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Chinese Journal of Polymer Science 2015年第11期33卷 1562-1573页

作者： jing-yi chen Zhong Jin 杨科大 School of Materials Science and Engineering Beihang University Supercomputing Center Computer Network Information Center Chinese Academy of Sciences

The morphological, dynamic and rheological characteristics in the viscoelastic phase separation（VPS） of sheared polymer solutions are investigated by three-dimensional（3D） numerical simulations of viscoelastic model. The simulations are accelerated by graphic process unit（GPU） to break through the limitation of computation power. Firstly, the morphological and dynamic characteristics of VPS under shear are presented by comparing with those in classic phase separation（CPS）. The results show that the phase inversion and phase shrink take place in VPS under shear. Then, the roles of bulk and shear relaxation moduli in VPS are investigated in details. The bulk relaxation modulus slows down the phase separation process under shear, but not affects the dynamic path of VPS. The dynamic path can be divided into three stages： freezing stage, growth stage and stable stage. The second overshoot phenomenon in the shear stress is observed, and explained by the breakdown and reform of string structures. The shear modulus affects morphology evolution in the late stage of VPS under shear.

关键词： Viscoelastic model Phase separation Polymer solution Shear

Inhibiting radiative recombination rate to enhance quantum yields in a quantum photocell

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Chinese Physics B 2020年第6期29卷 197-201页

作者： jing-yi chen Shun-Cai Zhao Department of Physics Faculty of ScienceKunming University of Science and TechnologyKunming 650500China

Inhibiting the radiative radiation is an efficient approach to enhance quantum yields in a solar *** work carries out the inhibition of radiative recombination rate(RRR)in a quantum photocell with two coupled *** perform explicit calculations of the transition rates,energy gaps and the absorbed solar wavelength-dependent RRR,and find that two different regimes play the crucial roles in inhibiting *** is the quantum coherence generated from two different transition channels,the other includes the absorbed photon wavelength and gaps between the donor and acceptor in this proposed photocell *** results imply that there may be some efficient ways to enhance the photoelectron conversion compared to the classic solar cell.

关键词： radiation recombination rate photoelectric conversion efficiency quantum photocell

Turning in a Bipedal Robot

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Journal of Bionic Engineering 2013年第3期10卷 292-304页

作者： Jau-Ching Lu jing-yi chen Pei-Chun Lin Department of Mechanical Engineering National Taiwan University Taipei 106 Taiwan

We report the development of turning behavior on a child-size bipedal robot that addresses two common scenarios： turning in place and simultaneous walking and turning. About turning in place, three strategies are investigated and compared, including body-first, leg-first, and body/leg-simultaneous, These three strategies are used for three actions, respectively： when walking follows turning immediately, when space behind the robot is very tight, and when a large turning angle is desired. Concerning simultaneous walking and turning, the linear inverted pendulum is used as the motion model in the single-leg support phase, and the polynomial-based trajectory is used as the motion model in the double-leg support phase and for smooth motion connectivity to motions in a priori and a posteriori single-leg support phases. Compared to the trajectory generation of ordinary walking, that of simultaneous walking and turning introduces only two extra parameters： one for determining new heading direction and the other for smoothing the Center of Mass （COM） trajectory. The trajectory design methodology is validated in both simulation and experimental environments, and successful robot behavior confirms the effectiveness of the strategy.

关键词： turning biped humanoid trajectory planning robot

Combined effects of physical activity and calcium on bone health in children and adolescents:a systematic review of randomized controlled trials

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World Journal of Pediatrics 2020年第4期16卷 356-365页

作者： Xi Yang yi Zhai Jian Zhang jing-yi chen Dan Liu Wen-Hua Zhao National Institution for Nutrition and Health Chinese Center for Disease Control and Prevention27 Nanwei RoadWest DistrictBeijingChina Department of Science and Technology Management Chinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijingChina China National Clinical Research Center for Neurological Diseases Capital Medical UniversityNo.119 South Fourth Ring West RoadFengtai DistrictBeijingChina

