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Phage-displayed heptapeptide sequence conjugation significantly improves the specific targeting ability of antimicrobial peptides against Staphylococcus aureus

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mLife 2024年第2期3卷 251-268页

作者： Tao Wang Peng Tan Qi Tang Chenlong Zhou Yakun Ding Shenrui xu Mengda Song huiyang Fu Yucheng Zhang Xiaohui Zhang Yueyu Bai Zhihong Sun Xi {2. State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina Luoyang Key Laboratory of Animal Genetic and Breeding College of Animal ScienceHenan University of Science and TechnologyLuoyangChina Key Laboratory of Innovative Utilization of Indigenous Cattle and Sheep Germplasm Resources(Co‐construction by Ministry and Province) Ministry of Agriculture and Rural AffairsZhengzhou UniversityZhengzhouChina Animal Health Supervision in Henan Province ZhengzhouChina Laboratory for Bio‐Feed and Molecular Nutrition Department of Animal Science and TechnologySouthwest UniversityChongqingChina

Broad-spectrum antibacterial drugs often lack specificity,leading to indiscriminate bactericidal activity,which can disrupt the normal microbial balance of the host flora and cause unnecessary cytotoxicity during systemic *** this study,we constructed a specifically targeted antimicrobial peptide against Staphylococcus aureus by introducing a phage-displayed peptide onto a broad-spectrum antimicrobial peptide and explored its structure–function relationship through one-factor ***2.obtained by screening based on the selectivity index and the targeting index showed specific killing ability against ***,SFK2.showed excellent biocompatibility in mice and piglet,and demonstrated significant therapeutic efficacy against *** *** conclusion,our screening of phage-derived heptapeptides effectively enhances the specific bactericidal ability of the antimicrobial peptides against ***,providing a theoretical basis for developing targeted antimicrobial peptides.

关键词： antimicrobial peptides membrane disruption mechanism microbial infection phage display technology Staphylococcus aureus

On applying the extended intrinsic mean spin tensor to modelling the turbulence in non-inertial frames of reference

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Science china(physics,Mechanics & Astronomy) 2008年第11期51卷 1691-1706页

作者： HUANG YuNing ma huiyang {2. {3. State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China College of physics Graduate University of the Chinese Academy of SciencesBeijing 100049China

Modelling the turbulent flows in non-inertial frames of reference has long been a challenging task. Recently we introduced the notion of the "extended intrinsic mean spin tensor" for turbulence modelling and pointed out that, when applying the Reynolds stress models developed in the inertial frame of reference to model-ling the turbulence in a non-inertial frame of reference, the mean spin tensor should be replaced by the extended intrinsic mean spin tensor to correctly account for the rotation effects induced by the non-inertial frame of reference, to conform in phys-ics with the Reynolds stress transport equation. To exemplify the approach, we conducted numerical simulations of the fully developed turbulent channel flow in a rotating frame of reference by employing four non-linear K-ε models. Our numerical results based on this approach at a wide range of Reynolds and Rossby numbers evince that, among the models tested, the non-linear K-ε model of Huang and ma and the non-linear K-ε model of Craft, Launder and Suga can better capture the rotation effects and the resulting influence on the structures of turbulence, and therefore are satisfactorily applied to dealing with the turbulent flows of practical interest in engineering. The general approach worked out in this paper is also ap-plied to the second-moment closure and the large-eddy simulation of turbulence.

关键词： turbulence modelling non-inertial frame of reference extended intrinsic mean spin tensor

宫颈息肉宫腔镜下切除术后复发的风险预测可视化模型建立及效能验证

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医学理论与实践 2024年第18期37卷 3081-3085页

作者：张静蕾徐流立马媛媛杨霄濮阳市安阳地区医院妇产科河南省安阳市455000 安阳市中医院妇产科

目的:建立宫颈息肉宫腔镜下切除术后复发的风险预测可视化模型,并验证其效能。方法:回顾性收集2.19年1月-2.2.年7月于本院行宫腔镜下切除术的42.例患者的临床资料,经计算机产生随机数表以2.1将其分为训练集(2.0例)、验证集(140例)。所... 详细信息

