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Isolation and structural elucidation of the compounds from the fruits of Camptotheca acuminate

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Asian Journal of Traditional Medicines 2021年第2期16卷 69-75页

作者： jingxian ren Zhuoyang Cheng Huan He Xiaoxiao Huang Shaojiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

The fruit of Camptotheca acuminate is used as a traditional Chinese *** compounds were isolated from the fruit of Camptotheca acuminate for the first time,including(+)-(S)-abscisic acid(1),blumenol A(2),(E)-3-hydroxymegastigm-7-en-9-one(3),(-)-(3R)-3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin(4),(-)-(3R)-8-methoxy-3-methyl-3,4-dihydro-1H-isochromen-1-one(5),neocnidilide(6),(3S)-butylphthalide(7)and senkyunolide I(8).Their structures were determined by comprehensive spectroscopic methods,including HRESIMS and 1D NMR.

关键词： Camptotheca acuminate separation and purification structure elucidation

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基于价值链理论演进的企业升级发展路径研究

北京经济管理职业学院学报 2019年第1期34卷 17-22页

作者：任婧娴中国农业大学国际学院北京100083

人类社会从工业时代进入知识经济时代,以知识为第一生产要素和以信息化为主要特征的价值创造方式是知识经济时代的主要发展方式。不断丰富的价值链理论不但更加全面地揭示了企业的价值创造机理,而且也更好地为企业的升级发展指明方向。... 详细信息

人类社会从工业时代进入知识经济时代,以知识为第一生产要素和以信息化为主要特征的价值创造方式是知识经济时代的主要发展方式。不断丰富的价值链理论不但更加全面地揭示了企业的价值创造机理,而且也更好地为企业的升级发展指明方向。本文通过对价值链的演进研究,提出了企业沿价值链升级的六条主要路径。

关键词：知识创新信息化价值链企业升级

Research review on the main chemical constituents and pharmacological activities of Viburnum awabuki

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Asian Journal of Traditional Medicines 2022年第5期17卷 244-252页

Viburnum awabuki(***),belonging to the Viburnum genus,is an ideal tree species for *** investigations of the *** have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and *** has been reported that the extracts of *** have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting *** research progress on the chemical constituents of *** and pharmacological activities were summarized in this review.

关键词： Viburnum awabuki chemical constituents pharmacological activities review

Chemical constituents and pharmacological activities of Salvia miltiorrhiza

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亚洲传统医药(英文) 2023年第2期18卷 69-80页

作者： Man Wang jingxian ren Zhuoyang Cheng Xiaoxiao Huang Department of Natural Product Chemistry Shenyang Pharmaceutical UniversityShenyang 110016China

Salvia miltiorrhiza Bunge(***),a perennial plant of the genus Salvia,is widely used in traditional folklore *** chemical research on this plant contains diterpenoid quinones,phenolic acids,polysaccharides and other *** pharmacological investigation of *** has shown that it has various pharmacological activities,such as cardiovascular system protection,anti-inflammatory,anti-oxidant,anti-tumor,liver protection,and neuroprotection *** research tends to give an overview of the main chemical constituents and pharmacological effects of ***,aiming to reveal its potential value and provide reference for its further development.

关键词： Salvia miltiorrhiza Bunge chemical constituents pharmacological effects

Study of the mechanism underlying inhibitory effect of terpenoids from Daphne plants on liver cancer cells using a network pharmacology-based approach

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Asian Journal of Traditional Medicines 2020年第5期15卷 255-262页

作者： jingxian ren Zhuoyang Cheng Peng Zhao Xiaoxiao Huang Shaojiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Daphne plants,belonging to Thymelaeaceae,have been used as traditional Chinese medicine for thousands of *** studies suggested that they exerted anti-tumor activities and reported a number of compounds with anti-tumor activities,isolated from the genus ***,the targets of these compounds have not been determined *** this study,network pharmacology was used to analyze 128 terpenoid compounds from the genus Daphne and 49 target proteins of liver *** results suggested that the target with the most number of directed edges was *** compound which docked with 5yz0 best is ***.25(acutilobin D),and the compounds with total docking score greater than 10 were almost all Daphnane *** network pharmacology results predicted that the 5yz0 protein was one of the potential targets of the terpenoids from the genus Daphne and then suggested several new targets and compounds for further liver cancer research.

