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Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer(RATICAL):a nationwide multicenter retrospective study

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Cancer Communications 2024年第9期44卷 992-1004页

作者： Lin Li Wencai Li ChunyanWu Yanfeng Xi Lei Guo yuan Ji Lili Jiang Ji Li jingping Yun Gang Chen yuan Li Yueping Liu DianbinMu Yuchen Han Leina Sun Qingxin Xia Xiaodong Teng Nanying Che WeiWu Xueshan Qiu Chao Liu Xiaochu Yan Daiqiang Li Zhihong Zhang ZheWang Yujun Li ZhengWang Lingchuan Guo Xiu Nie Jingshu Geng Jianhua Zhou Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Department of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Pathology Shandong Cancer HospitalJinanShandongP.R.China Department of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(ChiCTR2000030266),patientswith advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in China between October 1,2018 and December 31,2019 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHC)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 23,689 patients with advanced NSCLC and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-time polymerase chain reaction(RT-PCR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup(all P<0.05).Conclusions:This study highlights the real-world variability and challenges of ALK test in advanced NSCLC,demonstrating a predominant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

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Amphiphilic amino-acid derivatives promote gram-scale single-crystal COFs synthesis

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Science China Chemistry 2024年第2期67卷 415-416页

作者： Yijia yuan Kian Ping Loh Department of Chemistry National University of SingaporeSingapore117543Singapore

Covalent organic frameworks(COFs) are crystalline organic compounds synthesized from covalently linked building blocks that extend in space to form a framework structure with periodic pores. The covalent linkages used... 详细信息

关键词： synthesis correction reversible

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Integration of Multiple Spectral Data via a Logistic Regression Algorithm for Detection of Crop Residue Burned Areas:A Case Study of Songnen Plain,Northeast China

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Chinese Geographical Science 2024年第3期34卷 548-563页

作者： ZHANG Sumei ZHANG yuan ZHAO Hongmei College of Mining and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China

The burning of crop residues in fields is a significant global biomass burning activity which is a key element of the terrestrial carbon cycle,and an important source of atmospheric trace gasses and *** estimation of cropland burned area is both crucial and challenging,especially for the small and fragmented burned scars in *** we developed an automated burned area mapping algorithm that was implemented using Sentinel-2 Multi Spectral Instrument(MSI)data and its effectiveness was tested taking Songnen Plain,Northeast China as a case using satellite image of *** employed a logistic regression method for integrating multiple spectral data into a synthetic indicator,and compared the results with manually interpreted burned area reference maps and the Moderate-Resolution Imaging Spectroradiometer(MODIS)MCD64A1 burned area *** overall accuracy of the single variable logistic regression was 77.38%to 86.90%and 73.47%to 97.14%for the 52TCQ and 51TYM cases,*** comparison,the accuracy of the burned area map was improved to 87.14%and 98.33%for the 52TCQ and 51TYM cases,respectively by multiple variable logistic regression of Sentind-2 *** balance of omission error and commission error was also *** integration of multiple spectral data combined with a logistic regression method proves to be effective for burned area detection,offering a highly automated process with an automatic threshold determination *** method exhibits excellent extensibility and flexibility taking the image tile as the operating *** is suitable for burned area detection at a regional scale and can also be implemented with other satellite data.

关键词： crop residue burning burned area Sentinel-2 Multi Spectral Instrument(MSI) logistic regression Songnen Plain,China

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Fuzzy-Inverse-Model-Based Networked Tracking Control Frameworks of Time-Varying Signals

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1708-1710页

作者： Shiwen Tong Dianwei Qian Keya yuan Dexin Liu yuan Li Jiancheng Zhang the College of Robotics Beijing Union UniversityBeijing 100101China the School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China

Dear Editor,Tracking control in networked environment is a very challenging problem due to the contradiction of rapid response to the time-varying signal and the inevitable delay introduced by networks. This letter has proposed several fuzzy-inverse-model-based network tracking control frameworks which are helpful in handling the system with nonlinear dynamics and uncertainties.

