检索结果-南通市图书馆

Abnormal function of EPHA2/p.R957P mutant in congenital cataract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： jing-jin zhang Zong-Fu Cao Bi-Ting Zhou Ju-Hua Yang Zhong Li Shuang Lin Xiao-Le Chen Nan-Wen zhang Qin Ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

培育新质生产力高质量发展的税收政策研究

山西财政税务专科学校学报 2024年第4期26卷 17-21页

作者：张婧张进山西省财政税务专科学校山西太原030024

在后疫情时代,实体经济作为社会经济发展的“命门”,对我国经济整体稳定增长、国民生活水平提高具有“压舱石”作用。实体经济创新发展的具体指向,即要加快培育新质生产力。何为新质生产力?新质生产力如何促进实体经济高质量发展?各项... 详细信息

在后疫情时代,实体经济作为社会经济发展的“命门”,对我国经济整体稳定增长、国民生活水平提高具有“压舱石”作用。实体经济创新发展的具体指向,即要加快培育新质生产力。何为新质生产力?新质生产力如何促进实体经济高质量发展?各项税收政策该如何助力新质生产力高质量发展?通过梳理新质生产力的相关理论,研究税收政策对培育新质生产力高质量发展的影响机理,分析我国现行税收政策在培育新质生产力过程中面临的现实困境,并提出完善建议。

关键词：新质生产力高质量发展税收政策

Error analysis and a new steering law design for spacecraft control system using SGCMGs

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2011年第5期27卷 803-808页

作者： jin jin jing-Rui zhang Zao-Zhen Liu Beijing Institute of Technology School of Aerospace Engineering100081 Beijing China

Based on the singular value decomposition theory,this paper analyzed the mechanism of escaping/avoiding singularity using generalized and weighted singularity-robust steering laws for a spacecraft that uses single gimbal control moment gyros （SGCMGs） as the actuator for the attitude control *** expression of output-torque error is given at the point of singularity,proving the incompatible relationship between the gimbal rate and the output-torque *** method of establishing a balance between the gimbal rate and the output-torque error is discussed,and a new steering law is *** results show that the proposed steering law can effectively drive SGCMGs to escape away from singularities.

关键词： Single gimbal control moment gyros (SGCMGs) Attitude control Singularity analysis Steering law

Bilateral diffuse uveal melanocytic proliferation associated with endometrial carcinoma–multimodal imaging analysis

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2022年第7期15卷 1209-1213页

作者： Zhi-Peng Cai Hong zhang jin-jing zhang Chuan-Hong Jie Fang-Tian Dong Eye Hospital China Academy of Chinese Medical SciencesBeijing 100040China Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Dear Editor,We present a rare case of bilateral diffuse uveal melanocytic proliferation (BDUMP) associated with endometrial *** is a rare paraneoplastic ocular syndrome with generally poor *** features include:1) multiple subtle,round,or oval red patches in the retinal pigment epithelium (RPE) of the posterior fundus;2)multifocal areas of early hyperfluorescence corresponding to these patches;3) development of multiple,slightly elevated pigmented and non-pigmented uveal melanocytic tumours with diffuse thickening of the uveal tracts;4) exudative retinal detachment;5) rapid progression of *** patches progressively increase in size and merge into the giraffe-like pattern characteristic of *** signs may be present,including cysts in the ciliary body and iris,dilated episcleral vessels,and a shallow anterior chamber.

关键词： elevated epithelium modal

Taiji-TianQin-LISA network:Precisely measuring the Hubble constant using both bright and dark sirens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 59-77页

作者： Shang-Jie jin Ye-Zhu zhang Ji-Yu Song jing-Fei zhang Xin zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-TianQin-LISA network in constraining cosmological *** the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,Q3d,and *** results show that the TaijiTianQin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision ***,the Taiji-TianQin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy *** combined with the CMB data,the joint CMB+Taiji-TianQin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN *** also consider a conservative scenario in which EM counterparts are not *** to the precise sky localizations of MBHBs by the Taiji-TianQin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-TianQin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.

关键词： space-based gravitational wave detection standard sirens the Taiji-TianQin-LISA network the Hubble constant dark energy

A new gnetalean macrofossil from the Lower Cretaceous of the Laiyang Basin, eastern China

在线全文

学校读者我要写书评

暂无评论

Plant Diversity 2024年第5期46卷 678-682页

作者： Peihong jin Mingzhen zhang Baoxia Du jing zhang Bainian Sun Key Laboratory of Petroleum Resources Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesGansu ProvinceLanzhou 730000China Key Laboratory Western China's Mineral Resources of Gansu Province Lanzhou UniversityLanzhou 730000China

Gnetophytes are a key group of plant for understanding seed plant phylogeny,partly because of their unique and elusive morphology,such as xylem with vessels,phloem with chaperones,reticular veins,and double fertilization(Endress,1996).In particular,the ovule bears a membranous integument,the upper part of which extends beyond the seed envelope to form a micropylar ***,gnetophytes occupy a unique evolutionary position in the phylogeny of seed plants and apparently represent a transition between angiosperms and other gymnosperms(Ran et al.,2018).Modern gnetophytes consist of only three families:Ephedraceae,Gnetaceae,and Welwitschiaceae,and each family contains only one ***(Ephedra L.)are the earliest diverging group of Gnetales,with a total of 70 extant species,and usually occur in cold and arid places in Asia,Europe,northern Africa,western North America and South America(Price,1996;Yang et al.,2017b).