关键词： Daphne liver cancer terpenoids network pharmacology

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后处理工艺对抗静电滤料性能的影响

产业用纺织品 2024年第7期42卷 19-26页

作者：柳静献任磊东北大学资源与土木工程学院辽宁沈阳110819

选择基布中嵌织导电纱线的基布导电型和面层中混入导电纤维的面层导电型2种典型抗静电滤料作为基材,进行聚四氟乙烯(PTFE)乳液浸渍处理和PTFE微孔膜覆膜处理,得到面密度和厚度均匀的复合滤料。再基于电阻率、静电压衰减时间及摩擦带电电... 详细信息

选择基布中嵌织导电纱线的基布导电型和面层中混入导电纤维的面层导电型2种典型抗静电滤料作为基材,进行聚四氟乙烯(PTFE)乳液浸渍处理和PTFE微孔膜覆膜处理,得到面密度和厚度均匀的复合滤料。再基于电阻率、静电压衰减时间及摩擦带电电压3项指标,从静电荷的消散及积聚2个角度,探究了后处理工艺对抗静电滤料性能的影响。试验结果表明:浸渍处理后,滤料抗静电性能提升,2种滤料的迎尘面表面电阻率和体积电阻率均降低且降幅小于1个数量级,基布导电型滤料和面层导电型滤料的迎尘面静电压半衰期分别由0.40 s、0.23 s缩短至0.38 s、0.20 s,摩擦时间为60 s时摩擦带电电压分别由1043 V、596 V减小至668 V、67 V。覆膜处理后,滤料抗静电性能下降,基布导电型滤料迎尘面表面电阻率升高且升幅为1个数量级、体积电阻率升高但升幅小于1个数量级,面层导电型滤料迎尘面表面电阻率和体积电阻率均升高且升幅为4个数量级,基布导电型滤料和面层导电型滤料迎尘面静电压半衰期分别由0.40 s、0.23 s延长至0.53 s、0.77 s,摩擦时间为60 s时摩擦带电电压分别由1043 V、596 V增大至1952 V、920 V。

关键词：后处理工艺浸渍处理覆膜处理抗静电滤料表面电阻率体积电阻率静电压衰减时间摩擦带电电压

应用中断时间序列方法评估干预措施对陆家嘴水厂出厂水三卤甲烷的影响

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环境与职业医学 2024年第4期41卷 420-424页

作者：任洋洋钱海雷裴赛峰孙晓冬吴筝伍晨周婧娴杜爱民隋少峰上海市疾病预防控制中心健康危害因素监测与控制所上海200336 上海市疾病预防控制中心化学品毒性检定所上海200336

[背景]青草沙水库面临着水藻繁殖、富营养化的问题,由此引起水中的氯化消毒副产物含量增加一直是人们关注的重点。[目的]评估“青草沙水库藻类监测与应对方案”(后称“方案”)的实施对常规处理出厂水中三卤甲烷(THMs)的治理效果。[方法]... 详细信息

[背景]青草沙水库面临着水藻繁殖、富营养化的问题,由此引起水中的氯化消毒副产物含量增加一直是人们关注的重点。[目的]评估“青草沙水库藻类监测与应对方案”(后称“方案”)的实施对常规处理出厂水中三卤甲烷(THMs)的治理效果。[方法]从2011-2019年,每个季节采集陆家嘴水厂1次出厂水水样,每次采集1个样品,检测出厂水中四种THMs(三氯甲烷、二氯一溴甲烷、一氯二溴甲烷、三溴甲烷)的质量浓度(后称浓度)。以2014年“方案”的实施作为干预分界点,将整个研究阶段分为干预措施实施前(2011-2013年)和实施后(2014-2019年)两个阶段。应用中断时间序列分析方法进行分段线性回归,评估干预措施实施前后出厂水中THMs浓度和变化趋势。[结果]在“方案”实施前,时间每延长一个季节,出厂水中总THMs浓度上升1.561μg·L^(-1)(P=0.010),最高浓度达25.97μg·L^(-1)。干预措施实施后,出厂水中总THMs的浓度变化未见统计学意义(P=0.198);但出厂水中总THMs浓度回归线的斜率为-0.626(P=0.001),即THMs浓度随时间变化呈下降趋势。自2017年起至2019年,陆家嘴水厂出厂水中THMs的平均浓度保持在10μg·L^(-1)以下。[结论]青草沙水库藻类和富营养化治理措施达到了较好的效果,将出厂水中的THMs控制在较低水平,THMs的变化趋势由干预前的逐年上升,变为干预后的逐年降低。

