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Efficacy and Safety of Sanjie Analgesic Capsule in Patients with Endometriosis-Associated Pain:A Multicenter,3:1 Randomized,Double-Blind,Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 780-787页

作者： LENG Jin-hua DUAN Hua GUAN Zheng ZHOU Ying-fang QU hong xu Kai-hong ZHANG Shao-fen ZHANG Qin WANG Xin LIN Kai-qing LANG jing-he Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing100730China Department of Gynecology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing100006China Department of Gynecology Chinese PLA General HospitalBeijing100039China Department of Gynecology Peking University First HospitalBeijing100034China Department of Gynecology Beijing Chao-yang HospitalBeijing100020China Department of Gynecology Womens Hospital School of Medicine Zhejiang UniversityHangzhouZhejiang Province310006China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai200090China Department of Gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310007China Department of Gynecology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110032China

Objective:To assess the efficacy and safety of Sanjie Analgesic Capsule(SAC)in Chinese patients with endometriosis-associated ***:This was a multicenter,randomized,double-blind,placebo-controlled trial conducted at 15 centers between November 2013 and July 2017 in *** 323 patients with endometriosis were randomized at a 3:1 ratio to the SAC group(241 cases)and placebo group(82 cases)by stratified block *** in the SAC or placebo groups were given SAC or placebo 1.6 g 3 times per day,orally,respectively since the first day of menstruation for 3 consecutive menstrual *** primary endpoint was clinical response to dysmenorrhea evaluated using a 10-point Visual Analogue Scale at 3 and 6 *** secondary endpoint was the pain score evaluated by VAS(chronic pelvic pain,defecation pain,and dyspareunia)at 3 and 6 months,and the pain recurrence rate at 6 *** events(AEs)were recorded during the ***:A total of 241 women were included in the SAC group,and 82 were in the placebo *** these women,217(90.0%)and 71(86.6%)completed the intervention,*** 3 months,overall response rate(ORR)was significantly higher in women administered SAC(80.1%)compared with those who received a placebo(30.5%,P<0.01).Six months after treatment,the ORR for dysmenorrhea was 62.7%in the SAC group and 31.7%in the placebo group(P<0.01).Chronic pelvic pain and defecation pain were significantly improved by SAC compared with placebo(both P<0.05).The incidence rates of total AEs events in the SAC and placebo groups were 6.6%and 9.8%,respectively,and no significant difference was shown between the two groups(P=0.339).Conclusion:SAC is well-tolerated and may improve dysmenorrhea in women with endometriosis-associated pain.

关键词： endometriosis pain Sanjie Analgesic Capsule randomized controlled trial Chinese medicine

Effects of Poria cocos polysaccharide on growth performance,physiological parameters,and lipid metabolism of spotted sea bass Lateolabrax maculatus

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Journal of Oceanology and Limnology 2024年第1期42卷 316-331页

作者： jing LU Zhangfan HUANG Youling YE Anle xu Zhongbao LI Fisheries College Jimei UniversityXiamen 361021China Fujian Provincial Key Laboratory of Marine Fishery Resources and Eco-environment Xiamen 361021China

The aquaculture industry has developed significantly over the past few decades and has had a substantial impact on the global food supply and marine fisheries ***,some problems arise behind the scenes due to excessive intensive farming,such as slow animal growth,frequent disease,and lipid metabolism *** problems have limited the sustainable development of the aquaculture industry,and a continuable solution is *** use of fungal polysaccharide appears to provide a solution to these ***,different supplemented levels of Poria cocos polysaccharide(PCP)(0,0.4,0.8,1.2,1.6,and 2.0 g/kg,respectively)were fed to spotted sea bass(Lateolabrax maculatus)in similar size(30.28±0.18 g)in current *** effects of PCP on growth,physiological parameters,and lipid metabolism of spotted sea bass were investigated after a 4-week rearing *** showed,fish with PCP intake presented a significantly higher weight gain,specific growth rate,and a significantly lower feed conversion *** higher trypsin activity in liver and intestine were observed in fish with PCP *** superoxide dismutase activity in serum and liver of fish with PCP intake were significantly improved,while significantly higher serum total antioxidant capacity and hepatic catalase activity were also ***,no significant differences in lysozyme and alkaline phosphatase activity were evident among *** with PCP intake showed a significantly lower total cholesterol,but no noteworthy change in triglyceride and lipid-metabolismrelated genes expression were observed among *** indicated that intake of PCP has a positive effect on growth and antioxidant capacity of spotted sea bass,but seems to have a limited effect on the non-specific immunity and lipid metabolism of spotted sea *** on the regression analysis results,1.4 g/kg of PCP is the optimal dose for spotted sea bass in size(30.28±0.18 g).

