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Effect of Yizhitongxuan decoction on learning and memory ability,Gαq/11 expression and Na^+-K^+-ATP enzyme activity in rat models of Alzheimer's Disease

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Journal of Traditional Chinese Medicine 2014年第4期34卷 470-476页

作者： Jing Teng Zhexue Xu Jing Zhang jingmin li Department of Internal Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Department of Medical English Shandong University of Traditional Chinese Medicine

OBJECTIVE: To study the effects of Yizhitongxuan decoction on learning and memory abilities, Gαq/11expression and Na+-K+-ATPenzymeactivityin rat models of Alzheimer's disease(AD) caused by injecting Aβ25-35 into the ***: Ninety male Wistar rats(age ≥10 months)were selected and injected with Aβ25-35 into their hippocampi to establish model animals,which were randomly divided into six groups including a sham-operated group(blank group), a model group, a donepezil HCL group(Western Medicinegroup),and ahigh/general/dilute concentrations of Yizhitongxuan decoction groups(TCMⅠⅡⅢgroup).The Morris watermaze was used to examine the learning and memory abilities of rats in each group by place navigation and spatial probe ***, the rats were sacrificed to collect the hippocampi for biochemical tests, using western blotting to detect the expression of Gαq/11 and an ultramicro Na+-K+-ATP enzyme kit to measure Na+-K+-ATP enzyme ***:Yizhitongxuan decoction improved model rats' learning and memory abilities, and increased the expression of Gαq/11 in the hippocampus and the level of Na+-K+-ATP enzyme activity in ***: Yizhitongxuan decoction could improve model rats' learning and memory abilities,and had a regulating effect on the expression of Gαq/11and Na+-K+-ATP enzyme activity.

关键词： Alzheimer disease Sodium-potassium-exchanging ATPase Learning and memory ability Yizhitongxuan decoction

A bioinspired bubble removal method in microchannels based on angiosperm xylem embolism repair

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Microsystems & Nanoengineering 2022年第2期8卷 237-247页

作者： lihua Guo Yuanchang liu Penghui Ran Gang Wang Jie Shan Xudong li Chong liu jingmin li Key Laboratory for Micro/Nano Technology and System of liaoning Province Dalian University of TechnologyDalianChina Department of Mechanical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUK

It is difficult to remove and eliminate bubbles in microchannels in many devices used in various biomedical fields,such as those needed for microfluidic immunoassays,point-of-care testing,and cell biology *** bubbles are associated with a number of negative outcomes,including a decrease in device sensitivity,inaccuracy of analysis results,and even functional *** conduits of angiosperm have the ability to remove bubbles in obstructed *** by such an embolism repair mechanism,this paper proposes a bioinspired bubble removal method,which exhibits a prominent ability to dissolve bubbles continuously within a large range of flow rates(2μL/min-850 plVmin)while retaining the stability and continuity of the flow without auxiliary *** a method also shows significant bubble removal stability in dealing with Newtonian liquids and non-Newtonian fluids,especially with high viscosity(6.76 Pa s)and low velocity(152 nL/min).Such advantages associated with the proposed bioinspired method reveal promising application prospects in macro/microfluidic fields ranging from 3D printing,implantable devices,virus detection,and biomedical fluid processing to microscale reactor operation and beyond.

关键词： bubble remove method

Element and mineral characterization of dust emission from the saline land at Songnen Plain, Northeastern China

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Journal of Environmental Sciences 2009年第10期21卷 1363-1370页

作者： CHEN Bing KITAGAWA Hiroyuki HU Ke JIE Dongmei YANG Junpeng li jingmin Department of Hydrospheric-Atmospheric Sciences Graduate School of Environmental Studies Nagoya University Nagoya 464-8601 Japan. Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China College of Earth Sciences Jilin University Changchun 130061 China School of Marine Science China University of Geosciences Beijing 100038 China College of Urban and Environmental Sciences Northeast Normal University Changchan 130024 China

Recent observations of Asian dust storms show an eastern expansion of the source area to degraded lands, where dust emissions have been little studied. The dust concentrations over the saline land of the western Songnen Plain （SSL）, Northeastern China, are circumstantially higher than those from the northwestern Chinese deserts. These concentrations are sensitive to the surface soil conditions and wind velocity on the ground. The dust samples collected during dust storm events on the SSL contain abundant Na, Mg, A1, K, Ca, Fe and Ti, as well as toxic elements such as Cu, V, Zn and Ba. Individual particle analysis reveals that fine saline particles （〈 10 μm in diameter） on the saline land, consisting largely of carbonate, halite and sulfate together with lithogenic minerals such as SiO2 and aluminosilicate, are eventually uplifted during the interval from spring to autuum. The predominantly fine saline particles uplifted from the SSL are likely transported eastward by the winter monsoon circulation and westerlies. Recent degradation of saline lands in Northeastern China would not only increase the frequency of dust storm events in the downwind area, but also might change the chemical composition of the Asian dust emissions.

