检索结果-南通市图书馆

Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus

World Journal of Diabetes 2022年第10期13卷 861-876页

作者： Yun-yi Liang Ling-Yu Liu Yan Jia yi Li Jie-Na Cai yi Shu jing-yi tan Pei-yi Chen Hong-Wei Li Hui-Hua Cai Xiang-Sheng Cai Health Management Center The Sixth Affiliated HospitalSchool of MedicineSouth China University of TechnologyFoshan 528000Guangdong ProvinceChina The First Affiliated Hospital Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Shenzhen Hospital University of Chinese Academy of SciencesShenzhen 518001Guangdong ProvinceChina Clinical Laboratory Puning People’s HospitalPuning 515300Guangdong ProvinceChina Institute of Biotherapy Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Obstetrics and Gynecology Guangdong Provincial People's HospitalGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)places both the mother and offspring at high risk of *** evidence suggests that the gut microbiota plays a role in the pathogenesis of ***,it is still unclear whether the gut microbiota is related to blood biochemical traits,particularly glucagon-like peptide-1(GLP-1),in GDM *** To explore the correlation between the gut microbiota and blood biochemical traits,particularly GLP-1,in GDM *** The V4 region of the 16S ribosomal ribonucleic acid(rRNA)gene was sequenced based on the fecal samples of 35 pregnant women with GDM and was compared to that of 25 pregnant women with normal glucose tolerance(NGT).RESULTS The results showed that Ruminococcaceae_UCG-002,Ruminococcaceae_UCG-005,Clostridium_sensu_stricto_1,and Streptococcus were more abundant in the NGT group than in the GDM *** and Lachnoclostridium were more abundant in the GDM group than in the NGT ***’s correlation analysis was performed to identify the relationships between microbiota genera and blood biochemical ***,Roseburia,Faecalibacterium,and Ruminococcaceae_UCG-002 were significantly negatively correlated with ***_UCG-002 was significantly negatively correlated with hemoglobin *** was significantly positively correlated with ***,Oscillibacter,and Bifidobacterium were significantly positively correlated with GLP-1.A random forest model showed that 20 specific genera plus glucose provided the best discriminatory power,as indicated by the area under the receiver operating characteristic curve(0.94).CONCLUSION The results of this study reveal novel relationships between the gut microbiome,blood biochemical traits,particularly GLP-1,and GDM *** findings suggest that some genera are crucial for controlling blood glucose-related indices and may be beneficial for GDM *** in the microbial composition of the

关键词： Gut microbiome Glucagon-like peptide-1 Gestational diabetes mellitus Glucose

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Myricetin protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect

引用

Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 255-259页

作者： jing-yi tan Xue-Qin Chen Bi-Jun Kang Zi-Xi Qin Jia-Hong Chen Ren-Dong Hu Liang-Cai Wu Pharmacology Department of Basic Medical Sciences School of Medicine Jinan University The 6th Affiliated Hospital.Sun Yat-sen University

Objective: To explore the therapeutic effect and mechanism of myricctin on disseminated intravascular coagulation(DIC). Methods: The DIC model was established by injection of60 mg/kg LPS in KM mice, and the treatment groups were injected myricetin with different concentrations(25 or 50 mg/kg) 30 min before the model was established. Both coagulation indicators and organ function were tested, including PT, APTT, fibrinogen. AST, ALT. BUN and tissue section. In vitro, the inflammatory model of RAW 264.7 macrophage cells were established by 10 μg/mL LPS. The treatment group was treated with 50 μmol/mL myricetin for 30 min before LPS, and the expression of TNF-a and p-NF-KB was detected, further to explore the therapeutic mechanism. Results: LPS-induced DIC led to a reduction of fibrinogen and a rise of PT, APTT,AST, ALT, BUN levels, but the treatment of myricctin significantly inhibited these abnormalities. Histopathology analysis also revealed that myricetin remarkably protected the liver and renal damage. In vitro, the expression of TNF-α and p-NF-κB induced by LPS was repressed by myricetin. Conclusions: This study provides new insights into the protective effects of myricetin in LPS-induced DIC by anticoagulant and anti-inflammatory via suppressing the activation of p-NF-κB which decreased TNF-α level.

