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Eukaryotic initiation factor 5A2 and human digestive system neoplasms

World Journal of Gastrointestinal Oncology 2019年第6期11卷 449-458页

作者： Qing-Bin Meng jing-jing peng Zi-Wei Qu Xiao-Min Zhu Zhang Wen Wei-Ming Kang Department of Gastrointestinal Surgery the First Hospital of Wuhan CityWuhan 430022Hubei ProvinceChina Department of Gastroenterology General Hospital of the Yangtze River ShippingWuhan 430015Hubei ProvinceChina 不详 Department of Hepato-Biliary-Pancreatic Surgery and Liver Transplantation the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Eukaryotic initiation factor 5A2(eIF5A2),as one of the two isoforms in the family,is reported to be a novel oncogenic protein that is involved in multiple aspects of many types of human *** or gene amplification of EIF5A2 has been demonstrated in many *** evidence shows that eIF5A2 initiates tumor formation,enhances cancer cell growth,increases cancer cell metastasis,and promotes treatment resistance through multiple means,including inducing epithelial–mesenchymal transition,cytoskeletal rearrangement,angiogenesis,and metabolic *** of eIF5A2 in cancer correlates with poor survival,advanced disease stage,as well as metastasis,suggesting that eIF5A2 function is crucial for tumor development and maintenance but not for normal tissue *** these studies suggest that eIF5A2 is a useful biomarker in the prediction of cancer prognosis and serves as an anticancer molecular *** review focuses on the expression,subcellular localization,post-translational modifications,and regulatory networks of eIF5A2,as well as its biochemical functions and evolving clinical applications in cancer,especially in human digestive system neoplasms.

关键词： Eukaryotic translation initiation factor 5A2 Hypusine modification Acetylation modification Drug resistance Cancer therapeutics

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Recorded recurrent deep reinforcement learning guidance laws for intercepting endoatmospheric maneuvering missiles

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Defence Technology（防务技术） 2024年第1期31卷 457-470页

作者： Xiaoqi Qiu peng Lai Changsheng Gao Wuxing jing Department of Aerospace Engineering Harbin Institute of TechnologyHarbin150001China Shanghai Electro-Mechanical Engineering Institute Shanghai Academy of Spaceflight TechnologyShanghai201100China

This work proposes a recorded recurrent twin delayed deep deterministic(RRTD3)policy gradient algorithm to solve the challenge of constructing guidance laws for intercepting endoatmospheric maneuvering missiles with uncertainties and observation *** attack-defense engagement scenario is modeled as a partially observable Markov decision process(POMDP).Given the benefits of recurrent neural networks(RNNs)in processing sequence information,an RNN layer is incorporated into the agent’s policy network to alleviate the bottleneck of traditional deep reinforcement learning methods while dealing with *** measurements from the interceptor’s seeker during each guidance cycle are combined into one sequence as the input to the policy network since the detection frequency of an interceptor is usually higher than its guidance *** training,the hidden states of the RNN layer in the policy network are recorded to overcome the partially observable problem that this RNN layer causes inside the *** training curves show that the proposed RRTD3 successfully enhances data efficiency,training speed,and training *** test results confirm the advantages of the RRTD3-based guidance laws over some conventional guidance laws.

关键词： Endoatmospheric interception Missile guidance Reinforcement learning Markov decision process Recurrent neural networks

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Interface optimization of graphene paper-Cu composite prepared by electrodeposition

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Journal of Iron and Steel Research International 2024年第1期31卷 64-73页

作者： jing Guo Hai-jing Wang Shuang-juan Liu peng Zhang jing-yu Tang Wei-yang Zhang Han-jie Guo peng-cheng Wang Cai Meng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Advanced Technology and Materials Co. Ltd.Beijing100083China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei230027AnhuiChina

A room-temperature electrodeposition method with an organic electrolyte was developed to fabricate a HNO3-pretreated graphene paper Cu(GP'-Cu)*** improve the interfacial bonding of GP'-Cu composite,magnetron sputtering technology was used to create a"sandwich"structural gradient GP'-Cu *** selection of the intermediate transition layer metal was based on two-dimensional *** electron microscopy,X-ray photoelectron spectroscopy,and other analytical methods confirmed that the addition of an intermediate transition metal(Cr,Ni)layer reduced the gap distance and enhanced the interfacial bonding of the GP'and Cu deposited *** GP'-Ni-Cu composite exhibited the largest increase in tensile strength and *** addition,it had the highest thermal diffusivity and elongation at break among the GP'-Cu,GP'-Cr-Cu and GP'-Ni-Cu composites.

