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Characterization of functional transposable element enhancers in acute myeloid leukemia

Science China(Life Sciences) 2020年第5期63卷 675-687页

作者： Yingying Zeng Yaqiang Cao Rivka Sukenik Halevy Picard Nguyen Denghui Liu Xiaoli Zhang Nadav Ahituv jing-dong jhan CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthChinese Academy of Sciences Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center for Genetics and Developmental BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Department of Bioengineering and Therapeutic Sciences University of California San FranciscoSan Francisco 94158USA Institute for Human Genetics University of California San FranciscoSan Francisco 94143USA Sackler School of Medicine Tel-Aviv UniversityTel Aviv 6997801Israel Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative BiologyPeking UniversityBeijing 100871China

Transposable elements(TEs)have been shown to have important gene regulatory functions and their alteration could lead to disease *** myeloid leukemia(AML)develops as a consequence of a series of genetic changes in hematopoietic precursor cells,including mutations in epigenetic ***,we set out to study the gene regulatory role of TEs in *** first explored the epigenetic landscape of TEs in AML patients using ATAC-seq *** show that a large number of TEs in general,and more specifically mammalian-wide interspersed repeats(MIRs),are more enriched in AML cells than in normal blood *** obtained a similar finding when analyzing histone modification data in AML *** Ontology enrichment analysis showed that genes near MIRs in open chromatin regions are involved in *** functionally validate their regulatory role,we selected 19 MIR regions in AML cells,and tested them for enhancer activity in an AML cell line(Kasumi-1)and a chronic myeloid leukemia(CML)cell line(K562);the results revealed several MIRs to be functional *** together,our results suggest that TEs are potentially involved in myeloid leukemogenesis and highlight these sequences as potential candidates harboring AML-associated variation.

关键词： transposable element enhancer promoter MIR acute myeloid leukemia

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ETV6-RUNX1阳性儿童急性淋巴细胞白血病基因表达谱聚类的临床特征

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中华血液学杂志 2020年第5期41卷 405-411页

作者：郑雪岭王子阳孙嫣然张寒高超张瑞东刘怡彭亚光 jing-dong jhan 郑胡镛国家儿童医学中心首都医科大学附属北京儿童医院血液肿瘤中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室北京100045 北京大学前沿交叉学科研究院北大-清华生命科学联合中心定量生物学中心北京100871 国家儿童医学中心首都医科大学附属北京儿童医院儿科重大疾病研究教育部重点实验室临床流行病与循证医学中心北京100045 中国医学科学院医学生物学研究所昆明650118

目的通过基因表达谱研究儿童ETV6-RUNX1阳性急性淋巴细胞白血病(ALL)异质性,探索不同聚类分组临床特征,为临床个性化诊疗及利用测序技术探索预后相对不良组预测模型提供可行性参考。方法应用改进的基因片段分析技术对2016年8月至2019年... 详细信息

目的通过基因表达谱研究儿童ETV6-RUNX1阳性急性淋巴细胞白血病(ALL)异质性,探索不同聚类分组临床特征,为临床个性化诊疗及利用测序技术探索预后相对不良组预测模型提供可行性参考。方法应用改进的基因片段分析技术对2016年8月至2019年6月北京儿童医院收治的264例初诊ALL患儿的骨髓标本进行57个分型基因检测和聚类分析,重点分析56例ETV6-RUNX1阳性患者的基因表达谱与临床特点、免疫表型和早期化疗反应的关系。结果基因分型聚类显示ETV6-RUNX1阳性ALL被分为两组:E/R-1组(45例,80.4%)和E/R-2组(11例,19.6%)。E/R-2聚类离散度大于E/R-1,spearman相关系数分别为0.788、0.901;E/R-2、E/R-1组初诊PLT中位数分别为104(27~644)×10^9/L、50(8~390)×10^9/L(P<0.01),初诊骨髓原始幼稚细胞比例分别为0.830(0.270~0.975)、0.935(0.445~0.990)(P<0.05);CD22^+CD34^+CD20^CD117^-CD56^-免疫组合在E/R-2组占比更高(P<0.001);E/R-2和E/R-1组化疗第33天流式细胞术检测的微小残留病(MRD)转阴例数分别为5例(55.6%)和32例(88.9%)(P=0.064),去除临界值病例敏感性分析转阴例数分别为5例(55.6%)和32例(91.4%)(P=0.035);第33天PCR检测的MRD转阴例数分别为7例(77.8%)和36例(100.0%)(P=0.047)。结论ETV6-RUNX1阳性ALL患儿在基因表达谱层面存在异质性,符合E/R-2表达特征的患儿可能初诊时血小板减少倾向小但早期化疗反应相对不良。