关键词： Myricetin Lipopolysaccharide Disseminated intravascular coagulation Anti-inflammatory Macrophages

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of 15-Deoxy-A^12,14-prostaglandin J2 Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model

引用

Chinese Medical Journal 2017年第3期130卷 347-356页

作者： Qi tang Li-Li Chen Fen Wei Wei-Lian Sun Li-Hong Lei Pei-Hui Ding jing-yi tan Xiao-Tao Chen Yan-Min Wu Department of Oral Medicine The Second Affiliated Hospital of School of Medicine of Zhejiang University Hangzhou Zhejiang 310009 China

Background： 15-Deoxy-^△^12、14-prostaglandin J2 （15d-PGJ2）, one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-1oaded poly（D,L-lactide-co-glycolide） nanocapsules （15d-PGJ2-NC） on inflammatory responses and bone regeneration in local bone defect. Methods： The study was conducted on 96 Wistar rats from June 2014 to March 2016. Saline, unloaded nanoparticles, free 15d-PGJ2 or 15d-PGJ2-NC, were delivered through a collagen vehicle inside surgically created transcortical defects in rat femurs, lnterleukin-6 （IL-6）, interleukin-1 beta （IL-I~）, and tumor necrosis factor-alpha （TNF-o0 levels in the surrounding soft tissue were analyzed by Western blot and in the defect by quantitative real-time polymerase chain reaction over 14 days. Simultaneously, bone morphogenetic protein-6 （BMP-6） and platelet-derived growth factor-B （PDGF-B） messenger RNA （mRNA） in the defect were examined. New bone formation and EphrinB2 and osteoprotegerin （OPG） protein expression in the cortical defect were observed by Masson＇s Trichrome staining and immunohistochemistry over 28 days. Data were analyzed by one-way analysis of variance. Least-significant difference and Dunnett＇s T3 methods were used with a bilateral P 〈 0.05. Results： Application of 15d-PGJfNC （100μg/ml） in the local bone defect significantly decreased 1L-6, IL-Iβ, and TNF-α mRNA and protein, compared with saline-treated controls （P 〈 0.05）. 15d-PGJfNC upregulated BMP-6 and PDGF-B mRNA （P 〈 0.05）. New bone formation was observed in the cortical defect in 15d-PGJ2-NC-treated animals from 7th day onward （P 〈 0.001）. Expression of EphrinB2 and OPG presented early on day 3 and persisted through day 28 in 15d-PGJfNC group （P 〈 0.05）. Conclusion： Stable 15d-PGJz-NC complexes were prepared that could attenuate IL-6, IL-1 β, and TNF-α expression, while increasing new bone formation and growth f

关键词： 15-Deoxy-Am4-prostaglandin J, lnterleukin-I Beta Interleukin-6 Nanocapsules Osteogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

苏州市大气细颗粒物(PM_(2.5))工业源排放清单

引用

环境科学学报 2017年第2期37卷 453-459页

作者：刘松华周静谭译徐波张建荣武瑾苏州市环境科学研究所苏州215000 苏州市苏城环境科技有限责任公司苏州215000

通过发放调查表、现场咨询等形式,获得苏州市2012年工业企业基本信息,参照国内外已有研究成果,确定排放因子,并根据实际情况对钢铁行业进行了系数修订,得到苏州市工业源大气细颗粒物排放清单.结果表明:苏州地区工业源PM_(2.5)排放总量约... 详细信息

通过发放调查表、现场咨询等形式,获得苏州市2012年工业企业基本信息,参照国内外已有研究成果,确定排放因子,并根据实际情况对钢铁行业进行了系数修订,得到苏州市工业源大气细颗粒物排放清单.结果表明:苏州地区工业源PM_(2.5)排放总量约为6.57×10~4t,工艺过程源和固定燃烧源分别占94%和6%;张家港地区贡献率最大,为51%,其次为常熟13.8%;姑苏区贡献率最小,为0.13%;苏州市平均排放强度为10.42 t·km^(-2),张家港排放强度最大,达到了43.57 t·km^(-2),其次为新区12.38 t·km^(-2);钢铁与炼焦、火电、水泥行业是PM_(2.5)的主要贡献者,分别为50%、17%和14%;空间分布显示苏州北部相对细颗粒污染较大,重点企业多集中在张家港、常熟地区,东部污染较少.

