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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang jingkai wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Real-time object tracking via least squares transformation in spatial and Fourier domains for unmanned aerial vehicles

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Chinese Journal of Aeronautics 2019年第7期32卷 1716-1726页

作者： Xiaoyuan YANG Ridong ZHU jingkai wang Zhengze LI School of Mathematics and Systems Science Beihang University

This paper addresses the problem of real-time object tracking for unmanned aerial vehicles. We consider the task of object tracking as a classification problem. Training a good classifier always needs a huge number of samples, which is always time-consuming and not suitable for realtime applications. In this paper, we transform the large-scale least-squares problem in the spatial domain to a series of small-scale least-squares problems with constraints in the Fourier domain using the correlation filter technique. Then, this problem is efficiently solved by two stages. In the first stage, a fast method based on recursive least squares is used to solve the correlation filter problem without constraints in the Fourier domain. In the second stage, a weight matrix is constructed to prune the solution attained in the first stage to approach the constraints in the spatial domain. Then, the pruned classifier is used for tracking. To evaluate proposed tracker’s performance, comprehensive experiments are conducted on challenging aerial sequences in the UAV123 dataset. Experimental results demonstrate that proposed approach achieves a state-ofthe-art tracking performance in aerial sequences and operates at a mean speed of beyond 40 frames/s. For further analysis of proposed tracker’s robustness, extensive experiments are also performed on recent benchmarks OTB50, OTB100, and VOT2016.

关键词： Correlation filter Discrete Fourier transform Least squares Object tracking Unmanned aerial vehicle

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Study on the Influence of a Wake Vortex on an ARJ21 Aircraft Using the Strip Method

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1495-1509页

作者： Weijun Pan jingkai wang Hao wang Yuming Luo Civil Aviation Flight University of China Guanghan618307China

A model for the vortex distribution in the wake of an aircraft is elaborated to investigate the wake influence on the behaviour of other aircrafts potentially interacting with *** a realistic case,the interaction of an ARJ21 aircraft with a(leading)A330-200 aircraft is *** distances are considered,namely,6 km,7 km,8 km,9.3 km,and 10 *** based on the used wake dissipation mechanism are used to investigate different conditions,namely,the ARJ21 in take-off and level flight and the changes induced in the related lift by the front aircraft A330-200 during *** induced roll moment is also studied and analyzed by means of a strip *** a result,the roll moment coefficient is determined to quantify the roll degree of the aircraft when it is influenced by the wake *** results show the overall roll moment coefficient of the considered ARJ21 aircraft is less than 0.05,and the wing roll moment coefficient is less than *** results are interpreted and discussed according to existing standards.

关键词： Wake vortex dissipation safety interval induction velocity roll torque rolling moment coefficient

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Structured illumination microscopy based on asymmetric three-beam interference

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 40-50页

作者： Linyu Xu Yanwei Zhang Song Lang Hongwei wang Huijie Hu jingkai wang Yan Gong University of Science and Technology of China HefeiAnhui 230026P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences SuzhouJiangsu 215163P.R.China

Structured illumination microscopy(SIM)is a rapidly developing super-resolution *** has been widely used in various application fields of biomedicine due to its excellent two-and three-dimensional imaging ***,faster three-dimensional imaging methods are required to help enable more research-oriented living cell *** this paper,a fast and sensitive three-dimensional structured illumination microscopy based on asymmetric three-beam interference is *** innovative time-series acquisition method is employed to halve the time required to obtain each raw image.A segmented half-wave plate as a substantial linear polarization modulation method is applied to the three-dimensional SIM system for the first *** it needs to acquire 21 raw images instead of 15 to reconstruct one super-resolution image,the SIM setup proposed in this paper is 30%faster than the traditional spatial light modulator-SIM(SLM-SIM)in imaging each super-resolution *** related theoretical derivation,hardware system,and verification experiment are elaborated in this *** stable and fast 3D super-resolution imaging method proposed in this paper is of great significance to the research of organelle interaction,intercellular communication,and other biomedical fields.