关键词：儿童白血病,淋巴细胞,急性基因表达谱异质性

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Genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination

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生物物理学报 2009年第S1期25卷 28-28页

作者： Teng Fei Kai Xia Zhang Chen Hua Chen Zhongwei Li Jianping Zhang Bing Zhou Huasheng Xiao jing-dong jhan Ye-Guang Chen The State Key Laboratory of Biomembrane and Membrane Biotechnology Department of Biological Sciences and BiotechnologyTsinghua UniversityBeijing 100084China CAS Key Laboratory of Molecular Developmental Biology and Center for Molecular Systems Biology Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China National Engineering Center for Biochip at Shanghai Zhangjiang Hi-Tech ParkShanghai201203China

Embryonic stem (ES) cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling cascades.

关键词： Genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination BMP

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Biomarkers of aging

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Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying jing Dingfeng Li Jiaming Li jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao jing-dong jhan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao jing Nie Yaojin Peng jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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The Drought of Amazonia in 2023-2024

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American Journal of Climate Change 2024年第3期13卷 567-597页

作者： Jose A. Marengo Ana P. Cunha jhan-Carlo Espinoza Rong Fu Jochen Schöngart Juan C. Jimenez Mabel C. Costa Joao M. Ribeiro Sly Wongchuig Siyu Zhao National Center for Monitoring and Early Warning of Natural Disasters/CEMADEN So Jos dos Campos Brazil UNESP/CEMADEN So Jos dos Campos Brazil Graduate School of International Studies Korea University Seoul South Korea Institut des Gosciences de lEnvironnement (IGE) Institut de Recherche pour le Dvelopement (IRD) Saint Martin dHeres France Instituto de Investigacin sobre la Enseanza de las Matemticas (IREM PUCP) Pontificia Universidad Catlica del Per Lima Peru Department of Atmospheric and Oceanic Sciences University of California Los Angeles Los Angeles CA USA Departament of Environmental Dynamics Instituto Nacional de Pesquisas da Amaznia (INPA) Manaus Brazil Global Change Unit (GCU) of the Image Processing Laboratory (IPL) Universitat de Valncia Estudi General (UVEG) Paterna Spain Laboratoire dEtudes en Gophysique et Ocanographie Spatiales (LEGOS) Universit de Toulouse CNES/CNRS/IRD/UT3 Toulouse France

The Amazon basin has experienced an extreme drought that started in the austral summer of 2022-23 and extends into 2024. This drought started earlier than other previous droughts. Although some rain fell during the austral summer, totals remained below average. Higher temperatures during austral winter and spring 2023, which affected most of Central South America, then aggravated drought conditions. This coincided with an intense El Niño and abnormally warm tropical North Atlantic Ocean temperatures since mid-2023. Decreased rainfall across the Amazon basin, negative anomalies in evapotranspiration (derived from latent heat) and soil moisture indicators, as well as increased temperatures during the dry-to-wet transition season, September-October-November (SON) 2023, combined to delay the onset of the wet season in the hydrological year 2023-24 by nearly two months and caused it to be uncharacteristically weak. SON 2023 registered a precipitation deficit of the order of 50 to 100 mm/month, and temperatures +3˚C higher than usual in Amazonia, leading to reduced evapotranspiration and soil moisture indicators. These processes, in turn, determined an exceptionally late onset and a lengthening of the dry season, affecting the 2023-2024 hydrological year. These changes were aggravated by a heat wave from June to December 2023. Drought-heat compound events and their consequences are the most critical natural threats to society. River levels reached record lows, or dried up completely, affecting Amazonian ecosystems. Increased risk of wildfires is another concern exacerbated by these conditions.

关键词： El Niño SST in the Tropical Atlantic Amazon Drought River Levels Heatwave Dry Season Length

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钨钼合金的电子结构和光学性质的研究

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成都信息工程大学学报 2024年第1期39卷 108-112页

作者：李叶古沈艳红虞游邓江韩玉娇杨运洲成都信息工程大学光电工程学院四川成都610225

采用基于密度泛函理论的第一性原理研究钨金属及其掺杂合金W0.75Mo0.25和W0.5Mo0.5的电子结构和光学性能。电子结构的计算结果显示:随着纯W中掺入Mo的比例不断增加,其合金的整体费米能级上升,导带宽度变窄,热导率上升。光学性质的计算... 详细信息

