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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues

Protein & Cell 2024年第8期15卷 594-611页

作者： Jian Wu Chaoye Wang Shuhui Sun Tianmin Ren Lijie Pan Hongyi Liu Simeng Hou Shen Wu Xuejing Yan jingxue zhang Xiaofang Zhao Weihai Liu Sirui Zhu Shuwen Wei Chi zhang Xu Jia Qi zhang Ziyu Yu Yehong Zhuo Qi Zhao Chenlong Yang Ningli Wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China Spencer Center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo AltoCA 94304USA

The progressive degradation in the trabecular meshwork(TM)is related to age-related ocular diseases like primary open-angle ***,the molecular basis and biological significance of the aging process in TM have not been fully ***,we established a dynamic single-cell transcriptomic landscape of aged macaque TM,wherein we classified the outflow tissue into 12 cell subtypes and identified mitochondrial dysfunction as a prominent feature of TM ***,we divided TM cells into 13 clusters and performed an in-depth analysis on cluster O,which had the highest aging score and the most significant changes in cell proportions between the two ***,we found that the APOE gene was an important differentially expressed gene in cluster O during the aging process,highlighting the close relationship between cell migration and extracellular matrix regulation,and TM *** work further demonstrated that silencing the APOE gene could increase migration and reduce apoptosis by releasing the inhibition on the PI3K-AKT pathway and downregulating the expression of extracellular matrix components,thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal *** work provides valuable insights for future clinical diagnosis and treatment of glaucoma.

关键词： single-cell transcriptomic atlas macaque trabecular meshwork ocular outflow tissue aging

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“双碳”目标下欠发达地区碳排放效率时空演变与驱动因素——超效率SBM模型测度与GTWR模型的异质性分析

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商业研究 2024年第2期 93-103页

作者：张竞雪王海杰郑州大学商学院郑州450001

在“双碳”目标约束下,欠发达地区的传统高碳经济增长模式难以为继,如何在保持经济稳步发展的同时减少碳排放是欠发达地区面临的重要挑战。本文基于超效率SBM模型测度典型欠发达地区2006—2020年间的碳排放效率,探究了碳排放效率的时空... 详细信息

在“双碳”目标约束下,欠发达地区的传统高碳经济增长模式难以为继,如何在保持经济稳步发展的同时减少碳排放是欠发达地区面临的重要挑战。本文基于超效率SBM模型测度典型欠发达地区2006—2020年间的碳排放效率,探究了碳排放效率的时空演变特征,采用空间面板计量模型测度碳排放效率影响因素,运用GTWR模型研究驱动因素异质性。研究表明:欠发达地区碳排放效率高-高集聚区表现出极化效应,而低-低集聚区呈现溢出效应;人口规模、技术进步与经济发展是影响碳排放效率的主要驱动因素,碳排放效率受自身滞后效应影响;驱动因素存在时空异质性特征,经济发展水平较低地区存在环境“逐底”竞争效应,大多数城市的人口集聚效应逐渐增强,技术进步呈现“学习效应”。因此,应当推进区域间协同治理碳污染问题,因地制宜实施低碳发展战略,助力欠发达地区实现绿色发展。

关键词：碳排放效率时空演变驱动因素异质性

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Influence of dysprosium concentration on sensitivity of luminescent thermometers of phosphors Ca_(9)Tb(PO_(4))_(5)(SiO_(4))F_(2)

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Journal of Rare Earths 2021年第8期39卷 946-951页

作者： jingxue zhang Lefu Mei Yuanyuan zhang Qingfeng Guo Libing Liao Haikun Liu Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing 100083China School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China School of Gemmology China University of GeosciencesBeijing 100083China School of Chemical Engineering and Energy Technology Dongguan University of TechnologyDongguan 523808China

