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Chinese Journal of Chemical Engineering 2024年第5期69卷 63-71页

作者： Hui Tan Xiaodong Hong Zuwei Liao jingyuan sun Yao Yang Jingdai Wang Yongrong Yang State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China

Heat integration is important for energy-saving in the process *** is linked to the persistently challenging task of optimal design of heat exchanger networks(HEN).Due to the inherent highly nonconvex nonlinear and combinatorial nature of the HEN problem,it is not easy to find solutions of high quality for large-scale *** reinforcement learning(RL)method,which learns strategies through ongoing exploration and exploitation,reveals advantages in such ***,due to the complexity of the HEN design problem,the RL method for HEN should be dedicated and designed.A hybrid strategy combining RL with mathematical programming is proposed to take better advantage of both *** insightful state representation of the HEN structure as well as a customized reward function is introduced.A Q-learning algorithm is applied to update the HEN structure using theε-greedy *** results are obtained from three literature cases of different scales.

关键词： Heat exchanger network Reinforcement learning Mathematical programming Process design

Hydrodynamics characterization of a choanoid fluidized bed bioreactor used in the bioartificial liver system： Fully resolved simulation with a fctitious domain method

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Particuology 2017年第3期15卷 39-48页

作者： jingyuan sun Zhaosheng Yu Shangjun Ye Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China

Choanoid fluidized bed bioreactors （CFBBs） are newly developed core devices used in bioartificial liver- support systems to detoxify blood plasma of patients with microencapsulated liver cells. Direct numerical simulations （DNS） with a direct-forcing/fictitious domain （DF/FD） method were conducted to study the hydrodynamic performance of a CFBB. The effects of particle-fluid density ratio, particle number, and fil- ter screens preventing particles flowing out of the reactor were investigated. Depending on density ratio, two flow patterns are evident： the circulation mode in which the suspension rises along one sidewall and descends along the other sidewall, and the non-circulation mode in which the whole suspension roughly flows upward. The circulation mode takes place under non-neutral-buoyancy where the particle sedimentation dominates, whereas the non-circulation mode occurs under pure or near-neutral buoy- ancy with particle-fluid density ratios of unity or near unity. With particle-fluid density ratio of 1.01, the bioartificial liver reactor performs optimally as the significant particle accumulation existing in the non-circulation mode and the large shear forces on particles in the circulation mode are avoided. At higher particle volume fractions, more particles accumulate at the filter screens and a secondary counter circulation to the primary flow is observed at the top of the bed. Modelled as porous media, the filter screens play a negative role on particle fluidization velocities; without screens, particles are fluidized faster because of the higher fluid velocities in the jet center region. This work extends the DF/FD-based DNS to a fluidized bed and accounts for effects from inclined side walls and porous media, providing some hydrodynamics insight that is important for CFBB design and operation optimization.

关键词： Choanoid fluidized-bed bioreactor Particle-laden flows Direct numerical simulation Direct-forcing/fctitious domain method Hydrodynamic characteristics

UBE2T通过调节性T细胞诱导肝细胞癌的放疗抵抗

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南方医科大学学报 2024年第6期44卷 1149-1158页

作者：何欣容熊斯丽朱真如孙景苑曹传辉王惠南方医科大学南方医院放疗科广东广州510515

目的探索泛素结合酶2T(UBE2T)对肝细胞癌放疗敏感性的影响及机制。方法采用空白对照载体或过表达UBE2T慢病毒载体转染小鼠Hepa1-6肝癌细胞建立对照组(LV-Control)和过表达组(LV-UBE2T),qPCR以及Western blotting检测上述细胞UBE2T表... 详细信息

