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Au-Fe_(3)O_(4) dumbbell-like nanoparticles based lateral flow immunoassay for colorimetric and photothermal dual-mode detection of SARS-CoV-2 spike protein

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Chinese Chemical Letters 2024年第6期35卷 536-540页

作者： Gengchen Guo Tianyu Zhao Ruichang Sun Mingzhe Song Hongyu liu Sen Wang jingwen li Jingbin Zeng College of Chemistry and Chemical Engineering and State Key Laboratory of heavy oil processing China University of Petroleum(East China)Qingdao 266580China Huangdao Customs of the People’s Republic of China Qingdao 266580China

Lateral flow immunoassay(LFIA)has become popular in laboratories,at-home testing,and medical diagnostics due to its minimal cost and ***,conventional test strips based on colloidal gold can only obtain qualitative or semi-quantitative results with low *** this work,AuFe_(3)O_(4) dumbbell-like nanoparticles were synthesized and used as the LFIA labelling marker for highly sensitive colorimetric-photothermal dual-mode detection of SARS-CoV-2 spike(S)*** unique dumbbell structure of Au-Fe_(3)O_(4) NPs makes it possible to combine the best features of both Au NPs and Fe_(3)O_(4) *** increased surface area of these NPs enhances their LSPR effect and photothermal effect,which achieves signal amplification to increase *** Au-Fe_(3)O_(4) NPs modified with S protein antibody could identify S protein in samples,which were recognized and accumulated on T-line by another antibody,generating color band for qualitative colorimetric *** T-line was irradiated by laser to obtain temperature change for quantitative detection of *** optimized conditions,the detection limit was 1.22 pg/m L,three orders of magnitude more sensitive than colorimetric ***,the approach was performed on SARS-CoV-2 pseudovirus samples and outperformed traditional colloidal gold *** LFIA platform exhibits significant promise for practical implementation,as it can satisfy the need for low-cost,high-sensitivity,and home-based quantitative detection for respiratory infectious diseases.

关键词： Au-Fe_(3)O_(4) dumbbell-like nanoparticles Photothermal effect LFIA S protein

Advanced development of grain boundaries in TMDs from fundamentals to hydrogen evolution application

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Chinese Chemical Letters 2024年第5期35卷 117-129页

作者： Ziyang Yin lingbin Xie Weinan Yin Ting Zhi Kang Chen Junan Pan Yingbo Zhang jingwen li Longlu Wang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China

Grain boundary(GB),as a kind of lattice defect,widely exists in two-dimensional transition metal dichalcogenides(2D TMDs),which has complex and diverse influences on the physical/chemical properties of 2D *** are universally considered to be a double-edged sword,although some electrical and mechanical properties of 2D TMDs would be adversely affected leading to the reduced overall quality,certain structure-oriented applications could be realized based on its unique *** this review,we first detailed the atomic structure characteristics of GBs and the corresponding techniques,then we systematically summarized the methods of introducing GBs into 2D ***,we expounded unique electrical,mechanical,and chemical properties of the GBs in 2D TMDs and clarified its internal relationship with the atomic ***,the application of GB structure in hydrogen evolution reaction(HER)is also *** the end,we make a conclusion and put forward outlooks,hoping to further promote the basic research of GB and boost the wide application of 2D TMDs.

关键词： Grain boundary Transition metal dichalcogenides Two-dimensional materials Hydrogen evolution reaction Dislocation Molybdenum disulfide

Evaluation of co-spoilage potential of Pseudomonas fragi and Pseudomonas lundensis isolated from chilled pork: in vitro and in situ

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Food Science and Human Wellness 2024年

作者： Han Dou Anthony Pius Bassey jingwen li Xianming Zeng Keping Ye State Key Laboratory of Meat Quality Control and Cultured Meat Development Jiangsu Collaborative Innovation Center of Meat Production and Processing College of Food Science and Technology Nanjing Agricultural University

Pseudomonas (P.) fragi and P. lundensis have been reported as key spoilage bacteria in aerobically-stored chilled meat. However， the co-spoilage effect of these bacteria has not been effectively evaluated. This study evaluated the spoilage potential of P. fragi， P. lundensis and P. fragi + P. lundensis in vitro and in situ at 4 ℃. The results showed that P. fragi + P. lundensis performed the highest growth rate and displayed larger decomposition zone diameters on Raw-pork juice agar (RJA) plates. P. fragi + P. lundensis inoculants exhibited the strongest proteolytic activity， which resulted in the highest values of trichloroacetic acid (TCA)-soluble peptides， total volatile basic nitrogen (TVB-N) and myofibril fragmentation index (MFI) in chilled pork. Moreover， the inoculated samples showed different pH and sensory changes. Notably， increased amounts of volatile organic compounds (VOCs)， such as octanal， nonanal， 2-nonanone， 1-propanol， 1-octanol， isopropyl acetate， and 2，6-dimethylpyazine， were observed in inoculated P. fragi + P. lundensis samples， hinting their potential use as spoilage markers for spoilage monitoring of co-cultures. This study would provide a deeper understanding of meat spoilage and serve as a reference for future studies to inhibit meat spoilage.