关键词： Graphene paper Two-dimensional disregistry Magnetron sputtering Metal composite

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How the enhanced East Asian summer monsoon regulates total gross primary production in eastern China

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Advances in Climate Change Research 2024年第2期15卷 244-252页

作者： Ming-Yu HAN Yong ZHANG jing peng China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China China Meteorological Administration Institute for Development and Programme Design Beijing 100081China CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of Sciences(CAS)Beijing 100029China

Recognizing the relationship between gross primary production(GPP)and precipitation in eastern China,the East Asian Summer Monsoon(EASM)plays a crucial role in shaping *** confirmation of the strong link between EASM and GPP,there remains a notable research gap in understanding the specific impact of the EASM on GPP in different regions of eastern *** we used simulations from Trends in Net Land-Atmosphere Carbon Exchanges(TRENDY)models from 1951 to 2010 and divided eastern China into five subregions for the *** also used the New East Asian Summer Monsoon Index(NEWI)as a quantitative metric to distinguish between periods of strong and weak *** on this,this study aims to investigate the response of GPP in different subregions of eastern ***,under strengthened EASM years(1954,1957,1965,1969,1977,1980,1983,1987,1993 and 1998),East China experienced the most pronounced increase in GPP at 12±21(mean±1 sigma)gC m^(-2) mon^(-1) compared to the weak EASM years(1958,1961,1972,1973,1978,1981,1985,1994,1997 and 2004).In contrast,Southwest China showed a decline in GPP at-4±10 gC m^(-2) mon^(-1).Moreover,GPP also increased in Northeast and North China when EASM strengthened,while South China showed a decline in *** indicated that GPP changed with monsoon *** to the mechanism analysis,during strong EASM,there was intense moisture convergence through alterations in the atmospheric circulation field over East China and abundant precipitation,which further contributed to the increase in *** solar radiation in Southwest China decreased with EASM enhancement,which suppressed GPP and hindered vegetation ***,the results highlight the importance of accurately predicting the impact of different EASM intensities of regional carbon fluxes.

关键词： Gross primary production Surface air temperature Precipitation Solar radiation Eastern China Carbon cycle

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Mapping of QTL Associated with Drought Tolerance in a Semi-Automobile Rain Shelter in Maize (Zea mays L.)

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Agricultural Sciences in China 2011年第7期10卷 987-996页

作者： ZHU jing-jing WANG Xiao-peng SUN Cui-xia ZHU Xiu-miao LI Meng ZHANG Guo-dong TIAN Yan-chen WANG Ze-li National Key Laboratory of Crop Biology Ministry of Science and Technology/College of Life Sciences Shandong Agricultural University Tai＇an 271018 P.R.China

Drought is a major constraint in maize production worldwide. We studied quantitative trait loci （QTL） underlying drought tolerance for maize plants grown in two different environments. Traits investigated included ASI, plant height, grain yield, ear height, and ear setting. A genetic linkage map was constructed with 120 simple sequence repeat （SSR） markers based on an F2 population derived from a cross between D5 （resistant parent） and 7924 （susceptible parent）. Correlation and heritability were calculated. QTLs of these traits were identified by composite interval mapping combined with a linkage map covering 1 790.3 cM. The markers were arranged in ten linkage groups. QTL mapping was made of the mean trait performance of the 180 F2：3 population. The results showed five, five, six, four, and five QTLs for ASI, plant height, grain yield, ear height, and ear setting under full irrigation condition, respectively, and four, seven, six, four, and four QTLs for ASI, plant height, grain yield, ear height, and ear setting under severe late stress conditions, respectively. Especially the four QTLs detected for five traits in 2008 and 2009. The universal QTLs information generated in this study will aid in undertaking an integrated breeding strategy for further genetic studies in drought tolerance improvement in maize.

