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Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： Yan Li Li-Na Jiang Bo-Kang zhao Mei-Ling Li Yi-Yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye jing-min zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor ***,the mechanism of metastasis remains poorly *** To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version *** machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC *** was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC *** analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in *** data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model

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Communication efficiency optimization of federated learning for computing and network convergence of 6G networks

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 713-727页

作者： Yizhuo CAI Bo LEI Qianying zhao jing PENG min WEI Yushun ZHANG Xing ZHANG Wireless Signal Processing and Network Laboratory Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Telecom Beijing 100011China

Federated learning effectively addresses issues such as data privacy by collaborating across participating devices to train global ***,factors such as network topology and computing power of devices can affect its training or communication process in complex network *** and network convergence(CNC)of sixth-generation(6G)networks,a new network architecture and paradigm with computing-measurable,perceptible,distributable,dispatchable,and manageable capabilities,can effectively support federated learning training and improve its communication *** guiding the participating devices'training in federated learning based on business requirements,resource load,network conditions,and computing power of devices,CNC can reach this *** this paper,to improve the communication eficiency of federated learning in complex networks,we study the communication eficiency optimization methods of federated learning for CNC of 6G networks that give decisions on the training process for different network conditions and computing power of participating *** simulations address two architectures that exist for devices in federated learning and arrange devices to participate in training based on arithmetic power while achieving optimization of communication efficiency in the process of transferring model *** results show that the methods we proposed can cope well with complex network situations,effectively balance the delay distribution of participating devices for local training,improve the communication eficiency during the transfer of model parameters,and improve the resource utilization in the network.

关键词： Computing and network convergence Communication efficiency Federated learning Two architectures

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New pimarane diterpenoids with antibacterial activity from fungus Arthrinium ***03

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Chinese Journal of Natural Medicines 2024年第4期22卷 356-364页

作者： zhao Songfeng jing Ziwei Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designated arthrinoids A–G (1–7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL^(−1).

关键词： Arthrinium sp.ZS03 Pimarane diterpenoids Structural elucidation Antibacterial activity

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Advances in bio-inspired electrocatalysts for clean energy future

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Nano Research 2024年第2期17卷 515-533页

作者： jing-Wen Duan Mu min-Rui Gao Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Electrocatalysis can enable efficient energy storage and conversion and thus is an effective way to achieve carbon *** unique structure and function of organisms can offer many ideas for the design of electrocatalysts,which has become one of the most promising research ***,the understanding of the mechanism of bio-inspired electrocatalysis has become clearer,which has promoted the design of bio-inspired catalysts and catalytic *** bio-inspired catalysts(enzyme-like catalysts,layered porous catalysts,superhydrophobic/superhydrophilic surfaces,and so on)have been developed to enable efficient electrocatalytic ***,we discuss the key advances in the field of bio-inspired electrocatalysts progressed in recent ***,the role of bio-inspiration in increasing the intrinsic activity and number of active sites of catalysts is ***,the structure and mechanism of layered porous catalytic systems that mimic biological transport systems are comprehensively ***,the design of three-phase interfaces from micro-nanoscale to atomic scale is highlighted,including the wettability of the electrode surface and the transport system near the *** conclude the review by identifying challenges in bio-inspired electrocatalysts and providing insights into future prospects for the exciting research field.

关键词： bio-inspired electrocatalysts active sites layered porous structure three-phase interface

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The Strategic Analysis of Demand Forecast-Sharing in a Hybrid-Format Online Platform Supply Chain

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 281-310页

作者： jing zhao Zijun Yin Guobiao Zhou School of Mathematical Sciences Tiangong UniversityTianjin300387China

