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Hypophysitis induced by anti-programmed cell death protein 1 immunotherapy in non-small cell lung cancer:Three case reports

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World Journal of Clinical Cases 2022年第30期10卷 11049-11058页

作者： yun Zheng chen-yu Zhu jing Lin Wang-Shan chen yu-Jie Wang Hong-Ye Fu Qiong Zhao Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310030Zhejiang ProvinceChina Department of Thoracic Oncology Shulan(Hangzhou)Hospital affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000Zhejiang ProvinceChina Zhejiang Chinese Medical University Hangzhou 311402Zhejiang ProvinceChina

BACKGROUND Hypophysitis induced by programmed cell death 1 protein(PD-1)immune checkpoint inhibitors is rare and poorly *** report three patients with non-small cell lung cancer who developed hypophysitis after anti-PD-1 *** SUMMARY Both case 1 and case 2 presented with common symptoms of fatigue,nausea,and ***,case 3 showed rare acute severe symptoms such as hoarse voice,bucking,and difficulty in breathing even when *** two cycles of immunotherapy in case 3,the above severe symptoms and pituitary gland enlargement were found on magnetic resonance imaging at the onset of *** symptoms were relieved after 10 d of steroid *** 3 was the first patient with these specific symptoms,which provided a new insight into the diagnosis of *** addition,we found that the clinical prognosis of patients with hypophysitis was related to the dose of steroid *** 3 was treated with high-dose hormone therapy and her pituitary-corticotropic axis dysfunction returned to normal after more than 6 mo of steroid *** 1 and 2 were treated with the low-dose hormone,and dysfunction of the pituitary-corticotropic axis was still present after up to 7 mo of steroid *** The clinical symptoms described in this study provide a valuable reference for the diagnosis and treatment of immune-related hypophysitis.

关键词： Programmed cell death protein 1 Immunotherapy Hypophysitis Lung cancer Case reports

基于动态能力视角的品牌生态圈形成过程机制研究——以仁和集团为例

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管理案例研究与评论 2024年第1期17卷 89-104页

作者：余可发高劲章汪华林江西财经大学工商管理学院南昌330013

在数字经济时代,品牌生态圈的构建为品牌可持续发展提供了强大支撑,但对其形成过程的内在机理研究不足。基于动态能力视角,选取仁和集团作为研究对象,通过纵向解构其多年品牌发展历程,总结品牌生态圈的形成过程机制。研究发现:(1)品牌... 详细信息

在数字经济时代,品牌生态圈的构建为品牌可持续发展提供了强大支撑,但对其形成过程的内在机理研究不足。基于动态能力视角,选取仁和集团作为研究对象,通过纵向解构其多年品牌发展历程,总结品牌生态圈的形成过程机制。研究发现:(1)品牌生态圈本质上是一个以核心品牌企业为中心、以数字技术平台为基础的产业链体系完整、多方利益相关者紧密合作、品牌族群协同发展的闭环开放生态系统;(2)品牌生态圈的形成过程会出现“点—线—面”即“品牌核心圈培育(市场破局)—品牌产业圈发展(产业链整合)—品牌生态圈形成(价值共创)”的成长特征;(3)在品牌生态圈形成过程中,企业的动态能力呈现出“市场破局能力—产业链整合能力—价值共创能力”等从低阶能力向高阶能力的演变。最终形成的理论框架可为数字经济时代企业品牌生态圈的构建提供一定的参考。

关键词：品牌生态圈动态能力仁和集团案例研究

某校1300名高中女生睡眠问题与痛经、应激水平的关联性研究

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中国校医 2024年第1期38卷 19-22页

作者：陈静万宇辉徐静南京医科大学附属妇产医院南京市妇幼保健院群保科江苏南京210000 安徽医科大学公共卫生学院安徽合肥230032 镇江市妇幼保健院妇保科江苏镇江212000

目的了解高中女生睡眠问题的现状,分析痛经和应激水平共同作用对睡眠问题的影响。方法通过整群抽样方式在镇江中学选取高中3个年级20个班1 283名女生为研究对象,了解其睡眠问题、痛经情况、应激水平等,通过卡方检验比较不同组间睡眠... 详细信息