目的探索泛素结合酶2T(UBE2T)对肝细胞癌放疗敏感性的影响及机制。方法采用空白对照载体或过表达UBE2T慢病毒载体转染小鼠Hepa1-6肝癌细胞建立对照组(LV-Control)和过表达组(LV-UBE2T),qPCR以及Western blotting检测上述细胞UBE2T表达情况;对两组细胞进行射线照射(IR)处理,克隆形成实验检测UBE2T过表达对Hepa1-6肝癌细胞放疗敏感性影响;分别在裸鼠和C57BL/6小鼠皮下注射上述细胞建立肝癌皮下荷瘤小鼠模型,对皮下瘤予IR处理,建立LV-Control组、LVControl+IR组、LV-UBE2T组和LV-UBE2T+IR组,5~6只/组,观察皮下瘤生长速度及体积。通过CIBERSORT算法分析肝癌免疫细胞浸润情况与UBE2T表达量的关系。流式细胞术检测上述4组小鼠的肝癌中CD4+T细胞以及调节性T细胞(Tregs)浸润情况。比色法测定细胞培养上清液中葡萄糖及乳酸的含量;癌症和肿瘤基因图谱(TCGA)的公共数据分析肝癌UBE2T表达量与糖酵解水平和Tregs浸润关系。Western blotting检测UBE2T表达与糖酵解相关蛋白HK1、LDHA表达相关关系。体外共培养模型联合流式细胞术以及qPCR验证UBE2T过表达肝癌与Tregs关系。结果 qPCR、Western blotting结果显示过表达组中UBE2T表达显著升高(P<0.0001)。克隆形成实验、裸鼠肝癌皮下瘤实验显示UBE2T过表达导致肝细胞癌放疗抵抗(P<0.05),UBE2T导致的放疗抵抗在C57BL/6小鼠肝癌皮下瘤模型上更显著(P<0.01)。CIBERSORT分析提示UBE2T高表达组肝癌中树突状细胞(P<0.01)、滤泡辅助性T细胞(P<0.001)、M2型巨噬细胞(P<0.01)、单核细胞(P<0.05)、总体淋巴细胞(P<0.05)以及Tregs(P<0.0001)浸润比例上调。流式细胞术显示过表达UBE2T小鼠肝癌免疫微环境中Tregs数量上调(P<0.05),IR导致UBE2T组CD4+T细胞以及Tregs浸润增加(P<0.01或P<0.001)。与对照组细胞培养上清液相比,过表达UBE2T组的培养上清液葡萄糖浓度降低(P<0.05),乳酸浓度上调(P<0.01)。GSEA分析提示UBE2T高表达肝癌与糖酵解水平(P<0.001)、Tregs浸润水平呈正相关(P<0.001)。Western blotting显示糖酵解相关蛋白HK1、LDHA表达水平与UBE2T表达水平相关。体外共培养模型显示UBE2T过表达肝癌使Tregs细胞内乳酸含量上调(P<0.001),增殖能力增加(P<0.05)以及免疫抑制功能上调(Il-10,P<0.05;TGF-β,P<0.001)。结论 UBE2T介导的肝癌细胞放疗抵抗可能与肝癌细胞糖酵解水平提高介导的免疫微环境中Tregs富集相关。

关键词：泛素结合酶2T 肝细胞癌放疗抵抗肿瘤免疫微环境调节性T细胞

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强夯双向土压力模型试验测试及加固效果分析

太原理工大学学报 2024年第5期55卷 850-856页

作者：李沛轩葛忻声田亚东孙静苑章敏太原理工大学土木工程学院太原030024

【目的】从土体应力分布特征的角度研究不同夯击方式对砂土强夯加固效果的影响。【方法】通过室外场地进行的强夯模型试验对夯击过程中土体内部的竖向与径向土压力以及落锤加速度进行监测,并结合数值模拟的方法对土体内部的位移进行分... 详细信息

【目的】从土体应力分布特征的角度研究不同夯击方式对砂土强夯加固效果的影响。【方法】通过室外场地进行的强夯模型试验对夯击过程中土体内部的竖向与径向土压力以及落锤加速度进行监测,并结合数值模拟的方法对土体内部的位移进行分析。【结果】研究得出:在强夯法施工中竖向土压力存在冲击与震荡衰减两种波形,径向土压力则主要以冲击波形为主;在砂土强夯加固过程中存在两种加固模式,夯击点正下方土体主要以竖向压实为主,而斜下方土体同时兼有显著的径向挤密作用;在同能级强夯施工中,“重锤低落”组合适合对深层土体与径向土体进行加固,“轻锤高落”组合适合对浅层土体进行快速加固。【结论】研究成果对同能级强夯夯击方式的选用具有一定的指导意义。