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Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions

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CCS Chemistry 2024年第1期6卷 165-176页

作者： Huanhuan Song Weihao li Xiaoying Wang Kaiteng Wang jingwen li Shuai liu Pin Gao Xin-Hua Duan Jinbo Hu Mingyou Hu School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Key Laboratory of Sustainable Energy Material ChemistryXi’an Jiaotong UniversityXi’an 710049 Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032

A general method for the synthesis of bench-stable bis(difluoromethyl)pentacoordinate phosphoranes has been *** reaction is rapid,operationally simple,and easily *** pentacoordinate phosphoranes can generate both difluoromethyl radical(·CF_(2)H)and difluorocarbene(:CF_(2))***,a variety of fluoroalkylation transformations havebeen achieved by·CF_(2)H,such asoxidativedifluoromethylation of electron-deficient heterocycles,nickel/photoredox dual-catalyzed difluoromethylation of aryl bromides,and photoredox difluoromethylation of alkenes,or by:CF_(2),such as gem-difluorocyclopropanation of alkenes,base-promoted difluoromethylation of heteroatom nucleophiles,Pd-catalyzed difluoromethylation of arylboronic acids,and Cu-mediated trifluoromethylation of aryl iodides(via:CF_(2) and recombined CF_(3)-).These fluoroalkylation methods have been successfully applied to late-stage fluoroalkylation of drugs and drug-like molecules.

关键词： pentacoordinate phosphorane difluoromethyl radical difluorocarbene difluoromethylation fluoroalkylation

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基于偏振比检测和支持向量机的颗粒在线检测

激光与光电子学进展 2024年第4期61卷 253-261页

作者：赵儒强李璟文江南大学理学院江苏无锡214122

提出一种基于偏振比检测和支持向量机的颗粒物实时检测与分类方法。采用双波长的半导体激光器作为光源,使用高灵敏度的雪崩光电二极管分别测量散射光的两个偏振分量,计算出单个颗粒散射光的偏振比,从而实现颗粒分类与识别。结合支持向... 详细信息

提出一种基于偏振比检测和支持向量机的颗粒物实时检测与分类方法。采用双波长的半导体激光器作为光源,使用高灵敏度的雪崩光电二极管分别测量散射光的两个偏振分量,计算出单个颗粒散射光的偏振比,从而实现颗粒分类与识别。结合支持向量机算法与神经网络模型可进一步提升颗粒物的分类精度。针对所研究的二元及三元分类场景,分类精度分别由64%和83%提升至100%和98%。该方法在制药、化妆品以及工业生产控制与检测等领域具有很好的应用前景。

关键词：光散射偏振比支持向量机颗粒检测

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家族创业研究:现状、理论演进与展望

南开管理评论 2024年第1期27卷 116-127,157,I0021,I0022页

作者：贺小刚陈元李婧文李鑫上海财经大学商学院上海财经大学浙江学院武汉轻工大学管理学院

家族创业作为一种普遍且重要的经济活动,受到学者广泛关注。但学术界目前还缺乏对家族创业研究现状与理论进展的系统总结,尤其是缺乏一个家族创业研究的整合体系。在家族创业概念界定和国内外研究总体状况分析基础上,本文从研究主题、... 详细信息

家族创业作为一种普遍且重要的经济活动,受到学者广泛关注。但学术界目前还缺乏对家族创业研究现状与理论进展的系统总结,尤其是缺乏一个家族创业研究的整合体系。在家族创业概念界定和国内外研究总体状况分析基础上,本文从研究主题、研究视角、理论基础、研究方法四个维度构建了家族创业研究的整合体系,基于“影响因素—中介机制/调节机制—影响结果”的逻辑梳理了家族创业形成、治理、决策与效应的研究内容,并借鉴文献计量法将家族创业研究的理论演进历程归纳为理论探索、理论融合、理论深化三个阶段。最后,本文基于现有研究状况,从家族创业的主题拓展、理论整合和中国本土化三个方面提出未来研究方向。研究结果丰富了家族创业研究的理论基础和框架体系,对推动家族创业的深化发展具有重要意义。

关键词：家族创业文献研究研究现状理论进展未来展望

γ-谷维素对淀粉酯-磷脂纳米乳液氧化稳定性的影响机制

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食品与发酵工业 2024年第11期50卷 102-109页