关键词： maize drought tolerance simple sequence repeat quantitative trait loci

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Spatial Variation in CO_(2) Concentration Improves the Simulated Surface Air Temperature Increase in the Northern Hemisphere

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Advances in Atmospheric Sciences 2024年第8期41卷 1614-1628,1676-1685页

作者： jing peng Li DAN Xiba TANG CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) Institute of Atmospheric PhysicsBeijing 100029China

The increasing concentration of atmospheric CO_(2) since the Industrial Revolution has affected surface air ***,the impact of the spatial distribution of atmospheric CO_(2) concentration on surface air temperature biases remains highly *** incorporating the spatial distribution of satellite-derived atmospheric CO_(2) concentration in the Beijing Normal University Earth System Model,this study investigated the increase in surface air temperature since the Industrial Revolution in the Northern Hemisphere(NH) under historical conditions from *** comparison with the increase in surface temperature simulated using a uniform distribution of CO_(2),simulation with a nonuniform distribution of CO_(2)produced better agreement with the Climatic Research Unit(CRU) data in the NH under the historical condition relative to the baseline over the period *** June-July-August(JJA) surface air temperature increased by 1.28℃ ±0.29℃ in simulations with a uniform distribution of CO_(2),by 1.00℃±0.24℃ in simulations with a non-uniform distribution of CO_(2),and by 0.24℃ in the CRU *** decrease in downward shortwave radiation in the non-uniform CO_(2) simulation was primarily attributable to reduced warming in Eurasia,combined with feedbacks resulting from increased leaf area index(LAI) and latent heat *** effects were more pronounced in the non-uniform CO_(2)simulation compared to the uniform CO_(2) *** indicate that consideration of the spatial distribution of CO_(2)concentration can reduce the overestimated increase in surface air temperature simulated by Earth system models.

关键词： spatial variations of CO_(2) surface air temperature Earth system model land surface albedo leaf area index

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Local saliency consistency-based label inference for weakly supervised salient object detection using scribble annotations

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 239-249页

作者： Shuo Zhao peng Cui jing Shen Haibo Liu School of Computer Science and Technology Harbin University of Science and TechnologyHarbinChina School of Computer Science and Technology Harbin Engineering UniversityHarbinChina

Recently,weak supervision has received growing attention in the field of salient object detection due to the convenience of ***,there is a large performance gap between weakly supervised and fully supervised salient object detectors because the scribble annotation can only provide very limited foreground/background ***,an intuitive idea is to infer annotations that cover more complete object and background regions for *** this end,a label inference strategy is proposed based on the assumption that pixels with similar colours and close positions should have consistent ***,k-means clustering algorithm was first performed on both colours and coordinates of original annotations,and then assigned the same labels to points having similar colours with colour cluster centres and near coordinate cluster ***,the same annotations for pixels with similar colours within each kernel neighbourhood was set *** experiments on six benchmarks demonstrate that our method can significantly improve the performance and achieve the state-of-the-art results.

关键词： label inference salient object detection weak supervision

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Reoxidation of liquid steel and evolution of inclusions during protective atmosphere electroslag remelting of Ce-containing heat-resistant stainless steel

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Journal of Iron and Steel Research International 2024年第8期31卷 1923-1935页

作者： Yu Zhao Cheng-bin Shi Shijun Wang peng Ren jing Li State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing(USTB)Beijing 100083China

