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Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus

World Journal of Diabetes 2022年第10期13卷 861-876页

作者： Yun-yi Liang Ling-Yu Liu Yan Jia yi Li Jie-Na Cai yi Shu jing-yi tan Pei-yi Chen Hong-Wei Li Hui-Hua Cai Xiang-Sheng Cai Health Management Center The Sixth Affiliated HospitalSchool of MedicineSouth China University of TechnologyFoshan 528000Guangdong ProvinceChina The First Affiliated Hospital Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Shenzhen Hospital University of Chinese Academy of SciencesShenzhen 518001Guangdong ProvinceChina Clinical Laboratory Puning People’s HospitalPuning 515300Guangdong ProvinceChina Institute of Biotherapy Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Obstetrics and Gynecology Guangdong Provincial People's HospitalGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)places both the mother and offspring at high risk of *** evidence suggests that the gut microbiota plays a role in the pathogenesis of ***,it is still unclear whether the gut microbiota is related to blood biochemical traits,particularly glucagon-like peptide-1(GLP-1),in GDM *** To explore the correlation between the gut microbiota and blood biochemical traits,particularly GLP-1,in GDM *** The V4 region of the 16S ribosomal ribonucleic acid(rRNA)gene was sequenced based on the fecal samples of 35 pregnant women with GDM and was compared to that of 25 pregnant women with normal glucose tolerance(NGT).RESULTS The results showed that Ruminococcaceae_UCG-002,Ruminococcaceae_UCG-005,Clostridium_sensu_stricto_1,and Streptococcus were more abundant in the NGT group than in the GDM *** and Lachnoclostridium were more abundant in the GDM group than in the NGT ***’s correlation analysis was performed to identify the relationships between microbiota genera and blood biochemical ***,Roseburia,Faecalibacterium,and Ruminococcaceae_UCG-002 were significantly negatively correlated with ***_UCG-002 was significantly negatively correlated with hemoglobin *** was significantly positively correlated with ***,Oscillibacter,and Bifidobacterium were significantly positively correlated with GLP-1.A random forest model showed that 20 specific genera plus glucose provided the best discriminatory power,as indicated by the area under the receiver operating characteristic curve(0.94).CONCLUSION The results of this study reveal novel relationships between the gut microbiome,blood biochemical traits,particularly GLP-1,and GDM *** findings suggest that some genera are crucial for controlling blood glucose-related indices and may be beneficial for GDM *** in the microbial composition of the

关键词： Gut microbiome Glucagon-like peptide-1 Gestational diabetes mellitus Glucose

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Myricetin protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 255-259页

作者： jing-yi tan Xue-Qin Chen Bi-Jun Kang Zi-Xi Qin Jia-Hong Chen Ren-Dong Hu Liang-Cai Wu Pharmacology Department of Basic Medical Sciences School of Medicine Jinan University The 6th Affiliated Hospital.Sun Yat-sen University

Objective: To explore the therapeutic effect and mechanism of myricctin on disseminated intravascular coagulation(DIC). Methods: The DIC model was established by injection of60 mg/kg LPS in KM mice, and the treatment groups were injected myricetin with different concentrations(25 or 50 mg/kg) 30 min before the model was established. Both coagulation indicators and organ function were tested, including PT, APTT, fibrinogen. AST, ALT. BUN and tissue section. In vitro, the inflammatory model of RAW 264.7 macrophage cells were established by 10 μg/mL LPS. The treatment group was treated with 50 μmol/mL myricetin for 30 min before LPS, and the expression of TNF-a and p-NF-KB was detected, further to explore the therapeutic mechanism. Results: LPS-induced DIC led to a reduction of fibrinogen and a rise of PT, APTT,AST, ALT, BUN levels, but the treatment of myricctin significantly inhibited these abnormalities. Histopathology analysis also revealed that myricetin remarkably protected the liver and renal damage. In vitro, the expression of TNF-α and p-NF-κB induced by LPS was repressed by myricetin. Conclusions: This study provides new insights into the protective effects of myricetin in LPS-induced DIC by anticoagulant and anti-inflammatory via suppressing the activation of p-NF-κB which decreased TNF-α level.

关键词： Myricetin Lipopolysaccharide Disseminated intravascular coagulation Anti-inflammatory Macrophages

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Effect of 15-Deoxy-A^12,14-prostaglandin J2 Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model

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Chinese Medical Journal 2017年第3期130卷 347-356页

作者： Qi tang Li-Li Chen Fen Wei Wei-Lian Sun Li-Hong Lei Pei-Hui Ding jing-yi tan Xiao-Tao Chen Yan-Min Wu Department of Oral Medicine The Second Affiliated Hospital of School of Medicine of Zhejiang University Hangzhou Zhejiang 310009 China