目的了解高中女生睡眠问题的现状,分析痛经和应激水平共同作用对睡眠问题的影响。方法通过整群抽样方式在镇江中学选取高中3个年级20个班1 283名女生为研究对象,了解其睡眠问题、痛经情况、应激水平等,通过卡方检验比较不同组间睡眠问题、痛经和应激水平检出率的差异,利用logistic回归模型分析应激水平和痛经共同对睡眠问题的影响。结果睡眠问题的检出率为20.1%,痛经增加了睡眠问题发生的风险[OR(95%CI)=2.42(1.77-3.31)]。应激水平的升高,也增加了睡眠问题的发生风险[OR(95%CI)=7.23(4.47-11.69)]。logistic回归分析显示,与无痛经且低应激水平相比,有痛经且高应激水平会明显增加睡眠问题的发生风险[OR(95%CI)=12.32(6.71-22.63)]。结论痛经和高应激水平是睡眠问题的重要影响因素,缓解痛经症状和高应激水平,对改善高中女生睡眠有重要作用。

关键词：睡眠问题痛经应激水平高中女生

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财政支出效率对企业逃税的影响研究

武汉纺织大学学报 2024年第2期37卷 100-106页

作者：周靖陈利民武汉纺织大学经济学院湖北武汉430200

财政是国家治理的基石和重要支柱,保障财力是发挥财政作用的基础。本文利用2002-2021年上市企业的微观数据匹配26个省会城市的财政数据实证检验了财政支出效率对于企业逃税的影响。研究发现:第一,提高财政支出效率能够有效抑制企业逃税... 详细信息

财政是国家治理的基石和重要支柱,保障财力是发挥财政作用的基础。本文利用2002-2021年上市企业的微观数据匹配26个省会城市的财政数据实证检验了财政支出效率对于企业逃税的影响。研究发现:第一,提高财政支出效率能够有效抑制企业逃税;第二,通过异质性分析发现,财政支出效率的反逃税作用对小规模企业、处于弱财政压力城市的企业影响更为明显,企业控股方式的不同没有产生差异化影响;第三,经过各种稳健性检验后财政支出效率的影响依旧成立;第四,财政支出效率抑制企业逃税的可能机制包括资源配置效应与减少企业盈余管理。

关键词：企业逃税财政支出效率财政压力

赋权改革试点单位职务科技成果转化收益分配机制优化研究——以江西省为例

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科技广场 2024年第3期 73-80页

作者：陈静屈喜琴江西省科学技术信息研究所江西南昌330046

合理的科技成果转化收益分配机制是进一步深化职务科技成果权属改革,完善科技成果转化激励机制,有效激发科研人员创新创造活力,加快科技成果向现实生产力转化的重要环节。本文基于对江西省赋权改革试点单位调查研究,总结各单位探索职务... 详细信息

合理的科技成果转化收益分配机制是进一步深化职务科技成果权属改革,完善科技成果转化激励机制,有效激发科研人员创新创造活力,加快科技成果向现实生产力转化的重要环节。本文基于对江西省赋权改革试点单位调查研究,总结各单位探索职务科技成果转化收益分配现状,对比美国29所常春藤大学职务科技成果转化收益分配经验,分析试点单位职务科技成果转化收益分配的制约因素,从成果转化处置模式、收益分配比例和收益配置模式方面提出优化江西省试点单位职务科技成果转化收益分配的对策建议。

关键词：赋权改革试点科技成果转化收益分配对策研究

两种城市源有机固体废物生物质炭理化特性研究

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环境卫生工程 2024年第4期32卷 29-35页

作者：马想陈平梁晶上海市园林科学规划研究院上海200232

我国厨余垃圾厌氧发酵沼渣和园林废弃物等有机固体废物资源量巨大,热解炭化是对有机固体废物进行资源化处置的有效途径,不同生物质原料热解生物质炭得率、理化性质和结构表征还需系统研究。以厨余垃圾厌氧发酵沼渣和园林废弃物为原料,... 详细信息

我国厨余垃圾厌氧发酵沼渣和园林废弃物等有机固体废物资源量巨大,热解炭化是对有机固体废物进行资源化处置的有效途径,不同生物质原料热解生物质炭得率、理化性质和结构表征还需系统研究。以厨余垃圾厌氧发酵沼渣和园林废弃物为原料,分析两种固体废物热解生物质炭的养分含量、微观结构、官能团种类等理化性质及结构特点。沼渣生物质炭和园林废弃物生物质炭得率分别为62.7%、70.1%,pH分别为9.61、10.01,电导率分别为1.25、0.55 mS/cm,总养分含量分别为6.26%、4.63%,固定碳含量分别为54.80%、67.90%。沼渣生物质炭比表面积与园林废弃物生物质炭基本一致(分别为7.73、8.03 m~2/g),孔容分别为0.025、0.011 cm~3/g,孔径分别为10.14、4.70 nm。两种生物质炭官能团种类具有较大差异,沼渣生物质炭官能团较园林废弃物生物质炭更为丰富,但两者晶体结构基本一致。沼渣和园林废弃物均可用于生产生物炭基肥料,但沼渣生物质炭养分含量和孔隙结构优于园林废弃物生物质炭,可用于土壤综合肥力提升,园林废弃物生物质炭有机碳含量更高,有利于增加土壤碳汇。