This paper examines the optimal forecast-sharing strategy in a hybrid-format online platform supply chain where a supplier sells a product through agency format and reselling format provided by a platform retailer who possesses demand forecasts from two *** asymmetry and co-opetitive relationship arise between the platform retailer and the supplier,which affect their operational decisions and the supply chain’s *** improve supply chain efficiency,we compare different forecast-sharing strategies(i.e.,no forecast sharing,sharing a single forecast,and sharing two forecasts),and analyze the effects of co-opetitive parameters on the optimal forecast-sharing *** analysis shows that forecast sharing is always beneficial to the supplier,and sharing two forecasts is more beneficial than sharing a single *** for the platform retailer and the whole supply chain,forecast sharing is beneficial only under certain conditions,depending on the co-opetitive *** optimal forecast-sharing strategy is the result of a combination of the negative effect of double marginalization in reselling channel and the positive effect of responding pricing to demand uncertainty in agency *** illustrate the parameter regions of the platform retailer’s voluntary sharing,contract sharing,and no sharing,and also find that higher channel competition intensity,higher market share of agency channel,and higher commission rate can promote the platform retailer’s voluntary *** study extends the research scope of demand forecast-sharing and sheds light on the decision-making processes for managing a hybrid-format online platform supply chain.

关键词： Supply chain management hybrid-format online platform demand forecast-sharing co-opetitive relationship channel competition intensity

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Universal method for designing periodic orbits by homotopy classes in the elliptic restricted three-body problem

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Astrodynamics 2024年第1期8卷 175-188页

作者： Yue Zheng min zhao School of Electronic Engineering Xi’an Aeronautical InstituteXi’an710077China School of Aircraft Engineering Xi’an Aeronautical InstituteXi’an710077China School of Astronautics Northwestern Polytechnical UniversityXi’an710072China

The current methods for designing periodic orbits in the elliptic restricted three-body problem(ERTBP)have the disadvantages of targeting limited orbits and ergodic searches and considering only symmetric orbits.A universal method for designing periodic orbits is proposed in this ***,the homotopy classes of orbits are structured based on their topological ***,a dynamic model based on homotopy classes,ranging from the circular restricted three-body problem(CRTBP)to the ERTBP,can be built using the homotopy ***,a multi-and a single-period orbit were selected based on the resonance ***,the corresponding orbit in the ERTBP was computed by modifying the initial condition of the orbit in the *** method,without an ergodic search,can extend to any orbit,including an asymmetric orbit in the CRTBP,to the ERTBP model,and the two orbits are of the same homotopy *** of the Earth–Moon ERTBP are presented to verify the efficiency of this method.

关键词： periodic orbit elliptic restricted three-body problem(ERTBP) topology homotopy circular restricted three-body problem(CRTBP)

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Two Matrix Theorems Arising from Nilpotent Groups

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ALGEBRA COLLOQUIUM 2024年第3期31卷 499-504页

作者： zhao, jing Liu, Heguo Hainan Univ Sch Math & Stat Haikou 570228 Peoples R China

For a nilpotent group G without pi-torsion, and x, y is an element of G , if x(n) = y(n) for a pi-number n, then x=y ; if x(m) y(n) = y(n) x(m) for pi-numbers m, n, then xy = yx . This is a well-known result in group theory. In this paper, we prove two analogous theorems on matrices, which have independence significance. Specifically, let m be a given positive integer and A a complex square matrix satisfying that (i) all eigenvalues of A are nonnegative, and (ii) rank A(2) = rank A; then A has a unique m-th root X with rank X-2 = rank X , all eigenvalues of X are nonnegative, and moreover there is a polynomial f( lambda) with X = f (A). In addition, let A and B be complex nxn matrices with all eigenvalues nonnegative, and rank A(2) = rank A, rank B-2 = rank B; then (i) A=B when A (R) = B (R) for some positive integer r, and (ii) AB = BA when A(s) B-t = B-t A(s) for two positive integers s and t.

