检索结果-南通市图书馆

Comparison of laparoscopic vs open liver lobectomy(segmentectomy) for hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第42期17卷 4725-4728页

作者： Ben-Shun Hu Ke Chen Hua-Min tan Xiang-Ming Ding jing-wang tan Hepato-bilio-pancreatic Surgery Department Northern Jiangsu People＇s Hospital Yangzhou 225001 Jiangsu Province China Hua-Min Tan General Surgery Department Fuzhou General Hospital of Nanjing Military Command Fuzhou 350000 Fujian Province China

AIM:To investigate the effects of laparoscopic hepatectomy for the treatment of hepatocellular carcinoma(HCC) .METHODS:From 2006 to January 2011,laparoscopic hepatectomies were performed on 30 cases of HCC at Northern Jiangsu People's Hospital. During this sametime period,30 patients elected to undergo conventional open hepatectomy over laparoscopic hepatectomy at the time of informed consent. The degree of invasiveness and outcomes of laparoscopic hepatectomy compared to open hepatectomy for HCC were ***:Both groups presented with similar bloodloss amounts,operating times and complications. Patients in the laparoscopic hepatectomy group started walking and eating significantly earlier than those inthe open hepatectomy group,and these more rapid recoveries allowed for shorter hospitalizations. There were no significant differences between procedures insurvival ***:Laparoscopic hepatectomy is beneficial for patient quality of life if the indications are appropriately based on preoperative liver function and the location and size of the HCC.

关键词： Laparoscopy Hepatocellular carcinoma Liver resection Liver Iobectomy

Impact of mesocaval shunt on safe minimal liver remnant:Porcine model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第31期19卷 5076-5084页

作者： Yu-Liang Tu Xuan wang Da-Dong wang Zi-Man Zhu jing-wang tan Department of Hepatobiliary Surgery the First Affiliated Hospital Chinese PLA General Hospital Department of Hepatobiliary Surgery Chinese PLA No. 81 Hospital

AIM: To investigate the capacity of shunts to relieve portal hypertension and decrease the safe minimal liver remnant in ***: A subtotal hepatectomy with < 60 mL blood loss and without hepatic pedicle occlusion was *** mesenteric venous inflow was diverted through a mesocaval shunt(MCS) constructed using the prepared left renal vein with an end-to-side running suture of 5-0 *** 21 animals that underwent subtotal hepatectomy and/or MCS were divided into three *** the 15% group,the residual volume was 14%-19% of total liver volume(TLV);in the 15%+ S group,the residual volume was also 14%-19% of TLV with a mesocaval shunt(MCS);and in the 10%+ S group,the residual volume was 8%-13% of TLV with an *** the three groups,the intraoperative portal vein pressure(PVP) and portal vein flow(PVF) were monitored and compared at laparotomy and 1 h *** survival rate,sinusoidal endothelial damage,tissue analysis,and serum analysis were investigated among the three ***: The percentage residual liver volume was 15.9%,16.1% and 11.8% in the 15%,15%+ S,10%+ S groups,*** hepatectomy,PVF and portal-to-arterial flow ratio in the 15%+ S group significantly decreased and hepatic artery flow(HAF) per unit volume significantly increased,compared to those in the 15% *** PVP in the 15%+ S group and 10%+ S group increased slightly from that measured at laparotomy;however,in the 15% group,the PVP increased immediately and significantly above that observed in the other two *** 14-d survival rates were 28.5%,85.6%,and 14.2% in the 15%,15%+ S,and 10%+ S groups,*** the 15%+ S group,the shunts effectively attenuated injury to the sinusoidal endothelium,and the changes in the serum and tissue analysis results were significantly reduced compared to those in the 15% and 10%+ S ***: MCS can decompress the portal vein and so attenuate liver injury from hyperperfusion,and make extreme or margin

关键词： Hepatectomy Safe minimal remnant volume Mesocaval shunt Pigs

WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第23期18卷 3020-3026页

作者： Ben-Shun Hu jing-wang tan Guo-Hua Zhu Dan-Feng wang Xian Zhou Zhi-Qiang Sun Department of General Surgery Jiang Yuan Hospital affiliated to Jiangsu Institute of Nuclear Medicine Wuxi 214063 Jiangsu Province China Department of Hepatobiliopancreatic Surgery Northern Jiangsu People's Hospital Yangzhou 225001 Jiangsu Province China