关键词：强夯夯击方式加固效果模型试验同能级强夯

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预混进料对废树脂流化裂解反应中颗粒团聚的抑制作用

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化工学报 2024年第9期75卷 3094-3102页

作者：黄正梁冯铭瑞宋琦任聪静杨遥孙婧元王靖岱阳永荣浙江省化工高效制造技术重点实验室浙江大学化学工程与生物工程学院浙江大学宁波科创中心

针对放射性废树脂流化裂解反应过程中颗粒团聚问题，提出了高岭土和陶瓷颗粒预混进料抑制颗粒团聚的新思路，在流化裂解实验装置中通过测量床层压降和对产物的XRD、SEM以及元素分析，考察预混时高岭土添加量对流化特性和颗粒团聚的影响... 详细信息

针对放射性废树脂流化裂解反应过程中颗粒团聚问题，提出了高岭土和陶瓷颗粒预混进料抑制颗粒团聚的新思路，在流化裂解实验装置中通过测量床层压降和对产物的XRD、SEM以及元素分析，考察预混时高岭土添加量对流化特性和颗粒团聚的影响规律。研究结果表明，高岭土与陶瓷球预混后可在陶瓷球颗粒表面形成均匀的涂覆层，当高岭土添加量≥0.20%(质量分数)时具有显著的抑制废树脂流化裂解反应中颗粒团聚的作用，但存在一定的作用时长，应定期补加预混高岭土的陶瓷球颗粒以维持陶瓷球表面的高岭土覆层，当高岭土预混添加量为0.20%(质量分数)时高岭土预混进料抑制团聚的作用时长约为70 min。与高岭土和废树脂共混进料相比，预混进料可在更低的高岭土添加量条件下达到颗粒团聚抑制效果，有利于放射性废树脂的减量化处理。

关键词：放射性废树脂热解流态化团聚高岭土

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Scaling Factor Optimization of Turbo-Polar Iterative Decoding

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China Communications 2018年第6期15卷 169-177页

作者： Zhenzhen Liu Kai Niu Jiaru Lin jingyuan sun Hao Guan Beijing University of Posts and Telecommunications Beijing 100876China Nokia Shanghai Bell Co. Ltd.Beijing 100876China

In this paper, we investigate the weighted iterative decoding to improve the performance of turbo-polar code. First of all, a minimum weighted mean square error criterion is proposed to optimize the scaling factors(SFs). Secondly, for two typical iterative algorithms,such as soft cancellation(SCAN) and belief propagation(BP) decoding, genie-aided decoders are proposed as the ideal reference of the practical decoding. Guided by this optimization framework, the optimal SFs of SCAN or BP decoders are obtained. The bit error rate performance of turbo-polar code with the optimal SFs can achieve 0.3 dB or 0.7 dB performance gains over the standard SCAN or BP decoding respectively.

关键词： turbo-polar code BP decoder SCAN decoder mean square error scaling factors

针对性护理管理对放射治疗后肝癌患者的干预效果分析

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肝癌电子杂志 2024年第1期11卷 34-37页

作者：都孟雅陈佩娟孙景苑南方医科大学南方医院放疗科广东广州510515

目的:探究针对性护理在肝癌患者放射治疗中的干预效果。方法:选取2017年10月至2019年10月就诊于南方医科大学南方医院行肝癌放射治疗患者208例,经电脑随机抽取方式分为对照组106例和试验组102例。对照组采用常规护理,试验组采用针对性... 详细信息

目的:探究针对性护理在肝癌患者放射治疗中的干预效果。方法:选取2017年10月至2019年10月就诊于南方医科大学南方医院行肝癌放射治疗患者208例,经电脑随机抽取方式分为对照组106例和试验组102例。对照组采用常规护理,试验组采用针对性护理。对比两组患者的基线资料,以及视觉模拟疼痛评分、焦虑抑郁评分、生活质量评分、并发症发生率、患者依从性、护理满意度。结果:两组患者的基线资料相比差异无统计学意义(均P>0.05)。针对性干预前两组患者的视觉模拟疼痛评分、焦虑抑郁评分、生活质量评分相比差异无统计学意义(均P>0.05)。护理3个月后试验组视觉模拟疼痛评分、焦虑抑郁评分、生活质量评分均高于对照组(均P<0.05);并发症发生率低于对照组(9.8%∶30.2%,P<0.05),患者依从性好于对照组(96.07%∶84.91%,P<0.05);护理满意度高于对照组(均P<0.05)。结论:针对性护理能够降低肝癌放射治疗患者的并发症,提升患者的整体满意度。

