检索结果-南通市图书馆

Myotis bat STING attenuates aging-related inflammation in female mice

Zoological Research 2024年第5期45卷 961-971页

作者： Xi Wang jing-kun jia Qi Wang jing-Wen Gong Ang Li jia Su Peng Zhou Wuhan Institute of Virology Chinese Academy of SciencesWuhanHubei 430071China Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhouGuangdong 510005China University of Chinese Academy of Sciences Beijing 100000China State Key Laboratory of Respiratory Disease First Affiliated Hospital of Guangzhou Medical SchoolGuangzhouGuangdong 510005China

Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 ***,the mechanisms underlying these distinctive traits remain incompletely *** our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced *** substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse *** monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging *** transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in *** results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent *** the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.

关键词： Bat STING Longevity Aging-related inflammation Virus reservoir host

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Myotis bat STING attenuates aging-related inflammation in female mice

引用

动物学研究 2024年第5期 961页

作者： Xi Wang jing-kun jia Qi Wang jing-Wen Gong Ang Li jia Su Peng Zhou Wuhan Institute of Virology Chinese Academy of Sciences Guangzhou National Laboratory Guangzhou International Bio Island University of Chinese Academy of Sciences State Key Laboratory of Respiratory Disease First Affiliated Hospital of Guangzhou Medical School

Bats, notable as the only flying mammals, serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g., SARS-CoV and Ebola virus). Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size, particularly the Myotis bats, which can live up to 40 years. However, the mechanisms underlying these distinctive traits remain incompletely understood. In our prior research, we demonstrated that bats exhibit dampened STING-interferon activation, potentially conferring upon them the capacity to mitigate virus-or aging-induced inflammation. To substantiate this hypothesis, we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(Md STING) into the mouse genome. We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on Md STING and wild-type mice over a 3-year aging process. Blood transcriptomic analysis indicated a reduction in agingrelated inflammation in female Md STING mice, as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines, immunopathology, and neutrophil recruitment in aged female Md STING mice compared to aged wild-type mice in vivo. These results indicated that Md STING knock-in attenuates the agingrelated inflammatory response and may also improve the healthspan in mice in a sex-dependent manner. Although the underlying mechanism awaits further study, this research has critical implications for bat longevity research, potentially contributing to our comprehension of healthy aging in humans.

关键词：

来源：博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progression from ductal carcinoma in situ to invasive breast cancer:molecular features and clinical significance

引用

Signal Transduction and Targeted Therapy 2024年第5期9卷 1841-1868页

作者： jing Wang Baizhou Li Meng Luo jia Huang kun Zhang Shu Zheng Suzhan Zhang jiaojiao Zhou The Key Laboratory of Cancer Prevention and Intervention China National Ministry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Breast Surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Clinical Research Center for Cancer HangzhouChina Department of Pathology the Fourth Affiliated HospitalZhejiang University School of MedicineYiwuChina Department of Plastic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityHangzhouChina

Ductal carcinoma in situ(DCIS)represents pre-invasive breast *** untreated cases,25-60%DCIS progress to invasive ductal carcinoma(IDC).The challenge lies in distinguishing between non-progressive and progressive DCIS,often resulting in over-or under-treatment in many *** increasing screen-detected DCIS in these years,the nature of DCIS has aroused worldwide attention.A deeper understanding of the biological nature of DCIS and the molecular journey of the DCIS-IDC transition is crucial for more effective clinical ***,we reviewed the key signaling pathways in breast cancer that may contribute to DCIS initiation and *** also explored the molecular features of DCIS and IDC,shedding light on the progression of DCIS through both inherent changes within tumor cells and alterations in the tumor *** addition,valuable research tools utilized in studying DCIS including preclinical models and newer advanced technologies such as single-cell sequencing,spatial transcriptomics and artificial intelligence,have been systematically ***,we thoroughly discussed the clinical advancements in DCIS and IDC,including prognostic biomarkers and clinical managements,with the aim of facilitating more personalized treatment strategies in the *** on DCIS has already yielded significant insights into breast carcinogenesis and will continue to pave the way for practical clinical applications.