关键词：工业源排放清单细颗粒(PM2.5) 苏州市

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

引用

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liquid metal corrosion sculpture to fabricate quickly complex patterns on aluminum

引用

Science China(Technological Sciences) 2017年第1期60卷 65-70页

作者： LU JinRong yi LiTing WANG Lei tan SiCong GUI Han LIU jing Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China

A liquid metal enabled corrosion sculpture technique for quickly fabricating complex pattems on aluminum substrate is proposed and experimentally demonstrated. According to the conceptual investigation, it is clarified that the width and the depth of a printed track are dominated by sculpture time and working temperature. The printed size can reach small values of 38 μm through controlling the sculpture time for 60 s. As the sculpture time was increased from 5 to 25 rain at 20℃, the depth of the fabricated pattern was improved from 13.3 to 25.6 μm. The sculptured depth of the pattern would increase from 13.3 to 106.9 μm when the sculpture time was fixed at 5 min and the temperature was raised from 20 to 60℃. To investigate the sculpture behavior in detail, the phases and microstructure of sculpture surface were quantitatively measured via a group of microscope imaging system with fundamental mechanisms interpreted. The present liquid metal sculpture method on aluminum substrate adds a new valuable soft tool for current metal engraving technology family.

关键词： sculpture printing corrosion liquid metal aluminum substrate soft fabrication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

引用

Friction 2022年第1期10卷 68-79页

作者： Li WAN yi WANG Xiaolong tan Yulong SUN jing LUO Hongyu ZHANG State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China College of Mining Guizhou UniversityGuiyang 550025China Beijing Research Institute of Automation for Machinery Industry Co. Ltd.Beijing 100120China

Osteoarthritis is characterized by lubrication failure of the articular cartilage and severe inflammation of the joint *** mesoporous silica nanoparticles(MSNs)have been developed for the treatment of osteoarthritis based on enhanced lubrication and local drug ***,MSNs are difficult to degrade in vivo in a short time,resulting in potential toxic effect due to *** this study,biodegradable MSNs(bMSNs)were prepared through an oil–water biphase stratification method,and modified with poly(2-methacryloyloxyethyl phosphocholine)(PMPC)to synthesize lubricating drug-loaded nanoparticles(bMSNs–NH_(2)@PMPC)by *** in vitro degradation test demonstrated that the bMSNs and bMSNs–NH_(2)@PMPC almost degraded within 7 *** tribiological test showed that the lubrication property of the bMSNs–NH2@PMPC was greatly improved,with a reduction of 50%in the friction coefficient(COF)compared with the *** was attributed to hydration lubrication mechanism by which a tenacious hydration layer is formed surrounding the zwitterionic headgroups(N+(CH_(3))^(3)and PO4-)in PMPC polyelectrolyte ***,the bMSNs–NH_(2)@PMPC maintained excellent lubrication property under degradation and achieved sustained drug release behavior compared with the *** summary,the biodegradable bMSNs–NH2@PMPC developed in this study with the properties of enhanced lubrication and drug delivery may be a promising approach for osteoarthritis therapy.

