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Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

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Environment & Health 2024年第6期2卷 390-400页

作者： Lu-Yin Wu Li-Xia Liang Yang Zhou Zeeshan Mohammed Zhengmin Min Qian Stephen Edward McMillin Maya Tabet Chu Chu Yuan-Yuan Fan Jia-Xin Zhou jing-wen huang Wei-Hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and Health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population Health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 Health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

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Technology of fiber-optic temperature sensing and its application in ＆ temperature measuring of gob area

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Journal of Coal Science & Engineering(China) 2011年第2期17卷 171-175页

作者： LIU jing-wen huang Li-ming Department of Business Management Heibei Normal University of Science and Technology Qinhuangdao 066004 China

Based on advantages of technology of distributive fiber-optic temperature sensing and specific to its applications in monitoring mine conflagration, the corresponding Processes such as connection arrangement, signal transmission and monitoring were illustrated. As applied in Sitai Coal Mine of Datong Coal Mine Group Co., this method is effective and accurate and could provide reliable gist for monitoring spontaneous combustion in gob area of mines.

关键词： distributive optical fiber gob area temperature sensing fire source detection

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Microstructure evolution of Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14)amorphous alloy after semi-solid isothermal treatment

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China Foundry 2024年第3期21卷 287-294页

作者： Xin-hua huang jing-wen Pu Yong-xin Luo Yue-jun Ouyang School of Material Electricity and Intelligent ManufacturingHuaihua UniversityHuaihua 330031HunanChina Hunan Renewable Aluminum Innovation Research Center Huaihua UniversityHuaihua 330031HunanChina

The as-cast amorphous Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14)composites,comprising in situ formedβ-Ti ductile crystalline precipitates,were prepared by water cooled copper mold suction ***,the semi-solid composites were obtained after the as-cast composites were treated by semi-solid isothermal *** microstructure evolution and kinetics of the composites were *** show that the microstructures of both the as-cast and semi-solid composites comprise ofβ-Ti crystal phases and amorphous matrix *** and after treatment,the crystals evolve from fine granular or fine dendritic crystals to coarse *** the treatment temperature increasing or the time prolonging,the average crystal size gradually increases and the surface morphology of the crystals gradually becomes *** studying the microstructural evolution and dynamics during the isothermal treatment process,it is found that the final morphology ofβ-Ti crystals is influenced by the isothermal treatment temperature and time(t),and theβ-Ti evolution rate increases with an increase in treatment *** addition,a linear relationship was observed between the size of cubicβ-Ti crystals(D^(3))and t;the growth kinetics factor K is 3.8μm^(3)·s^(-1).As the K value closes to 4μm^(3)·s^(-1),it is inferred the morphology evolution ofβ-Ti crystals is a coarsening behavior controlled by the diffusion of solute elements.

关键词： Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14) amorphous matrix composites semi-solid as-cast microstructure

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Annual advances of acupuncture research in 2022

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Traditional Medicine Research 2023年第7期8卷 24-34页

作者： Jia-Qi Li wen-jing huang Kai Zhang Mei-Dan Zhao Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Acupuncture and Moxibustion Tianjin Gong An HospitalTianjin 300042China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin 301617China

This article reviews the major advances in acupuncture research in 2022,including clinical reports,basic research,and *** terms of the type of literature,most of them are systematic reviews and clinical trials,while high-quality basic studies can also be *** innovative inventions and researches in this field are of increasing quality and in a wide range of fields,acupuncture is attracting more and more attention in the international *** particular,some acupuncture combined sensors such as H2-EC/SD co-therapy,precise positioning,and vivo monitoring of neurotransmitter has been used for oncological diseases and neuropathic *** has been shown to be beneficial in the treatment of pain,stroke,psychiatric disorders,cancer,COVID-19 and *** of the studies show that acupuncture can play a positive role in various diseases and provide evidence for clinical applications and mechanism research.

关键词： acupuncture pain stroke cancer COVID-19 review

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Dynamic simulation analysis of molten salt reactor-coupled air-steam combined cycle power generation system

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Nuclear Science and Techniques 2024年第2期35卷 222-233页

作者： jing-Lei huang Guo-Bin Jia Li-Feng Han wen-Qian Liu Li huang Zheng-Han Yang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power *** model considers the impact of thermal properties of fluid variation on accuracy and has been validated with *** study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet ***,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also *** results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial *** simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.

关键词： Molten salt reactor Combined cycle Dynamic characteristic Control

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PD-1 and PD-1L expression in peripheral blood T lymphocytes of patients with chronic periodontitis and their correlation with the degree of inflammation

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Journal of Hainan Medical University 2017年第2期23卷 135-138页

作者： jing-wen huang Department of Stomatology Qingyuan People's Hospital of Guangdong ProvinceQingyuan CityGuangdong Province511518