AIM: To investigate the effects of the WWOX gene on the human hepatic carcinoma cell line SMMC-7721. METHODS: Full-length WWOX cDNA was amplified from normal human liver tissues. Full-length cDNA was subcloned into pEGFP-N1, a eukaryotic expression vector. After introduction of the WWOX gene into cancer cells using liposomes, the WWOX protein level in the cells was detected through Western blotting. Cell growth rates were assessed by methyl thiazolyl tetrazolium (MTT) and colony formation assays. Cell cycle progression and cell apoptosis were measured by flow cytometry. The phosphorylated protein kinase B (AKT) and activated fragments of caspase-9 and caspase-3 were examined by Western blotting analysis. RESULTS: WWOX significantly inhibited cell proliferation, as evaluated by the MTT and colony formation assays. Cells transfected with WWOX showed significantly higher apoptosis ratios when compared with cells transfected with a mock plasmid, and overexpression of WWOX delayed cell cycle progression from G1 to S phase, as measured by flow cytometry. An increase in apoptosis was also indicated by a remarkable activation of caspase-9 and caspase-3 and a dephosphorylation of AKT (Thr308 and Ser473) measured with Western blotting analysis. CONCLUSION: Overexpression of WWOX induces apoptosis and inhibits proliferation of the human hepatic carcinoma cell line SMMC-7721.

关键词： WWOX SMMC-7721 Apoptosis Prolifera-tion Hepatic carcinoma

Should temporary extracorporeal continuous portal diversion replace meso/porta-caval shunts in “small-for-size” syndrome in porcine hepatectomy?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第3期21卷 888-896页

作者： Da-Dong wang Yong Xu Zi-Man Zhu Xiang-Long tan Yu-Liang Tu Ming-Ming Han jing-wang tan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chinese PLA General Hospital

AIM:To investigate the feasibility of temporary extracorporeal continuous porta-caval diversion(ECPD) to relieve portal hyperperfusion in "small-for-size" syndrome following massive hepatectomy in ***:Fourteen pigs underwent 85%-90% liver resection and were then randomly divided into thecontrol group(n = 7) and diversion group(n = 7).In the diversion group,portal venous blood was aspirated through the portal catheter and into a tube connected to a centrifugal *** filtration,the blood was returned to the pig through a double-lumen catheter inserted into the internal jugular or subclavian *** the conversion pump,portal venous inflow was partially diverted to the inferior vena cava through a catheter inserted via the gastroduodenal vein at 100-130 m L/*** hemodynamics,injury,and regeneration in the liver remnant were compared between the two ***:Compared to the control group,porta-caval diversion via ECPD significantly mitigated excessive portal venous flow and portal vein pressure(PVP); the portal vein flow(PVF),hepatic artery flow(HAF),and PVP in the two groups were not significantly different at baseline; however,the PVF(431.8 ± 36.6 vs 238.8 ± 29.3,P < 0.01; 210.3 ± 23.4 vs 122.3 ± 20.6,P < 0.01) and PVP(13.8 ± 2.6 vs 8.7 ± 1.4,P < 0.01; 15.6 ± 2.1 vs 10.1 ± 1.3,P < 0.05) in the control group were significantly higher than those in the diversion group,*** HAF in the control group was significantly lower than that in the diversion group at 2 h and 48 h post hepatectomy,and ECPD significantly attenuated injury to the sinusoidal lining and hepatocytes,increased the regeneration index of the liver remnant,and relieved damage that the liver remnant suffered due to endotoxin and bacterial ***:ECPD,which can dynamically modulate portal inflow,can reduce injury to the liver remnant and facilitate liver regeneration,and therefore should replace permanent meso/porta-caval shunts in "smallfor-size" synd

关键词： small-for-size syndrome Extracorporeal continuous

Extracorporeal continuous portal diversion plus temporal plasmapheresis for “small-for-size” syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第33期19卷 5464-5472页

作者： Peng Hou Chao Chen Yu-Liang Tu Zi-Man Zhu jing-wang tan Institute of Gastroenterology The First Affiliated Hospital of Chinese PLA General Hospital Institute of Hepatobiliary Surgery The First Affiliated Hospital of Chinese PLA General Hospital

