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Effects of Altered Intra-abdominal Pressure on the Upper Airway Collapsibility in a Porcine Model

Chinese Medical Journal 2015年第23期128卷 3204-3210页

作者： Shu-Lin Ren Yan-Ru Li Ji-Xiang Wu jing-ying ye Rachel Jen Department of General Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Head and Neck Surgery Beijing Tsinghua Changgung Hospital Tsinghua University Beijing 102218 China Department of Medicine Respiratory Division University of British Columbia Vancouver BC Canada

Background： Obstructive sleep apnea is strongly associated with obesity, particularly abdominal obesity common in centrally obese males. Previous studies have demonstrated that intra-abdominal pressure （IAP） is increased in morbid obesity, and tracheal traction forces may influence pharyngeal airway collapsibility. This study aimed to investigate that whether IAP plays a role in the mechanism of upper airway （UA） collapsibility via IAP-related caudal tracheal traction. Methods： An abdominal wall lifting （AWL） system and graded CO2 pneumoperitoneum pressure was applied to four supine, anesthetized Guizhou miniature pigs and its effects on tracheal displacement （TD） and airflow dynamics of UA were studied. Individual run data in 3 min obtained before and after AWL and obtained before and after graded pneumoperitoneum pressure were analyzed. Differences between baseline and AWL/graded pneumoperitoneum pressure data of each pig were examined using a Student＇s t-test or analysis of variance. Results： Application of AWL resulted in decreased IAP and significant caudal TD. The average displacement amplitude was 0.44 mm （P 〈 0.001 ）. There were three subjects showed increased tidal volume （TV）（P 〈 0.01 ） and peak inspiratory airflow （P 〈 0.01 ）; however, the change of flow limitation inspiratory UA resistance （Rua） was not significant. Experimental increased lAP by pneumoperitoneum resulted in significant cranial TD. The average displacement amplitude was 1.07 mm （P 〈 0.001） when lAP was 25 cmH2O compared to baseline. There were three subjects showed reduced Rua while the TV increased （P 〈 0.01 ）. There was one subject had decreased TV and elevated Rua （P 〈 0.001）. Conclusions： Decreased IAP significantly increased caudal TD, and elevated lAP significantly increased cranial TD. However, the mechanism of UA collapsibility appears primarily mediated by changes in lung volume rather than tracheal traction effect. TV plays an independent role in the mechanism of UA collapsibil

关键词： Abdominal Obesity Intra-abdominal Pressure Lung Volume Obstructive Sleep Apnea Trachea Traction

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Esophageal Functional Changes in Obstructive Sleep Apnea/Hypopnea Syndrome and Their Impact on Laryngopharyngeal Reflux Disease

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Chinese Medical Journal 2015年第16期128卷 2162-2167页

作者： Yue Qu jing-ying ye De-Min Han Li Zheng Xin Cao Yu-Huan Zhang Xiu Ding Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Otolaryngology Head and Neck Surgery Beijing Tsinghua Changgung Hospital Tsinghua University Beijing 102218 China Department of Otolaryngology Head and Neck Surgery Beijing Children's Hospital Capital Medical University Beijing 100045 China

Background：Obstructive sleep apnea/hypopnea syndrome （OSAHS） and laryngopharyngeal reflux （LPR） disease have a high comorbidity rate,but the potential causal relation between the two diseases remains *** objectives were to investigate the esophageal functional changes in OSAHS patients and determine whether OSAHS affects LPR by affecting esophageal ***：Thirty-six OSAHS patients and 10 healthy controls underwent 24-h double-probed combined esophageal multichannel intraluminal impedance and pH monitoring simultaneously with ***-resolution impedance manometry was applied to obtain a detailed evaluation of pharyngeal and esophageal ***：There were 13 OSAHS patients （36.1%） without LPR （OSAHS group） and 23 （63.9%） with both OSAHS and LPR （OSAHS and LPR group）.Significant differences were found in the onset velocity of liquid swallows （OVL,P =0.029） and the percent relaxation of the lower esophageal sphincter （LES） during viscous swallows （P =0.049） between the OSAHS and control *** percent relaxation of LES during viscous swallows was found to be negatively correlated with upright distal acid percent time （P =0.016,R =-0.507）,and OVL was found to be negatively correlated with recumbent distal acid percent time （P =0.006,R =-0.557） in the OSAHS and LPR ***：OSAHS patients experience esophageal functional changes,and linear correlations were found between the changed esophageal functional parameters and reflux indicators,which might be the reason that LPR showed a high comorbidity with OSAHS and why the severity of the two diseases is correlated.