Background： 15-Deoxy-^△^12、14-prostaglandin J2 （15d-PGJ2）, one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-1oaded poly（D,L-lactide-co-glycolide） nanocapsules （15d-PGJ2-NC） on inflammatory responses and bone regeneration in local bone defect. Methods： The study was conducted on 96 Wistar rats from June 2014 to March 2016. Saline, unloaded nanoparticles, free 15d-PGJ2 or 15d-PGJ2-NC, were delivered through a collagen vehicle inside surgically created transcortical defects in rat femurs, lnterleukin-6 （IL-6）, interleukin-1 beta （IL-I~）, and tumor necrosis factor-alpha （TNF-o0 levels in the surrounding soft tissue were analyzed by Western blot and in the defect by quantitative real-time polymerase chain reaction over 14 days. Simultaneously, bone morphogenetic protein-6 （BMP-6） and platelet-derived growth factor-B （PDGF-B） messenger RNA （mRNA） in the defect were examined. New bone formation and EphrinB2 and osteoprotegerin （OPG） protein expression in the cortical defect were observed by Masson＇s Trichrome staining and immunohistochemistry over 28 days. Data were analyzed by one-way analysis of variance. Least-significant difference and Dunnett＇s T3 methods were used with a bilateral P 〈 0.05. Results： Application of 15d-PGJfNC （100μg/ml） in the local bone defect significantly decreased 1L-6, IL-Iβ, and TNF-α mRNA and protein, compared with saline-treated controls （P 〈 0.05）. 15d-PGJfNC upregulated BMP-6 and PDGF-B mRNA （P 〈 0.05）. New bone formation was observed in the cortical defect in 15d-PGJ2-NC-treated animals from 7th day onward （P 〈 0.001）. Expression of EphrinB2 and OPG presented early on day 3 and persisted through day 28 in 15d-PGJfNC group （P 〈 0.05）. Conclusion： Stable 15d-PGJz-NC complexes were prepared that could attenuate IL-6, IL-1 β, and TNF-α expression, while increasing new bone formation and growth f

关键词： 15-Deoxy-Am4-prostaglandin J, lnterleukin-I Beta Interleukin-6 Nanocapsules Osteogenesis

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Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu yifei Yang yike jing Zhen Zeng Xuesong yi Wei Sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

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苏州市大气细颗粒物(PM_(2.5))工业源排放清单

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环境科学学报 2017年第2期37卷 453-459页

作者：刘松华周静谭译徐波张建荣武瑾苏州市环境科学研究所苏州215000 苏州市苏城环境科技有限责任公司苏州215000

通过发放调查表、现场咨询等形式,获得苏州市2012年工业企业基本信息,参照国内外已有研究成果,确定排放因子,并根据实际情况对钢铁行业进行了系数修订,得到苏州市工业源大气细颗粒物排放清单.结果表明:苏州地区工业源PM_(2.5)排放总量约... 详细信息

通过发放调查表、现场咨询等形式,获得苏州市2012年工业企业基本信息,参照国内外已有研究成果,确定排放因子,并根据实际情况对钢铁行业进行了系数修订,得到苏州市工业源大气细颗粒物排放清单.结果表明:苏州地区工业源PM_(2.5)排放总量约为6.57×10~4t,工艺过程源和固定燃烧源分别占94%和6%;张家港地区贡献率最大,为51%,其次为常熟13.8%;姑苏区贡献率最小,为0.13%;苏州市平均排放强度为10.42 t·km^(-2),张家港排放强度最大,达到了43.57 t·km^(-2),其次为新区12.38 t·km^(-2);钢铁与炼焦、火电、水泥行业是PM_(2.5)的主要贡献者,分别为50%、17%和14%;空间分布显示苏州北部相对细颗粒污染较大,重点企业多集中在张家港、常熟地区,东部污染较少.

关键词：工业源排放清单细颗粒(PM2.5) 苏州市

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma yi-Xiang He jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Liquid metal corrosion sculpture to fabricate quickly complex patterns on aluminum

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Science China(Technological Sciences) 2017年第1期60卷 65-70页

作者： LU JinRong yi LiTing WANG Lei tan SiCong GUI Han LIU jing Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China

A liquid metal enabled corrosion sculpture technique for quickly fabricating complex pattems on aluminum substrate is proposed and experimentally demonstrated. According to the conceptual investigation, it is clarified that the width and the depth of a printed track are dominated by sculpture time and working temperature. The printed size can reach small values of 38 μm through controlling the sculpture time for 60 s. As the sculpture time was increased from 5 to 25 rain at 20℃, the depth of the fabricated pattern was improved from 13.3 to 25.6 μm. The sculptured depth of the pattern would increase from 13.3 to 106.9 μm when the sculpture time was fixed at 5 min and the temperature was raised from 20 to 60℃. To investigate the sculpture behavior in detail, the phases and microstructure of sculpture surface were quantitatively measured via a group of microscope imaging system with fundamental mechanisms interpreted. The present liquid metal sculpture method on aluminum substrate adds a new valuable soft tool for current metal engraving technology family.

