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Chinese Chemical Letters 2024年第6期35卷 404-408页

作者： Xiuzheng Deng Changhai Liu Xiaotong Yan jingshan fan Qian Liang Zhongyu Li Advanced Catalysis and Green Manufacturing Collaborative Innovation Center CNPC-CZU Innovation AllianceSchool of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China School of Materials Science&Engineering Changzhou UniversityChangzhou 213164China

The efficient conversion of CO_(2) into hydrocarbon fuels(CH_(4))with high selectivity is considered as a great challenge in photocatalysis owing to the multiple-electron transfer pathway and competitive H_(2) ***,we developed carbon dots(CDs)-modulated S-scheme heterojunction of CDs/NiAl-LDH@In_(2)O_(3)(C-DH@IN)through a facile in-situ hydrothermal *** to the multi-shell nanotube structure,the C-DH@IN shows an enhanced CH_(4) evolution rate of 10.67μmol h^(-1)g^(-1)and higher selectivity of CH_(4)(85.70%)compared with In_(2)O_(3) and Ni Al-LDH@In_(2)O_(3) binary catalyst in the pure water without sacrificial *** spin resonance(ESR)and in situ Fourier transform infrared spectra verify that the constructed S-scheme heterojunction can possess the strong redox capability and the HCOOand CH_(3)O-as critical intermediates play an important role in selective CO_(2) reduction to generate CH_(4).Furthermore,CDs with superior photoabsorption can boost the electron transfer and absorb H^(+),thus improving the integration of H^(+)and CO_(2) ***,this work emphasizes a facile strategy to achieve efficient CO_(2)-to-CH_(4) conversion based on construction of CDs-based heterojunction catalysts.

关键词： Carbon dots In_(2)O_(3) Layered double hydroxides Photocatalytic CO_(2) reduction S-scheme

功能性MOFs材料对水体中抗生素的高效吸附研究进展

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中州大学学报 2021年第6期38卷 112-116页

作者：李玉玲范景珊王迎欣刘滢洁张淼郑州工程技术学院化工食品学院河南郑州450044

近年来,人类对各种抗生素的使用越来越频繁,各大制药公司研制生产的抗生素通过废水、食物和生物富集等途径流入环境中,长此以往会给环境带来不良影响,进而影响人类的身体健康。金属有机框架材料简称为MOFs材料,该类材料的优势是比表面... 详细信息

近年来,人类对各种抗生素的使用越来越频繁,各大制药公司研制生产的抗生素通过废水、食物和生物富集等途径流入环境中,长此以往会给环境带来不良影响,进而影响人类的身体健康。金属有机框架材料简称为MOFs材料,该类材料的优势是比表面积较大,合成条件温和,污染小,质量轻,因而被应用到各个领域。分析了常见抗生素及其去除方法,综述了MOFs化合物以及MOFs复合材料对抗生素的吸附研究进展,提出了功能性MOFs材料在高效吸附水体中抗生素的应用方面面临的挑战和未来展望。

关键词：金属-有机框架材料高效吸附抗生素研究进展

Numerical analysis of thermal fluid transportation during electron beam welding of 2219 aluminum alloy plate and experimental validation

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China Welding 2016年第2期25卷 21-26页

作者： Liu Chengeai He jingshan fan Yongbin State key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Harbin 150001 Harbin JianCheng Group Co. Ltd. Harbin 150030

A three-dimensional mathematical model using volume-of-fluid method is developed to investigate the heat transfer, fluid flow and keyhole dynamics during electron beam welding of 2219 aluminum alloy plate. In the model, an adaptive heat source is employed to simulate the heating process of electron beam. Fluid flow is mainly driven by surface tension, thermo-capillary force, recoil pressure, hydrostatic pressure and thermal buoyancy. The thermal-fluid transport behaviors of welding pool during the drilling and backfilling stages of keyhole and the formation reason of the nail-shaped weld with an arc crater are systematically analyzed. Finally, all calculation results are validated by experiments and show good agreements.