关键词： Esophageal Function Laryngopharyngeal Reflux Disease Obstructive Sleep Apnea/Hypopnea Syndrome

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基于小波变换的行波测距法在铁路信号电源系统中的应用研究

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铁道学报 2005年第1期27卷 70-74页

作者：和敬涵季英业毛志芳周文北京交通大学电气工程学院北京100044

针对铁路10kV信号电源供电系统的特点,提出了一种基于小波变换的外加电压脉冲式行波测距法,就一些关键技术问题,提出了波速度折算算法和等效波速度法,分析了系统单相分支线路的影响,以及波速度确定等问题。文中以一条实际的铁路10kV信... 详细信息

针对铁路10kV信号电源供电系统的特点,提出了一种基于小波变换的外加电压脉冲式行波测距法,就一些关键技术问题,提出了波速度折算算法和等效波速度法,分析了系统单相分支线路的影响,以及波速度确定等问题。文中以一条实际的铁路10kV信号电源供电系统为模型进行了仿真,仿真结果证明了所提方法的可行性。

关键词：电压脉冲行波测距小波变换波速度折算等效波速度

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甘肃一年生、二年生红芪和黄芪HPLC-ELSD指纹图谱比较

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中国实验方剂学杂志 2018年第6期24卷 71-76页

作者：许京叶迎王瑞海苗青刘丽梅中国中医科学院中医基础理论研究所

目的：建立甘肃一年生、二年生红芪和黄芪指纹图谱,对比研究红芪和黄芪指纹图谱相似度。方法：采用HPLCELSD,选用Agilent ZROBAX-SBC18色谱柱（4.6 mm×250 mm,5μm）,以水（A）-乙腈（B）为流动相,梯度洗脱,柱温35℃,进样体积15μL,All... 详细信息

目的：建立甘肃一年生、二年生红芪和黄芪指纹图谱,对比研究红芪和黄芪指纹图谱相似度。方法：采用HPLCELSD,选用Agilent ZROBAX-SBC18色谱柱（4.6 mm×250 mm,5μm）,以水（A）-乙腈（B）为流动相,梯度洗脱,柱温35℃,进样体积15μL,Alltech ELSD 2000蒸发光检测器,漂移管温度110℃,载气流速3.0 L·min-1,分别建立一年生和二年生红芪各24批以及一年生和二年生黄芪各24批药材指纹图谱。结果：一年生、二年生红芪药材共有峰分别为8,7个,相似度分别为0.923,0.825,相同色谱峰6个,分别为毛蕊异黄酮苷,芒柄花苷,大豆皂苷Ⅰ,芒柄花素,异黄芪皂苷Ⅱ,黄芪皂苷Ⅰ;一年生、二年生黄芪药材共有峰分别为25,17个,相似度分别为0.980,0.997,相同色谱峰7个,分别为毛蕊异黄酮苷,芒柄花苷,毛蕊异黄酮,黄芪甲苷,黄芪皂苷Ⅲ,异黄芪皂苷Ⅱ,黄芪皂苷Ⅰ;一年生红芪与黄芪相似度为0.032,二年生红芪与黄芪相似度为0.023,共有色谱峰均为4个,分别为毛蕊异黄酮苷,芒柄花苷,异黄芪皂苷Ⅱ,黄芪皂苷Ⅰ。结论：在所确定的色谱条件下,一年生和二年生红芪和黄芪药材指纹图谱差异明显,可有效区分两种药材,二者共有成分少,相似度低,故红芪和黄芪不宜替代使用。