采用基于密度泛函理论的第一性原理研究钨金属及其掺杂合金W0.75Mo0.25和W0.5Mo0.5的电子结构和光学性能。电子结构的计算结果显示:随着纯W中掺入Mo的比例不断增加,其合金的整体费米能级上升,导带宽度变窄,热导率上升。光学性质的计算结果表明:随着Mo掺入比例的增加,其合金的介电常数先增大后减小,吸收范围减小,吸收强度降低,能量损失峰值减小,且曲线总体向低能方向移动。

关键词： W-Mo合金能带态密度光学性质密度泛函理论

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想一分钟 2

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2005年

作者： jhan Iris Tiafau Hurst

本书搜集了较为经典的外语益智类的文章、演讲，可供各类人员阅读。配光盘。

ISBN: (纸本)7888501214

本书搜集了较为经典的外语益智类的文章、演讲，可供各类人员阅读。配光盘。

关键词：成功心理学 cheng gong xin li xue 英语汉语对照读物

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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A Prediction Method for In-Plane Permeability and Manufacturing Applications in the VARTM Process

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Engineering（科研） 2011年第7期3卷 691-699页

作者： Ya-Jung Lee Yu-Ti jhan Cheng-Hsien Chung Yao Hsu Engineering Science and Ocean Engineering National Taiwan University Taipei

VARTM (Vacuum Assisted Resin Transfer Molding) is a popular method for manufacturing large-scaled, single-sided mold composite structures, such as wind turbine blades and yachts. Simulation to find the proper infusion scenario before manufacturing is essential to avoid dry spots as well as incomplete saturation and various fiber weaves with different permeability affect numerical simulation tremendously. This study focused on deriving the in-plane permeability prediction method for FRP (Fiber Reinforced Plastics) laminates in the VARTM process by experimental measurements and numerical analysis. The method provided an efficient way to determine the permeability of laminates without conducting lots of experiments in the future. In-plane permeability imported into the software, RTM-Worx, to simulate resin flowing pattern before the infusion experiments of a 3D ship hull with two different infusion scenarios. The close agreement between experiments and simulations proved the correctness and applicability of the prediction method for the in-plane permeability.

关键词： Prediction Method In-Plane Permeability Manufacturing Simulation Infusion Scenarios

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成功始于毫末

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发现 2009年第3期 62-63页

作者： jhan Iris Tiafau Hurst

生活的惊奇记得欧洲伟大的探险家克里斯托弗·哥伦布吗?他计划航海横穿大西洋去发现亚洲,但是计划失败了。尽管他没找到亚洲,最终却发现了新大陆,就是现在的美洲。后面的故事你已经知道了。奇妙的是,人生的惊奇很多时候结局都很不错,有... 详细信息

生活的惊奇记得欧洲伟大的探险家克里斯托弗·哥伦布吗?他计划航海横穿大西洋去发现亚洲,但是计划失败了。尽管他没找到亚洲,最终却发现了新大陆,就是现在的美洲。后面的故事你已经知道了。奇妙的是,人生的惊奇很多时候结局都很不错,有时还能好得超过原来的预期。

关键词：本尼斯拉托亨利梦想成真罪犯犯罪现场

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潜盾隧道穿越台、高铁下方挡土壁之案例探讨

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隧道建设 2007年第S2期27卷 354-360页

作者：张武训詹荣锋程道信台北市政府捷运工程局南区工程处台北市政府捷运工程局南区工程处工务所

台北捷运新庄线于松江南京站与忠孝新生站之间,其潜盾隧道工程必须自营运中的台铁与即将营运高铁隧道结构下方通过,且需穿越既有地铁结构下方之六道挡土壁体,包括不规则之连续壁体及非连续性之基桩群等。本项工程由于基地外部环境条件... 详细信息

台北捷运新庄线于松江南京站与忠孝新生站之间,其潜盾隧道工程必须自营运中的台铁与即将营运高铁隧道结构下方通过,且需穿越既有地铁结构下方之六道挡土壁体,包括不规则之连续壁体及非连续性之基桩群等。本项工程由于基地外部环境条件诸多限制,捷运隧道线形与穿越之壁体及基桩群又非正交,壁体无法维持一般完整性与连续性之需求,造成穿越过程中莫大之困扰与风险。本施工案例采取之工法系由潜盾机盾首进行挡土壁体前后之水平灌浆地盘改良,并配合出舱挖掘作业以玻璃纤维喷凝土工法及点井工法搭配使用,以确保挡土壁体敲除作业之安全,敲除过程藉由仅约85cm×55cm之进出通道,进入潜盾机前方狭隘的工作区间内,以人工敲除方式排除障碍。特就穿越前述地下障碍所实行对策与施工方法,以及穿越过程所面临困难、危险状况之发生、因应与克服,做深入之案例探讨。

关键词：地下挡土壁水平灌浆玻璃纤维喷凝土点井

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