关键词： Super-resolution structured illumination asymmetric three-beam interference three-dimensional imaging

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Boosting High-Voltage Practical Lithium Metal Batteries with Tailored Additives

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Nano-Micro Letters 2024年第12期16卷 23-41页

作者： Jinhai You Qiong wang Runhong Wei Li Deng Yiyang Hu Li Niu jingkai wang Xiaomei Zheng Junwei Li Yao Zhou Jun-Tao Li College of Energy Xiamen UniversityXiamen 361005People’s Republic of China Magnetism Key Laboratory of Zhejiang Province College of Materials and ChemistryChina Jiliang UniversityHangzhou 310018People’s Republic of China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium State Key Lab of Physical Chemistry of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of Chemical Engineering KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuPeople’s Republic of China

The lithium(Li)metal anode is widely regarded as an ideal anode material for high-energy-density ***,uncontrolled Li dendrite growth often leads to unfavorable interfaces and low Coulombic efficiency(CE),limiting its broader ***,an ether-based electrolyte(termed FGN-182)is formulated,exhibiting ultra-stable Li metal anodes through the incorporation of LiFSI and LiNO3 as dual *** synergistic effect of the dual salts facilitates the formation of a highly robust SEI film with fast Li+transport ***,Li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium cobalt oxide(LCO,3 mAh cm^(-2))cathodes,ultrathin Li chips(25μm),and lean electrolytes(5 g Ah-1)demonstrate outstanding cycling performance,retaining 80%capacity after 125 *** address the gas issue in the cathode under high voltage,cathode additives 1,3,6-tricyanohexane is incorporated with FGN-182;the resulting high-voltage LCO||Li(4.4 V)pouch cells can cycle steadily over 93 *** study demonstrates that,even with the use of ether-based electrolytes,it is possible to simultaneously achieve significant improvements in both high Li utilization and electrolyte tolerance to high voltage by exploring appropriate functional additives for both the cathode and anode.

关键词： Li metal anode Li dendrites LiNO_(3) 1,3,6-tricyanohexane Pouch cells

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Clinical Efficacy of Chaihu Shugan Powder Classical Formula in Treating Chronic Superficial Gastritis with Liver-Stomach Disharmony

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Medicinal Plant 2024年第6期15卷 70-72页

作者： Dongsheng ZHANG jingkai wang Helan County Traditional Chinese Medicine Hospital Yinchuan 750200China General Hospital of Ningxia Medical University Yinchuan 750004China

[Objectives] To investigate the clinical efficacy of Chaihu Shugan Powder on chronic superficial gastritis with liver-stomach disharmony syndrome.[Methods] A total of 72 patients diagnosed with chronic superficial gastritis characterized by liver-stomach disharmony syndrome between September 2023 and August 2024 were randomly assigned into two groups. The control group received treatment with western medicine, and the treatment group was administered both western medicine and Chaihu Shugan Powder. The therapeutic effects, TCM syndrome scores, adverse reactions, and recurrence rate were compared between the two groups.[Results] The total effective rate was 88.89% in the treatment group and 80.56% in the control group. The differences between the two groups were statistically significant ( P <0.05), indicating that the improvement observed in the treatment group was significantly greater than that in the control group ( P <0.05). In comparison to pre-treatment levels, the TCM syndrome scores for both patient groups exhibited a reduction following treatment. Notably, the extent of this reduction in the treatment group was significantly greater than that observed in the control group ( P <0.05). Neither group of patients experienced serious adverse reactions during treatment. Furthermore, the recurrence rate among patients in the control group was found to be higher than that in the treatment group.[Conclusions] The clinical efficacy of Chaihu Shugan Powder in the treatment of chronic superficial gastritis with liver-stomach disharmony syndrome is significant, demonstrating a notable reduction in the recurrence rate of the condition.

关键词： Chaihu Shugan Powder Stomachache Chronic superficial gastritis Liver-stomach disharmony syndrome

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An estimation framework of regional rooftop photovoltaic potential based on satellite remote sensing images

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Global Energy Interconnection 2022年第3期5卷 281-292页

作者： Boyu Chen Yanbo Che jingkai wang Hongfeng Li Linjun Yu Dacheng wang Key Laboratory of Smart Grid of Education Ministry Tianjin UniversityTianjin 300072P.R.China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094P.R.China