Tb^(3+),Dy^(3+)-co-doped Ca_(9)Tb_(x)Dy_(1-x)(PO_(4))_(5)(SiO_(4))F_(2) phosphors were prepared via high-temperature solidphase reaction method and the potential application in optical temperature measurements due to their color-tunable property was investigated in *** photoluminescence emission(PL) and photoluminescence excitation(PLE) spectra results show that the as-prepared phosphors exhibit both Tb^(3+) and Dy^(3+) emissions at 546 nm(^(5)D_(4)-^(7)F_(5) transition of Tb^(3+)) and 587 nm(^(4)F_(9/2)-^(6)H_(13/2) transition of Dy^(3+)) upon 376 nm excitation,*** addition,the fluorescence decay analysis shows that the lifetime of the Tb3+emission rapidly decreases,which confirms the energy transfer existence between Dy^(3+) and Tb^(3+).Under 376 nm excitation,the temperature dependence of the fluorescence intensity ratios for the dualmission bands peaked at 546 and 587 nm was studied in the temperature range from 303 to 573 *** results show that with the increase of Dy^(3+) concentration,the relative sensitivity first increases and then decreases,what’s more,the maximum relative sensitivity is 3.142×10^(-3)%/K for Ca_(9)Tb_(x)Dy_(1-x)(PO_(4))_(5)(SiO_(4))F_(2)(x=0.4).As a consequence,this preliminary study provides a novel method for exploring the novel thermo meters.

关键词： Temperature measurement Apatite Fluorescence intensity ratios Phosphor Thermometers Rare earths

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东北漫川漫岗黑土区典型农业小流域切沟沟头形态特征及其影响因素

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水土保持通报 2024年第3期44卷 1-8,25页

作者：杨帆巩子瑞郭明明张立波鲁文龙刘欣王百阳张靖雪吉林农业大学资源与环境学院吉林长春130061 中国科学院东北地理与农业生态研究所黑龙江哈尔滨150001 吉林省水利科学研究院吉林长春130022

[目的]研究中国东北漫川漫岗黑土区典型农业小流域切沟沟头形态特征及其影响因素,为控制黑土区沟壑侵蚀提供基础数据和理论支撑。[方法]以黑龙江省海伦市海南乡典型农业小流域切沟沟头为研究对象,野外实地调查沟头形态特征及土壤类型和... 详细信息

[目的]研究中国东北漫川漫岗黑土区典型农业小流域切沟沟头形态特征及其影响因素,为控制黑土区沟壑侵蚀提供基础数据和理论支撑。[方法]以黑龙江省海伦市海南乡典型农业小流域切沟沟头为研究对象,野外实地调查沟头形态特征及土壤类型和土体构型,解析沟头形态特征与沟头内因(土壤特性)及外部环境因素的相关性,分析内外因素对沟头形态的影响。[结果](1)海南乡小流域切沟沟头土壤类型为典型黑土、草甸黑土和冲积土,土体构型以腐殖质层(A)+淀积层(B)+母质层(C)型为主,以腐殖质层(A)+母质层(C)及腐殖质层(A)+母质层(C)+埋藏层(Ab)型为辅。(2)相关性分析表明,沟头形态与内外因素呈现复杂的相关性,单一形态不仅受内外因素的影响,同时受自身形态的共同作用影响。(3)冗余分析表明,土体构型、汇水面积、沟头坡度是影响沟头形态的主要因子,且与沟头形态呈正相关关系;沟头植被覆盖度、作物距沟头距离、沟头垄向与沟头立面夹角与沟头形态呈负相关关系。[结论]切沟沟头形态特征复杂,土壤垂向差异性是内因的根本,沟头形态受内外因素共同影响。

关键词：漫川漫岗黑土区沟头形态土体构型

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What Kind of Contemporary Chinese Literature do Western Readers “Fancy”？

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China & The World Cultural Exchange 2014年第12期80卷 47-48页

作者： zhang jingxue

Interview with Cultural Celebrity on China Economic Net invited three experts in translation to discus how contemporary Chinese literature could “go global”. The three experts, who also participated in the 2014 Contemporary Chinese Literature Translation and Introduction Program, are： Ms. Lv Hong, Editor-in-Chief of Redwoods Magazine;Prof. Martin Woesler, Projessor at Munich University of Applied Languages, Mr. Sang Yichuan, President of Canada Maple Press.

