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Lipase-activated glycopeptide nano-assemblies as an antibiotic nano-adjuvant to inhibit Pseudomonas aeruginosa biofilm and enhance antibacterial activity

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Science China Chemistry 2022年第12期65卷 2538-2547页

作者： Yifei Song jingkai zhang Yue Fei zhangjian Huang Xiaoxuan Liu Li-Li Li CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing100190China College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Drug DiscoveryCenter of Advanced Pharmaceutics and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Bacterial infections,especially those caused by biofilms,pose a serious threat to public *** this work,we propose a glycopeptide-based antibiotic nano-adjuvant(GalAc-2) that can synergistically enhance the antibacterial activity of antibiotics through its biofilm inhibition *** glycopeptide nanoparticles can be specifically activated by bacterial infection overexpressed lipase and sequentially enlarged by glycosyl exposure on the *** stability and bonding affinity of the nanoparticles were enhanced through the increase in β-sheet *** bacterial growth inhibition rate of the mixture of levofloxacin(LEV) and GalAc-2 at 0.54 μg/m L was over sevenfold higher than that of LEV alone because of the electrostatic and multivalence Lec A interactions that inhibited biofilm formation on the bacterial ***,the mixture of the antibiotic with GalAc-2 significantly inhibited the abscess exposed to skin infection and significantly reduced the infiltration of immune *** believe that GalAc-2 can be further used to enhance broad-spectrum antibiotic sensitization and prolong the lifetime of antibiotics.

关键词： glycopeptide self-assembly antibiotic nano-adjuvant bacteria biofilm

Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice

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Cellular & Molecular Immunology 2017年第8期14卷 702-711页

作者： Xiangda Meng Sijie Fang Zhuhong zhang Yang Wang Caiyun You jingkai zhang Hua Yan Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China

Uveitis is a common cause of blindness *** autoimmune uveitis(EAU)is an animal model of noninfectious ***(5,7-dihydroxyflavone)is a member of the flavonoid family and has anti-inflammatory *** immunized C57BL/6J mice with human interphotoreceptor retinoid-binding protein peptide 1–20 to induce *** was administered intragastrically at 25 mg/kg daily to the chrysin-treated mice from 3 days before immunization to 21 days after *** was administered to the mice in the control group according to the same *** clinical and histopathological scores,increased integrity of the blood–retinal barrier(BRB)and higher expression of tight junction proteins were observed in the chrysin-treated *** significantly decreased the proportions of Th1,Th17 and CD4^(+)CD3^(+)CD62L^(+)Th0 cells,and increased the proportion of Treg *** macrophage infiltration and the expression of inducible nitric oxide synthase in the retina were efficiently inhibited by chrysin *** chrysin-treated mice,the expression of interferon-γ,interleukin(IL)-17A,IL-6,IL-1βand tumor necrosis factor-αwas reduced in the retina,whereas higher levels of transforming growth factor-βwere ***,NF-κBp65 was downregulated after chrysin *** conclusion,as an anti-inflammatory molecule,chrysin exerts a preventive effect on EAU by modulating the balance among helper T-cell subsets and suppressing ocular inflammation,thereby maintaining the integrity of the BRB.

关键词： blood-retinal barrier chrysin experimental autoimmune uveitis NF-κB T helper-cell subsets

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基于虚拟仪器的绿篱机手柄三维振动测试

农业工程学报 2010年第4期26卷 127-133页

作者：张京开北京市农业机械试验鉴定推广站北京100079

为了找出简单实用的测试绿篱机手柄三维振动的方法,将虚拟仪器技术应用于手柄三维振动测试,探索一种检测模式,使"通用硬件+软件设计=多套专用测试设备"变为现实。虚拟仪器的软件设计了达到实时准确采集、显示、试验数据处理的目的;试验... 详细信息

为了找出简单实用的测试绿篱机手柄三维振动的方法,将虚拟仪器技术应用于手柄三维振动测试,探索一种检测模式,使"通用硬件+软件设计=多套专用测试设备"变为现实。虚拟仪器的软件设计了达到实时准确采集、显示、试验数据处理的目的;试验方案的选择找出了各因素对测试结果的影响程度大小;通用硬件的配置减少了专用硬件的使用。试验结果表明,测试样机手柄振动值与发动机转速、安装位置和接触面积有关;左手柄在中转速、中部、小接触面积条件下振动值最大,右手柄在高转速、后部、中接触面积条件下振动值最大;左、右手柄出现最大振动值时,其时域和频域的结果不一致,测试时应在同一条件下进行比较才能说明问题。由此可见,将虚拟仪器应用于手柄三维振动的测试简单有效,具有实际应用价值。

