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Sin1-mediated mTOR signaling in cell growth, metabolism and immune response

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National Science Review 2019年第6期6卷 1149-1162页

作者： Chun Ruan Xinxing Ouyang Hongzhi Liu Song Li jingsi jin Weiyi Tang Yu Xia Bing Su Shanghai Institute of Immunology Department of Immunology and Microbiology and the Minister of Education Key Laboratory of Cell Death and DifferentiationShanghai Jiao Tong University School of Medicine Zhiyuan College Shanghai Jiao Tong University

The mammalian target of rapamycin(mTOR) is an evolutionarily conserved Ser/Thr protein kinase with essential cellular function via processing various extracellular and intracellular inputs. Two distinct multi-protein m TOR complexes(mTORC), m TORC1 and m TORC2, have been identified and well characterized in eukaryotic cells from yeast to human. Sin1, which stands for ■,also known as mitogen-activated protein kinase■ (MAPKAP)1, is an evolutionarily conserved adaptor protein. Mammalian Sin1 interacts with many cellular proteins, but it has been widely studied as an essential component of m TORC2, and it is crucial not only for the assembly of m TORC2 but also for the regulation of its substrate specificity. In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the m TOR pathway that could account for various cellular functions of m TOR in growth,metabolism, immunity and cancer.

关键词： Sin1 AGC kinases mTOR complex Akt metabolism and immune response

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中医学视角下城市物质空间的生命要素探析

城市规划 2015年第4期39卷 35-42页

作者：金广君蔡瑞定金敬思哈尔滨工业大学深圳研究生院中国城市规划设计研究院深圳分院

通过借鉴中医学整体观和生命观的相关理论,从认识城市有机体的生命属性入手,发现并提炼能够产生和传递城市运营所需各种能量的生命要素:廊道和功能体。阐释了其多层级、多性质和多形态的特点,提出了功能体有动力、廊道成系统、敏感点有... 详细信息

通过借鉴中医学整体观和生命观的相关理论,从认识城市有机体的生命属性入手,发现并提炼能够产生和传递城市运营所需各种能量的生命要素:廊道和功能体。阐释了其多层级、多性质和多形态的特点,提出了功能体有动力、廊道成系统、敏感点有活力的疏通策略,旨在促进城市各种能量的有机循环,从而维护城市的健康与安全,提高城市生活的效率与质量。

关键词：中医学城市物质空间生命要素廊道功能体

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc

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Cellular & Molecular Immunology 2019年第9期16卷 757-769页

作者： Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan jingsi jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su Shanghai Institute of Immunology Department of Immunology and MicrobiologyKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Immunobiology and the Vascular Biology and Therapeutics Program Yale University School of Medicine333 Cedar StreetNew HavenConnecticut 06520USA Present address:EMD Serono Research&Development Institute Inc.45 Middlesex TpkeBillericaMA 01821–3936USA Hongqiao International Institute of Medicine Shanghai Tongren Hospital and Faculty of Basic MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Public Health Clinical Center and School of Basic Medical Sciences Key Laboratory of Medical Molecular Virology of MOE/MOHFudan UniversityShanghaiChina

Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely *** this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and *** ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs ***1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral *** the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,***,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.

关键词： metabolism immunity stimulation

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非小细胞肺癌分子靶向治疗药物的现状及进展

中国肿瘤临床 2015年第17期42卷 881-885页

作者：金静思贺巾钊周黎明四川大学华西基础医学与法医学院成都市610041 四川大学药理学教研室成都市610041

目前肺癌以高发病率、高死亡率居我国恶性肿瘤病死率的首位，严重威胁着人类的健康，其中非小细胞肺癌（non-small cell lung cancer，NSCLC）约占肺癌的80%～90%。遗憾的是大多数患者就诊时已为晚期，错失了外科手术的机会，故内科治... 详细信息

目前肺癌以高发病率、高死亡率居我国恶性肿瘤病死率的首位，严重威胁着人类的健康，其中非小细胞肺癌（non-small cell lung cancer，NSCLC）约占肺癌的80%～90%。遗憾的是大多数患者就诊时已为晚期，错失了外科手术的机会，故内科治疗成为NSCLC晚期患者的主要治疗方法。近些年来分子靶向治疗药物取得了巨大的进展，为NSCLC晚期患者提供了新的治疗手段。本文将就NSCLC的分子靶向药物治疗作一介绍，希望能对临床上NSCLC晚期患者的个体化治疗有所裨益。

