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miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke

Neural Regeneration Research 2023年第9期18卷 1983-1989页

作者： Li-Xia Xue Lin-Yuan Shu Hong-Mei Wang Kai-Li Lu Li-Gang Huang jing-yan xiang Zhi Geng Yu-Wu Zhao Hao Chen Department of Neurology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Emergency Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina

Promotion of new blood vessel formation is a new strategy for treating ischemic ***-coding miRNAs have been recently considered potential therapeutic targets for ischemic ***-181b has been shown to promote angiogenesis in hypoxia and traumatic brain injury model,while its effect on ischemic stroke remains *** this study,we found that overexpression of miR-181b in brain microvascular endothelial cells subjected to oxygen-glucose deprivation in vitro restored cell prolife ration and enhanced *** rat models of focal cerebral ischemia,ove rexpression of miR-181b reduced infarction volume,promoted angiogenesis in ischemic penumbra,and improved neurological *** further investigated the molecular mechanism by which miR-181b participates in angiogenesis after ischemic stroke and found that miR-181b directly bound to the 3’-UTR of phosphatase and tensin homolog(PTEN) mRNA to induce PTEN downregulation,leading to activation of the protein kinase B(Akt) pathway,upregulated expression of vascular endothelial growth facto rs,down-regulated expression of endostatin,and promoted *** togethe r,these results indicate that exogenous miR-181b exhibits neuroprotective effects on ischemic stro ke through activating the PTEN/Akt signal pathway and promoting angiogenesis.

关键词： Akt angiogenesis endostatin ischemic stroke middle cerebral artery occlusion miR-181b neurological function recovery oxygen-glucose deprivation PTEN vascular endothelial growth factor

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尿激酶联合低分子肝素与经皮冠状动脉介入治疗急性心肌梗死的疗效对比研究

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中国现代医学杂志 2014年第25期24卷 66-68页

作者：颜景祥鹿庆华山东大学医学院山东济南250012 山东大学第二医院心内科山东济南250033

目的分析尿激酶联合低分子肝素与经皮冠状动脉介入治疗急性心肌梗死的疗效差异。方法选择在本院接受治疗的急性心肌梗死患者86例作为研究对象,随机分为接受尿激酶联合低分子肝素治疗的溶栓组及接受经皮冠状动脉介入治疗的介入组。比较... 详细信息

目的分析尿激酶联合低分子肝素与经皮冠状动脉介入治疗急性心肌梗死的疗效差异。方法选择在本院接受治疗的急性心肌梗死患者86例作为研究对象,随机分为接受尿激酶联合低分子肝素治疗的溶栓组及接受经皮冠状动脉介入治疗的介入组。比较两组患者治疗后的心脏功能、心电图及胸痛情况、心血管事件发生率等差异。结果介入组患者接受治疗后的LVESD、LVEDD值小于溶栓组,LVEF及6-MWT水平高于溶栓组(P0.05)。结论经皮冠状动脉介入治疗急性心肌梗死可以有效缓解心肌重构、提高心脏功能,在改善远期预后方面两组疗效相当。

关键词：急性心肌梗死冠状动脉介入尿激酶低分子肝素

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脉冲中子探测器用国产PMT的批量测试研究

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原子能科学技术 2016年第11期50卷 2081-2084页

作者：马烈华艾杰马景芳向艳军中国工程物理研究院流体物理研究所四川绵阳621900

针对脉冲中子探测器研制的需求,对国产GDB-235型PMT进行了批量测试与研究。通过相对测量的方法,获得了该型PMT阳极灵敏度的分布状态。为考核PMT对极端气温条件的适应性,通过高、低温贮存实验,获得了PMT灵敏度变化的统计规律。最后通过... 详细信息

针对脉冲中子探测器研制的需求,对国产GDB-235型PMT进行了批量测试与研究。通过相对测量的方法,获得了该型PMT阳极灵敏度的分布状态。为考核PMT对极端气温条件的适应性,通过高、低温贮存实验,获得了PMT灵敏度变化的统计规律。最后通过李萨如图形法测得该型PMT的最大线性输出幅度平均达369.9mV,可满足中子探测器研制的要求。

关键词： PMT 批量测试脉冲线性幅度

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肝细胞癌患者射频消融前后的免疫状态研究进展

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介入放射学杂志 2017年第1期26卷 87-91页

作者：徐晓林朱争艳经翔天津医科大学第三中心临床学院 300170 天津市人工细胞重点实验室天津市第三中心医院超声科

射频消融(RFA)治疗肝细胞癌(HCC)后,肿瘤细胞发生凝固性坏死与凋亡,产生原位肿瘤抗原,直接或间接激发机体固有免疫及适应性免疫反应,帮助逆转机体免疫抑制状态。本文主要对RFA治疗HCC引起的局部及全身性免疫反应、适应性免疫及固有免疫... 详细信息

射频消融(RFA)治疗肝细胞癌(HCC)后,肿瘤细胞发生凝固性坏死与凋亡,产生原位肿瘤抗原,直接或间接激发机体固有免疫及适应性免疫反应,帮助逆转机体免疫抑制状态。本文主要对RFA治疗HCC引起的局部及全身性免疫反应、适应性免疫及固有免疫及其对细胞因子的调节发挥的作用进行综述,进而对RFA治疗HCC后的机体免疫改变进行阐明。

关键词：肝细胞癌射频消融免疫

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao jing-Wen Li Hui Ye Xue-Zhi Zhang Jian-xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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基于Yolo的结直肠息肉CT影像分析算法研究

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南通职业大学学报 2021年第4期35卷 82-87页

作者：代国威晏静香中国农业科学院农业信息研究所北京100081 德阳市第七人民医院老年科四川德阳618000

为实现结直肠息肉的图像识别,提出改进YOLO网络结构的Yolo-polyps模型,使用深度学习实现结直肠息肉CT影像目标检测。对原始CT影像数据集增广增强,再通过改进k-means获取合适锚框,并作为Yolo-polyps模型快速获取特征的基准;对多个超参数... 详细信息

为实现结直肠息肉的图像识别,提出改进YOLO网络结构的Yolo-polyps模型,使用深度学习实现结直肠息肉CT影像目标检测。对原始CT影像数据集增广增强,再通过改进k-means获取合适锚框,并作为Yolo-polyps模型快速获取特征的基准;对多个超参数进行微调,选择最优超参数,经实验验证,在较少样本下取得了94.8%的准确率;选择Yolo系列的多个算法在相同数据集进行测试,结果显示,Yolo-polyps模型识别准确率平均高出其他模型3.865%,表明该方法优于传统基于内窥镜检查的方法,对CT影像下的结直肠息肉检测有一定的辅助作用。

关键词： YOLOv3 CT图像结直肠息肉检测卷积神经网络数据集增广增强

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing Zhang jing yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-xiang He jing Jin Hong-Lian Wang Yun-Feng Wang Fan yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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