关键词： sculpture printing corrosion liquid metal aluminum substrate soft fabrication

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Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

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Friction 2022年第1期10卷 68-79页

作者： Li WAN yi WANG Xiaolong tan Yulong SUN jing LUO Hongyu ZHANG State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China College of Mining Guizhou UniversityGuiyang 550025China Beijing Research Institute of Automation for Machinery Industry Co. Ltd.Beijing 100120China

Osteoarthritis is characterized by lubrication failure of the articular cartilage and severe inflammation of the joint *** mesoporous silica nanoparticles(MSNs)have been developed for the treatment of osteoarthritis based on enhanced lubrication and local drug ***,MSNs are difficult to degrade in vivo in a short time,resulting in potential toxic effect due to *** this study,biodegradable MSNs(bMSNs)were prepared through an oil–water biphase stratification method,and modified with poly(2-methacryloyloxyethyl phosphocholine)(PMPC)to synthesize lubricating drug-loaded nanoparticles(bMSNs–NH_(2)@PMPC)by *** in vitro degradation test demonstrated that the bMSNs and bMSNs–NH_(2)@PMPC almost degraded within 7 *** tribiological test showed that the lubrication property of the bMSNs–NH2@PMPC was greatly improved,with a reduction of 50%in the friction coefficient(COF)compared with the *** was attributed to hydration lubrication mechanism by which a tenacious hydration layer is formed surrounding the zwitterionic headgroups(N+(CH_(3))^(3)and PO4-)in PMPC polyelectrolyte ***,the bMSNs–NH_(2)@PMPC maintained excellent lubrication property under degradation and achieved sustained drug release behavior compared with the *** summary,the biodegradable bMSNs–NH2@PMPC developed in this study with the properties of enhanced lubrication and drug delivery may be a promising approach for osteoarthritis therapy.

关键词： silica hydration property

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Highly Stretchable and Tunable Thermo-fluorochromic Polymer Elastomer through Eu^(3+)Dynamic Coordination Cross-linking

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Chinese Journal of Polymer Science 2024年第10期42卷 1449-1458,I0008页

作者： Qiu-Li tan Kai Gou jing-Zhi tang Ming-Hui Wei Chong Wang yi-jing Nie Geng-Sheng Weng School of Materials Science and Chemical Engineering State Key Laboratory Base of Novel Functional Materials and Preparation ScienceNingbo UniversityNingbo315211China Institute of Polymer Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang212013China

Thermochromic polymers with tunable thermochromism,high stretchability and mechanical strength are of interests for optical information storage and *** this work,we demonstrate a new design of thermo-fluorochromic carboxylated nitrile butadiene rubber(XNBR)elastomer cross-linked by Eu^(3+)-COOH dynamic coordination with deprotonated imidazole(DPIm)as the ancillary *** presence of DPIm not only improves the mechanical strength and stretchability,but also dramatically intensifies the fluorescence emission and lifetime of the Eu-containing *** elastomer behaves reversible thermo-fluorochromism with easily tunable transition temperature and emission intensity by the simple change of the deprotonation degree of *** facile tunable thermo-fluorochromism,exceptional mechanical strength,and high stretchability(up to about 5000%)enable the Eu-containing XNBR elastomer with potential applications in soft electronics where optical information storage and encryption are required.

关键词： Dynamic coordination Thermochromism Highly stretchable Elastomer Europium

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Proportional directional valve based automatic steering system for tractors

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Frontiers of Information Technology & Electronic Engineering 2016年第5期17卷 458-464页

作者： Jin-yi LIU jing-quan tan En-rong MAO Zheng-he SONG Zhong-xiang ZHU Beijing Key Laboratory of Optimized Design for Modern Agricultural Equipment China Agricultural University

Most automatic steering systems for large tractors are designed with hydraulic systems that run on either constant flow or constant pressure. Such designs are limited in adaptability and applicability. Moreover, their control valves can unload in the neutral position and eventually lead to serious hydraulic leakage over long operation periods. In response to the problems noted above, a multifunctional automatic hydraulic steering circuit is presented. The system design is composed of a 5-way-3-position proportional directional valve, two pilot-controlled check valves, a pressure-compensated directional valve, a pressurecompensated flow regulator valve, a load shuttle valve, and a check valve, among other components. It is adaptable to most open-center systems with constant flow supply and closed-center systems with load feedback. The design maintains the lowest pressure under load feedback and stays at the neutral position during unloading, thus meeting the requirements for steering. The steering controller is based on proportional-integral-derivative(PID) running on a 51-microcontroller-unit master control chip. An experimental platform is developed to establish the basic characteristics of the system subject to stepwise inputs and sinusoidal tracking. Test results show that the system design demonstrates excellent control accuracy, fast response, and negligible leak during long operation periods.

关键词： Automatic steering system Hydraulic circuit Proportional directional valve Proportional-integral-derivative(PID) control

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