关键词：非小细胞肺癌分子靶向治疗药物个体化治疗

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从品质到品位——论景观的创作与塑造

城市建筑 2009年第8期6卷 112-113页

作者：金敬思同济大学建筑与城市规划学院上海200092

本文基于现代景观学观点,从美学和文化两方面探讨景观的内在含义,提出从品质到品位的提升是现代人对景观的需求所在。

关键词：景观景观品质景观品位

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城市设计与当代城市设计

城市建筑 2014年第10期11卷 20-23页

作者：金广君金敬思哈尔滨工业大学深圳研究生院中国城市规划设计研究院深圳分院

本文简要介绍了城市设计的沿革及其内涵经历"学科交叉""多学科渗透"和"学科融贯"的演变过程,在阐述当代城市设计"二次订单设计"的概念后,提出当代城市设计思潮所体现出的多元的设计集群、动态的设计成果和理性的行动计划这三个主要特征。

关键词：城市设计当代城市设计二次订单设计决策环境城市设计集群

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非小细胞肺癌的相关驱动基因研究进展

四川解剖学杂志 2015年第3期23卷 19-23,41页

作者：金静思贺巾钊吴江刘肖珩四川大学华西基础医学与法医学院生物医学工程研究室成都610041

肺癌高居我国恶性肿瘤病死率的首位,严重威胁着人类的健康,其中非小细胞肺癌（non-small cell lung cancer,NSCLC）包括鳞状细胞癌、腺癌等,与小细胞癌比较其癌细胞生长分裂较慢,扩散转移较晚,约占肺癌的80%~90%。大多数患者就诊时已处... 详细信息

肺癌高居我国恶性肿瘤病死率的首位,严重威胁着人类的健康,其中非小细胞肺癌（non-small cell lung cancer,NSCLC）包括鳞状细胞癌、腺癌等,与小细胞癌比较其癌细胞生长分裂较慢,扩散转移较晚,约占肺癌的80%~90%。大多数患者就诊时已处于晚期,错失了外科手术的最佳时机,因此,内科治疗成为NSCLC晚期患者的主要治疗方法。近些年来,随着NSCLC相关驱动基因的陆续发现,分子靶向治疗方面的研究取得了质的飞跃,为NSCLC晚期患者提供了新的治疗手段。本文就NSCLC的相关驱动基因进行综述,希望对临床上NSCLC晚期患者的个体化治疗有所裨益。

关键词：非小细胞肺癌驱动基因分子靶向治疗

Recovery of lithium using H_(4)Mn_(3.5)Ti_(1.5)O_(12)/reduced graphene oxide/polyacrylamide composite hydrogel from brine by Ads-ESIX process

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Chinese Journal of Chemical Engineering 2022年第4期35卷 20-28页

作者： jingsi Cui Huanxi Xu Yanfeng Ding jingjing Tian Xu Zhang Guanping jin Anhui Key Lab of Controllable Chemical Reaction&Material Chemical Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Powdery Li^(+)-imprinted manganese oxides adsorbent was widely used to the recovery of Li^(+),but there are some difficulties,such as poor stability in acid solution,inconvenience of operation and *** this work,a useful hydrogel composite based H_(4)Mn_(3.5)Ti_(1.5)O_(12)/reduced graphene oxide/polyacrylamide(HMTO-rGO/PAM)was fabricated by thermal initiation method with promising stable,conductive and selective *** resulting materials were characterized by field emission scanning electron microscope,infrared absorption spectrum,X-ray diffraction,X-ray photoelectron spectroscopy and electrochemical *** recovery of Li^(+)was investigated using HMTO-rGO/PAM from brine by a separated two-stage sorption statically and electrically switched ion exchange desorption *** adsorption capacity of 51.5 mg·g^(-1)could be achieved with an initial Li^(+)concentration of 200 mg·L^(-1)in pH 10,at 45℃ for 12 ***^(+)ions could be quickly desorbed by cyclic voltammetry(CV)in pH 3,0.1 mol·L^(-1)HCl/NH;Cl accompanying the exchange of Li^(+)and H+(NH;)and the transfer of LMTO-rGO/PAM to HMTO-rGO/PAM.

关键词： Lithium recovery Titanium doped lithium ion sieve Hydrogel Adsorption-electrically switched ion exchange(Ads-ESIX)

On the Complex Oscillation of Second Order Linear Differential Equations with Entire Coefficients of [p, q]-Order

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Journal of Mathematical Research with Applications 2015年第2期35卷 172-180页

作者： jin TU jingsi WEI Chunfang CHEN College of Mathematics and Information Science Jiangxi Normal University

In this paper, the authors investigate the zeros and growth of solutions of second order linear differential equations with entire coefficients of [p, q]-order and obtain some results which improve and generalize some... 详细信息

关键词： linear differential equations [p,q]-order [p,q] exponent of convergence of zerosequence