关键词： heat transfer fluid flow keyhole dynamics electron beam welding

高通量测序分析牙周基础治疗对65岁以上糖尿病合并慢性牙周炎患者龈下菌群的影响

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临床与病理杂志 2022年第2期42卷 346-351页

作者：牛家慧李创李蓉胡永权张江畔苑学微樊静珊张亚宏石家庄市第二医院口腔科石家庄050051

目的:采用高通量测序技术分析牙周基础治疗对65岁以上糖尿病合并慢性牙周炎(diabetes mellitus with chronic periodontitis,DMCP)患者龈下菌群的影响。方法:选取100例65岁以上DMCP患者作为研究对象,采用随机数据表法将患者分为研究组... 详细信息

目的:采用高通量测序技术分析牙周基础治疗对65岁以上糖尿病合并慢性牙周炎(diabetes mellitus with chronic periodontitis,DMCP)患者龈下菌群的影响。方法:选取100例65岁以上DMCP患者作为研究对象,采用随机数据表法将患者分为研究组与对照组,每组50例。对照组给予强化控制血糖、基础疾病对症治疗、口腔卫生知识宣教等常规治疗,研究组在此基础上给予牙周基础治疗,治疗及复诊在4周内完成。比较2组患者的基线资料,采用高通量测序技术比较2组患者治疗前、治疗后3个月时牙周龈下菌群中致病菌的相对含量。结果:研究组与对照组分别有2例和5例患者失访,最终分别纳入48例和45例患者。2组患者各项基线资料的差异均无统计学意义(均P>0.05)。2组患者治疗前牙周龈下菌群中各类病原菌相对含量及牙周龈沟液中各种氧化还原物质水平的差异无统计学意义(P>0.05)。在治疗后3个月时,2组患者牙周龈下菌群中各类病原菌相对含量均较治疗前下降,差异均有统计学意义(P>0.05),研究组牙周龈下菌群中各类病原菌相对含量均低于对照组,差异均有统计学意义(P>0.05)。结论:牙周基础治疗能够显著减少DMCP患者牙周龈下菌群中致病菌的含量,纠正口腔菌群失调。

关键词：高通量测序牙周基础治疗糖尿病合并牙周炎龈下菌群氧化应激

Neuroprotective Nanoscavenger Induces Coaggregation of β-Amyloid and Facilitates Its Clearance in Alzheimer’s Disease Brain

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CCS Chemistry 2021年第8期3卷 2321-2335页

作者： Yu Zhao Yu Jiang jingshan Chai fan Huang Zhanzhan Zhang Qi Liu Zhuo Yang Yang Liu Linqi Shi Key Laboratory of Functional Polymer Materials of Ministry of Education College of ChemistryNankai UniversityTianjin 300071 State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071 Key Laboratory of Bioactive for Materials Ministry of Education School of MedicineNankai UniversityTianjin 300071 Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192

The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent ***,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.

关键词： solubleβ-amyloid aggregates nanoscavengers cross the BBB coaggregate microglial clearance

Expression of HLA-DR genes in gliomas: correlation with clinicopathological features and prognosis

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Chinese Neurosurgical Journal 2017年第3期3卷 154-162页

作者： Xing fan jingshan Liang Zhifeng Wu Xia Shan Hui Qiao Tao Jiang Beijing Neurosurgical Institute Capital Medical University Beijing China Beijing Neurosurgical Institute Capital Medical University Beijing ChinaBeijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Clinical Oncology Beijing Academy of Critical Illness in Brain Beijing 100069 China

Background: Human leukocyte antigen (HLA)-DR is a classical major histocompatibility complex (MHC) class II molecule encoded by five genes: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5. The current study aimed to investigate the role of these genes in gliomas by analyzing microarray data. Methods: We enrolled 305 patients with histologically confirmed gliomas, and performed microarray data analysis along with studying their clinical characteristics. A new variable, termed HLA-DR score, was defined to explain the expression information of all five HLA-DR genes by factor analysis. HLA-DR scores in each grade of glioma and normal brain tissue were compared using one-way ANOVA. Lastly, correlations of HLA-DR scores with progression-free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier and Cox analysis. Results: Our study indicated that an increased HLA-DR score, i.e. overexpression of HLA-DR genes, was correlated with a more aggressive glioma tumor grade (p < 0.001, One-way ANOVA). Moreover, the HLA-DR score was significantly higher in astrocytic tumors than oligodendroglial tumors (?0.718 ± 3.177 versus ?2.975 ± 2.662, t-test) in low-grade gliomas (LGGs). Kaplan-Meier analysis of both PFS (p = 0.046, log-rank test; p = 0.021, Breslow test) and OS (p = 0.029, Breslow test) showed significant differences in the clinical outcomes between LGG patients with high versus low HLA-DR scores. Finally, the HLA-DR score was further identified to be an independent prognostic factor of clinical outcomes by multivariate analysis (p = 0.042 and p = 0.025, for PFS and OS, respectively) in LGG patients. Conclusion: Expression of HLA-DR genes can be used to predict the tumor grade in gliomas, and the histological subtype in LGG. Furthermore, they are also an independent predictor for LGG patient survival.