关键词：针对性护理干预效果肝癌放射治疗

Modelling and simulation of two-bed PSA process for separating H2 from methane steam reforming

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Chinese Journal of Chemical Engineering 2019年第8期27卷 1870-1878页

作者： Huiru Li Zuwei Liao jingyuan sun Binbo Jiang Jingdai Wang Yongrong Yang Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027 China State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027 China

Methane steam reforming is the main hydrogen production method in the industry. The product of methane steam reforming contains H2, CH4, CO and CO2 and is then purified by pressure swing adsorption(PSA) technology. In this study, a layered two-bed PSA process was designed theoretically to purify H2 from methane steam reforming off gas. The effects of adsorption pressure, adsorption time and purgeto-feed ratio(P/F ratio) on process performance were investigated to design a PSA process with more than99.95% purity and 80% recovery. Since the feed composition of the PSA process changes with the upstream process, the effect of the feed composition on the process performance was discussed as *** result showed that the increase of CH4 concentration, which was the weakest adsorbate, would have a negative impact on product purity.

关键词： Hydrogen Adsorption Purity Recovery Feed composition

Dynamic response analysis of liquefiable ground due to sinusoidal waves of different frequencies of shield construction

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 637-646页

作者： Wang Jingyue Ge Xinsheng sun jingyuan Liu Yasheng Shang Zhuo Wang Zhiqiang Tian Maoguo College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030024China The 3rd Engineering Co.Ltd.of China Railway 18th Bureau Zhuozhou 072750China

Vibration induced by shield construction can lead to liquefaction of saturated *** on FLAC3D software,a numerical model of tunnel excavation is established and sinusoidal velocity loads with different frequencies are applied to the excavation *** pattern of the excess pore pressure ratio with frequency,as well as the dynamic response of soil mass under different frequency loads before excavation,is *** the velocity sinusoidal wave acts on the excavation surface of the shield tunnel with a single sand layer,soil liquefaction ***,the ranges and locations of soil liquefaction are different at different frequencies,which proves that the vibration frequency influences the liquefaction location of the *** sand-clay composite strata with liquefiable layers,the influence of frequency on the liquefaction range is different from that of a single *** the frequency range of 5-30 Hz,the liquefaction area and surface subsidence decrease with an increase in vibration *** research results in this study can be used as a reference in engineering practice for tunneling liquefiable strata with a shield tunneling machine.

关键词： shield tunnel liquefiable formation FLAC3D numerical simulation excess pore pressure ratio dynamic response analysis

Scale-up and thermal stability analysis of fluidized bed reactors for ethylene polymerization

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Chinese Journal of Chemical Engineering 2023年第10期62卷 281-290页

作者： Xiaoqiang Fan jingyuan sun Jingdai Wang Zhengliang Huang Zuwei Liao Guodong Han Yongrong Yang Ningbo Research Institute Zhejiang UniversityNingbo 315100China State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology Hangzhou 310027China Sinopec Tianjin Company Tianjin 300271China

A set of hydrodynamic similarity laws is applied to the scale-up of ethylene polymerization fluidized bed reactors(FBRs)under the condensed mode *** thermal stability of open-loop controlled FBRs is investigated by the homotopy continuation *** the Hopf bifurcation point is selected as an index of the thermal stability *** simulation results show the similarity in state variables,operation parameters,the space-time yield(STY),and the thermal stability of FBRs with different ***,the thermal stability behaviors and similarity of the closed-loop controlled FBRs with different scales are *** observed similar trend of Hopf bifurcation curves reveals the similarity in the thermal stability of closed-loop controlled FBRs with different scaling *** general,the results of the thermal stability similarity confirm that the hydrodynamics scaling laws proposed in the work are applicable to the scale-up of FBRs under the condensed mode operation.

关键词： Stability Scale-up Polymerization Bifurcation theory Fluidized bed