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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin wu Jinzhong wu Jianguo wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

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The physiological role of the unfolded protein response in the nervous system

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Neural Regeneration Research 2024年第11期19卷 2411-2420页

作者： Shuangchan wu Wensheng Lin Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfolded *** UPR aims to restore endoplasmic reticulum homeostasis by enhancing protein folding capacity,reducing protein biosynthesis,and promoting protein *** also plays a pivotal role in coordinating signaling cascades to determine cell fate and function in response to endoplasmic reticulum *** research has highlighted the significance of the UPR not only in maintaining endoplasmic reticulum homeostasis but also in influencing various physiological processes in the nervous ***,we provide an overview of recent findings that underscore the UPR’s involvement in preserving the function and viability of neuronal and myelinating cells under physiological conditions,and highlight the critical role of the UPR in brain development,memory storage,retinal cone development,myelination,and maintenance of myelin thickness.

关键词： myelin neuron oligodendrocyte Schwann cell unfolded protein response

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南海北部深水区新生代断裂特征与油气聚集

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地质科学 2012年第3期47卷 746-761页

作者：陈玮常漆家福吴景富张功成何玉平能源中国石油大学地球科学学院北京102249 中海石油研究总院北京100027 中国石油塔里木油田公司勘探开发研究院新疆库尔勒841000

为了揭示南海北部深水区新生代断裂构造特征及其与油气聚集的关系,以地震资料解释为基础结合钻测井资料,通过编制构造几何学图件,运用油区构造解析原理,对南海北部深水区新生代断裂特征及其发育演化进行系统分析。该区主要发育东西,北... 详细信息

为了揭示南海北部深水区新生代断裂构造特征及其与油气聚集的关系,以地震资料解释为基础结合钻测井资料,通过编制构造几何学图件,运用油区构造解析原理,对南海北部深水区新生代断裂特征及其发育演化进行系统分析。该区主要发育东西,北东—南西,北东东—南东东3个走向的断裂;北东和北东东走向的断裂形成时间早于近东西走向的断裂。以珠江组—三亚组为界,南海北部深水区形成了基底和盖层上下两套断裂系统,主要发育持续型、中衰型和晚生型3种类型的正断层,形成了伸展、走滑和垂直3种构造样式。断裂活动控制了南海北部烃源岩的演化与分布、圈闭形成以及油气的运聚;断陷期是主要的烃源岩形成期,持续沉降有利于烃源岩保存和成熟;强烈的构造活动形成了多种类型的圈闭,其中在古近系和早中新统时期断裂发育密集,形成众多与断裂和背斜有关的构造圈闭。根据断裂发育和演化特征,由于持续性基底断裂的长期活动,在缓坡带和盆地中的坳中隆和凸起等构造高部位是油气聚集的有利场所,也是深水区下一步油气勘探的重要方向。

关键词：南海北部深水区新生代断裂油气聚集

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The photosynthetic oxygen evolution does not exclude the important role and contribution of bicarbonate photolysis

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Acta Geochimica 2024年第1期43卷 174-179页

作者： Yanyou wu Shaogang Guo State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Photosynthesis is the most important biochemical reaction on Earth. It has co-evolved and developed with the Earth, driving the biogeochemical cycle of all elements on the planet and serving as the only chemical process in nature that can convert light energy into chemical energy. Some heavy oxygen isotopic(^(18)O) labeling experiments have"conclusively" demonstrated that the oxygen released by photosynthesis comes only from water and are written into textbooks. However, it is not difficult to find that bicarbonate has never been excluded from the direct substrate of photosynthesis from beginning to end during the history of photosynthesis research. No convincing mechanism can be used to explain photosynthetic oxygen evolution solely from water photolysis. The bicarbonate effect, the Dole effect, the thermodynamic convenience of bicarbonate photolysis, the crystal structure characteristics of photosystem Ⅱ, and the reinterpretation of heavy oxygen isotopic labeling(^(18)O)experiments all indicate that the photosynthetic oxygen evolution does not exclude the important role and contribution of bicarbonate photolysis. The recently proposed view that bicarbonate photolysis is the premise of water photolysis, bicarbonate photolysis and water photolysis work together with a 1:1(mol/mol) stoichiometric relationship, and the stoichiometric relationship between oxygen and carbon dioxide released during photosynthetic oxygen evolution is also 1:1, has excellent applicability and objectivity, which can logically and reasonably explain the precise coordination between light and dark reactions during photosynthesis, the bicarbonate effect, the Dole effect, the Kok cycle and the neutrality of water and carbon in *** is of great significance for constructing the bionic artificial photosynthetic reactors and scientifically answering the question of the source of elemental stoichiometric relationships in nature.