目的:建立宫颈息肉宫腔镜下切除术后复发的风险预测可视化模型,并验证其效能。方法:回顾性收集2.19年1月-2.2.年7月于本院行宫腔镜下切除术的42.例患者的临床资料,经计算机产生随机数表以2.1将其分为训练集(2.0例)、验证集(140例)。所有患者均接受随访,将复发患者纳入复发组,其余纳入无复发组。比较训练集复发组、无复发组一般资料;用logistic回归模型分析宫颈息肉宫腔镜下切除术后复发的影响因素,并建立回归方程;用受试者工作特征曲线(ROC)、Calibration曲线、决策曲线评价模型的预测效能、校准能力及临床净获益。结果:随访时间12.3.个月,中位随访时间18个月。训练集患者宫颈息肉宫腔镜下切除术后复发率11.79%;logistic回归模型显示,年龄、月经不规则、人乳头瘤病毒(HPV)感染、产次、术后未治疗是宫颈息肉宫腔镜下切除术后复发的影响因素(P3.X_(1)+0.752.X_(2.+0.854 X_(3.+0.62. X_(4)+0.806 X_(5);基于训练集logistic回归分析结构建立宫颈息肉宫腔镜下切除术后复发的风险预测列线图模型,该模型预测训练集、验证集术后复发的灵敏度分别为97.14%、94.2.%,特异度分别为91.74%、80.73.,曲线下面积(AUC)分别为0.956、0.911;训练集、验证集Calibration曲线经Hosmer-Lemeshow检验,差异无统计学意义(P>0.05);Bootstrap法内部验证结果显示,训练集、验证集的C-index指数分别为0.911(95%CI:0.83.0}0.990)、0.905(95%CI:0.841~0.969);训练集、验证集分别在风险阈值0~0.83.0~0.61范围内获取临床净收益。结论:年龄、月经不规则、HPV感染、产次、术后未治疗是宫颈息肉宫腔镜下切除术后复发的影响因素,据此建立的风险预测列线图模型效能良好。

关键词：宫颈息肉宫腔镜下切除术复发列线图模型

微创三窗切口新型解剖锁定钢板治疗跟骨骨折的疗效分析

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中华创伤骨科杂志 2021年第10期23卷 871-876页

作者：畅宁徐静磊徐晨阳邓俊森苗万坡易先达马献忠河南省洛阳正骨医院河南省骨科医院郑州院区郑州450000

目的探讨微创三窗切口新型解剖锁定钢板治疗跟骨骨折的疗效。方法回顾性分析2.15年2.至2.17年5月河南省洛阳正骨医院骨盆创伤外科收治的46例SandersⅡ、Ⅲ型跟骨骨折患者资料,男2.例,女2.例;年龄19~59岁,平均3..0岁;左侧16例,右侧3.例... 详细信息

目的探讨微创三窗切口新型解剖锁定钢板治疗跟骨骨折的疗效。方法回顾性分析2.15年2.至2.17年5月河南省洛阳正骨医院骨盆创伤外科收治的46例SandersⅡ、Ⅲ型跟骨骨折患者资料,男2.例,女2.例;年龄19~59岁,平均3..0岁;左侧16例,右侧3.例;所有患者均采用微创三窗切口新型跟骨微创解剖锁定钢板治疗。比较患者术前、术后即刻、末次随访时跟骨Böhler角、Gissane角、跟骨高度、宽度及长度,采用美国足踝外科协会(AOFAS)的踝-后足评分评价功能,并记录并发症。结果46例患者术后均获随访,时间14~18个月(平均16个月);骨折均获骨性愈合,时间2.4个月(平均3.月)。术后即刻和末次随访时跟骨Böhler角(3..2.°±3.62.和3..05°±3.65°)、Gissane角(13..45°±6.04°和13..2.°±5.88°)、跟骨高度[(41.05±2.76)mm和(40.90±2.86)mm]、宽度[(2..65±1.53.mm和(2..55±1.64)mm]、长度[(76.82.1.70)mm和(76.73.1.78)mm]均较术前[10.55°±7.51°、95.3.0}±12.16°、(2..10±4.54)mm、(3..71±3.42.mm、(65.91±2.10)mm]显著改善,差异有统计学意义(P0.05)。末次随访时按AOFAS的踝-后足评分标准评估疗效:优2.例,良12.,可6例,优良率为87.0%。术后未发生切口感染。结论微创三窗切口新型跟骨解剖锁定钢板内固定治疗SandersⅡ、Ⅲ型跟骨骨折,复位满意,固定牢固,有效减少术后切口并发症。

