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Comprehensive pathogenesis and clinical therapy in striae distensae: An overview and current perspective

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第4期4卷 203-207页

作者： Yichen Shen Qianqian Pang jinghong xu Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003ZhejiangChina Department of Plastic Surgery Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010ZhejiangChina

The pathogenesis of striae distensae(SD) is complicated and has not yet been fully elucidated. Hormonal changes,overstretched skin, and structural and functional changes in the skin may be crucial factors in the development of SD. Therapy aims to stimulate dermal collagen synthesis and improve skin texture. Mainstream treatments include topical medications, chemical peeling, laser and radiofrequency therapy, microdermabrasion, microneedle therapy, and filler injection therapy. In the present review, we summarize current perspectives on the pathogenesis and clinical therapy of SD.

关键词： Striae distensae Pathogenesis Clinical therapy

Long-term complications after liquid silicone injection:A case report and literature review

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第4期3卷 189-192页

作者： Yichen Shen Qianqian Pang jinghong xu Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009ZhejiangChina

Liquid silicone injection for cosmetic purposes has a long and notorious ***,reports of delayed and extensive lesions are ***,we report a case of long-term complications after the use of liquid silicone materials for the correction of facial *** this case,the complications of foreign body granulomas and unique silicone nodules lasting for more than 10 years were *** silicone injection can induce delayed adverse reactions,which are difficult to *** case presents the successful surgical treatment of a mass injection of liquid *** focus of treatment should be to remove the injected material and degenerated tissue as much as possible while protecting normal tissue and its *** open reconstructive surgery with an appropriate incision,postoperative scars can be ***,both functional and aesthetic outcomes can be achieved.

关键词： Facial filler Liquid silicone Delayed complications Foreign body granulomas

Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第2期5卷 53-59页

作者： KaHo LUI Haibo Zhao Jiaqi Sun Zeren Shen jinghong xu Department of Plastic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Background:Skin aging has recently gained significant attention in both society and skin care *** the biological processes of photoaging caused by long-term skin exposure to ultraviolet radiation is critical for preventing and treating skin ***,it is important to identify genes related to skin photoaging and shed light on their ***:We used data from the Gene Expression Omnibus(GEO)database and conducted bioinformatics analyses to screen and extract microRNAs(miRNAs)and their downstream target genes related to skin photoaging,and to determine possible biological mechanisms of skin ***:A total of 34 differentially expressed miRNAs and their downstream target genes potentially related to the biological process of skin photoaging were *** Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these target genes were enriched in pathways related to human papillomavirus infection,extracellular matrix(ECM)-receptor signaling,estrogen receptor,skin development,epidermal development,epidermal cell differentiation,keratinocyte differentiation,structural components of the ECM,structural components of the skin epidermis,and ***:Based on the GEO database-derived findings,we determined that target genes of two miRNAs,namely miR-4667-5P-KRT79 and miR-139-5P-FOS,play an important role in skin *** observations could provide theoretical support and guidance for further research on skin aging-related biological processes.

关键词： Skin photoaging miRNAs GEO database

Laser-assisted Liposuction Combined with Masseter Dissection for Mid-Lower Facial Recontouring

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第2期2卷 78-87,106页

作者： Rui LEI Wenjun WANG Xi CHEN Rizwan ALI Mingyuan xu Yuming WANG jinghong xu Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Background Asian women usually view the oval face,with a beautiful curve and clear outline,as *** fat and bloated mid-lower face,with an undefined outline,takes away from what they perceive to be a beautiful *** only a bone but also soft tissue determine the shape of the mid-lower *** this article,we introduce a modified surgical method of soft tissue for mid-lower facial recontouring,which can improve the fat and undefined outline of the mid-lower face caused by benign masseter muscle hypertrophy and reduce subcutaneous fat accumulation at the same *** operative technique is simple and effective with few *** The surgical treatment of 36 patients who met the adaptation criteria was carried out by laser-assisted liposuction combined with masseter muscle *** patients were followed up postoperatively,and the surgical efficacy was evaluated on the basis of:the comparison of facial contours of patients before and after surgery,the change of masseter muscle thickness detected by B-ultrasound imaging,the satisfaction of patients with postoperative facial contour improvement,and the incidence of *** Between March 1,2018,and August 31,2019,36 patients with indications underwent this *** follow-up lasted 6 to 12 months postoperatively and demonstrated that all patients were satisfied with the postoperative results,of which 33 cases(91.7%)were very satisfied,and 3 cases(8.3%)were satisfied with the treatment and had obvious improvement of the appearance of their mid-lower ***,the average mandibular bigonial breadth was 138.6±8.3 mm,and the average thickness of the masseter muscle was 13.9±0.8 mm;the postoperative breadth was 123.3±7.7 mm,and the thickness was 10.1±0.2 *** average reduction of the lower face width and masseter thickness were 15.2±2.1 mm and 3.8±0.1 mm,*** complications occurred among the 36 *** The described method makes a great im

关键词： Lower beautiful treatment

Pilomatrixoma causing irreversible peripheral eyebrow shedding:A case report

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第1期5卷 30-32页

作者： Zeren Shen Fei Cheng Yanqin Dai Yijia Yu Lulu Ye jinghong xu Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003ZhejiangChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003ZhejiangChina

Pilomatrixomas are benign tumors derived from hair stromal cells;however,their exact etiology is unknown.A 31-year-old woman presented with a subcutaneous mass located precisely above the left eyebrow,with shedding of eyebrow hair around the mass,and the shedding area gradually *** removal of the mass failed to prevent eyebrow loss,and the entire left eyebrow shed 6 months *** and histology of the biopsy specimen revealed a pilomatrixoma comprising basaloid cells and ghost cells,with basaloid cells expressing high bcl-2 *** of apoptosis,the emergence and growth of pilomatrixoma-induced microinflammation around the hair follicles of the eyebrow may lead to eyebrow loss.