关键词：红芪黄芪指纹图谱高效液相色谱-蒸发光散射法

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing Xue Yuejia Ma Ke ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Screening Effect in Isotropic Gaussian Processes

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Acta Mathematica Sinica,English Series 2020年第5期36卷 512-534页

作者： jing Yu BAO Fei ye ying YANG Department of Mathematical Sciences Tsinghua UniversityBeijing 100062.P.R.China School of Statistics Capital University of Economics and BusinessBeijing 100026P.R.China

The screening effect is the phenomenon that optimal linear prediction of a spatial process on an unobserved location mostly depends on nearby *** is,the optimal predictor based on just nearby observations yields a good approximation of which based on the whole large ***,the approximation does not always perform well since the screening effect may not hold in all *** determine when the screening effect holds is an important issue in spatial *** paper provides some sufficient conditions for ensuring an asymptotic screening effect in Rd based on the spectral density of the underlying isotropic Gaussian process and the geometries of nearby *** results apply to isotropic processes with an arbitrary degree of *** we are predicting at origin,the conditions are(1)the spectral density is nearly a constant in balls of finite radius far from the origin,(2)the positions of nearby observations do not fall on a curve with non-zero intercept whose degree is less or equal to the order of mean square differentiability of the *** conditions are easy to verify in *** rates of the asymptotic screening effect are also *** rates depend on the rate of decrease of the spectral *** studies on the screening effect for finite samples are also provided.

关键词： Spatial statistics spectral analysis kriging screening effect

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Fault tolerance on-chip: a reliable computing paradigm using self-test, self-diagnosis, and self-repair (3S) approach

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Science China(Information Sciences) 2018年第11期61卷 31-47页

作者： Xiaowei LI Guihai YAN jing ye ying WANG State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of Sciences University of Chinese Academy of Sciences

If your computer crashes, you can revive it by a reboot, an empirical solution that usually turns out to be effective. The rationale behind this solution is that transient faults, either in hardware or software,can be fixed by refreshing the machine state. Such a "silver bullet", however, could be futile in the future because the faults, especially those existing in the hardware such as Integrated Circuit(IC) chips, cannot be eliminated by refreshing. What we need is a more sophisticated mechanism to steer the system back to the right track. The "magic cure" is the Fault Tolerance On-Chip(FTOC) mechanism, which relies on a suite of built-in design-for-reliability logic, including fault detection, fault diagnosis, and error recovery, working in a self-supportive manner. We have exploited the FTOC to build a holistic solution ranging from on-chip fault detection to error recovery mechanisms to address faults caused by chips progressively aging. Besides fault detection, the FTOC paradigm provides attractive benefits, such as facilitating graceful performance degradation, mitigating the impact of verification blind spots, and improving the chip yield.

关键词： fault tolerance on-chip self-test self-diagnosis self-repair

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting ye Yan Sun jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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基于信息平台的延续性干预在糖尿病社区管理中的应用

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广东医科大学学报 2017年第2期35卷 189-191页

作者：孙红吴静曾茹英叶青松邓彩金王家婧广东医科大学附属中山陈星海医院广东中山528415

目的探讨基于信息平台的延续性干预在糖尿病社区管理中的应用效果。方法 62例糖尿病出院患者随机分为观察组和对照组,分别给予基于信息平台的延续干预、常规出院指导,12个月后比较两组患者对糖尿病知识的掌握水平、自我管理水平、饮食... 详细信息

目的探讨基于信息平台的延续性干预在糖尿病社区管理中的应用效果。方法 62例糖尿病出院患者随机分为观察组和对照组,分别给予基于信息平台的延续干预、常规出院指导,12个月后比较两组患者对糖尿病知识的掌握水平、自我管理水平、饮食控制、运动锻炼、血糖达标率、并发症等指标。结果观察组中糖尿病自我管理测评分与运动锻炼、空腹血糖、餐后2 h血糖和糖化血红蛋白达标率均高于对照组(P<0.05)。结论利用信息平台实施延续干预可明显提高糖尿病出院患者的自我管理能力,改善临床症状,提高生活质量。

关键词：信息平台糖尿病护理干预

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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