AIM:To investigate the effect of plasmapheresis via the portal vein for"small-for-size"syndrome(SFSS)aided by extracorporeal continuous portal diversion(ECPD).METHODS:Extensive or total hepatectomy in the pig is usually adopted as a postoperative liver failure(PLF)or SFSS *** this study,animals which underwent85%-90%hepatectomy were randomized into either the Systemic group(n=7)or the Portal group(n=7).In the Systemic group,all pigs received temporal plasmapheresis(PP)via the extracorporeal catheter circuit(systemic to systemic circulation)from 24 to 30 h posthepatectomy(PH);in the Portal group,all pigs received ECPD to divert partial portal vein flow(PVF)to the systemic circulation after hepatectomy,then converted to temporal PP from 24 to 30 h PH,and subsequently converted to ECPD again until 48 h *** the Portal group,the PVF was preserved at 3.0-3.3 times that of the baseline value,similar to that following 70%hepatectomy,which was regarded as the optimal PVF to the hypertrophic liver *** 48 h PH,all pigs were re-opened and the portal vein pressure(PVP),PVF,and HAF(hepatic artery flow)were measured,and then diversion of the portal venous flow was ***1 h the PVP,PVF,and HAF were *** portal hemodynamic changes,liver injury,liver regeneration and bacterial/lipopolysaccharide(LPS)translocation were evaluated in the two ***:The PVP in the Portal group was significantly lower than that in the Systemic group during the time period from 2 to 49 h PH(P<0.05).Serum alanine aminotransferase(ALT),total bilirubin(TB)and ammonia were significantly reduced in the Portal group compared with the Systemic group from 24 to 48 h PH(P<0.05).The Portal group may have attenuated sinusoidal endothelial injury and decreased the level of HA compared with the Systemic *** the Systemic group,there was significant sinusoidal dilation,hydropic changes in hepatocytes and hemorrhage into the hepatic parenchyma,and the sinusoidal endothelial

关键词： Small-for-size syndrome Postoperative liver failure Extracorporeal portal diversion Plasmapheresis Hepatectomy

Individualized peri-operative fluid therapy facilitating early-phase recovery after liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第16期18卷 1981-1986页

作者： Guo-Qing Jiang Ping Chen Dou-Sheng Bai jing-wang tan Hao Su Min-Hao Peng Departmentof Hepatobiliary Surgery Clinical Medical College of Yangzhou University Yangzhou 225000 Jiangsu Province China Department of Hepatobiliary Surgery First Affiliated Hospital Guangxi Medial University Nanning 530021 Guangxi Zhuang Autonomous Region China

AIM:To investigate the correlation between peri-operative fluid therapy and early-phase recovery after liver transplantation(LT) by retrospectively reviewing 102 consecutive ***:Based on whether or not the patients had pulmonary complications,the patients were categorized into non-pulmonary and pulmonary *** peri-operative variables were analyzed in both groups to screen for the factors related to the occurrence of early pulmonary ***:The starting hemoglobin(Hb) value,an intra-operative transfusion > 100 mL/kg,and a fluid balance ≤-14 mL/kg on the first day and the second or third day post-operatively were significant factors for early pulmonary *** extubation time,time to initial passage of flatus,or intensive care unit length of stay were significantly prolonged in patients who had not received an intra-operative transfusion ≤ 100 mL/kg or a fluid balance ≤-14 mL/kg on the first day and the second or the third day ***,these patients had poorer results in arterial blood gas ***:It is important to offer a precise and individualized fluid therapy during the peri-operative period to the patients undergoing LT for cirrhosis-associated hepatocellular carcinoma.

关键词： Fluid therapy Liver transplantation Earlyphase recovery Pulmonary complications Hemoglobin

Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第37期18卷 5197-5204页

作者： Lei Xiang jing-wang tan Li-Jie Huang Lin Jia Ya-Qian Liu Yu-Qiong Zhao Kai wang Jia-Hong Dong Animal Experiment Centers PLA General Hospital Beijing 100853 China Institute of Hepatobiliary Surgery PLA General Hospital Beijing 100853 China