关键词： clinical breast alterations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Downscaling Seasonal Precipitation Forecasts over East Africa with Deep Convolutional Neural Networks

引用

Advances in Atmospheric Sciences 2024年第3期41卷 449-464页

作者： Temesgen Gebremariam ASFAW jing-jia LUO Institute for Climate and Application Research(ICAR)/CIC-FEMD/KLME/ILCEC Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Geophysics Space Science and Astronomy Addis Ababa UniversityAddis Ababa 1176Ethiopia

This study assesses the suitability of convolutional neural networks(CNNs) for downscaling precipitation over East Africa in the context of seasonal forecasting. To achieve this, we design a set of experiments that compare different CNN configurations and deployed the best-performing architecture to downscale one-month lead seasonal forecasts of June–July–August–September(JJAS) precipitation from the Nanjing University of Information Science and Technology Climate Forecast System version 1.0(NUIST-CFS1.0) for 1982–2020. We also perform hyper-parameter optimization and introduce predictors over a larger area to include information about the main large-scale circulations that drive precipitation over the East Africa region, which improves the downscaling results. Finally, we validate the raw model and downscaled forecasts in terms of both deterministic and probabilistic verification metrics, as well as their ability to reproduce the observed precipitation extreme and spell indicator indices. The results show that the CNN-based downscaling consistently improves the raw model forecasts, with lower bias and more accurate representations of the observed mean and extreme precipitation spatial patterns. Besides, CNN-based downscaling yields a much more accurate forecast of extreme and spell indicators and reduces the significant relative biases exhibited by the raw model predictions. Moreover, our results show that CNN-based downscaling yields better skill scores than the raw model forecasts over most portions of East Africa. The results demonstrate the potential usefulness of CNN in downscaling seasonal precipitation predictions over East Africa,particularly in providing improved forecast products which are essential for end users.

关键词： East Africa seasonal precipitation forecasting downscaling deep learning convolutional neural networks(CNNs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical review and literature analysis of hepatic epithelioid angiomyolipoma in alcoholic cirrhosis: A case report

引用

World Journal of Clinical Cases 2024年第14期12卷 2382-2388页

作者： jing-Qiang Guo jia-Hui Zhou kun Zhang Xin-Liang Lv Chao-Yong Tu Department of Hepatobiliary and Pancreatic Surgery Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack ***,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis *** article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this *** SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the *** on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was *** pathology showed *** outpatient follow-up,the patient showed no sign of *** HEA is difficult to make a definite diagnosis before *** has the poten-tial for malignant *** conditions permit,surgical treatment is recom-mended.

关键词： Hepatic epithelioid angiomyolipoma Alcoholic cirrhosis Magnetic resonance imaging Computed tomography Immunohistochemistry Misdiagnose analysis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

THE GLOBAL WELL-POSEDNESS OF SOLUTIONS TO COMPRESSIBLE ISENTROPIC TWO-FLUID MAGNETOHYDRODYNAMICS IN A STRIP DOMAIN

引用

Acta Mathematica Scientia 2024年第5期44卷 1997-2018页

作者： Zefu FENG jing jia School of Mathematical Sciences Chongqing Normal UniversityChongqing401331China

In this paper,we consider a model of compressible isentropic two-fluid magneto-hydrodynamics without resistivity in a strip domain in three dimensional *** exploiting the two-tier energy method developed in[Anal PDE,2013,6:1429–1533],we prove the global well-posedness of the governing model around a uniform magnetic field which is non-parallel to the horizontal ***,we show that the solution converges to the steady state at an almost exponential rate as time goes to *** to the work of Tan and Wang[SIAM J Math Anal,2018,50:1432–1470],we need to overcome the difficulties caused by particles.

关键词： two-fluid magnetohydrodynamics global well-posedness compressiblility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Role of Consumer Privacy Concerns in Shaping Platform Strategy for Online Markets

引用

Journal of the Operations Research Society of China 2024年第2期12卷 363-386页

作者： Jin-kun Yang Yong-Rui Duan jia-Zhen Huo School Economics and Management Tongji UniversityShanghai 200092China

We investigate the effects of consumer privacy concerns on the pricing and personal data collection strategy of an online *** online platform derives revenues from disclosing consumer information to *** compete for the information in order to enable them to price discriminate and thus derive revenues from consumer purchases.A novel aspect of our research is that we allow the online platform to sell only a subset of consumer *** develop analytical models where consumers can/cannot protect their *** analysis yields three main ***,in the monopoly case,we find that when the consumer privacy disclosure aversion cost is relatively low,it is optimal for the platform to sell all consumer information to the ***,in the duopoly case,we illustrate that when the consumer privacy disclosure aversion cost is relatively low,the platform will sell all consumer information to only one firm;when the cost is moderate,the platform will choose to sell the information of only some consumers and to only one firm;when the cost is relatively high,the platform will select only some of the consumers and sell their information to both ***,it will be better for the platform to provide the information protection service for free when the privacy cost is low.