关键词： silica hydration property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly Stretchable and Tunable Thermo-fluorochromic Polymer Elastomer through Eu^(3+)Dynamic Coordination Cross-linking

引用

Chinese Journal of Polymer Science 2024年第10期42卷 1449-1458,I0008页

作者： Qiu-Li tan Kai Gou jing-Zhi tang Ming-Hui Wei Chong Wang yi-jing Nie Geng-Sheng Weng School of Materials Science and Chemical Engineering State Key Laboratory Base of Novel Functional Materials and Preparation ScienceNingbo UniversityNingbo315211China Institute of Polymer Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang212013China

Thermochromic polymers with tunable thermochromism,high stretchability and mechanical strength are of interests for optical information storage and *** this work,we demonstrate a new design of thermo-fluorochromic carboxylated nitrile butadiene rubber(XNBR)elastomer cross-linked by Eu^(3+)-COOH dynamic coordination with deprotonated imidazole(DPIm)as the ancillary *** presence of DPIm not only improves the mechanical strength and stretchability,but also dramatically intensifies the fluorescence emission and lifetime of the Eu-containing *** elastomer behaves reversible thermo-fluorochromism with easily tunable transition temperature and emission intensity by the simple change of the deprotonation degree of *** facile tunable thermo-fluorochromism,exceptional mechanical strength,and high stretchability(up to about 5000%)enable the Eu-containing XNBR elastomer with potential applications in soft electronics where optical information storage and encryption are required.

关键词： Dynamic coordination Thermochromism Highly stretchable Elastomer Europium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Proportional directional valve based automatic steering system for tractors

引用

Frontiers of Information Technology & Electronic Engineering 2016年第5期17卷 458-464页

作者： Jin-yi LIU jing-quan tan En-rong MAO Zheng-he SONG Zhong-xiang ZHU Beijing Key Laboratory of Optimized Design for Modern Agricultural Equipment China Agricultural University

Most automatic steering systems for large tractors are designed with hydraulic systems that run on either constant flow or constant pressure. Such designs are limited in adaptability and applicability. Moreover, their control valves can unload in the neutral position and eventually lead to serious hydraulic leakage over long operation periods. In response to the problems noted above, a multifunctional automatic hydraulic steering circuit is presented. The system design is composed of a 5-way-3-position proportional directional valve, two pilot-controlled check valves, a pressure-compensated directional valve, a pressurecompensated flow regulator valve, a load shuttle valve, and a check valve, among other components. It is adaptable to most open-center systems with constant flow supply and closed-center systems with load feedback. The design maintains the lowest pressure under load feedback and stays at the neutral position during unloading, thus meeting the requirements for steering. The steering controller is based on proportional-integral-derivative(PID) running on a 51-microcontroller-unit master control chip. An experimental platform is developed to establish the basic characteristics of the system subject to stepwise inputs and sinusoidal tracking. Test results show that the system design demonstrates excellent control accuracy, fast response, and negligible leak during long operation periods.

关键词： Automatic steering system Hydraulic circuit Proportional directional valve Proportional-integral-derivative(PID) control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes

引用

Genes & Diseases 2023年第5期10卷 2151-2166页

作者： Huiwen Liu Yanting Sun Hao Xu Bin tan Qin yi Jie Tian jing Zhu Department of Pediatric Research Institute Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Pediatrics Chongqing 400014China Department of Clinical Laboratory Children's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Cardiovascular(Internal Medicine) Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)have attracted attention in the field of regenerative medicine due to their potential ability to repair damaged ***,the immature phenotype of these cells limits their clinical *** maturation is accompanied by changes in mitochondrial ***-induced putative kinase 1(PINK1)has been linked to mitochondrial quality ***,whether the changes in mitochondrial quality in hiPSC-CMs are associated with PINK1,and the impact of PINK1 on hiPSC-CMs development are not *** this study,we found that knockdown of PINK1 in hiPSC-CMs resulted in mitochondrial fragmentation and impaired mitochondrial functions such as mitophagy and mitochondrial ***1 deletion also inhibited the maturation of hiPSC-CMs,reverting them to a naive structural and functional *** found that restoring the mitochondrial structure did not completely rescue the mitochondrial dysfunction caused by PINK1 deletion,while activation of PINK1 kinase activity using kinetin promoted mitochondrial fusion,increased the mitochondrial membrane potential and ATP production,and maintained the development and maturation of *** conclusion,PINK1 regulates the mitochondrial structure and function of hiPSC-CMs,and is essential for the maturation of hiPSC-CMs.

关键词： hiPSC-CMs hiPSCs Maturation Mitochondrial quality PINK1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：