作者：李静雯钟金锋刘敏李怡菲刘雄覃小丽西南大学食品科学学院重庆400715 食品科学与工程国家级实验教学示范中心(西南大学) 重庆400715

抗氧化剂的添加能有效提高纳米乳液氧化稳定性。该研究探索γ-谷维素(γ-oryzanol,GO)添加量对以辛烯基琥珀酸淀粉酯(octenyl succinic anhydride modified starch,OSAS)-磷脂(phosphatidylcholine,PC)为乳化剂的纳米乳液性质的影响。... 详细信息

抗氧化剂的添加能有效提高纳米乳液氧化稳定性。该研究探索γ-谷维素(γ-oryzanol,GO)添加量对以辛烯基琥珀酸淀粉酯(octenyl succinic anhydride modified starch,OSAS)-磷脂(phosphatidylcholine,PC)为乳化剂的纳米乳液性质的影响。结果表明,与未添加GO的纳米乳液(46.12 m V)相比,GO质量浓度为37.5 mg/L的纳米乳液ζ-电位绝对值增加至49.47 m V,所有乳液贮藏4周后未出现分层、絮凝等现象。在25℃贮藏4周的过程中,与未添加GO的纳米乳液相比,含GO的纳米乳液的过氧化值增长较慢,表现出较强的氧化稳定性。分子动力学模拟结果显示,PC-GO(-1.67×10^(5)k J/mol)和甘油三酯(triacylglycerol,TAG)-GO(-1.66×10^(5)k J/mol)的结合能显著低于OSAS-GO的结合能(-1.56×10^(5)k J/mol),表明GO倾向分布于水包油纳米乳液的分散相且靠近界面处。当GO数量由1增至3时,GO与TAG间的结合能由-1.66×10^(5)k J/mol减小至-4.94×10^(5)k J/mol,说明GO的数量影响着其与TAG的结合强度。该研究从实验和理论计算的角度阐明了GO对OSAS-PC纳米乳液的氧化稳定性有着重要影响,有望拓展GO等抗氧化剂提高纳米乳液稳定性方面的基础研究,为开发新式功能乳液产品提供借鉴。

关键词：谷维素纳米乳液分子动力学模拟相互作用

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双圈图的邻点可约全标号

华中师范大学学报（自然科学版） 2024年第4期58卷 409-418页

作者：王丽李敬文宋晨常文文兰州交通大学电子与信息工程学院兰州730070

图G(V,E)的邻点可约全标号(adjacent vertex reducible total labeling,AVRTL)是一个从V(G)∪E(G)到连续整数集{1,2,…,|V(G)|+|E(G)|}的双射,且图中所有相邻同度顶点的标号之和均相同,为S(u)=f(u)+∑uw∈E(G)f(uw).该文结合现实问题,借鉴传统遗传算法、蜂群算法等智能算法思路,设计了一种新型的AVRTL算法,通过预处理函数、调整函数等,利用循环迭代寻优的方式得到有限点内所有双圈图的邻点可约全标号结果.对实验结果进行分析,发现几类图的标号规律,总结得到若干定理并给出证明,最后给出猜想:所有的双圈图均为AVRTL图.

关键词：双圈图邻点可约全标号算法图标号

子痫前期孕妇产时中转剖宫产的临床特征和危险因素

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实用妇科内分泌电子杂志 2024年第6期11卷 19-21页

作者：李静文内蒙古自治区妇幼保健院产科内蒙古呼和浩特010020

目的探讨子痫前期(PE)患者阴道试产中转剖宫产的相关危险因素。方法选取300例实施阴道试产的PE患者为研究对象,按照阴道试产结局分为阴道试产成功组(n=177)、中转剖宫产组(n=123),回顾性分析两组临床资料并对所得数据进行统计学分析。... 详细信息

目的探讨子痫前期(PE)患者阴道试产中转剖宫产的相关危险因素。方法选取300例实施阴道试产的PE患者为研究对象,按照阴道试产结局分为阴道试产成功组(n=177)、中转剖宫产组(n=123),回顾性分析两组临床资料并对所得数据进行统计学分析。结果阴道试产成功组体质量指数(BMI)为(26.25±0.99)kg/m^(2),低于中转剖宫产组的(29.13±1.12)kg/m^(2),瘢痕子宫、胎位为枕横位、未接受分娩镇痛占比均低于中转剖宫产组,子宫下段肌壁厚度大于中转剖宫产组,差异有统计学意义(P<0.05)。结论PE患者阴道试产中转剖宫产的主要危险因素包括胎位、瘢痕子宫、分娩镇痛、子宫下段肌壁厚度、BMI等,医师应准确掌握该类患者的临床特征,针对存在中转剖宫产危险因素者进行积极干预,以确保母婴安全。

关键词：子痫前期阴道试产中转剖宫产临床特征危险因素