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Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2024年第1期9卷 295-307页

作者： Xiaoxiao Liu Xing Zhang Zhiying shao Xiaorong Zhong Xin Ding Liang Wu Jie Chen Ping He Yan Cheng Kunrui Zhu Dan Zheng jing jing Ting Luo Institute for Breast Health Medicine Cancer CenterBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical University221000 XuzhouChina Department of Orthopedics Trauma and Reconstructive SurgeryUniversity Hospital RWTH AachenAachen 52074Germany Cancer Institute Xuzhou Medical University221000 XuzhouJiangsuChina Division of Nephrology and Transplantation Department of Internal MedicineUniversity Medical Center Rotterdam Erasmus MCRotterdam 3015 GDThe Netherlands Institute for Breast Health Medicine Department of General SurgeryBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Institute for Breast Health Medicine West China HospitalSichuan University610041 ChengduSichuanChina

Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor *** that pyrotinib,a new HER2 inhibitor,has led to dramatic improvements in prognosis,the efficacy of pyrotinib monotherapy remains largely restricted due to its acquired ***,identifying a new potential antitumor drug in combination with pyrotinib to amplify therapeutic efficacy is a pressing ***,we reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive *** determined that pyrotinib combined with chrysin yielded a potent synergistic effect to induce more evident cell cycle arrest,inhibit the proliferation of BT-474 and SK-BR-3 BC cells,and repress in vivo tumor growth in xenograft mice *** may be attributed to enhanced autophagy induced by endoplasmic reticulum ***,the combined treatment of pyrotinib and chrysin induced ubiquitination and glucose-6-phosphate dehydrogenase(G6PD)degradation by upregulating zinc finger and BTB/POZ domain-containing family protein 16(ZBTB16)in tumorigenesis of ***,we identified that miR-16-5p was a potential upstream regulator of ZBTB16,and it showed a significant inverse correlation with *** of miR-16-5p overexpression by restoring ZBTB16 significantly potentiated the overall antitumor efficacy of pyrotinib combined with chrysin against HER2-positive ***,these findings demonstrate that the combined treatment of pyrotinib and chrysin enhances autophagy in HER2-positive BC through an unrecognized miR-16-5p/ZBTB16/G6PD axis.

关键词： HER2 synergistic Together

Genetic Analysis of Structural Styles in the Makran Accretionary Wedge–Insight from Physical Simulations

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Journal of Ocean University of China 2024年第1期23卷 157-172页

作者： shao Longfei YU Fusheng GONG Jianming LIAO jing YU Zhifeng TANG Liang CHEN Jiangong WANG Yuefeng NENG Yuan School of Earth Sciences China University of PetroleumBeijing 102249China State Key Laboratory of Petroleum Resources and Processing China University of PetroleumBeijing 102249China Qingdao Institute of Marine Geology China Geological SurveyQingdao 266071China China University of Petroleum–Beijing at Karamay Karamay 834000China

The Makran accretionary wedge has the smallest subduction angle among any accretionary prism in the world. The factors controlling the spacing and morphological development of its deep thrust faults, as well as the formation mechanism of shallow normal faults, remain unclear. Meanwhile, the factors affecting the continuity of plane faults must be comprehensively discussed. Clarifying the development characteristics and deformation mechanisms of the Makran accretionary wedge is crucial to effectively guide the exploration of gas hydrate deposits in the area. This study aims to interpret seismic data to identify typical structures in the Makran accretionary wedge, including deep imbricate thrust faults, shallow and small normal faults, wedge-shaped piggyback basins, mud diapirs with fuzzy and disorderly characteristics of reflection, décollements with a northward tilt of 1° – 2°, and large seamounts. Physical simulation-based experiments are performed to comprehensively analyze the results of the plane, section, and slices of the wedge. Results reveal that the distances between and shapes of thrust faults in the deep parts of the Makran accretionary wedge are controlled by the bottom décollement. The uplift of the thrust fault-related folds and the upwelling of the mud diapirs primarily contribute to the formation of small normal faults in the shallow part of the area. The mud diapirs originate from plastic material at the bottom, while those that have developed in the area near the trench are larger. Seamounts and mud diapirs break the continuity of fault plane distribution.