关键词：仪器三维振动测试

Quantitative prediction of mining subsidence and its impact on the environment

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International Journal of Mining Science and Technology 2012年第1期22卷 69-73页

作者： Jianjun Song Chunjian Han Ping Li Junwei zhang Deyuan Liu Minde Jiang Lin Zheng jingkai zhang Jianying Song State Key Laboratory of Coal Resources and Safety Mining School of Geosdences and Surveying EngineeringChina University of Mining&TechnologyBeijing 100083China Resources and Environment Investigation Center of Henan Provincial Coalfield Geology Bureau Zhengzhou 450003China Zhengzhou Shuqing Medical College Zhengzhou 430064 China Institute of Foreign Language Huanghe Science and Technology UniversityZhengzhou 450001China

This study is focused on the prediction of mining subsidence and its impact on the environment in the Hongqi mining area. The study was carried out by means of a probability integral model based, in first instance based on field surveys and the analysis of data collected from this area. Isolines of mining sub- sidence were then drawn and the impact caused by mining subsidence on the environment was analyzed quantitatively by spatial analysis with Geographic Information System （GIS）. The results indicate that the subsidence area of the first working-mine can be as large as 2.54 km2, the maximum subsidence is 3440 mrn which will cause 1524 houses to be relocated. The entire subsidence area of the mine can reach 8.09 km2, with a maximum subsidence of 3590 ram. Under these circumstances the value of the loss of ecosystem services Will reach 5.371 million Yuan and the cost of relocating buildings will increase to 6.858 million Yuan.

关键词： Mining subsidence Prediction Ecological environment Quantitative analysis

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

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American Journal of Analytical Chemistry 2011年第7期2卷 768-775页

作者： Xun Yao jingkai zhang Jianguo Li 不详

In this paper, a novel chemiluminescence (CL) method for the determination of tramadol has been developed by combining the flow injection technique and its sensitizing effect on the weak CL reaction between sulfite and acidic KMnO4. A mechanism for the CL reaction has been proposed on the basis of fluorescent and CL spectra. Under the optimized conditions, the proposed method allows the measurement of tramadol hydrochloride over the range of 0.04 - 4 ?g/mLwith a correlation coefficient of 0.9995 (n = 8) and a detection limit of 0.01 ?g/mL (3σ), and the relative standard deviation for 2.0 ?g/mL tramadol (n = 11) is 2.1%. The utility of this method was demonstrated by determining tramadol hydrochloride in tablets and injections.

关键词： Chemiluminescence Tramadol hydrochloride KMnO4 Sodium Sulfite Flow-Injection Analysis

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宋代户绝田法制化管理及其史鉴价值

中国高校社会科学 2019年第4期 48-62,158页

作者：张京凯中国政法大学博士后流动站

宋代户绝田是依据户绝条贯没纳入官的户绝之家的庄田,关涉宋代继承制度、土地制度、财税制度、法律制度等,是了解中国传统文化的一个重要窗口。通过明确管理机构、制定专项条令、规范流转程序、严明赏罚措施、加强权益保障,宋廷实现了... 详细信息

宋代户绝田是依据户绝条贯没纳入官的户绝之家的庄田,关涉宋代继承制度、土地制度、财税制度、法律制度等,是了解中国传统文化的一个重要窗口。通过明确管理机构、制定专项条令、规范流转程序、严明赏罚措施、加强权益保障,宋廷实现了对户绝田的法制化管理。宋代户绝田法制化管理与宋代法制发展存在交互影响的关系:宋代法律体系的完善推动了宋代户绝田法制化管理;同时,宋代户绝田法制化管理推进了宋代刑罚赦宥与量刑规则的规范化、法制化和常态化。研究宋代户绝田法制化管理对于推动中华优秀传统法文化的创造性转化、创新性发展具有重要的理论和现实意义,可为当代法治建设提供历史镜鉴。

关键词：户绝田没纳入官法制化管理传统法文化史鉴价值

Nonlinear Attitude Control of Tiltrotor Aircraft in Helicopter Mode based on ADRSM Theory

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Nonlinear Attitude Control of Tiltrotor Aircraft in Helicopt...