关键词： Bicarbonate effect Dole effect Kok cycle Heavy oxygen isotope Artificial photosynthetic reactor

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Influence mechanism of government subsidy on the green transformation of coal company in China

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International Journal of Mining Science and Technology 2024年第7期34卷 1033-1040页

作者： Xiaolei Li Changsong wu School of Management China University of Mining and Technology-BeijingBeijing 100083China School of Economics and Management China University of Mining and TechnologyXuzhou 221116China

The optimization of government subsidies to enhance the efficiency of coal companies’green transformation constitutes a critical component in the pursuit of global *** investigate the influence mechanism of government subsidies on the green transformation using data from the listed coal companies in China from 2007 to *** to our findings and hypothesis testing,previous government subsidies did not have a significant direct impact on coal companies’green ***,government subsidies can help coal companies transition to greener practices by promoting innovative green ***,we confirmed an indirect route:that government subsidies enable the adoption of low-carbon initiatives,which in turn could facilitate the transition of coal companies towards green *** addition,we discovered that the coal company’s digitization will improve this indirect ***,we propose increasing the effectiveness of government subsidies in facilitating coal companies’transition to green practices by focusing on technological advancements and enhancing company digitalization.

关键词： Government subsidy Green transformation Coal company Digitalization Innovation

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珠江口盆地白云-荔湾深水区珠江组大型水道体系的发现与勘探意义

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石油学报 2013年第S2期34卷 48-56页

作者：曾清波吴景富赵志刚纪沫赵钊中海油研究总院北京100027

综合利用大量二维、三维地震及钻井资料，首次在珠江口盆地白云一荔湾凹陷东侧珠江组中部发现了大型深水水道体系，呈“S”型近SN向展布，北起白云凹陷东北部，经南部隆起，往南延伸进入荔湾凹陷，总长约152km，宽3．0～7．5km。受物源... 详细信息

综合利用大量二维、三维地震及钻井资料，首次在珠江口盆地白云一荔湾凹陷东侧珠江组中部发现了大型深水水道体系，呈“S”型近SN向展布，北起白云凹陷东北部，经南部隆起，往南延伸进入荔湾凹陷，总长约152km，宽3．0～7．5km。受物源远近及古地形影响，该水道在不同区段具不同的形态与沉积充填特征：北段形态相对较顺直，剖面上呈“V”型或“u”型，以垂向叠置的多期水道充填为主，钻井揭示为正旋回叠加的细砂岩；中段充填了下窄上宽的“U”型复合水道，内部可见天然堤一溢岸、水道及滑塌体；南段演化为形态弯曲的分支水道，加积充填为主，天然堤一溢岸沉积较发育，水道末端沉积了席状朵叶体。水道体系内发育优质储盖组合，经断层及底辟作用与下伏源岩沟通，油气成藏条件优越。中下部水道、天然堤一溢岸中的岩性、地层等非构造圈闭及上部水道、朵叶体中发育的构造岩性复合圈闭为有利勘探目标。珠江组大型水道的发现，将进一步拓宽珠江组深水沉积的勘探领域，有力椎动深水区油气勘探的深入。

关键词：水道体系沉积充填勘探目标珠江组深水区珠江口盆地

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Roles of Upper-Level Descending Inflow in Moat Development in Simulated Tropical Cyclones with Secondary Eyewall Formation

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Advances in Atmospheric Sciences 2024年第6期41卷 1100-1114页

作者： Nannan QIN Liguang wu Nanjing Joint Institute for Atmospheric Sciences Nanjing 210041China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Innovation Center of Ocean and Atmosphere System Zhuhai Fudan Innovation Research InstituteZhuhai 518057China

This study investigated the effects of upper-level descending inflow(ULDI)associated with inner-eyewall convection on the formation of the moat in tropical cyclones(TCs)with secondary eyewall formation(SEF).In our numerical experiments,a clear moat with SEF occurred in TCs with a significant ULDI,while no SEF occurred in TCs without a significant *** eyewall convection developed more vigorously in the control run.A ULDI occurred outside the inner-eyewall convection,where it was symmetrically *** ULDI was initially triggered by the diabatic warming released by the inner eyewall and later enhanced by the cooling below the anvil *** ULDI penetrated the outer edge of the inner eyewall with relatively dry air and prevented excessive solid-phase hydrometeors from being advected further *** produced extensive sublimation cooling of falling hydrometeors between the eyewall and the outer *** sublimation cooling resulted in negative buoyancy and further induced strong subsidence between the eyewall and the outer *** a result,a clear moat was *** of the moat in the ongoing SEF prevented the outer rainband from moving farther inward,helping the outer rainband to symmetrize into an outer *** the sensitivity experiment,no significant ULDI formed since the eyewall convection was weaker,and the eyewall anvil developed relatively lower,meaning the formation of a moat and thus an outer eyewall was less *** study suggests that a better-represented simulation of inner-eyewall convective structures and distribution of the solid-phase hydrometeors is important to the prediction of SEF.