Objective:To study the PD-1 and PD-1L expression in peripheral blood T lymphocytes of patients with chronic periodontitis and their correlation with the degree of inflammation. Methods:A total of 58 patients diagnosed with chronic periodontitis and 50 healthy volunteers receiving physical examination in our hospital between May 2012 and October 2015 were selected as the periodontitis group and the control group of the study respectively, the peripheral blood was collected to determine the PD-1 and PD-1L expression in T lymphocytes, and the gingival crevicular fluid and serum were determined to determine the content of inflammatory cytokines, adhesion molecules and protease ***:PD-1 and PD-1L fluorescence intensity on peripheral blood CD4+T lymphocyte and CD8+T lymphocyte surface of periodontitis group were significantly higher than those of control group, and IL-1β, IL-8, TNF-α, sICAM-1, sVCAM-1, MMP-1, MMP-7 and MMP-13 content in serum and gingival crevicular fluid were significantly higher than those of control group;PD-1 and PD-1L fluorescence intensity on peripheral blood CD4+T lymphocyte and CD8+T lymphocyte surface were positively correlated with IL-1β, IL-8, TNF-α, sICAM-1, sVCAM-1, MMP-1, MMP-7 and MMP-13 content in serum and gingival crevicular ***:Highly expressed PD-1 and PD-1L in the peripheral blood T lymphocytes of patients with chronic periodontitis can enhance the inflammatory response and promote the alveolar bone resorption and destruction through negative immunomodulatory effect.

关键词： Chronic periodontitis Programmed death-1 Inflammatory cytokine Adhesion molecule Matrix metalloproteinase

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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu jing Yang wen-jing Zhang Yi-Ling Zhou Gui-Jun Zhao Ya huang Shu-Yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies

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World Journal of Diabetes 2024年第8期15卷 1663-1671页

作者： jing-wen Liu Xiao huang Ming-Ke Wang Ji-Shun Yang School of Pharmacy Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Naval Medical Center Naval Medical UniversityShanghai 200052China

Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased ***,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 *** worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral ***,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral *** may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive *** review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients.

关键词： Diabetes mellitus SARS-CoV-2 COVID-19 Susceptibility Prevention Treatment

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Three-dimensional(3D)parametric measurements of individual gravels in the Gobi region using point cloud technique

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Journal of Arid Land 2024年第4期16卷 500-517页

作者： jing Xiangyu huang Weiyi KAN Jiangming College of Engineering Beijing Forestry UniversityBeijing 100083China Key Laboratory of State Forestry Administration on Forestry Equipment and Automation Beijing 100083China

Gobi spans a large area of China,surpassing the combined expanse of mobile dunes and semi-fixed *** presence significantly influences the movement of sand and ***,the complex origins and diverse materials constituting the Gobi result in notable differences in saltation processes across various Gobi *** is challenging to describe these processes according to a uniform ***,it becomes imperative to articulate surface characteristics through parameters such as the three-dimensional(3D)size and shape of *** morphology information for Gobi gravels is essential for studying its genesis and sand *** enhance the efficiency and information yield of gravel parameter measurements,this study conducted field experiments in the Gobi region across Dunhuang City,Guazhou County,and Yumen City(administrated by Jiuquan City),Gansu Province,China in March 2023.A research framework and methodology for measuring 3D parameters of gravel using point cloud were developed,alongside improved calculation formulas for 3D parameters including gravel grain size,volume,flatness,roundness,sphericity,and equivalent grain *** multi-view geometry technology for 3D reconstruction allowed for establishing an optimal data acquisition scheme characterized by high point cloud reconstruction efficiency and clear ***,the proposed methodology incorporated point cloud clustering,segmentation,and filtering techniques to isolate individual gravel point *** point cloud algorithms,including the Oriented Bounding Box(OBB),point cloud slicing method,and point cloud triangulation,were then deployed to calculate the 3D parameters of individual *** systematic processes allow precise and detailed characterization of individual *** gravel grain size and volume,the correlation coefficients between point cloud and manual measurements all exceeded 0.9000,confirming the feasibility of the proposed methodol

关键词： Gobi gravels three-dimensional(3D)parameters point cloud 3D reconstruction Random Sample Consensus(RANSAC)algorithm Density-Based Spatial Clustering of Applications with Noise(DBSCAN)

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Energy beam-based direct and assisted polishing techniques for diamond:A review

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International Journal of Extreme Manufacturing 2024年第1期6卷 93-124页

作者： Zhuo Li Feng Jiang Zhengyi Jiang Zige Tian Tian Qiu Tao Zhang Qiuling wen Xizhao Lu jing Lu Hui huang Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021People’s Republic of China School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021People’s Republic of China State Key Laboratory of High Performance Tools Huaqiao UniversityXiamen 361021People’s Republic of China

Diamond is a highly valuable material with diverse industrial applications,particularly in the fields of semiconductor,optics,and high-power ***,its high hardness and chemical stability make it difficult to realize high-efficiency and ultra-low damage machining of *** address these challenges,several polishing methods have been developed for both single crystal diamond(SCD)and polycrystalline diamond(PCD),including mechanical,chemical,laser,and ion beam processing *** this review,the characteristics and application scope of various polishing technologies for SCD and PCD are ***,various energy beam-based direct and assisted polishing technologies,such as laser polishing,ion beam polishing,plasma-assisted polishing,and laser-assisted polishing,are *** current research progress,material removal mechanism,and infuencing factors of each polishing technology are *** some of these methods can achieve high material removal rates or reduce surface roughness,no single method can meet all the ***,the future development prospects and application directions of different polishing technologies are presented.

关键词： single crystal diamond polycrystalline diamond energy beam polishing technology material removal mechanism influencing factors

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