关键词：厨余垃圾沼渣园林废弃物热解炭化生物质炭结构表征

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On P-sober Spaces

数学学报:英文版 2023年第9期39卷 1768-1780页

作者： yu jing Zhang Bin Zhao School of Mathematics and Statistics Shaanxi Normal UniversityXi’an710119P.R.China

In this paper,we focus on p-sober spaces and prove that(1)the To space X is p-sober if and only if the Smyth power space of X is p-sober;(2)the space X has a p-sober dcpo model if and only if X is T_(1)and p-sober;(3)every non-p-sober T_(0)space does not have a p-sobrification;(4)the T_(0)space X is sober if and only if X is p-sober and PD.

关键词： P-sober dcpo poset model of topological space p-sobrification

Tumor-to-tumor metastasis of clear cell renal cell carcinoma to contralateral synchronous pheochromocytoma:A case report

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World Journal of Clinical Cases 2022年第19期10卷 6750-6758页

作者： Hsin-yu Wen jing Hou Hao Zeng Qiao Zhou Ni chen Department of Pathology State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Urology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Tumor-to-tumor metastasis(TTM)is an uncommon *** a few cases of renal cell carcinoma(RCC)as donor tumor of TTM have been reported in literature,and none of these studies have described RCC metastasizing to synchronous pheochromocytoma(PCC).CASE SUMMARY The patient was a 54-year-old woman who presented with recurrent dull abdominal pain for six months,which was further aggravated for one more *** computed tomography revealed a tumor mass in the right kidney and another mass in the left retroperitoneum/adrenal *** and immunochemistry of resected specimens confirmed the diagnosis of clear cell renal cell carcinoma(CCRCC)of the right kidney,and the left retroperitoneum revealed a typical PCC with CCRCC *** exome sequencing revealed the presence of a c.529A>T somatic mutation of the Von Hippel Lindau(VHL)gene in the metastasized CCRCC,which was also present in the primary right kidney CCRCC,as confirmed by Sanger *** VHL mutation was detected in the PCC or in normal right kidney *** in situ hybridization revealed loss of chromosome 3p in both the primary right kidney CCRCC and CCRCC metastasized to PCC in the left *** This is the first case showing metastasis of CCRCC to PCC,thus leading to tumorto-tumor metastasis.

关键词： Tumor-to-tumor metastasis Clear cell renal cell carcinoma Pheochromocytoma Von Hippel Lindau somatic mutation Case report

Climatology of Shear Line and Related Rainstorm over the Southern Yangtze River Valley Based on an Improved Intelligent Identification Method

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Journal of Tropical Meteorology 2022年第4期28卷 413-424页

作者： LIU Jin-qing chen He XU jing-yu Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction CMAGuangzhou 510641 China Hunan Meteorological Observatory/Hunan Key Laboratory of Meteorological Disaster Prevention and Reduction Changsha 410118 China Heavy Rain and Drought Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Chengdu 610072 China

Based on four reanalysis datasets including CMA-RA,ERA5,ERA-Interim,and FNL,this paper proposes an improved intelligent method for shear line identification by introducing a second-order zonal-wind *** characteristics of shear lines and related rainstorms over the Southern Yangtze River Valley(SYRV)during the summers(June-August)from 2008 to 2018 are then analyzed by using two types of unsupervised machine learning algorithm,namely the t-distributed stochastic neighbor embedding method(t-SNE)and the k-means clustering *** results are as follows:(1)The reproducibility of the 850 hPa wind fields over the SYRV using China’s reanalysis product CMARA is superior to that of European and American products including ERA5,ERA-Interim,and FNL.(2)Theory and observations indicate that the introduction of a second-order zonal-wind shear criterion can effectively eliminate the continuous cyclonic curvature of the wind field and identify shear lines with significant discontinuities.(3)The occurrence frequency of shear lines appearing in the daytime and nighttime is almost equal,but the intensity and the accompanying rainstorm have a clear diurnal variation:they are significantly stronger during daytime than those at nighttime.(4)Half(47%)of the shear lines can cause short-duration rainstorms(≥20 mm(3h)^(-1)),and shear line rainstorms account for one-sixth(16%)of the total summer short-duration *** caused by shear lines are significantly stronger than that caused by other synoptic forcing.(5)Under the influence of stronger water vapor transport and barotropic instability,shear lines and related rainstorms in the north and middle of the SYRV are stronger than those in the south.

关键词： transverse shear line second-order zonal-wind shear short-duration rainstorm shear line rainstorm unsupervised machine learning