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银行客户敏感信息保护技术实践

金融科技时代 2025年第1期33卷 51-54页

作者：李景莹杜望延浦发银行广州分行

随着科技高速发展和数字经济的蓬勃发展，数据的规模和价值不断提升，数据安全变得越来越重要。作为金融机构，银行必须采取有效措施确保敏感信息的安全。文章讨论了一些可以用于保护敏感信息的措施和技术，包括加密技术、数据匿名化技... 详细信息

随着科技高速发展和数字经济的蓬勃发展，数据的规模和价值不断提升，数据安全变得越来越重要。作为金融机构，银行必须采取有效措施确保敏感信息的安全。文章讨论了一些可以用于保护敏感信息的措施和技术，包括加密技术、数据匿名化技术、DLP技术、网络安全技术和机器学习技术，并以浦发银行广州分行为例，介绍如何采取这些措施和技术开展客户敏感信息保护工作，如办公终端数据泄露预防技术和客户敏感信息扫描检测技术。

关键词：数据安全个人信息保护 DLP技术网络安全机器学习

A Switched Event-triggered H∞ Control Approach to Nonlinear Network Control System

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A Switched Event-triggered H∞ Control Approach to Nonlinear...

第36届中国控制会议

作者： jingying li Xianlin Huang Center for Control Theory and Guidance Technology Harbin Institute of Technology

This paper reinvestigates the problem of event-triggered H control for a class of nonlinear networked control system.A switched event-triggered transmission scheme is adopted to reduce the network bandwidth *** this transmission scheme,the nonlinear network control system is formulated as a Takagi-Sugeno(T-S) fuzzy model with asynchronous membership *** taking the variation ranges of asynchronous membership functions into consideration,some less conservative event-triggered parameter and fuzzy sampled-data controller co-design conditions are ***,an exponential decay rate can be set in advance to achieve better system ***,an illustrative example is provided to illustrate the applicability and effectiveness of the proposed method.

关键词： Nonlinear network control system Fuzzy control Switched event-triggered scheme linear matrix inequality

CRISPR/Cpf1-mediated precision genome editing in rice

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CRISPR/Cpf1-mediated precision genome editing in rice

2018全国植物生物学大会

作者： Shaoya li jingying li Langin Xia Institute of Crop Sciences (ICS) Chinese Academy of Agricultural Sciences (CAAS)

CRISPR/Cpf1,as a new class 2,type VCRISPR/Cas system,was recently exploited as an alternative tool for genome editing in several organisms including *** a thymidine-rich PAM site "TTTN" and is guided by a single CRISPR RNA(crRNA).These advantages of Cpf1 make it easier to generate constructs and perform multiplex gene ***,CRISPR/Cpfl system is emerging as an attracting tool enabling precise editing in AT-rich regions such as 5’ and 3’ UTR and promoter ***,we generated two modified LbCpfl variants and illustrated that only LbCpfl(RR) variant enables editing and multiplex editing of target genes containing TYCVPAMs in *** demonstration of genome editing at this noncanonical PAM site expands the scope of LbCpf1-mediated genome editing in rice(li et ah,Molecular Plant,2018,11:995-998).Furthermore,we investigated the feasibility of gene replacement in rice through CRISPR/Cpf1-mediated *** provide evidence of synthesis-dependent repair of Cpf1-induced DSBs,which enables us to precisely replace the wild-type ALS gene with the intended mutant version that carries two discrete point mutations conferring rice plants herbicide *** observation that the donor repair template(DRT) with only left homologous arm is sufficient for precise targeted allele replacement offers a better understanding of the mechanism underlying HDR in plants,and greatly simplifies the design of DRTs for precision genome editing in crop improvement(li et ah,J Exp Bot,2018,doi/10.1093/jxb/ery245).