关键词： Glioma Human leukocyte antigen-DR Prognosis

Component Analysis and Calculation for Social Benefits of UHV Assessment

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Smart Grid and Renewable Energy 2016年第10期7卷 261-269页

作者： jingshan Luo Dichen Liu Jun Wu fan Gao Qixin Wang Kai Wang Xuedong Zhu School of Electrical Engineering Wuhan University Wuhan China State Power Economic Research Institute Beijing China

With the rapid development of the UHV power grid, evaluation of the economic and social benefits of the UHV power grid is conducive to guiding the planning and construction of UHV power grid. At present economic benefit evaluation system of the UHV power grid is driving to maturity stage on the whole at home and abroad, but it invariably tends to regard social benefits as part of economic benefits, without evaluating social benefit separately. The social benefit evaluation model of UHV power grid is built in case of sufficient investigation. The differentials between social benefit and social cost are calculated respectively by three kinds of solutions according to the constructed social cost evaluation index system and social benefits evaluation index system, conclusion that UHV power grid transmission has better social benefits can be reached by contrastively analyzing the social three kinds of solutions corresponding to benefits. At last, the evaluation model and method are verified and analyzed through the analysis of engineering projects.

关键词： UHV Power Grid Social Benefit Assessment Model Contrastive Analysis Social Cost Social Income Planning and Construction

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利用分子理论估算四氢呋喃的热物理特性参数

西安交通大学学报 2015年第3期49卷 44-49页

作者：樊祥山孙德魁王井山王锡斌西安交通大学能源与动力工程学院西安710049

为了开展四氢呋喃作为发动机代用燃料的喷雾燃烧的数值模拟,对四氢呋喃的密度、黏度、表面张力、蒸气压、气化潜热、比热容、导热系数、扩散系数等随温度变化的热物理特性参数进行了估算,并基于分子理论提出了四氢呋喃各参数与温度的关... 详细信息

为了开展四氢呋喃作为发动机代用燃料的喷雾燃烧的数值模拟,对四氢呋喃的密度、黏度、表面张力、蒸气压、气化潜热、比热容、导热系数、扩散系数等随温度变化的热物理特性参数进行了估算,并基于分子理论提出了四氢呋喃各参数与温度的关系式。估算过程中应用了对比态原理与基团贡献法,通过分子状态的相对特性值或分子结构预测出了相应物性,对分子偏心带来的影响进行了修正。通过与实验值的比对,各参数关系式的最大误差均小于10%,可满足喷雾和燃烧过程数值模拟的要求;四氢呋喃在能量密度、黏度、饱和蒸气压和沸点等方面具有的优势,使其有望成为内燃机的代用燃料;运用分子理论,在较少实验值的基础上可以得到满足数值模拟要求的热物性数据。

关键词：四氢呋喃热特性分子理论

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1386-1388页

作者： Ruxue Zhang Yumin Zhang Wei Zheng Weijuan Shang Yan Wu Ning Li Jun Xiong Hualiang Jiang jingshan Shen Gengfu Xiao Yuanchao Xie Leike Zhang State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Shanghai Junshi Biosciences Co. Ltd.Shanghai 200126China Lingang Laboratory Shanghai 200031China

Dear Editor,Respiratory syncytial virus(RSV)is the leading cause of serious lower respiratory tract disease in children under 5 years of age worldwide,causing an estimated 3.2 million hospitalizations and 120,000 deaths in children globally per ***,nearly all children can be infected with RSV by 2 years of age,and individuals can be repeatedly re-infected with RSV throughout life,which poses great threats to infants,the elderly.

关键词： respiratory syncytial repeatedly

Alteration of gut microbiota in type 2 diabetes complicated with cholelithiasis patients

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Chinese Medical Journal 2022年第17期135卷 2125-2127页

作者： Jiajia Chen Linlin Yan Xingfan Ma Ping Yuan fan Zhao Zihan Han jingshan Liu Wenbo Wang Donghai Zhou Hongyu Zhao Nan Feng Dandan Huang Shoukui Hu Jin Gui Peking University Shougang Hospital Beijing 100144China Key Laboratory of Carcinogenesis and Translational Research Ministry of EducationDepartment of Gastrointestinal Surgery IIIPeking University Cancer Hospital&InstituteBeijing 100142China

To the Editor:Type 2 diabetes(T2D)and cholelithiasis are both common diseases with a high,*** China,the,prevalence of T2D,is.0.90% and that offadult cholelithiasis is 6.83%.

关键词： cholelithiasis prevalence diabetes