关键词： spotted sea bass Poria cocos polysaccharide growth lipid metabolism

Exploring Paths of Students'Academic Burden Reduction in the East Asian Educational Circle:An Analysis of Learning Time Investment and Efficiency Based on PISA 2022

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Frontiers of Education in China 2024年第3期19卷 235-250页

作者： xu Jinjie LU jing Lab for Educational Big Data and Policymaking under the Ministry of Education of the People's Republic of China Shanghai 200234China Shanghai Academy of Educational Sciences Shanghai 200032China China Research Institute for International Comparative Education Shanghai Normal UniversityShanghai 200234China

By comparing the changes from the Organization for Economic Co-operation and Development's results of Programme for International Student Assessment(PISA)2018 and 2022,it is found that 15-year-old students in East Asian countries and economies maintain a commanding lead in reading,mathematics,and *** students from regions such as Singapore,Japan,the Republic of Korea,hong Kong(China),Macao(China),and Chinese Taipei not only sustain their academic excellence but also experience improvements in learning efficiency and their sense of belonging at *** on the PISA 2022 data,this study analyzes students'learning time investment,out-of-school-hours(OsH)services,and their relationship with student academic *** results show that the above countries and economies have achieved encouraging results in academic burden reduction by decreasing learning time in regular school lessons,controlling homework time,and providing OsH *** distinctive policy interventions can serve as valuable reference points for the Chinese Mainland's ongoing implementation of the"double reduction"policy while facilitating an informed judgment of potential risks.

关键词： Programme for International Student Assessment(PISA)2022 East Asian educational circle academic burden reduction learning time

Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1821-1832页

作者： xu Ren Yong-Ping Qu Chun-Lan Zhu Xiao-hong xu hong Jiang Yi-Xia Lu hong-Peng xue Digestive Disease Hospital of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Digestive Endoscopy Center of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Second Department of Gastroenterology Digestive Disease Hospital of Heilongjiang Provincial Hospitaland Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Department of Pathology Heilongjiang Provincial HospitalHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous *** reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and *** have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since *** To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of *** Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were ***-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with *** primary outcome was its feasibility,indicated by technical *** secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and *** Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were ***-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,*** cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type *** five patients achieved technical success of *** patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN h

关键词： Intraductal papillary neoplasm of the bile duct Percutaneous transhepatic cholangioscopy Biliary polypectomy Feasibility Efficacy

Survey and clinical considerations of gender identity in lower primary school children

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World Journal of Psychiatry 2024年第1期14卷 36-43页

作者： Ya-Lin Zhang hong-Mei Zhang jing-Xia xu Qi-Ying Zhou He Wang Xiao-Cheng Pan Department of Pediatrics Hangzhou Ninth People’s HospitalHangzhou 311225Zhejiang ProvinceChina Department of Nursing Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Pediatric Intensive Care Unit Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Out-patient infection Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Traditional Chinese Medicine Ward Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Gender consciousness directly affects the development of gender identity,which is a continuous and lifelong ***,hospitalization is a part of many children's lives and has an impact on their gender *** To investigate the current situation of gender identity in lower primary school children by conducting a survey of 202 hospitalized children in the lower grades and to provide a theoretical basis and foundation for the cultivation of gender identity and medical treatment of children based on the *** study aims to inspire clinical medical staff to scientifically and reasonably arrange hospital wards for lower primary school children and pay attention to gender protection during the medical treatment process and to help children shape a unified and clear gender identity,which will enable them to better integrate into society and promote their personality *** The gender consciousness scale for elementary and middle school students was RESULTS Gender identity was already present in lower primary school *** children's gender roles and gender equality consciousness were strong,exceeding the critical value,but their gender characteristics,gender identity,and gender ideal consciousness were *** aged 6 had the weakest gender identity,and girls had significantly stronger gender identity than *** Gender identity is already present in lower primary school children,providing a basis and inspiration for the cultivation of gender identity and medical treatment of lower primary school *** medical staff should be aware of and understand these results and should scientifically and reasonably arrange hospital wards for lower primary school children.