Background A better understanding of the role of exercise and nutrition in bone health is significant for preventing *** aim of this review was to assess the combined effects of physical activity and calcium intake on improving bone mineral density in children and *** A search of electronic databases(MedLine,ISI Web of Science,Science Direct)and the literature references were *** controlled trials published between 1997 and 2017,evaluating the effect of both physical activity and calcium intake intervention on bone mineral density or bone mineral content among children aged 3–18 years were *** Improved Jadad Rating Scale was used to assess the methodological quality of the included *** characteristics were summarized in accordance with the review’s PICO *** in bone mineral content were detected at several different bone *** A total of nine studies involving 908 participants were included in this *** combined intervention of physical activity and calcium increased bone mineral in children and adolescents,especially when baseline calcium intake level was low and among participants on the stage of early *** Regular physical activity combined with high level of calcium intake is beneficial for bone health in young *** research is needed to evaluate the dose–response associations and long-term effects of the interaction between physical activity and calcium intake.

关键词： Adolescents Bone health Calcium Children Physical activity

Challenges and opportunities for China entering global research and development for emerging infectious diseases:a case study from Ebola experience

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Infectious Diseases of Poverty 2020年第2期9卷 98-99页

作者： Chao Li jing-yi chen Yang-Mu Huang 不详 School of Public Health Peking University38 Xueyuan RoadHaidian DistrictBeijing 100191China

Background:China has emerged as a powerful platform for global pharmaceutical research and development(R&D)amid the 2014 Ebola *** research and development impact of developing countries on prevention and control of infectious disease outbreaks has long been underestimated,particularly for emerging economies like ***,we studied its research and development progress and government support in response to Ebola outbreak by timeline,input,and output at each research and development *** study will contribute to a deeper understanding of the research and development gaps and challenges faced by China,as well as providing evidence-based suggestions on how to accelerate the drug development process to meet urgent needs during future ***:Data were obtained from the National Nature Science Foundation of China database,PubMed database,Patent Search System of the State Intelleaual Property Office of China,National Medical Products Administration,national policy reports and literature between Jan 1st,2006 and Dec 31st,*** overview of research funding,research output pharmaceutical product patent,and product licensed was described and analyzed by Microsoft Excel.A descriptive analysis with a visualization of plotting charts and graphs was conducted by reporting the mean±standard ***:China has successfully completed the research and development of the Ebola Ad5-EBOV vaccine within 26 months,while the preparation and implementation of clinical trials took relative long *** National Nature Science Foundation of China funded CNY 44.05 million(USD 6.27 million)for Ebola-related researches and committed strongly to the phase of basic research(87.8%).A proliferation of literature arose between 2014 and 2015,with a 1.7-fold increase in drug research and a 2.5-fold increase in diagnostic research within 1 *** years on from the Ebola outbreak,six Ebola-related produas in China were approved by the National Medical Products

关键词： Emerging infectious disease Research and development Ebola virus disease

Optimizing sludge dewatering with a combined conditioner of Fenton’s reagent and cationic surfactant

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Journal of Environmental Sciences 2020年第2期32卷 21-30页

作者： Dong-Qin He jing-yi chen Bo Bao Xiang-Liang Pan Jun Li chen Qian Han-Qing Yu Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of EnvironmentZhejiang University of TechnologyHangzhou 310014China CAS Key Laboratory of Urban Pollutant Conversion Department of Applied ChemistryUniversity of Science&Technology of ChinaHefei 230026China

Enhancing sludge dewatering is of importance in reducing environmental burden and disposal *** this work, a cationic surfactant, cetyl trimethyl ammonium bromide(CTAB), was combined with Fenton’s reagent for sludge *** show that the Fenton-CTAB conditioning significantly promotes the sludge *** combined techniques of response surface methodology and uniform design, dosages of Fe2+, H2O2, and CTAB for water content response were optimized to be 89, 276, and 233 mg/g dry solids(DS),*** water content of sludge decreased from 79.0% to 66.8% under the optimal *** with cationic polyacrylamide, the Fenton-CTAB system exhibited superior sludge dewatering *** gain insights into the mechanisms involved in sludge dewatering, the effects of Fenton-CTAB conditioning on the composition of extracellular polymeric substances(EPS) and the morphology of the sludge flocs were *** decomposition of EPS into some dissolved organics and the release of proteins in tightly bound EPS facilitated the conversion of bound water to free water and further reduced the water content of sludge *** conditioning, morphology of sludge showed ***, the enhanced sludge dewatering by Fenton-CTAB treatment provides an efficient way for management of sewage sludge.