第37届中国控制会议

作者： Zhen Pan Chengzhi Chi jingkai zhang National Key Laboratory of Avionics System Integration China Aeronautical Radio Electronic Research Institute

Tiltrotor aircraft is a kind of aircraft which can fly as a fixed wing aircraft or a helicopter. However, it is difficult to control especially in helicopter mode. To control it well, a nonlinear mathematical model based on Pitt-Peters dynamic inflow theory is established. A novel control method named active disturbance rejection sliding mode theory（ADRSM） based on active disturbance rejection controller（ADRC） and sliding mode controller（SMC） is designed. First of all, a tracking differentiator（TD） is utilized to get the command of attitude and angular rate. Because the disturbance of the novel model includes the model error and coupling between different channels, a novel sliding mode extended state observer（SMESO） base on sliding mode theory is developed to estimate the disturbance of model. After that, a novel control law based on dynamic surface control theory is developed. And the stability of ADRSM is proved. The parameters of ADRSM are not changed during the whole process of simulation. Simulation results in various flight conditions show that ADRSM is feasible and parameters are available in a wide range.

关键词： tiltrotor aircraft helicopter mode ADRSM ADRC tracking differentiator

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宋代户绝财产的纠纷解决及其史鉴价值

法律适用 2019年第6期 121-129页

作者：张京凯中国政法大学博士后流动站

随着宋代法制的发展和传统义利观的改变,宋代户绝财产纠纷较之前代有所增加。宋人在长期的司法活动中探索、总结出了一套解决户绝财产纠纷的法制经验。在户绝财产纠纷、户绝田纠纷的司法实践中,裁判者谙熟法律程序,注意把握当事人的诉... 详细信息

随着宋代法制的发展和传统义利观的改变,宋代户绝财产纠纷较之前代有所增加。宋人在长期的司法活动中探索、总结出了一套解决户绝财产纠纷的法制经验。在户绝财产纠纷、户绝田纠纷的司法实践中,裁判者谙熟法律程序,注意把握当事人的诉讼心理,并采取一系列法制保障措施,以确保司法活动的公正与效率。宋代户绝财产纠纷的解决是管窥宋代财产纠纷解决机制的一扇窗,其背后有着深厚的传统法文化根基。充分挖掘并总结宋代户绝财产纠纷解决的史鉴价值,可为当今涉外无人继承遗产的处置,《民法典》继承编相关法律制度的构建和相关法律规范的制定,以及司法体制改革的完善,提供历史经验和传统法文化支撑。

关键词：户绝财产纠纷解决司法史鉴价值

高效通道注意力和特征融合的协同显著性检测算法

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哈尔滨工业大学学报 2022年第11期54卷 103-111页

作者：张德华李俊豪张静凯肖启阳河南大学人工智能学院郑州450046 河南大学迈阿密学院河南开封475004

针对现有的协同显著性检测算法在多显著目标复杂场景下表现不佳的问题,提出了一种基于高效通道注意力和特征融合的协同显著性检测算法。首先,检测算法利用预训练的深度卷积神经网络对场景进行多尺度特征的提取,结合边缘显著信息设计了... 详细信息

针对现有的协同显著性检测算法在多显著目标复杂场景下表现不佳的问题,提出了一种基于高效通道注意力和特征融合的协同显著性检测算法。首先,检测算法利用预训练的深度卷积神经网络对场景进行多尺度特征的提取,结合边缘显著信息设计了显著性语义特征提取模块,以避免全卷积神经网络导致边缘信息的缺失;其次,通过内积基本原理得到组内图片间的关联性信息并根据其关联程度进行自适应加权,结合高效通道注意力层设计了协同特征提取算法;最后,为了将各级高层语义特征经过协同显著性特征提取之后的结果与浅层次的特征进行融合,并实现对预测结果进行多分支同步监督,设计了基于高效通道注意力的特征融合模块。通过对3个经典的数据集进行测试,并与6种现有的协同显著检测算法进行对比,结果表明本文所提算法提高了复杂场景中图像的协同显著性检测的精度以及边缘信息的丰富程度,并具有更优的协同显著性信息检测性能;通过消融实验进一步验证了所提设计算法各个模块的有效性和必要性。

关键词：深度卷积神经网络协同显著性检测多尺度特征特征提取特征融合注意力机制