关键词： nilpotent group root matrix Chinese remainder theorem

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Modified constitutive models for Inconel 718 considering current density and temperature in electrically assisted forming process

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Chinese Journal of Aeronautics 2024年第2期37卷 524-540页

作者： Xuan CUI Rui zhao min WAN School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Jiangxi 330000China

Electrically Assisted Forming(EAF)technology has obvious advantages in material *** develop an effective constitutive model considering electrical effects,room temperature and electrically assisted quasi-static uniaxial tensile tests were conducted using ultrathin nickelbased superalloy plates with a thickness of 0.25 *** research focused on the two most widely recognized effects:the Joule thermal and the electric athermal *** mechanism of current action can be divided into two scenarios:one considering the Joule thermal effect only,and the other considering both effects *** basic constitutive models,namely the Modified-Hollomon model and the Johnson-Cook(J-C)model,were selected to be optimized through the classification of two different situations,and four optimized constitutive models were *** was found that the J-C model with simultaneous consideration of the Joule thermal effect and electric athermal effect had the best prediction effect by comparing the results of these four ***,the accuracy of the optimization model was verified by finite element simulation of the electrically assisted stretching optimization *** results show that the constitutive model can effectively predict the temperature effect caused by the Joule heat effect and the athermal effect of current on the material.

关键词： Joule heating Elastoplasticity Plastic deformation Superalloys Constitutive models

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Event-triggered distributed cross-dimensional formation control for heterogeneous multi-agent systems

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Frontiers of Information Technology & Electronic Engineering 2024年第8期25卷 1123-1133页

作者： Huimin WEI Chen PENG min zhao School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China School of Mathematics and Statistics Nantong UniversityNantong 226019China

This paper concerns the event-triggered distributed cross-dimensional formation control problem of heterogeneous multi-agent systems(HMASs)subject to limited network *** central aim is to design an effective distributed formation control scheme that will achieve the desired formation control objectives even in the presence of restricted ***,a multi-dimensional HMAS is first developed,where a group of agents are assigned to several subgroups based on their ***,to mitigate the excessive consumption of communication resources,a cross-dimensional event-triggered communication mechanism is designed to reduce the information interaction among agents with different *** the proposed event-based communication mechanism,the problem of HMAS cross-dimensional formation control is transformed into the asymptotic stability problem of a closed-loop error ***,several stability criteria for designing a cross-dimensional formation control protocol and communication schedule are presented in an environment where there is no information interaction among follower ***,a simulation case study is provided to validate the effectiveness of the proposed formation control protocol.

关键词： Heterogeneous multi-agent systems Formation control Cross-dimensional event-triggered mechanism

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RebL1 is required for macronuclear structure stability and gametogenesis in Tetrahymena thermophila

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Marine Life Science & Technology 2024年第2期6卷 183-197页

作者： Huijuan Hao Yinjie Lian Chenhui Ren Sitong Yang min zhao Tao Bo jing Xu Wei Wang Key Laboratory of Chemical Biology and Molecular Engineering of ministry of Education Institute of BiotechnologyShanxi UniversityTaiyuan 030006China School of Life Science Shanxi UniversityTaiyuan 030006China Shanxi Key Laboratory of Biotechnology Taiyuan 030006China

Histone modification and nucleosome assembly play important roles in chromatin-related *** chaperones form different complexes and coordinate histone transportation and *** histone chaperone complexes have been identified in different *** ciliate protozoa(ciliates)have various chromatin structures and different nuclear ***,histone chaperone components and functions of different subunits remain unclear in ***-rahymema thermophila contains a transcriptionally active macronucleus(MAC)and a transcriptionally inactive micronu-cleus(MIC)which exhibit multiple replication and various chromatin remodeling progresses during vegetative growth and sexual developmental ***,we found histone chaperone RebL1 not only localized evenly in the transcriptionally active MAC but also dynamically changed in the MIC during vegetative growth and sexual developmental ***1 knockdown inhibited cellular *** macronuclear morphology became bigger in growing *** abnormal macronuclear structure also occurred in the starvation ***,micronuclear meiosis was disturbed during sexual development,leading to a failure to generate new gametic ***1 potentially interacted with various factors involved in histone-modifying complexes and chromatin remodeling complexes in different developmental ***1 knockdown affected expression levels of the genes involved in chromatin organization and *** together,RebL1 plays a vital role in maintaining macronuclear structure stability and gametogenesis in ***.

关键词： Gametogenesis Histone chaperone Macronuclear structure RebL1 Tetrahymena thermophilaIntroduction

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