关键词： Cpfl gene replacement homology-directed DNA repair(HDR) LbCpf1(RR) rice(Oryza sativa L) synthesis-dependent strand annealing(SDSA)

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人工调控细胞表面受体聚集状态及功能

高等学校化学学报 2020年第5期41卷 892-900页

作者：李婧影陈琛李娟杨黄浩福州大学化学学院食品安全与生物分析教育部重点实验室福州350108 福州大学化学学院生物科学与工程学院福州350108

从利用物理刺激和生物大分子诱导两个方面综述了人工调控细胞表面受体聚集状态的策略.前者是利用相应的纳米材料在光、磁场、温度等物理刺激作用下实现人工调控受体聚集;后者则利用包括蛋白/多肽类分子、核酸在内的生物分子的自组装对... 详细信息

从利用物理刺激和生物大分子诱导两个方面综述了人工调控细胞表面受体聚集状态的策略.前者是利用相应的纳米材料在光、磁场、温度等物理刺激作用下实现人工调控受体聚集;后者则利用包括蛋白/多肽类分子、核酸在内的生物分子的自组装对其靶向识别的受体进行人工调控.系统介绍了相关研究领域取得的最新进展,并阐述和展望了该领域现存的挑战和发展方向.

关键词：受体聚集人工调控功能细胞表面

Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy forSelective Inhibition of Receptor Function

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Bispecific Aptamer Induced Artificial Protein-Pairing: A Str...

第十一届全国化学生物学学术会议

作者： liping Wang Hong liang Jin Sun jingying li Juan li Huang-Hao Yang MOE Key Laboratory of Analytical Science of Food Safety and Biology College of ChemistryFuzhou University

Cell surface receptors play a critical role in modulating intracellular signal transduction, making them important drug targets. However, it remains challenging to develop a selective and efficient strategy for regulating receptor function. Herein, we develop a strategy, called bispecific aptamer induced artificial protein-pairing, to selectively regulate receptor function. In this strategy, bispecific aptamer probes act as molecular mediators to bind to both a target receptor protein and a paired protein, which brings the two proteins into close proximity on the living cell membrane. Importantly, the paired proteins work not only as a cancer biomarker for enhancing cell selectivity but also as a blocking assistant to inhibit target receptor function via strong steric hindrance effect. Compared with single-aptamer-mediated regulation, the proposed bispecific aptamer probes afford substantial improvement in selective and efficient regulation of receptor function and downstream signaling pathways. This work offers a versatile methodology to design molecular mediators that can modulate receptor function, thereby providing a new way for developing novel therapeutic drugs.[1]

关键词： Artificial Protein Pairing Bispecific Aptamer Cellular Behaviors Receptors Signal Transduction

Critical Solvation Structures Arrested Active Molecules for Reversible Zn Electrochemistry

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Nano-Micro Letters 2024年第8期16卷 64-78页

作者： Junjie Zheng Bao Zhang Xin Chen Wenyu Hao Jia Yao jingying li Yi Gan Xiaofang Wang Xingtai liu Ziang Wu Youwei liu lin Lv li Tao Pei liang Xiao Ji Hao Wang Houzhao Wan Hubei Yangtze Memory Laboratories Wuhan 430205People’s Republic of China Hubei Key Laboratory of Micro‑Nanoelectronic Materials and Devices School of MicroelectronicsHubei UniversityWuhan 430062People’s Republic of China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Institute of Optoelectronics Technology China Jiliang UniversityHangzhou 310018People’s Republic of China