关键词：当代中国文学读者西方花式慕尼黑大学文化名人中国人

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氮杂环卡宾-铁配合物催化碳-碳偶联反应的研究进展

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合成化学 2024年第5期32卷 469-484页

作者：代祯王亚鹏赵慧慧张斌刘万聪张静学何俊胡嘉涛刘浩张翔成都大学药学院(四川抗菌素工业研究所) 四川成都610052

作为传统贵金属催化剂的理想替代品,铁具有来源广泛、毒性低和环境兼容性好等特点,目前被用于多种环境友好的催化过程。近年来,氮杂环卡宾(NHC)由于其独特的空间和电子性质,常作为配体,不仅能够被应用于贵金属(如钯、镍和铑等)催化,在... 详细信息

作为传统贵金属催化剂的理想替代品,铁具有来源广泛、毒性低和环境兼容性好等特点,目前被用于多种环境友好的催化过程。近年来,氮杂环卡宾(NHC)由于其独特的空间和电子性质,常作为配体,不仅能够被应用于贵金属(如钯、镍和铑等)催化,在铁催化中也得到了广泛的应用。本文综述了氮杂环卡宾及铁配合物催化剂的特点,并重点讨论了近十年其催化的碳-碳偶联包括芳基-芳基交叉偶联、芳基-烷基交叉偶联、烷基-烷基交叉偶联等反应中的研究进展。

关键词：氮杂环卡宾配体铁催化剂 Suzuki偶联反应 Kumada偶联反应合成催化活性

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Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

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Signal Transduction and Targeted Therapy 2023年第3期8卷 912-915页

作者： Xiao Liu Fei Hao Peng Hao jingxue zhang Liqiang Wang Si-Wei You Ningli Wang Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical University100069 BeijingChina School of Engineering Medicine Beijing Key Laboratory for Biomaterials and Neural RegenerationBeihang University100083 BeijingChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key Laboratory100005 BeijingChina Department of Ophthalmology The Third Medical CenterChinese PLA General Hospital100089 BeijingChina Department of Ophthalmology Xijing HospitalThe Fourth Military Medical University710032 Xi’anShanxi ProvinceChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan University510632 GuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) 510530 GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong999077 Hong KongChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area510515 GuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong University226001 NantongJiangsu ProvinceChina Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang University100083 BeijingChina

Dear Editor,The optic nerve,which belongs to the central nervous system(CNS),cannot regenerate when injured in adult mammals.1 Up to now,no readily translatable measures are available for repairing a severely injured optic *** we demonstrated that ciliary neurotrophic factor(CNTF)-chitosan enabled the reconstruction and functional recovery of the adult rat visual system,thus shedding light on the clinical potential for repairing the severely injured optic nerve.

关键词： Regeneration functional CNTF

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检察公益诉讼专门立法的理论基础和法律框架

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国家检察官学院学报 2023年第3期31卷 73-88页

作者：孙佑海张净雪最高人民检察院检察基础理论研究基地(天津大学)

作为一项中国特色司法制度,检察公益诉讼在维护国家利益和社会公共利益方面发挥了重要作用。基于客观诉讼理论、社会公共利益代表理论、法律监督理论,检察公益诉讼的独立性得以证成。现行检察公益诉讼规范层级较低、内容散乱,且采用嵌... 详细信息