关键词： tropical cyclone secondary eyewall formation upper-level descending inflow eyewall convection

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UNIFORM SUPERCONVERGENCE ANALYSIS OF A TWO-GRID MIXED FINITE ELEMENT METHOD FOR THE TIME-DEPENDENT BI-WAVE PROBLEM MODELING D-WAVE SUPERCONDUCTORS

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Journal of Computational Mathematics 2024年第2期42卷 415-431页

作者： Yanmi wu Dongyang Shi PLA Information Engineering University Zhengzhou 450001China School of Mathematics and Information Sciences Yantai UniversityYantai 264005China

In this paper,a two-grid mixed finite element method(MFEM)of implicit Backward Euler(BE)formula is presented for the fourth order time-dependent singularly perturbed Bi-wave problem for d-wave superconductors by the nonconforming EQ_(1)^(rot) *** this approach,the original nonlinear system is solved on the coarse mesh through the Newton iteration method,and then the linear system is computed on the fine mesh with Taylor’s *** on the high accuracy results of the chosen element,the uniform superclose and superconvergent estimates in the broken H^(1)-norm are derived,which are independent of the negative powers of the perturbation parameter appeared in the considered *** results illustrate that the computing cost of the proposed two-grid method is much less than that of the conventional Galerkin MFEM without loss of accuracy.

关键词： Time-dependent Bi-wave problem Two-grid mixed finite element method Uniform superclose and superconvergent estimates

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Numerical simulation of fluid-thermal-structural coupling characteristics of stratospheric non-rigid airship

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Chinese Journal of Aeronautics 2024年第9期37卷 224-236页

作者： Huafei DU Mingyun LYU Chuan YU Yifei wu Yongmei wu Kangwen SUN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Linzhou(Ningbo)Technology Co.Ltd Yuyao 315042China

The voluminous stratospheric non-rigid airship is very sensitive to the external thermal *** temperature change of internal gas caused by the variation in the external ther-mal environment and wind speed will lead to a change in the shape and buoyancy of the airship,thereby affecting its flight *** traditional static analysis method is difficult to accurately reflect this fuid-thermal-structural coupling *** this paper,the iterative analysis method was established for the fluid-thermal-structural coupling effect of stratospheric non-rigid airship based on the models of fluid,thermal,and structural *** the load such as the internal thermal effect and external flow field of the airship,the simulation of the thermo-induced structural deformation effect was conducted using Fluent and Abaqus *** influ-ence of local time and external wind speed on the structural deformation,volume,and equilibrium altitude of the airship was *** results demonstrate that,at low wind speed,the influence of aerodynamic pressure on the deformation of the airship is ***,a great amount of heat is carried away by the wind,then the structural deformation caused by internal and external pressure difference is alleviated and the equilibrium altitude of the airship change *** can serve as a guideline for the design and flight test of the long-endurance stratospheric non-rigid airship.

关键词： Altitude change Fluid-thermal-structural coupling Stratospheric non-rigid airship Structural deformation Wind speed

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Precontrol of short-period motion for a Tension Leg Platform

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Journal of Ocean Engineering and Science 2024年第3期9卷 264-277页

作者： Hao wu Yan Lin Yongxi wu School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China Department of Naval Architecture Dalian University of TechnologyDalian 116023China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116023China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China

The Tension Leg Platform(TLP)is a hybrid,compliant platform designed to sustain springing and ringing responses that are correlated to short-period *** the period of short-period motion is within the wave energy concentration region,TLPs may experience sensitive short-period motion,such as resonance and green water,that usually cause serious damage to *** this study,a precontrol methodology is presented as a solution to prevent TLP-sensitive short-period *** applying the precontrol methodology,the parameters of TLP can be predetermined,allowing TLP motion performance to meet the requirements of short-period motion before sensitive motions actually *** example,the damping coefficient should be less than 4.3,the tendons’stiffness should be larger than 0.91×10^(8),and the dimensionless draft should be less than *** development of a precontrol methodology is based on a solid theoretical ***,a series of simple and high-fidelity numerical models are proposed to simulate the natural period of roll,natural period of heave,and green water ***,a constraint regime is generated based on the numerical models and the sensitive motion range of short-period *** constraint regime is divided into two parts:the control range(corresponding to sensitive shortperiod motion)and the feasible range(the complementary set of control ranges in the whole parameter constraint domain).Finally,TLP parameters are derived from the calculated feasible *** precontrol methodology goes beyond the conventional approach of real-time control by changing the control from a remedial action to a preventive action.

关键词： Precontrol Constraint regime Short-period motion TLP

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