关键词： Price discrimination User privacy Consumer information Two-sided market Privacy disclosure aversion cost

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

引用

Signal Transduction and Targeted Therapy 2024年第7期9卷 3077-3096页

作者： Pengcheng Zhou Xuanlong Du Weilu jia kun Feng Yewei Zhang Department of General Surgery Affiliated Hospital of Nantong UniversityNantongChina School of Medicine Southeast UniversityNanjingChina Nanjing Medical University NanjingChina Hepatobiliary and Pancreatic Center The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina

Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for *** tumor microenvironment(TME)in pancreatic cancer,distinguished by fibrosis and the existence of cancer-associated fibroblasts(CAFs),exerts a pivotal influence on both tumor advancement and resistance to *** advancements in the field of engineered extracellular vesicles(EVs)offer novel avenues for targeted therapy in pancreatic *** study aimed to develop engineered EVs for the targeted reprogramming of CAFs and modulating the TME in pancreatic *** obtained from bone marrow mesenchymal stem cells(BMSCs)were loaded with miR-138-5p and the anti-fibrotic agent pirfenidone(PFD)and subjected to surface modification with integrinα5-targeting peptides(named IEVs-PFD/138)to reprogram CAFs and suppress their pro-tumorigenic ***α5-targeting peptide modification enhanced the CAF-targeting ability of ***-138-5p directly inhibited the formation of the FERMT2-TGFBR1 complex,inhibiting TGF-βsignaling pathway *** addition,miR-138-5p inhibited proline-mediated collagen synthesis by directly targeting the FERMT2-PYCR1 *** combination of miR-138-5p and PFD in EVs synergistically promoted CAF reprogramming and suppressed the pro-cancer effects of *** experiments using the orthotopic stroma-rich and patient-derived xenograft mouse models yielded promising *** particular,IEVs-PFD/138 effectively reprogrammed CAFs and remodeled TME,which resulted in decreased tumor pressure,enhanced gemcitabine perfusion,tumor hypoxia amelioration,and greater sensitivity of cancer cells to ***,the strategy developed in this study can improve chemotherapy *** IEVs-PFD/138 as a targeted therapeutic agent to modulate CAFs and the TME represents a promising therapeutic approach for pancreatic cancer.

关键词： inhibited targeted chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TIPE2 is Essential for Apocynin-mediated Protection against Intestinal Ischemia/Reperfusion-induced Acute Lung Injury

引用

Biomedical and Environmental Sciences 2024年第8期37卷 936-942页

作者： Huirong jing Wenyan jia Xuewen Tang Affiliated Banan Hospital of Chongqing Medical University Chongqing 401320China Chongqing Traditional Chinese Medicine Hospital Chongqing 400021China Qingdao Municipal Hospital Qingdao 266000ShandongChina Healthy Management&Physical Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Intestinal ischemia/reperfusion(II/R)is a severe clinical circumstance which is frequently apparent in situations including midgut volvulus,superior mesenteric vessels closure and hemorrhagic ***/R not only brings about severe intestinal local damage but also leads to remote organs injury including lung,liver etc[1].Lung injury is the most common and severe complications which manifested as pulmonary susceptibility,respiratory dysfunction,and even acute respiratory distress syndrome(ARDS)[2].

关键词： Lung respiratory organs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Forecast Skills and Predictability Sources of Marine Heatwaves in the NUIST-CFS1.0 Hindcasts

引用

Advances in Atmospheric Sciences 2024年第8期41卷 1589-1600页

作者： jing MA Haiming XU Changming DONG jing-jia LUO Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/KLME/ILCEC/Institute of Climate and Application Research(ICAR) Nanjing University of Information Science and TechnologyNanjingJiangsu 210044China

Using monthly observations and ensemble hindcasts of the Nanjing University of Information Science and Technology Climate Forecast System(NUIST-CFS1.0) for the period 1983–2020, this study investigates the forecast skill of marine heatwaves(MHWs) over the globe and the predictability sources of the MHWs over the tropical oceans. The MHW forecasts are demonstrated to be skillful on seasonal-annual time scales, particularly in tropical oceans. The forecast skill of the MHWs over the tropical Pacific Ocean(TPO) remains high at lead times of 1–24 months, indicating a forecast better than random chance for up to two years. The forecast skill is subject to the spring predictability barrier of El Nino-Southern Oscillation(ENSO). The forecast skills for the MHWs over the tropical Indian Ocean(TIO), tropical Atlantic Ocean(TAO), and tropical Northwest Pacific(NWP) are lower than that in the TPO. A reliable forecast at lead times of up to two years is shown over the TIO, while a shorter reliable forecast window(less than 17 months) occurs for the TAO and ***, the forecast skills for the TIO, TAO, and NWP are seasonally dependent. Higher skills for the TIO and TAO appear in boreal spring, while a greater skill for the NWP emerges in late summer-early autumn. Further analyses suggest that ENSO serves as a critical source of predictability for MHWs over the TIO and TAO in spring and MHWs over the NWP in summer.

关键词： marine heatwaves NUIST-CFS1.0 hindcasts forecast skill predictability source ENSO

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：