关键词： element geochemistry individual particle analysis Asian dust dust storm saline soil land degradation

Tectonic boundaries in the South China Sea from aeromagnetic signature

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Journal of Oceanology and limnology 2023年第2期41卷 550-561页

作者： Yao LUO Hang YIN Qiang liU jingmin li Shihua liU Wei GAO Rui li Yi YANG China Aero Geophysical Survey and Remote Sensing Center for Natural Resources Beijing 100083China

Magnetic data has been widely applied in the tectonic ***-resolution magnetic data were used to analyze the geotectonic zoning of the South China *** on the newly compilated magnetic data,the processing results and the distribution of known faults,we consider that the U-shaped line approximately along the South China Sea national boundary of China shown in the magnetic map is a significant geological and geophysical *** first described the linear characteristics of the magnetic data and then applied pseudo-gravity,Euler deconvolution,tilt derivatives,and the texture segmentation method to process the *** show that the dividing line between the South China Sea and the surrounding blocks is approximately along this U-shaped *** dividing line between the South China domain and the South China Sea domain is along with the Dongsha Islands to Xisha Trough,which is different from the previous geophysical zoning *** results are almost consistent with those of the gravity data indicating roughly the tectonic zonation along the U-shaped line.

关键词： South China Sea U-shaped line tectonic zoning aeromagnetic map texture segmentation

Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer

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解剖学杂志 2021年第S1期44卷 197-198页

作者： Wu Na li jingmin Wang Dong Bai Xianyong School of Basic Medical Sciences Binzhou Medical UniversityYantai 264003

Hydroxysafflor yellow A(HSYA)extracted from the herb Cathartics tinctorius *** regulates liver cancer ***,the exact mechanism of HSYA action in liver cancer remains largely *** this study,HSY A inhibited liver cancer cell growth in vivo and in vitro,evidenced by cell proliferation inhibition detected by CCK8,numerous apoptotic cells shown by flow cytometry assay,and expression of apoptosis-related proteins determined by Western blot.

关键词： liver yellow apoptosis

论音乐文化的过渡与融合——以淮河流域民间音乐文化区的基本特质为例

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音乐研究 2011年第3期 36-46页

作者：李敬民信阳师范学院音乐学院

长期以来，区域研究一直在围绕着两个方面进行，“一个偏重于用数理的方法确定和制作正确的地图，另一个着重掌握地区的自然情况和居民情况。”①前者一般被认为是制图学的研究领域，它是以地球、地区、地方和地点为对象，模拟地表各种... 详细信息

长期以来，区域研究一直在围绕着两个方面进行，“一个偏重于用数理的方法确定和制作正确的地图，另一个着重掌握地区的自然情况和居民情况。”①前者一般被认为是制图学的研究领域，它是以地球、地区、地方和地点为对象，模拟地表各种自然与社会现象的结构与特性，并采用数字化、图形化的表达方式传递一定的空间信息。

关键词：基本特质民间音乐淮河流域音乐文化文化区区域研究社会现象空间信息

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论豫南皖西杠天神仪式用乐的三种观念

音乐研究 2009年第5期 16-24页

作者：李敬民信阳师范学院音乐学院

音乐成品的“神圣性”／“世俗性”，不仅受到“近信仰”／“远信仰”的控制，同时也受到“时间性”／“空间性”以及“行为性”／“象征性”的控制，因而构成一般含义和特殊含义的融合。豫南皖西杠天神仪式①的用乐反映了仪式主持者（... 详细信息

音乐成品的“神圣性”／“世俗性”，不仅受到“近信仰”／“远信仰”的控制，同时也受到“时间性”／“空间性”以及“行为性”／“象征性”的控制，因而构成一般含义和特殊含义的融合。豫南皖西杠天神仪式①的用乐反映了仪式主持者（神师和乐师）对上述三种观念的理解，并将这种理解付诸仪式的运作过程中，以努力实现仪式的灵验性。

关键词：仪式天神皖西豫南特殊含义一般含义运作过程世俗性

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淮西山歌的句式结构分析

中国音乐 2003年第3期 88-91页

作者：李敬民河南信阳师范学院艺术系

本文从淮西山歌的自身结构规律入手,试图揭示淮西山歌的句式结构特点以及由此而引起的曲式结构的变化,并对其结构形态、结构样式以及淮西山歌的陈述性与抒咏性的特征加以分析,从中探寻它们的生成规律和发展路径。

关键词：淮西山歌句式结构曲式结构结构形态结构样式陈述性抒咏性

Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer

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Hydroxysafflor yellow A promotes apoptosis via blocking auto...