关键词： School-age children Gender consciousness Gender identity Hospitalization Gender weakening

Chain Dynamics Heterogeneity in Plasticized Poly(vinyl butyral)(PVB) as Elucidated by Solid-State NMR

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Chinese Journal of Polymer Science 2024年第1期42卷 113-124,I0010页

作者： jing Lv xu Chen Zi-Shuo Wu Ya-Hui Li Wei Chen National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Scienceand Technology of ChinaHefei 230026China

The chain dynamics heterogeneity of the poly(vinyl butyral)(PVB) plasticized by triethylene glycol bis(2-ethylhexa noate)(TEG-EH) was investigated by various solid-state NMR *** plasticized PVB shows two domains in distinct molecular dynamics differences,namely,rigid and soft domains,where the latter is the plasticizer-rich *** time domain low field NMR was first used to investigate the dynamics heterogeneity of the plasticized PVB,and the results show the decreasing activated energy of components in the soft domain of plasticized PVB(E_a=20.2 kJ/mol) as compared with that of the pristine one(E_a=24.3 kJ/mol).Detailed dynamics heterogeneity was obtained by high-field NMR with site-specific *** quadrupole-echo ~2H-NMR was adopted to elucidate the dynamics heterogeneity of the vinyl alcohol(VA) units,where only the hydroxyl group of VA is *** ~1H-^(13)C WISE NMR spectra show that there is not much difference in the mobility of the VB unit in PVB with and without plasticizer,whereas the glass transition temperature differed by approximately 53℃.This is further supported by Torchia's T_1 relaxation *** origin of such an unusual phenomenon is attributed to the critical role of the remaining VA(~22%) in the soft domain,where the VA units locally aggregate through hydrogen ***,the existence of a mobility gradient in the VB unit has been ***,the mobility difference for VB with different stereo-geometry(meso or racemic conformation) is observed for the first *** indicates the importance of modulating the ratio of meso over racemic VB for controlling the macroscopic perfo rmance of PVB.

关键词： Poly(vinyl butyral) Dynamics heterogeneity Plasticizer Solid state NMR

Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： hong-Xiao Wu Xiao-Yan Ding Ya-Wen xu Ming-Hua Yu Xiao-Mi Li Na Deng jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

Resolving the geometric structure of trastuzumab by mobility capillary electrophoresis and native mass spectrometry

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Chinese Chemical Letters 2024年第3期35卷 221-225页

作者： Wenjing Zhang Jie hong Lei Yang Zuqiang xu Yu Xiang Wei xu School of Life Science Beijing Institute of TechnologyBeijing 100081China

Available online Immunoglobulins G(IgGs)are Y-shaped globular proteins,however,their high flexibility and heterogeneity pose great challenges to their structure and conformation *** structure of IgG closely correlates to its biofunctions,such as the antibody escape of human immunodeficiency virus(HIV)could attribute to the distance mismatch between the ends of two Fab arms(antigen-binding sites)and envelope glycoprotein spikes on virion ***,we report the first use of mobility capillary electrophoresis(MCE)and native mass spectrometry(nMS)to resolve the internal geometric structure and conformation of an IgG(trastuzumab)in solution *** proteolysis,the ellipsoid dimensions of IgG and its subunits were measured by MCE-nMS *** was then reconstructed,in which the sizes and relative positions of these three subunits in three-dimensional space were *** was found that the two Fab arms have an angle of~102.1°and a distance of~11.0 nm between the two antigen-binding sites under native condition,and the Fc arm was tilted~16.0°towards one of the Fab *** was not on the plane of Fab-Fab,but has an angle of no larger than 103.1°.Under acidic environment(pH 3.0),each subunit of the IgG would unfold into larger dimensions,and the angles between these subunits also *** great potential for tumor imaging and therapy,the structure of F(ab')_(2)fragments was also measured and validated by molecular dynamic *** was found that the electrostatic force among these three subunits and steric hindrance stemming from Fc help maintaining the angle between two Fab arms.

关键词： Native mass spectrometry Mobility capillary electrophoresis Trastuzumab Protein structure Geometric structure

0^(--) hidden-heavy tetraquark states via QCD sum rules

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Chinese Physics C 2024年第9期48卷 50-59页

作者： Bing-Dong Wan hong-Tai xu Department of Physics Liaoning Normal UniversityDalian 116029China Center for Theoretical and Experimental High Energy Physics Liaoning Normal UniversityDalian 116029China

In this study,we evaluated the mass spectra of the prospective 0^(--) hidden-charm and hidden-bottom tetraquark states in molecular configuration via QCD sum *** our calculation,the nonperturbative condensate contributions are considered up to dimension eight in operator product *** is found that there could exist 4possible 0^(--) hidden-charm tetraquark states with masses(4.68±0.07),(4.22±0.09),(4.53±0.09),and(4.26±0.13) *** corresponding hidden-bottom partners are found lying at(11.04±0.10),(10.71±0.12),(11.09±0.10),and(11.82±0.14) GeV,*** possible tetraquark decay modes were analyzed,which are expected to be measured in BESⅢ,BELLEⅡ,and LHCb experiments.

关键词： exotic hadronic states QCD sum rules tetraquarks