关键词： Makran accretionary wedge structural styles faults distribution physical simulation

Correlation between abdominal computed tomography signs and postoperative prognosis for patients with colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2145-2156页

作者： shao-Min Yang Jie-Mei Liu Rui-Ping Wen Yu-Dong Qian jing-Bo He jing-Song Sun Department of Radiology Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical UniversityFoshan 528315Guangdong ProvinceChina Department of Rehabilitation Medicine Shunde HospitalSouthern Medical UniversityFoshan 528399Guangdong ProvinceChina Department of Radiology Lecong Hospital of ShundeFoshan 528315Guangdong ProvinceChina Department of Ultrasound Lecong Hospital of ShundeFoshan 528315Guangdong ProvinceChina

BACKGROUND Patients with different stages of colorectal cancer(CRC)exhibit different abdominal computed tomography(CT)***,the influence of CT signs on CRC prognosis must be *** To observe abdominal CT signs in patients with CRC and analyze the correlation between the CT signs and postoperative *** The clinical history and CT imaging results of 88 patients with CRC who underwent radical surgery at Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical University were retrospectively *** and multivariate Cox regression analyses were used to explore the independent risk factors for postoperative death in patients with *** three-year survival rate was analyzed using the Kaplan-Meier curve,and the correlation between postoperative survival time and abdominal CT signs in patients with CRC was analyzed using Spearman correlation *** For patients with CRC,the three-year survival rate was 73.86%.The death group exhibited more severe characteristics than the survival group.A multivariate Cox regression model analysis showed that body mass index(BMI),degree of periintestinal infiltration,tumor size,and lymph node CT value were independent factors influencing postoperative death(P<0.05 for all).Patients with characteristics typical to the death group had a low three-year survival rate(log-rankχ2=66.487,11.346,12.500,and 27.672,respectively,P<0.05 for all).The survival time of CRC patients was negatively correlated with BMI,degree of periintestinal infiltration,tumor size,lymph node CT value,mean tumor long-axis diameter,and mean tumor short-axis diameter(r=-0.559,0.679,-0.430,-0.585,-0.425,and-0.385,respectively,P<0.05 for all).BMI was positively correlated with the degree of periintestinal invasion,lymph node CT value,and mean tumor short-axis diameter(r=0.303,0.431,and 0.437,respectively,P<0.05 for all).CONCLUSION The degree of periintestinal infiltration,tumor size,and lymph node CT value are c

关键词： Colorectal cancer Abdominal Computed tomography signs Radical surgery Prognosis Correlation

Emerging tropane alkaloids:Global development and potential health threats

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Food Quality and Safety 2024年第1期8卷 12-26页

作者： Zile Wang Shiqi Chen Pimiao Zheng Zhenhui Ren Huixia Zhang jing Zhang Bing shao Congming Wu Haiyang Jiang Department of Veterinary Pharmacology and Toxicology Beijing Key Laboratory of Detection Technology for Animal-Derived Food SafetyBeijing Laboratory for Food Quality and SafetyNational Key Laboratory of Veterinary Public Health and SafetyCollege of Veterinary MedicineChina Agricultural UniversityBeijingChina. College of Veterinary Medicine Shandong Agricultural UniversityTaianChina. Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry College of Animal Science and Veterinary MedicineTianjin Agricultural UniversityTianjinChina Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijingChina.

Tropane alkaloids(TAs)are a kind of plant secondary metabolite that mainly originate from *** have potent anticholinergic activity,and are well-known anticholinergic drugs,but have also been reported as plant *** studies have been conducted on TAs,but no scientometric research has been *** study aimed to expound the knowledge network and development of the feld of TAs and predict the emerging development topics based on *** particular,this research combined VOSviewer and CiteSpace for visualization and covered 1,298 related scientifc publications(1953–2022).The research on TAs is rapidly developing,with the participation of 86 countries,1,129 research institutions,and 4,087 ***,the University of Geneva,and *** are the most productive country,institution,and researcher,***,the main research topics on TAs include biosynthesis,in vitro synthesis,chemical synthesis,and determination *** 2018,the monitoring of TAs in food related to human health has shown citation burst characteristics,which is considered an emerging development trend in the *** fndings of this study will enable researchers to quickly tap into the knowledge background/structure of TAs from massive data to provide a reference for further research.