Aqueous Zn-ion batteries(AZIBs)have attracted increasing attention in next-generation energy storage systems due to their high safety and ***,the side reactions,dendrites and hydrogen evolution effects at the zinc anode interface in aqueous electrolytes seriously hinder the application of aqueous zinc-ion ***,we report a critical solvation strategy to achieve reversible zinc electrochemistry by introducing a small polar molecule acetonitrile to form a“catcher”to arrest active molecules(bound water molecules).The stable solvation structure of[Zn(H_(2)O)_(6)]^(2+)is capable of maintaining and completely inhibiting free water ***[Zn(H_(2)O)_(6)]^(2+)is partially desolvated in the Helmholtz outer layer,the separated active molecules will be arrested by the“catcher”formed by the strong hydrogen bond N-H bond,ensuring the stable desolvation of Zn^(2+).The Zn||Zn symmetric battery can stably cycle for 2250 h at 1 mAh cm^(-2),Zn||V_(6)O_(13) full battery achieved a capacity retention rate of 99.2%after 10,000 cycles at 10 A g^(-1).This paper proposes a novel critical solvation strategy that paves the route for the construction of high-performance AZIBs.

关键词： Zinc-ion battery Critical solvation Helmholtz layer Arrest active molecule Reversible zinc anode

胺功能化沸石吸附剂载体的结构性质对CO_(2)吸附性能的影响

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煤炭学报 2024年第6期49卷 2840-2850页

作者：刘天祥李蓉李晶莹马晓迅西北大学化工学院陕西西安710069 国家碳氢资源清洁利用国际科技合作基地陕西西安710069

为了探究胺功能化沸石吸附剂载体的结构性质对其CO_(2)吸附性能的影响并进一步探索出低成本制备高效CO_(2)吸附剂的有效方法,采用不同的后处理方法对MCM–41沸石的孔道结构进行改造,并将四乙烯五胺(TEPA)负载在这些沸石上制备胺功能化... 详细信息

为了探究胺功能化沸石吸附剂载体的结构性质对其CO_(2)吸附性能的影响并进一步探索出低成本制备高效CO_(2)吸附剂的有效方法,采用不同的后处理方法对MCM–41沸石的孔道结构进行改造,并将四乙烯五胺(TEPA)负载在这些沸石上制备胺功能化吸附剂。利用N_(2)吸脱附、扫描电镜、X射线衍射、红外光谱等方法对沸石载体进行表征,并利用热重分析仪(TGA)对吸附剂的吸附性能进行评价,系统研究了载体的结构性质、活性胺负载量以及吸附温度对CO_(2)吸附性能的影响,计算了吸附剂的吸附动力学和吸附活化能。最后,通过循环吸脱附实验评估了吸附剂的稳定性。结果表明,通过合理设计载体的结构,可以有效提升基于不同吸附原理的吸附剂的CO_(2)吸附性能。微孔沸石对物理吸附过程更有利,而具有宽孔径分布的多级介孔沸石则比微孔沸石在负载TEPA后表现出更好的化学吸附性能。在80℃和15%(体积分数)CO_(2)条件下,经结构改造并负载TEPA的吸附剂(M–N−T60)的最大吸附容量达到4.04 mmol/g。10次吸脱附循环后,其吸附容量仅下降8.4%,表现出良好的循环稳定性能,这表明M–N−T60为一种有望应用于烟气中CO_(2)捕集的吸附材料。

关键词： CO_(2)捕集胺功能化吸附剂 MCM–41沸石后处理改性循环稳定性

矿井水水化学特征及资源化利用研究——以张集煤矿为例

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煤炭科学技术 2023年第4期51卷 254-263页

作者：李竞赢刘启蒙杨明慧中国石油大学(北京)地球科学学院北京102200 安徽理工大学地球与环境学院安徽淮南232001

由于煤炭开采活动大量矿井水被抽排至地面,造成严重水资源浪费和环境污染,为发展“绿色矿业”理念,探寻矿井水资源化利用的有效途径。以淮南煤田张集煤矿为研究对象,采集了矿区不同来源矿井水共82个水样,并选取Ca^(2+)、Mg^(2+)、Na^(+)... 详细信息