关键词：跟骨骨折微创性骨折固定术,内解剖锁定钢板

解剖型锁定钢板与普通重建钢板固定治疗髋臼后壁骨折的疗效比较

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中华创伤骨科杂志 2021年第12期23卷 1018-1024页

作者：畅宁徐静磊徐晨阳邓俊森易先达苗万坡白雪马献忠河南省洛阳正骨医院河南省骨科医院骨盆创伤外科郑州450000 郑州大学第一附属医院病理科 450000

目的比较解剖型锁定钢板与普通重建钢板固定治疗髋臼后壁骨折的疗效。方法回顾性分析2.15年2.至2.2.年2.期间河南省洛阳正骨医院骨盆创伤外科收治的50例髋臼后壁骨折患者资料。根据不同时间段采用的内固定方式不同分为两组:重建钢板... 详细信息

目的比较解剖型锁定钢板与普通重建钢板固定治疗髋臼后壁骨折的疗效。方法回顾性分析2.15年2.至2.2.年2.期间河南省洛阳正骨医院骨盆创伤外科收治的50例髋臼后壁骨折患者资料。根据不同时间段采用的内固定方式不同分为两组:重建钢板组2.例,男2.例,女3.;年龄为(3..9±10.9)岁;2.15年2.至2.17年6月期间采用普通重建钢板固定治疗。解剖钢板组2.例,男2.例,女6例;年龄为(3..0±10.0)岁;2.17年7月至2.2.年2.期间采用解剖型锁定钢板固定。记录并比较两组患者的手术时间、术中出血量、骨折复位质量、末次随访时髋关节功能及并发症发生情况等。结果两组患者术前一般资料的比较差异均无统计学意义(P>0.05),具有可比性。50例患者术后获18~2.个月(平均2.个月)随访。解剖钢板组患者的手术时间[(13.0}8±8.6)min]显著短于重建钢板组患者[(177.2.5.9)min],术中出血量[(3.7.0±14.7)mL]显著少于重建钢板组患者[(492.0±17.6)mL],差异均有统计学意义(P2.(2./2.)、91.7%(2./2.)的患者骨折台阶≤3.mm,差异无统计学意义(P>0.05)。末次随访时解剖钢板组患者的髋关节Harris评分优良率为92.3.(2./2.),显著高于重建钢板组患者[66.7%(16/2.)];并发症发生率为3.8%(1/2.),显著低于重建钢板组患者[2..2.(7/2.)],差异均有统计学意义(P<0.05)。结论解剖型锁定钢板固定治疗髋臼后壁骨折的疗效优于普通重建钢板固定。

关键词：髋臼骨折骨折固定术,内骨板解剖型后壁锁定钢板

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老年髋臼骨折臼顶压缩或移位的CT分型研究

中华创伤骨科杂志 2020年第12期22卷 1034-1040页

作者：易先达徐静磊邓俊森畅宁苗万坡徐晨阳白雪马献忠河南省洛阳正骨医院(河南省骨科医院)郑州院区骨盆创伤外科郑州450000 郑州大学第一附属医院病理科 450000

目的介绍一种老年髋臼骨折臼顶压缩或移位的CT分型,并评价基于此分型进行臼顶压缩或移位骨折复位的效果及术后功能。方法回顾性分析2.10年2.至2.19年12.期间河南省洛阳正骨医院郑州院区骨盆创伤外科收治的2.例合并臼顶压缩或移位的老... 详细信息