作为一项中国特色司法制度,检察公益诉讼在维护国家利益和社会公共利益方面发挥了重要作用。基于客观诉讼理论、社会公共利益代表理论、法律监督理论,检察公益诉讼的独立性得以证成。现行检察公益诉讼规范层级较低、内容散乱,且采用嵌入式立法模式,难以为检察公益诉讼提供有效的法律供给。稳固的政治基础、广泛的社会共识、丰富的司法解释、多年的法治探索为检察公益诉讼专门立法提供了有利条件。制定“检察公益诉讼法”应兼顾程序规则和实体规则、统筹检察行政公益诉讼和检察民事公益诉讼、平衡立法稳定性和灵活性。具体而言,这部专门立法应在整合现有规范的基础上,吸收司法实践经验,对现行制度加以完善,根据开展检察公益诉讼的实际需要设计科学的法律框架,为检察公益诉讼的有序进行提供系统的法律依据。

关键词：检察公益诉讼检察职能法律监督客观诉讼法律框架

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关键审计事项披露的模仿同构与股价同步性

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财经理论与实践 2023年第1期44卷 51-60页

作者：黄溶冰张竞雪浙江工商大学会计学院浙江杭州310018 郑州大学商学院河南郑州450001

基于组织社会学研究中的制度理论,以2016—2020年我国A股上市公司为样本,使用TF-IDF方法计算文本相似性指标,考察关键审计事项披露同构效应及其对资本市场信息效率的影响。结果表明:关键审计事项披露存在模仿同构效应,模仿导致的样板化... 详细信息

基于组织社会学研究中的制度理论,以2016—2020年我国A股上市公司为样本,使用TF-IDF方法计算文本相似性指标,考察关键审计事项披露同构效应及其对资本市场信息效率的影响。结果表明:关键审计事项披露存在模仿同构效应,模仿导致的样板化披露会释放更多行业层面信息,减少公司特质信息进入股价,提升了个股的股价同步性。进一步的分析表明,关键审计事项披露同构效应对股价同步性的影响机制源于行业信息“过载”而非信息“降噪”,这种机制是通过影响分析师和机构投资者判断而发挥作用的。

关键词：新审计报告准则关键审计事项模仿同构股价同步性制度理论

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Electroacupuncture with different waveforms for primary dysmenorrhea:A randomized controlled trial

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 357-362页

作者： Xiaona Wu jingxue Yuan Jinxia Ni Xiuli Ma Ziniu zhang Yini Hua Juwei Dong Bob Peng Wang Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China New Zealand College of Chinese Medicine Auckland 17467New Zealand

Objective To observe and compare the clinical effects of different electroacupuncture waveforms on primary *** This was a prospective,randomized,three-group,parallel-controlled *** with primary dysmenorrhea were randomly divided into dense-sparse wave,continuous wave,and discontinuous wave groups in a 1:1:1 *** lateral Ciliao(BL 32)points were *** three groups started treatment 3–5 days before menstruation,once a day for six sessions per course of treatment,one course of treatment per menstrual cycle,and three menstrual *** primary outcome measure was the proportion with an average visual analog scale(VAS)score reduction of≥50%from baseline for dysmenorrhea in the third menstrual cycle during *** secondary outcome measures included changes in dysmenorrhea VAS scores,Cox Menstrual Symptom Scale scores and the proportion of patients taking analgesic *** The proportion of cases where the average VAS score for dysmenorrhea decreased by≥50%from baseline in the third menstrual cycle was not statistically significant(P>.05).Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea,there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle(P<.05).Additionally,there was a statistically significant difference between the dense-sparse wave and discontinuous wave groups 24 h after acupuncture(P<.05).Conclusions Waveform electroacupuncture can alleviate primary dysmenorrhea and its related symptoms in *** three groups showed similar results in terms of short-and long-term analgesic efficacy and a reduction in the number of patients taking analgesic *** achieving immediate analgesia,the dense-sparse wave group was slightly better than the other two groups.

关键词： Waveforms Ciliao(BL 32) Electroacupuncture Primary dysmenorrhea Randomized controlled trial Dense-sparse waves Continuous waves Discontinuous waves

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