关键词： contradiction letter inverse

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Copper isotope constraints on the origins of basaltic and andesitic magmas in the Tengchong volcanic field,SE Tibet

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Geoscience Frontiers 2024年第4期15卷 290-303页

作者： yuan-Ru Qu Sheng-Ao Liu State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China

The Tengchong volcano field(TVF),situated at the southeastern margin of the Tibetan Plateau,holds crucial information regarding Cenozoic volcanic activities and geotectonic evolution of the SE *** provide new constraints on petrogenesis and evolution of the Tengchong volcanism,here we conducted copper(Cu)elemental and isotopic analyses on a suite of samples that document the evolution from basalts to andesites in the *** basalts are Cu-depleted(29.7-36.9 ppm)and have higherδ65Cu val-ues(0.19‰-0.40‰,mean=0.31‰±0.05‰;n=11)than those of mid-ocean ridge basalts(MORBs,~0.09‰)and the mantle(~0.06‰)as well as the majority of island arc *** with the low Cu/Zr ratios,these characteristics are interpreted to reflect the fractionation of isotopically light sulfides in the S-saturated systems during magma ascent,rather than source heterogeneity induced by recycled materials and redox *** with the basalts,the andesites have slightly lower Cu contents(14.4-29.4 ppm)and lighter Cu isotopic compositions(mean=-0.14‰±0.06‰;n=13).These differences cannot be attributed to progressive sulfide fractionation of basaltic magmas but require the assimilation of lower crustal materials with lowδ65Cu values during evolution of the andesitic *** results collectively suggest that Cu isotopes can provide valuable insights into magma origin and evolution.

关键词： Copper isotopes Sulfide segregation Magmatic differentiation Tengchong volcanic field

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An alternative 2D ICEEMDAN-based denoising method and its application in processing magnetic anomaly data

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Geodesy and Geodynamics 2024年第5期15卷 465-476页

作者： Jun Xu Jinsong Du Changqing yuan School of Geophysics and Geomatics China University of GeosciencesWuhan 430074China Hubei Subsurface Multi-scale Imaging Key Laboratory China University of GeosciencesWuhan 430074China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan 430074China

Due to environmental noise and human factors,magnetic data collected in the field often contain various noises and interferences that significantly affect the subsequent data processing and *** Mode Decomposition(EMD),an adaptive multiscale analysis method for nonlinear and non-stationary signals,is widely used in geophysical and geodetic data *** with traditional EMD,Improved Complete Ensemble EMD with Adaptive Noise(ICEEMDAN)is more effective in addressing the problem of mode *** on the principles of 1D ICEEMDAN,this paper presents an alternative algorithm for 2D ICEEMDAN,extending its application to two-dimensional *** effectiveness of the proposed approach is demonstrated through synthetic signal experiments,which show that the 2D ICEEMDAN exhibits a weaker mode mixing effect compared to the traditional bidimensional EMD(BEMD)***,to improve the performance of the denoising method based on 2D ICEEMDAN and preserve useful signals in high-frequency components,an improved soft thresholding technique is *** magnetic anomaly data testing indicates that our denoising method effectively preserves signal continuity and outperforms traditional soft thresholding *** validate the practical application of this improved threshold denoising method based on 2D ICEEMDAN,it is applied to ground magnetic survey data in the Yandun area of *** results demonstrate the effectiveness of the method in removing noise while retaining essential information from practical magnetic anomaly *** particular,practical applications suggest that 2D ICEEMDAN can extract trend signals more accurately than the *** conclusion,as a potential tool for multi-scale decomposition,the 2D ICEEMDAN is versatile in processing and analyzing 2D geophysical and geodetic data.