关键词： Sludge dewatering Fenton reaction Cationic surfactant–CTAB Extracellular polymeric substances Uniform design

Parallel Bulk-Loading of Spatial Data with MapReduce:An R-tree Case

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Wuhan University Journal of Natural Sciences 2011年第6期16卷 513-519页

作者： LIU yi jing Ning chen Luo chen Huizhong College of Electronic Science and Engineering NationalUniversity of Defense Technology Changsha 410073 HunanChina

Current literature on parallel bulk-loading of R-tree index has the disadvantage that the quality of produced spatial index decrease considerably as the parallelism increases. To solve this problem, a novel method of bulk-loading spatial data using the popular MapReduce framework is proposed. MapReduce combines Hilbert curve and random sampling method to parallel partition and sort spatial data, thus it balances the number of spatial data in each partition. Then the bottom-up method is introduced to simplify and accelerate the sub-index construction in each parti- tion. Three area metrics are used to test the quality of generated index under different partitions. The extensive experiments show that the generated R-trees have the similar quality with the gener- ated R-tree using sequential bulk-loading method, while the execution time is reduced considerably by exploiting parallelism.

关键词： parallel bulk-loading MapReduce R-tree queryprocessing

Dectin-1 rs3901533 and rs7309123 Polymorphisms Increase Susceptibility to Pulmonary Invasive Fungal Disease in Patients with Acute Myeloid Leukemia from a Chinese Han Population

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Current Medical Science 2019年第6期39卷 906-912页

作者： Mei-jing chen Rong HU Xiao-ying JIANG Yong WU Zhi-peng HE jing-yi chen Li ZHAN The School of Nursing Fujian Medical UniversityFuzhou 350122China Institute of Hematology Department of HematologyUnion HospitalFujian Medical UniversityFuzhou 350001China

This study aimed to assess whether genetic variants of dendritic cell-associated C-type lectine-1(Dectin-1),Toll-like receptor 2(TLR2),Toll-like receptor 4(TLR4),and myeloid differentiation primary response 88(MyDHH)influence the susceptibility to pulmonary invasive fungal disease(IFD)in patients with acute myeloid leukemia(AML)from a Chinese Han *** single nucleotide polymorphisms(SNPs)of Dectin-1(rs 16910526,rs3901533,and rs7309123),TLR2(rs5743708),TLR4(rs4986790 and rs4986791)and MyD88(rs4988453 and rs4988457)in the genomic DNA of 172 adult AML patients were *** IFD was diagnosed as proven or probable according to the 2008 European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group(EORTC/MSG)consensus *** that were significant in the univariate analysis were further analyzed using the multiple logistic regression analysis to determine their association with the occurrence of pulmonary *** mRNA expression of Dectin-1 was detected according to the genotype by quantitative realtime PCR(qRT-PCR),and the correlation of this expression with the occurrence of pulmonary IFD in AML patients was *** Dectin-1 intron SNPs(rs3901533 and rs7309123)were found to be significantly associated with the susceptibility to pulmonary IFD in AML patients in a Chinese Han *** associations were noted between pulmonary IFD and Dectin-1 rs3901533 dominant model(G/T+G/G vs.T/T,OR:2.158;95%Cl:1.109-4.2,P=0.02),Dectin-1 rs3901533 G allele(OR:2.201;95%Cl:1.206-4.019,P=0.01),or Dectin-1 rs7309123 C allele(OR:1.919;95%Cl:1.047-3.518,P=0.03).There were no significant associations between pulmonary IFD and the remaining Dectin-1 SNPs(rs 16910526),TLR2(rs5743708),TLR4(rs4986790 and rs4986791)or MyDHH(rs4988453 and rs4988457).In conclusion,two Dectin-1 SNPs(rs3901533 and rs7309123)are associated with incr

