effect compared with control,respectively. Gomisin A showed the highest effect as 64.67 % of neuroprotection in focal cerebral ischemia. In conclusion,it could be suggested that gomisin A in Schizandra chinensis. decursin and nodakenin in Angelica gigas. wogonin and baicalein in Scutellaria baicalensis are effective components for the treatment of stroke.

关键词： Scutellaria Schizandra Angelica brain ischemia stroke

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