The evolution of Ce-containing inclusions and its correlation with the reoxidation of liquid steel during protective atmosphere electroslag remelting(ESR)of heat-resistant steel were *** reoxidation of liquid steel took place during the ESR,resulting in the oxygen pickup from 0.0014 to 0.0053 wt.%.The inclusions in the consumable electrode,liquid metal pool and remelted ingot are Ce_(2)O_(2)S and Ce_(2)O,inclusions *** inclusions in the remelted ingot are originated from three ways:(I)the original inclusions from the electrode;(Il)the newly formed Ce_(2)O_(2)S and Ce_(2)O_(3) inclusions in the liquid metal pool by reoxidation remaining still in remelted ingot;(IlI)the newly generated Ce2O2S and Ce_(2)O_(3) inclusions during cooling and solidification of liquid *** relative proportions of Ce_(2)O_(3) inclusions in liquid metal pool and remelted ingot are 41% and 76.5%,*** inclusions ranging from 2 to 5μm in the remelted ingot take up 55%,followed by the inclusions smaller than 2μm(43%of total inclusions).The number proportion of the Ce_(2)0,inclusions in the liquid metal pool which were removed by floating up into slag is 1.96×10-5%.

关键词： Non-metallic inclusion Electroslag remelting Rare earth cerium Reoxidation Inclusion evolution

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Chromosome-scale genomes of Quercus sichourensis and Quercus rex provide insights into the evolution and adaptation of Fagaceae

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Journal of Genetics and Genomics 2024年第5期51卷 554-565页

作者： Xue Liu Weixiong Zhang Yongting Zhang jing Yang peng Zeng Zunzhe Tian Weibang Sun jing Cai Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'anShaanxi 710072China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

The Fagaceae,a plant family with a wide distribution and diverse adaptability,has garnered significant interest as a subject of study in plant speciation and ***,certain Fagaceae species are regarded as highly valuable wood resources due to the exceptional quality of their *** this study,we present two high-quality,chromosome-scale genome sequences for Quercus sichourensis(848.75 Mb)and Quercus rex(883.46 Mb).Comparative genomics analysis reveals that the difference in the number of plant disease resistance genes and the nonsynonymous and synonymous substitution ratio(Ka/Ks)of protein-coding genes among Fagaceae species are related to different environmental ***,most genes related to starch synthesis in the investigated Quercoideae species are located on a single chromosome,as compared to the outgroup species,Fagus ***,resequencing and population analysis of *** and *** reveal that *** has lower genetic diversity and higher deleterious mutations compared to *** high-quality,chromosome-level genomes and the population genomic analysis of the critically endangered *** and *** will provide an invaluable resource as well as insights for future study in these two species,even the genus Quercus,to facilitate their conservation.

关键词： Adaptation Quercus sichourensis Quercusrex Chromosome-scale genome assembly Tandem duplication genes Extremely small populations

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Coherence analysis of noise-like pulses generated by an erbium-doped fiber mode-locked laser

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Optoelectronics Letters 2024年第4期20卷 205-210页

作者： ZHANG Ziyi WANG Chuncan LI jing WANG peng Key Laboratory of All Optical Network and Advanced Telecommunication Network Ministry of EducationInstitute of Lightwave TechnologyBeijing Jiaotong University Beijing 100044China

The noise-like pulses(NLPs)with tunable fraction of the pedestal height in the whole intensity autocorrelation(AC)trace are numerically demonstrated in the designed erbium-doped fiber(EDF)mode-locked laser,which contains the saturable absorber(SA)with nonlinear polarization rotation(NPR),sinusoidal-shaped or Gaussian-shaped filter,two segments of EDFs,and two pieces of single-mode fibers(SMFs)with normal dispersion and anomalous dispersion,*** pedestal ratio of the intensity AC trace can be tuned by changing the gain saturation energies of *** results show that when the net cavity dispersion is 1.06 ps^(2),the tuning range of the pedestal ratio for the NLPs can reach its maximum values,which are 0.51—0.89 and 0.58—0.88 for the sinusoidal-shaped and Gaussian-shaped filters,*** addition,an appropriate choice of filter bandwidth is also conducive to obtain a wide range of the tuning pedestal ratio for the intensity AC trace.

关键词： fiber tuning polarization

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