AIM： To study the effect of H2 gas on liver injury in massive hepatectomy using the Intermittent Pringle maneuver in swine. METHODS： Male Bama pigs （n = 14） treated with ketamine hydrochloride and Sumianxin Ⅱ as induc- tion drugs followed by inhalation anesthesia with 2% isoflurane, underwent 70% hepatotectomy with loss of bleeding less than 50 mL, and with hepatic pedicle occlusion for 20 min, were divided into two groups： Hydrogen-group （n = 7）, the pigs with inhalation of 2% hydrogen by the tracheal intubation during major hepa- totectomy; Contrast-group （n= 7）, underwent 70% hepatotectomy without inhalation of hydrogen. Hemo- dynamic changes and plasma concentrations of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, hyaluronic acid （HA）, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, and malondialdehyde （MDA） in liver tissue were measured at pre-operation, post-hepatotectomy （PH） 1 h and 3 h. The apoptosis and proliferating cell nuclear antigen （PCNA） expres- sion in liver remnant were evaluated at PH 3 h. Then we compared the two groups by these marks to evalu- ate the effect of the hydrogen in the liver injury during major hepatotectomy with the Pringle Maneuver in the swine. RESULTS： There were no significant differences in body weight, blood loss and removal liver weight be- tween the two groups. There was no significant differ- ence in changes of portal vein pressure between two groups at pre-operation, PH 30 min, but in hydrogen gas treated-group it slightly decrease and lower than its in Contrast-group at PH 3 h, although there were no significant difference （P = 0.655）. ALT and AST in Hydrogen-group was significantly lower comparing to Contrast-group （P = 0.036, P = 0.011, vs P = 0.032, P = 0.013） at PH 1 h and 3 h, although the two groups all increased. The MDA level increased between the two group at PH i h and 3 h. In the hydrogen gas treated- group, the MDA level was not significantly significant at pre-operation and signif

关键词： Massive hepatotectomy Hydrogen gas, An-ti-oxidant Hyperperfusion Malondialdehyde Oxidativestress

Laparoscopic pancreaticoduodenectomy via a reverse-''V'' approach with four ports:Initial experience and perioperative outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第5期21卷 1588-1594页

作者： Zhao Liu Mu-Chuan Yu Rui Zhao Yan-Feng Liu Jian-Ping Zeng Xian-Qiang wang jing-wang tan Department of Hepatobiliary and Pancreatic Surgery Jinan Central HospitalShandong University Department of Hepatobiliary Surgery Zhangqiu People’s HospitalAffiliated Hospital of Jining Medical University Department of Hepatobiliary Surgery Qilu HospitalShandong University Department of Hepatobiliary Surgery Changgeng HospitalAffiliated to Tsinghua University Department of Hepatobiliary Surgery Hainan Hospitalthe Chinese PLA General Hospital

AIM:To evaluate the feasibility,safety,and efficacy of laparoscopic pancreaticoduodenectomy(LPD) using a reverse-"V" approach with four ***:This is a retrospective study of selected patients who underwent LPD at our center between April 2011 and April *** following data were collected and reviewed:patient characteristics,tumor histology,surgical outcome,resection margins,morbidity,and *** patients were thoroughly evaluated preoperatively by complete hematologic investigations,triple-phase helical computed tomography,upper gastrointestinal endoscopy,and biopsy of ampullary lesions(when present).Magnetic resonance cholangiopancreatography was performed for doubtful cases of lower common bile duct ***:There was no perioperative *** was performed with tumor-free margins in all patients,including patients with pancreatic ductal adenocarcinoma(n = 6),ampullary carcinoma(n = 6),intra-ductal papillary mucinous neoplasm(n = 2),pancreatic cystadenocarcinoma(n = 2),pancreatic head adenocarcinoma(n = 3),and bile duct cancer(n = 2).The mean patient age was 65 years(range,42-75 years).The median blood loss was 240 m L,and the mean operative time was 368 ***:LPD using a reverse-"V" approach can be performed safely and yields good results in elective *** preliminary experience showed that LDP can be performed via a reverse-"V" *** approach can be used to treat localized malignant lesions irrespective of histopathology.

关键词： Laparoscopic pancreaticoduodenectomy Operation Ind

Portal inflow preservation during portal diversion in small-for-size syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第4期20卷 1021-1029页

作者： Xian-Qiang wang Yue-Fang Xu jing-wang tan Wen-Ping Lv Zhe Liu Jian-Ping Zeng Jia-Hong Dong Department of Hepatobiliary Surgery Qilu Hospital Shandong University Department of Hepatobiliary Surgery the Chinese PLA General Hospital Department of Pharmacology First Hospital Affiliated to the Chinese PLA General Hospital Department of Hepatobiliary Surgery First Hospital Affiliated to the Chinese PLA General Hospital

AIM: To investigate the impact of portal inflow on liver remnants in a stable pig model of small-for-size syndrome.

关键词： Portal flow Portal diversion Small-for-size syndrome Mesocaval shunt