关键词： phylogeny occupy Cretaceous

Size-dependent thermomechanical vibration characteristics of rotating pre-twisted functionally graded shear deformable microbeams

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1015-1032页

作者： Songye jin Bo zhang Wuyuan zhang Yuxing WANG Huoming SHEN jing WANG Juan LIU School of Mechanics and Aerospace Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mechanical and Electrical Engineering Southwest Petroleum UniversityChengdu 610500China

A three-dimensional(3D)thermomechanical vibration model is developed for rotating pre-twisted functionally graded(FG)microbeams according to the refined shear deformation theory(RSDT)and the modified couple stress theory(MCST).The material properties are assumed to follow a power-law distribution along the chordwise *** model introduces one axial stretching variable and four transverse deflection variables including two pure bending components and two pure shear *** complex modal analysis and assumed mode methods are used to solve the governing equations of motion under different boundary conditions(BCs).Several examples are presented to verify the effectiveness of the developed *** coupling the slenderness ratio,gradient index,rotation speed,and size effect with the pre-twisted angle,the effects of these factors on the thermomechanical vibration of the microbeam with different BCs are *** is found that with the increase in the pre-twisted angle,the critical slenderness ratio and gradient index corresponding to the thermal instability of the microbeam increase,while the critical material length scale parameter(MLSP)and rotation speed *** sensitivity of the fundamental frequency to temperature increases with the increasing slenderness ratio and gradient index,and decreases with the other increasing ***,the size effect can suppress the dynamic stiffening effect and enhance the Coriolis ***,the mode transition is quantitatively demonstrated by a modal assurance criterion(MAC).

关键词： thermomechanical vibration rotating pre-twisted functionally graded(FG)microbeam refined shear deformation theory(RSDT) modified couple stress theory(MCST) modal assurance criterion(MAC)

First-Arrival Picking Method for Active Source Data with Ocean Bottom Seismometers Based on Spatial Waveform Variation Characteristics

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2024年第4期23卷 970-980页

作者： LIU Hongwei XING Lei ZHU Henghua zhang jin zhang jing LIU Huaishan Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266071China College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001China Shandong Institute of Geological Survey Jinan 250014China

The precision and reliability of first-arrival picking are crucial for determining the accuracy of geological structure inversion using active source ocean bottom seismometer(OBS)refraction *** methods for first-arrival picking based on sample points are characterized by theoretical errors,especially in low-sampling-frequency OBS data because the travel time of seismic waves is not an integer multiple of the sampling *** this paper,a first-arrival picking method that utilizes the spatial waveform variation characteristics of active source OBS data is ***,the distribution law of theoretical error is examined;adjacent traces exhibit variation characteristics in their ***,a label cross-correlation superposition method for extracting highfrequency signals is presented to enhance the first-arrival picking *** from synthetic and field data verify that the proposed approach is robust,successfully overcomes the limitations of low sampling frequency,and achieves precise outcomes that are comparable with those of high-sampling-frequency data.

关键词： first-arrival picking spatial waveform variation label cross-correlation superposition method

Evolution of tribo-magnetization during sliding of ferromagnetic materials

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第5期12卷 906-918页

作者： Fumin GAO Laibin zhang jin ZHOU Yi XIONG jing WU Jianchun FAN China University of Petroleum-Beijing Beijing102249China Key Laboratory of Oil and Gas Safety and Emergency Technology Ministry of Emergency ManagementBeijing102249China

Sliding-induced subsurface microstructure evolution is believed to be decisive for determining the friction and wear performance of metallic contacts as well as the development of *** expects to develop a new prediction method of wear state by elucidating the correlation between subsurface microstructure evolution and corresponding magnetic domain ***,subsurface microstructure evolution including crystal and magnetic domain under tribological action is investigated *** results demonstrate that dislocation mediated plastic deformation decisively influences microstructural changes during tribological contact,further determining the magnetic domain ***,sliding-induced plastic deformation causes an increase in the width of magnetic domains,but depth-dependent derived microstructure formed under severe plastic deformation such as the refined grains and sub-grains,in turn,promoted the refinement of magnetic domains and their discontinuity,forming depth-dependent magnetic domain *** results are helpful to clarify the evolution of tribo-magnetization and the pinning effect of dislocations on magnetic domains.

关键词： tribology magnetic domain microstructure tribo-magnetization dislocations