关键词： Pilomatrixoma Eyebrow shedding Microinflammation

Three-Dimensional M-Shaped Resection for Nasal Alar Hypertrophy in Asian Patients

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第1期3卷 1-4页

作者： Yiqing QIU Qingfang ZHAO Zhixiong CHEN Yichen SHEN Mengmeng LUO Qiaoyun QIU jinghong xu Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China

Background Nasal alarplasty is an important component of esthetic rhinoplasty in *** two main surgical techniques that correct alar hypertrophy by reducing the height or length often leave external scars and are associated with a high relapse *** We developed a new technique,called three-dimensional(3D)M-shaped resection,which corrects both the nasal alar height and length and simultaneously minimizes external *** performed this procedure from January 2013 to September 2016 in 49 consecutive female patients diagnosed with saddle nose and nasal alar *** mean age was 28.6(range,18–40)*** patients had previously undergone simple *** alar length and height,nostril length and width,and maximal nose width were analyzed preoperatively and postoperatively from *** After a mean of 9(range,3–24)months of follow-up,surgery was considered successful in 46 women(94%)with good cosmetic *** three patients,nasal alar hypertrophy recurred(6 months postoperatively).There were no early complications such as hematomas,infections,skin or mucosal necrosis,or wound *** mean reductions postoperatively were 1.7 mm and 0.9 mm for nasal alar length and height,respectively,1.6 mm for both nostril length and width,and 3.5 mm for nose *** The 3D M-shaped resection for nasal alar hypertrophy effectively reduced hypertrophy in 94%of patients for up to 24 months,producing minimal external scars and good cosmetic *** is a simple and convenient technique that is an effective and safe option for nasal alarplasty.

关键词： Nasal alar hypertrophy Three-dimensional M-shaped resection Invisible external scars

Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第8期23卷 699-704页

作者： Zeren SHEN Jinjin SHAO Jiaqi SUN jinghong xu Department of Plastic Surgery the First Affiliated Hospital Zhejiang University Scchool of MedicineHangzhou 310003China Center of Safety Evaluation and Research Hangzhou Medical CollegeHangzhou 310059China

Keloids are a common type of pathological scar as a result of skin healing,which are extremely difficult to prevent and treat without *** pathological mechanism of keloids is the excessive proliferation of fibroblasts,which synthesize more extracellular matrices(ECMs),including type I/III collagen(COL-1/3),mucopolysaccharides,connective tissue growth factor(CTGF),also known as cellular communication network factor 2(CCN2),and fibronectin(FN)in scar tissue,mostly through the abnormal activation of transforming growth factor-β(TGF-β)/Smads pathway(Finnson et al.,2013;Song et al.,2018).

关键词： al. healing cytes

Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3111-3122页

作者： Yang Zheng Cenglin xu Jinyi Sun Wenjie Ming Sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen jinghong xu Fan Fei Jiajia Fang xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen Department of Neurology Zhejiang Provincial Hospital of Chinese MedicineThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Epilepsy Center Department of NeurologySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou310009China Department of Neurology Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu322000China

Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure *** studies have primarily focused on the disruption of dysplastic lesions,rather than remote regions such as the ***,we first quantified the epileptogenicity of the hippocampus in patients with late-stage cortical *** further investigated the cellular substrates leading to the epileptic hippocampus,using multiscale tools including calcium imaging,optogenetics,immunohistochemistry and *** the first time,we revealed the role of hippocampal somatostatin-positive interneurons in cortical dysplasia-related ***-positive were recruited during cortical dysplasia-related ***,optogenetic studies suggested that somatostatin-positive interneurons paradoxically facilitated seizure *** contrast,parvalbumin-positive interneurons retained an inhibitory role as in *** recordings and immunohistochemical studies revealed glutamate-mediated excitatory transmission from somatostatin-positive interneurons in the dentate *** together,our study reveals a novel role of excitatory somatostatin-positive neurons in the seizure network and brings new insights into the cellular basis of cortical dysplasia.

关键词： somatostatin dysplasia seizure

开放科学的应用现状及其对中国传播学的借鉴意义

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学术前沿 2024年第20期 102-111页

作者：徐敬宏北京师范大学新闻传播学院

开放科学已成为提升传播学研究质量的重要手段。自2015年起,西方传播学领域便开始探索开放科学的多种实践路径,经过近十年的发展已取得显著进展。与此同时,中国在开放科学的应用上仍处于起步阶段,缺乏成熟的经验和体系。通过分析西方传... 详细信息

开放科学已成为提升传播学研究质量的重要手段。自2015年起,西方传播学领域便开始探索开放科学的多种实践路径,经过近十年的发展已取得显著进展。与此同时,中国在开放科学的应用上仍处于起步阶段,缺乏成熟的经验和体系。通过分析西方传播学如何运用预注册研究、分享研究材料与方法、实施开放科学徽章、鼓励复制性研究和推广透明度及开放性指南等措施,来增强研究的透明度与复制性,提高公众对科学研究的信任度,可以为开放科学于中国传播学应用的创新实践提供重要借鉴,推动国内传播学高质量研究与应用。

关键词：开放科学开放传播学研究透明性复制性研究