关键词： 2D ICEEMDAN Mode mixing effect Magnetic anomaly Denoising Improved soft thresholding

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Chipless textile electronics: human body-coupled fiber for wireless energy harvesting and signal transmission

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Science China Materials 2024年第7期67卷 2367-2368页

作者： Yixuan Wang Zuqing yuan Guozhen Shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China

Wearable technology is rapidly advancing through the integration of electronic devices and textiles,enabling intelligent interaction between clothing and the surrounding *** electronics are specifically designed to provide functions such as sensing,computation,display,and ***,traditional wearable devices that rely on rigid von Neumann architectures and incorporate silicon chips face challenges in seamless integration,energy efficiency,and comfort[1–3].Difficulties arise when attempting to integrate complex circuits and electronic components,which are traditionally relied upon for signal modulation,into soft fibers[4,5].Recent reports have begun to explore alternative architectures for wearable devices that can incorporate electronics into a single fiber[6].However,this process presents challenges in simultaneously controlling energy capture and release within a single fiber.

关键词： fiber signal energy

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Translation machinery: the basis of translational control

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Journal of Genetics and Genomics 2024年第4期51卷 367-378页

作者： Shu yuan Guilong Zhou Guoyong Xu State Key Laboratory of Hybrid Rice Institute for Advanced Studies(IAS)Wuhan UniversityWuhanHubei 430072China Hubei Hongshan Laboratory WuhanHubei 430070China

Messenger RNA(mRNA)translation consists of initiation,elongation,termination,and ribosome recycling,carried out by the translation machinery,primarily including tRNAs,ribosomes,and translation factors(TrFs).Translational regulators transduce signals of growth and development,as well as biotic and abiotic stresses,to the translation machinery,where global or selective translational control occurs to modulate mRNA translation efficiency(TrE).As the basis of translational control,the translation machinery directly determines the quality and quantity of newly synthesized peptides and,ultimately,the cellular ***,regulating the availability of diverse machinery components is reviewed as the central strategy of translational *** provide classical signaling pathways(e.g.,integrated stress responses)and cellular behaviors(e.g.,liquideliquid phase separation)to exemplify this strategy within different physiological contexts,particularly during hostemicrobe *** new technologies developed,further understanding this strategy will speed up translational medicine and translational agriculture.

关键词： Translational control Ribosome tRNA Translation machinery uORF Phase separation Immune response

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Benthodytes occidentpalauta ***.,a new species of deep-sea holothuroid(Elasipodida:Psychropotidae)from the west of Kyushu-Palau Ridge in the Western Pacific Ocean

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Journal of Oceanology and Limnology 2024年第1期42卷 252-262页

作者： Chongzhen yuan Chunsheng WANG Dongsheng ZHANG Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China

Benthodytes occidentpalauta *** collected from the Kyushu-Palau Ridge at a depth of 5481 m in *** new species is characterized by a gelatinous body wall,violet skin,six pairs of dorsal papillae,and a rough mid-ventral surface without tube *** dorsal deposits are rod-shaped and *** types of papillae deposits as crosses with four arms with central bipartite *** deposits are *** ossicles are rod-shaped with end *** deposits are rodshaped,tripartite,and *** phylogenetic analyses based on cytochrome oxidase subunit 1(COI)and 16S individually and a concatenated dataset of COI and 16S genes of this species support that *** *** to Benthodytes.

关键词： Holothuroidea Benthodytes cytochrome oxidase subunit 1(COI) 16S phylogenetic analysis

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Application of system identification in a practical active noise control system

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Control Theory and Technology 2024年第2期22卷 282-291页

作者： Yu yuan Zhaoyang Sun Hongwei Zhang School of Mechanical Engineering Xihua UniversityChengdu610039SichuanChina School of Electrical Engineering Southwest Jiaotong UniversityChengdu611756SichuanChina School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen518055GuangdongChina

Noise pollution has become increasingly severe around the world due to fast urbanization. How to soundproof windows from outside noise is of significant interest for both academia and industry. This paper reports an experimental implementation of normalized minmax active noise control (ANC) algorithm on an open window system, where identifying the model of acoustic sound paths plays a central role. By doing this, traffic noise is attenuated by the ANC system, leading to a relatively quiet indoor environment, while the natural lighting and ventilation functions of a window are remained. Our experiments show that an average of 19 dB(A) noise reduction is achieved.

关键词： Active noise control Multi-input-multi-output system Normalized minimax algorithm System identification

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