关键词： Tropane alkaloids bibliometrics biosynthesis in vitro synthesis chemical synthesis determination contamination food safety

Time-dependent model for two-phase flow in ultra-high water-cut reservoirs: Time-varying permeability and relative permeability

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Petroleum Science 2024年第4期21卷 2536-2553页

作者： shao-Chun Wang Na Zhang Zhi-Hao Tang Xue-Fei Zou Qian Sun wei Liu College of Energy Resources Chengdu University of Technology College of Petroleum Engineering Shandong Institute of Petroleum and Chemical Technology

For the ultra-high water-cut reservoirs, after long-term water injection exploitation, the physical properties of the reservoir change and the heterogeneity of the reservoir becomes increasingly severe, which further aggravates the spatial difference of the flow field. In this study, the displacement experiments were employed to investigate the variations in core permeability, porosity, and relative permeability after a large amount of water injection. A relative permeability endpoint model was proposed by utilizing the alternating conditional expectation(ACE) transformation to describe the variation in relative permeability based on the experimental data. Based on the time dependent models for permeability and relative permeability, the traditional oil-water two-phase model was improved and discretized using the mimetic finite difference method(MFD). The two cases were launched to confirm the validation of the proposed model. The impact of time-varying physical features on reservoir production performance was studied in a real water flooding reservoir. The experimental results indicate that the overall relative permeability curve shifts to the right as water injection increases. This shift corresponds to a transition towards a more hydrophilic wettability and a decrease in residual oil saturation. The endpoint model demonstrates excellent accuracy and can be applied to time-varying simulations of reservoir physics. The impact of variations in permeability and relative permeability on the reservoir production performance yields two distinct outcomes. The time-varying permeability of the reservoir results in intensified water channeling and poor development effects. On the other hand, the time-varying relative permeability enhances the oil phase seepage capacity, facilitating oil displacement. The comprehensive time-varying behavior is the result of the combined influence of these two parameters, which closely resemble the actual conditions observed in oil field expl

关键词： Mimetic finite difference Water flooding reservoir Time-varying physical properties Numerical simulation

Impact of frailty on short-term postoperative outcomes in patients undergoing colorectal cancer surgery:A systematic review and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 893-906页

作者： Yao Zhou Xiao-Lei Zhang Hong-Xia Ni Tian-jing shao Ping Wang Department of Operating Room Affiliated Tumor Hospital of Nantong University&Nantong Tumor HospitalNantong 226361Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Affiliated Tumor Hospital of Nantong University&Nantong Tumor HospitalNantong 226361Jiangsu ProvinceChina

BACKGROUND Colorectal cancer is a major global health challenge that predominantly affects older *** management,despite advancements,requires careful consideration of preoperative patient status for optimal *** To summarize existing evidence on the association of frailty with short-term postoperative outcomes in patients undergoing colorectal cancer *** A literature search was conducted using PubMed,EMBASE and Scopus databases for observational studies in adult patients aged≥18 years undergoing planned or elective colorectal surgery for primary carcinoma and/or secondary *** studies that conducted frailty assessment using recognized frailty assess-ment tools and had a comparator group,comprising nonfrail patients,were *** effect sizes were reported as weighted mean difference or relative risk(RR)with 95%confidence intervals(CIs).RESULTS A total of 24 studies were *** with nonfrail patients,frailty was associated with an increased risk of mortality at 30 d(RR:1.99,95%CI:1.47-2.69),at 90 d(RR:4.76,95%CI:1.56-14.6)and at 1 year(RR:5.73,95%CI:2.74-12.0)of follow *** patients had an increased risk of any complications(RR:1.81,95%CI:1.57-2.10)as well as major complications(Clavien-Dindo classification grade≥III)(RR:2.87,95%CI:1.65-4.99)compared with the control *** risk of reoperation(RR:1.18,95%CI:1.07-1.31),readmission(RR:1.70,95%CI:1.36-2.12),need for blood transfusion(RR:1.67,95%CI:1.52-1.85),wound complications(RR:1.49,95%CI:1.11-1.99),delirium(RR:4.60,95%CI:2.31-9.16),risk of prolonged hospitalization(RR:2.09,95%CI:1.22-3.60)and discharge to a skilled nursing facility or rehabilitation center(RR:3.19,95%CI:2.0-5.08)was all higher in frail *** Frailty in colorectal cancer surgery patients was associated with more complications,longer hospital stays,higher reoperation risk,and increased *** frailty assessment appears crucial for tailored surgical managem