关键词：饮用水消毒副产物三卤甲烷中断时间序列卫生干预措施

Rapid quantification of 50 fatty acids in small amounts of biological samples for population molecular phenotyping

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Biophysics Reports 2023年第6期9卷 299-308页

作者： Pinghui Liu Qinsheng Chen Lianglong Zhang Chengcheng ren Biru Shi jingxian Zhang Shuaiyao Wang Ziliang Chen Qi Wang Hui Xie Qingxia Huang Huiru Tang State Key Laboratory of Genetic Engineering School of Life Sciences Human Phenome Institute Zhangjiang Fudan International Innovation Center Metabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular Phenomics Zhongshan Hospital Fudan University Wuhan Laboratory for Shanghai Metabolome Institute (SMI) Ltd

Efficient quantification of fatty-acid(FA) composition(fatty-acidome) in biological samples is crucial for understanding physiology and pathophysiology in large population cohorts. Here, we report a rapid GC-FID/MS method for simultaneous quantification of all FAs in numerous biological matrices. Within eight minutes, this method enabled simultaneous quantification of 50 FAs as fatty-acid methyl esters(FAMEs) in femtomole levels following the efficient transformation of FAs in all lipids including FFAs,cholesterol-esters, glycerides, phospholipids and sphingolipids. The method showed satisfactory interday and intra-day precision, stability and linearity(R2 > 0.994) within a concentration range of 2–3 orders of magnitude. FAs were then quantified in typical multiple biological matrices including human biofluids(urine, plasma) and cells, animal intestinal content and tissue samples. We also established a quantitative structure-retention relationship(QSRR) for analytes to accurately predict their retention time and aid their reliable identification. We further developed a novel no-additive retention index(NARI) with endogenous FAMEs reducing inter-batch variations to 15 seconds; such NARI performed better than the alkanes-based classical RI, making meta-analysis possible for data obtained from different batches and platforms. Collectively, this provides an inexpensive high-throughput analytical system for quantitative phenotyping of all FAs in 8-minutes multiple biological matrices in large cohort studies of pathophysiological effects.

关键词： Fatty-acidomics High-throughput quantification Structure-retention relationship No-additive retention index

基于等效故障注入试验的列车风源系统故障影响规律与分析

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仪器仪表学报 2023年第5期44卷 44-52页

作者：丁景贤左建勇任利惠同济大学机械工程流动站上海201804 同济大学铁道与城市轨道交通研究院上海201804 同济大学上海市轨道交通结构耐久与系统安全重点实验室上海201804

为获取列车风源系统故障诊断所需特征参量及故障影响规律,针对部分故障模式不可注入或注入具有破坏性等问题,阐述了风源系统的构成原理和故障模式,提出了等效故障模型设计方法及等效故障注入流程,基于等效故障注入试验研究了5种典型故... 详细信息

为获取列车风源系统故障诊断所需特征参量及故障影响规律,针对部分故障模式不可注入或注入具有破坏性等问题,阐述了风源系统的构成原理和故障模式,提出了等效故障模型设计方法及等效故障注入流程,基于等效故障注入试验研究了5种典型故障模式在不同故障程度下的影响规律并分析了故障原因。研究结果表明:等效故障注入试验可以在不对风源系统造成破坏的情况下再现供气不足、油温高以及压缩机不加载3类典型故障现象,且不同故障模式的影响规律和特征参量不同。进气过滤器严重堵塞时总风压力不足740 kPa,造成供气不足现象;温控阀严重卡滞时最高喷油温度和机头排气温度分别较正常值增加了约20℃和17℃,冷却油流量最大减小了约14 L/min;冷却器积灰引起冷却效果下降,环境温度分别为20℃、35℃和50℃时,最大下降约3℃;油严重泄漏时喷油流量高出正常值约19 L/min,机头排气温度最高可达105℃,造成油温高现象;卸荷电磁阀卡滞造成开度为25%~100%时总风压力只有690 kPa,造成供气不足现象,开度为0时空压机第一次正常工作并停机后无法重新启动,造成压缩机不加载现象。研究结果为基于温度、压力等多传感器数据的故障诊断算法设计以及智能风源系统传感器布局提供了参考。

关键词：列车风源系统等效故障注入试验故障模式特征参量传感器布局