关键词： Dectin-1 polymorphisms invasive fungal infection acute myeloid leukemia

Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and fulllength Abelson interactor 1

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World Journal of Gastroenterology 2021年第15期27卷 1595-1615页

作者： Kun Li yi-Fan Peng jing-Zhu Guo Mei Li Yu Zhang jing-yi chen Ting-Ru Lin Xin Yu Wei-Dong Yu Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijing 100044China Department of Gastroenterology Peking University People’s HospitalPeking UniversityBeijing 100044China Gastrointestinal Cancer Center Unit IIIKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Pediatrics Peking University People’s HospitalBeijing 100044China Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People's HospitalBeijing 100044China Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100044China

BACKGROUND Expression of the full-length isoform of Abelson interactor 1(ABI1),ABI1-p65,is increased in colorectal carcinoma(CRC)and is thought to be involved in one or more steps leading to tumor progression or *** ABI1 splice isoform-L(ABI1-SiL)has conserved WAVE2-binding and SH3 domains,lacks the homeodomain homologous region,and is missing the majority of PxxP-and Pro-rich domains found in full-length ***,ABI1-SiL domain structure suggests that the protein may regulate CRC cell morphology,adhesion,migration,and metastasis via interactions with the WAVE2 complex *** To investigate the potential role and underlying mechanisms associated with ABI1-SiL-mediated regulation of *** ABI1-SiL mRNA expression in CC tissue and cell lines was measured using both qualitative reverse transcriptase-polymerase chain reaction(RT-PCR)and realtime quantitative RT-PCR.A stably ABI1-SiL overexpressing SW480 cell model was constructed using Lipofectamine 2000,and cells selected with *** J software,CCK8,and transwell assays were used to investigate SW480 cell surface area,proliferation,migration,and ***,Western blot,and co-localization assays were performed to explore intermolecular interactions between ABI1-SiL,WAVE2,and ABI1-p65 *** ABI1-SiL was expressed in normal colon tissue and was significantly decreased in CRC cell lines and *** of ABI1-SiL in SW480 cells significantly increased the cell surface area and inhibited the adhesive and migration properties of the cells,but did not alter their invasive *** to ABI1-p65,ABI1-SiL still binds WAVE2,and the ABI1-p65 isoform in SW480 ***,co-localization assays confirmed these intermolecular *** These results support a model in which ABI1-SiL plays an anti-oncogenic role by competitively binding to WAVE2 and directly interacting with phosphorylated and non-phosphorylated ABI1-p65,functioning as

关键词： Colon cancer Abelson interactor 1 isoform-L Cell adhesion Cell migration WAVE2

Enhanced and tunable circular dichroism in the visible waveband by coupling of the waveguide mode and local surface plasmon resonances in double-layer asymmetric metal grating

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Chinese Physics B 2022年第11期31卷 599-604页

作者： Liu-Li Wang Yang Gu yi-jing chen Ya-Xian Ni Wen Dong School of Physical Science and Technology Soochow UniversitySuzhou 215006China Soochow College Soochow UniversitySuzhou 215006China

Circular dichroism(CD)has shown very interesting possibilities as a means to characterize the chiral signal of a chiral ***,we theoretically demonstrated enhanced and tunable CD in the visible light regime using a composite structure consisting of a double-layer metal grating gaped by a dielectric waveguide *** on the coupling of the waveguide modes and the localized plasmonic resonances,the CD could reach a maximum value as high as 0.52 at635 nm,which is four times higher than the CD value obtained in a conventional double-layer grating without the waveguide coupling ***,the spectral positions of the enhanced CD bands could be easily tuned by controlling the structural *** proposed hybrid double-grating and waveguide structures could have potential applications in chiral selective imaging,sensing and spectroscopy,especially where the transmission measurement is required.

关键词： circular dichroism chiral metamaterial waveguide surface plasmon