关键词： Frailty Frail adults Colorectal surgery Colorectal cancer Complications Mortality Survival Slinical outcomes Meta-analysis

Local quantum Fisher information and quantum correlation in the mixed-spin Heisenberg XXZ chain

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Frontiers of physics 2024年第2期19卷 235-245页

作者： Peng-Fei wei Qi Luo Huang-Qiu-Chen Wang shao-Jie Xiong Bo Liu Zhe Sun School of Physics Hangzhou Normal UniversityHangzhou 310036China Zhejiang Institute of Modern Physics and School of Physics Zhejiang UniversityHangzhou 310027China School of Information and Electrical Engineering Hangzhou City UniversityHangzhou 310015China Zhejiang Provincial Key Laboratory of Urban Wetlands and Regional Change Hangzhou 311121China

We study the local quantum Fisher information(LQFI)in the mixed-spin Heisenberg XXZ *** the maximal and minimal LQFI are studied and the former is essential to determine the accuracy of the quantum parameter estimation,the latter can be well used to characterize the discord-type quantum *** investigate the effects of the temperature and the anisotropy parameter on the maximal LQFI and thus on the accuracy of the parameter *** we make use of the minimal LQFI to study the discord-type correlations of different site *** dimensions of the subsystems cause different values of the minimal LQFI which reflects the asymmetry of the discord-type *** addition,the site pairs at different positions of the spin chains have different minimal LQFI,which reveals the influence of the surrounding spins on the bipartite quantum *** results show that the LQFI obtained through a simple calculation process provides a convenient way to investigate the discord-type correlation in high-dimensional systems.

关键词： local quantum Fisher information quantum correlation mixed-spin Heisenberg XXZ chain

Safety and efficacy of transcatheter arterial embolization in autosomal dominant polycystic kidney patients with gross hematuria: Six case reports

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World Journal of Clinical Cases 2024年第11期12卷 1954-1959页

作者： wei-Fan Sui Yun-Xin Duan Jian-Yun Li wei-Bin shao Jian-Hua Fu Department of Interventional Radiology Zhenjiang First People's HospitalZhenjiang 212000Jiangsu ProvinceChina Department of Nephrology Zhenjiang First People’s HospitalZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND To retrospectively report the safety and efficacy of renal transcatheter arterial embolization for treating autosomal dominant polycystic kidney disease(ADPKD)patients with gross *** SUMMARY The purpose of this study is to retrospectively report the safety and efficacy of renal transcatheter arterial embolization for treating ADPKD patients with gross *** and methods:During the period from January 2018 to December 2019,renal transcatheter arterial embolization was carried out on 6 patients with polycystic kidneys and gross *** arteriography was performed first,and then we determined the location of the hemorrhage and performed embolization under digital subtraction angiography *** in routine blood test results,routine urine test results,urine color and postoperative reactions were observed and ***:Renal transcatheter arterial embolization was successfully conducted in 6 *** indices of 5 patients and the color of gross hematuria improved after surgery compared with before *** severe complication reactions *** For autosomal dominant polycystic kidney syndrome patients with gross hematuria,transcatheter arterial embolization was safe and effective.

关键词： Renal artery Autosomal dominant polycystic kidney disease Gross hematuria Interventional radiology Embolization Case report

Reconstructed anti-corrosive and active surface on hierarchically porous carbonized wood for efﬁcient overall seawater electrolysis

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Science Bulletin 2024年第15期69卷 2337-2341页

作者： Zhijie Chen Wenfei wei Xiaomin Xu Xiaosong Gu Changzhu Huang wei wei Zongping shao Bing-Jie Ni Hong Chen Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control SUSTech Energy Institute for Carbon NeutralitySchool of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China UNSW Water Research Centre School of Civil and Environmental EngineeringThe University of New South WalesSydney 2052Australia Key Laboratory of Comprehensive and Highly Efﬁcient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth 6845Australia Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315200China Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneySydney 2007Australia

Seawater electrolysis for sustainable hydrogen fuel production emerges as an auspicious practice to decarbonize the global energy sector [1]. However, direct seawater electrolysis is severely challenged by the corrosion of anodes by chloride ions, the unwanted chloride oxidation reaction (Cl OR), and the low activity and high cost of catalysts [2].

关键词： corrosion seawater carbon