由于煤炭开采活动大量矿井水被抽排至地面,造成严重水资源浪费和环境污染,为发展“绿色矿业”理念,探寻矿井水资源化利用的有效途径。以淮南煤田张集煤矿为研究对象,采集了矿区不同来源矿井水共82个水样,并选取Ca^(2+)、Mg^(2+)、Na^(+)+K^(+)、Cl^(−)、SO_(4)^(2-)、CO_(3)^(2−)、HCO_(3)^(-)七大离子和pH、TDS、EC、TH共11个指标作为水质检测依据,探讨了张集煤矿矿井水的一般水化学特征、主要离子成分、离子含量动态变化特征,并利用相关性和主成分分析方法深入探究矿区水样的水化学特征,然后依据水化学分析结果对矿井水进行水质评价,并按照“分级分类”标准进行水质等级划分,得到矿井水初步利用途径,最后计算水样钠吸附比(SAR),建立钠吸附比(SAR)和EC关系,划分张集煤矿矿井水盐渍化和钠毒害风险等级,最终判定研究区矿井水资源化利用的途径。得出结论:张集煤矿矿井水TDS含量为255.47~7291.74 mg/L,平均值高达2346.60 mg/L,严重超标,其中离子组成含量贡献度最高的是Na^(+)和K^(+);按照“分级分类”标准划分的水质分级结果为研究区Ⅴ类矿井水占比高达81%;钠吸附比(SAR)和EC关系显示,79.3%的水样点分布在S3-E4区和S4-E4区,说明张集煤矿矿井水存在较高的盐渍化和钠毒害风险,不适宜用做农业用水,矿井水水域只可作为一般工业用水区、人体非直接接触娱乐用水区或者一般景观水域。

关键词：淮南煤田矿井水资源化水化学分析水质分级钠毒害风险

CRISPR/Cas9-mediated genome editing for rice and wheat improvement

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CRISPR/Cas9-mediated genome editing for rice and wheat impro...

第八届全国小麦基因组学及分子育种大会

作者： jingying li Shaoya li Yonwei Sun Jiahui Zhang Jinfu Tian Suhas Sutar Wenming Du Lanqin Xia Institute of Gap Sciences(ICS) Chinese Academy of AgriculuralSciences(CAAS)

CRISPR/Cas9 technology enables precise modifications of DNA sequences in vivo and offers a great promise for harnessing plant genes for crop genetic *** error-prone non-homologous end joining(NHEJ) repair of a DSB at specific locations by CRISPR/Cas9 often generates mutations and gene knock-outs,homo logy-directed repair(HDR) potentially can achieve gene ***,it is still challenging to either create mutations or achieve gene replacement in some transformation-recalcitrant species including wheatHere,we report the generation of multiple mutants of several genes through CRISPR/Cas9-mediated genome editing such as SBEIIa related to the synthesis of amylopectin,J AV1 orthologs related to jasmonate signaling pathway and biotic stresses,phosphorus distribution transporter gene(spdt) in rice and wheat,and DERF1 orthologs related to drought tolerance,secalin gene related to quality and etc in *** and phenotype analyses of these mutant lines are under ***,we successfully generated multiple herbicide resistant rice lines through simultaneous substitutions of two amino acid residues of Acetolactate synthase(ALS),demonstrated the feasibility to achieve gene replacement by CRISPR/Cas9-mediated ***,we generated targeted point substitutions in several genes such as SBEIIa,PDS and NRT1.1 B in rice through base-editing via a modified CRISPR/nCas9-cytidine deaminase system Together,these results demonstrate that we can not only generate multiple rice and wheat mutant plants through NHEJ for either functional analysis or genetic improvement,but also precisely substitute single or several amino acid residues in proteins through CRISPR/Cas9-mediated base-editing or HDR,greatly expanding the ability to modify genes that confer agriculturally important traits in rice and wheat.

关键词： CRISPR/Cas9 Error-prone non-homologous end joining(NHEJ) Genome editing Homobgy-directed repair(HDR) Rice(Oryza sativa) Wheat(Triticum aestivum)