目的介绍一种老年髋臼骨折臼顶压缩或移位的CT分型,并评价基于此分型进行臼顶压缩或移位骨折复位的效果及术后功能。方法回顾性分析2.10年2.至2.19年12.期间河南省洛阳正骨医院郑州院区骨盆创伤外科收治的2.例合并臼顶压缩或移位的老年髋臼骨折患者资料。男8例,女12.;年龄为65~78岁,平均71.5岁。按冠状位CT对其臼顶压缩或移位进行分型,以臼顶骨折线为界将臼顶分为内外侧,A型(3.):臼顶整体移位;B型(8例):臼顶内侧压缩;C型(4例):臼顶内外侧均有压缩或移位;D型(5例):臼顶粉碎性骨折,内外侧之间有嵌顿骨块。根据不同分型采用不同复位方法:A型骨刀截骨复位;B型顶棒顶压复位;C型首先用顶棒复位内侧部分,然后用骨刀复位外侧部分;D型骨折首先处理嵌顿骨块,然后用顶棒复位内侧部分,最后如果外侧移位则用骨刀复位外侧部分。所有患者均应用钢板、螺钉固定。评价患者术后骨折复位效果及患肢功能。结果术后CT检查有18例患者复位后骨折台阶≤3.mm,2.复位后骨折台阶>3.mm。2.例患者术后获平均2.个月(18~3.个月)随访。所有患者骨折均获愈合,愈合时间平均为4个月(3.5个月)。末次随访时患侧髋关节Harris评分平均为85分(70~100分)。4例患者最终行髋关节置换术。4例患者出现创伤性关节炎,但不影响髋关节功能。结论老年髋臼骨折臼顶压缩或移位的CT分型对臼顶骨折复位具有重要指导作用。

关键词：髋臼骨折臼顶 CT分型老年人

克氏针联合支撑钢板治疗肘关节损伤三联征Regan-Morrey Ⅱ型冠状突骨折的疗效分析

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中华创伤骨科杂志 2021年第5期23卷 439-442页

作者：徐静磊白雪徐晨阳邓俊森畅宁苗万坡易先达马献忠河南省洛阳正骨医院河南省骨科医院郑州院区骨盆创伤外科郑州450000 郑州大学第一附属医院病理科郑州450000

目的探讨克氏针联合支撑钢板治疗肘关节损伤三联征Regan-MorreyⅡ型冠状突骨折的疗效。方法回顾性分析2.14年8月至2.18年8月河南省洛阳正骨医院骨盆创伤外科收治的2.例Regan-MorreyⅡ型冠状突骨折患者资料。男12.,女8例;左侧6例,右侧14... 详细信息

目的探讨克氏针联合支撑钢板治疗肘关节损伤三联征Regan-MorreyⅡ型冠状突骨折的疗效。方法回顾性分析2.14年8月至2.18年8月河南省洛阳正骨医院骨盆创伤外科收治的2.例Regan-MorreyⅡ型冠状突骨折患者资料。男12.,女8例;左侧6例,右侧14例;患者年龄18~60岁(平均3.岁)。所有冠状突骨折均经前侧入路使用克氏针联合支撑钢板固定,后外侧入路修复桡骨头及外侧韧带复合体。必要时修复内侧副韧带或使用铰链式外固定架。末次随访时记录肘关节活动度(ROM),并采用mayo肘关节功能评分(MEPS)、美国肩肘外科学评分(ASES)和拍摄肘关节X线片来评估疗效,同时记录并发症情况。结果所有患者术后获12.2.个月(平均18个月)随访,骨折愈合时间平均为5个月。末次随访时患侧肘关节屈伸ROM平均为13.0}5°,旋前-旋后ROM为平均150°,MEPS评分平均为88分,ASES评分平均为87分。肘关节术后未发生半脱位或脱位。仅1例冠状突骨折轻微移位,但最终获愈合,肘关节功能未受影响;2.患者后外侧切口出现脂肪液化,清创后愈合。5例患者出现创伤性关节炎改变,但肘关节无明显的功能障碍。结论克氏针联合支撑钢板治疗肘关节损伤三联征Regan-MorreyⅡ型冠状突骨折效果良好。

关键词：肘关节损伤冠状突骨折克氏针创伤性关节炎洛阳正骨医院脂肪液化内侧副韧带三联征

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet department of Biological sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53.marmosets;3. treated monocularly for 12.weeks 9 hrs/day(2. with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 2. marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 3. mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12.weeks of treatment only(T4,T8,T12..

关键词： removed treatment untreated