This paper proposes a comprehensive framework for estimating the regional rooftop photovoltaic(PV)*** required rooftop information is extracted from Gao Fen-7 satellite *** particular,the rooftop area is obtained using a semantic segmentation *** azimuth and inclination angles are calculated based on the digital surface *** addition,to improve the accuracy of the economic evaluation,buildings are divided into commercial and industrial buildings and residential *** on the difference in the roof inclination,the rooftops can be divided into flat roofs,on which the PV panels are installed with the optimal inclination angle,and sloped rooftops,on which the PV panels are installed in a lay-flat *** solar irradiation on the plane-of-array is calculated using the isotropic sky translocation ***,the available installed capacity and generation potential of the rooftop PV is ***,the net present value,dynamic payback period,and internal rate of return are used to evaluate the economic efficiency of the rooftop PV *** proposed framework is applied in the Da Xing district of Beijing,China,with a total area of 546.84 km^(2).The results show that the rooftop area and available installed capacity of PV are 25.63 km^(2)and 1487.45 MWp,*** annual rooftop PV generation potential is 2832.23 GWh,with significant economic returns.

关键词： Rooftop PV Potential estimation Economic efficiency evaluation GF7 satellite image

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A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury

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Bioactive Materials 2021年第8期6卷 2523-2534页

作者： Chenggui wang Min wang Kaishun Xia jingkai wang Feng Cheng Kesi Shi Liwei Ying Chao Yu Haibin Xu Shining Xiao Chengzhen Liang Fangcai Li Bo Lei Qixin Chen Department of Orthopedics Surgery 2nd Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangPR China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyFrontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an710054PR China

The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide *** inflammatory microenvironment is one of main obstacles on inhibiting the recovery of *** mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment ***,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not ***,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after *** orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal *** study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases.

关键词： Bioactive biomaterials Multifunctional hydrogel Extracellular vesicles release Spinal cord injury repair

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Using the Optical Glauber Monte Carlo Model to Calculate R<sub><i>AA</i></sub>Related Results Produced by the ATLAS Collaboration

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Natural Science 2020年第3期12卷 65-73页

作者： jingkai wang Kevin wang Zhe Yang David Sun Sendelta International Academy Shenzhen China Webb School of California Claremont CA USA Hawai’i Preparatory Academy Kamuela HI USA Beijing Tsinghua International School Beijing China.

The energy loss during jet quenching due to the existence of Quark Gluon Plasma (QGP) is calculated by Optical Glaube Monte Carlo model with data collected by ATLAS Collaboration using the LHC detector. An energy loss formula for this situation was modeled and took the form . The nuclear modification factor, RAA, for jets in a 208Pb + 208Pb nucleus collision with rapidity interval of ∣у∣=2.8 and the initial transverse momentum of 50 GeV ≤ pT ≤ 1000 GeV, are compared with various data plots produced by ATLAS Collaboration. RAA results are plotted in different centrality bins, which are defined by the distribution of number of participating nucleons Npart. The RAA value was found to slowly increase at lower transverse momenta and flatten out at higher transverse momenta. The model’s theoretical calculation results turned out to be similar to the plots produced by the ATLAS Collaboration using data from the LHC with small differences for higher systematic uncertainty events.

关键词： RAA Optical Monte Carlo Model Quark-Gluon Plasma Jet Quenching Energy Loss

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Experimental Studies on Thermo-mechanical Coupled Behavior of Pile-Clay Interface

Experimental Studies on Thermo-mechanical Coupled Behavior o...

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作者： jingkai wang Zhichao Zhang School of Civil Engineering Chongqing University Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of Education

The thermo-mechanical coupled behavior of pile-soil interface is very important for the mechanical performance of energy *** is studied in this paper by the thermo-mechanical coupled direct shear tests with a temperature controllable concrete specimen in the top shear box and a Kaolin clay specimen in the bottom shear *** results show that the strength of pile-clay interface significantly depends on the temperature,the temperature cycle number and the over-consolidation ratios of *** the heating-cooling cycles,the interface strength can increase and decrease monotonically or non-monotonically depending on the stress state and history of clay,which is generally a thermo-elasto-plastic *** is shown that the thermo-mechanical coupled pile-clay interface behavior is the net effect of the pore water transportation and the rearrangement of clay particles near the interface as well as the thermal consolidation/expansion of clay.

关键词： energy pile temperature cycle pile-clay interface direct shear test

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