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Cu-Al interfacial compounds and formation mechanism of copper cladding aluminum composites

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Transactions of Nonferrous Metals Society of China 2017年第11期27卷 2521-2528页

作者： Di CHU Jian-yu ZhanG Jin-jin YAO Yan-qiu han Chun-jing WU School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China School of Mechanical and Electrical Engineering Hebei University of Engineering Handan 056038 China

Copper cladding aluminum(CCA)rods with the section dimensions of12mm in diameter and2mm in sheath thickness were fabricated by vertical core-filling continuous casting(VCFC)*** kinds and morphology of interfacial intermetallic compounds(IMCs)were investigated by SEM,XRD and *** results showed that the interfacial structure of Cu/Al was mainly composed of layeredγ1(Cu9Al4),cellularθ(CuAl2),andα(Al)+θ(CuAl2)***,residual acicularε2(Cu3Al2+x)phase was observed at the Cu/Al *** comparing the driving force of formation forε2(Cu3Al2+x)andγ1(Cu9Al4)phases,the conclusion was drawn that theε2(Cu3Al2+x)formed firstly at the Cu/Al *** addition,the interfacial formation mechanism of copper cladding aluminum composites was revealed completely.

关键词： copper cladding aluminum composite vertical core-filling continuous casting interfacial formation mechanism

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黄土覆盖较厚山区三维地震勘探的应用

煤炭技术 2011年第4期30卷 142-144页

作者：韩洪涛黑龙江省煤田地质物测队哈尔滨150008

介绍了黄土山区进行三维地震勘探的采集条件,野外数据采集技术和措施,进行黄土山区资料与常规资料地震资料处理和解释的方法的差异,并通过实例进行了细致剖析。

关键词：采集因素采集技术采集措施

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劳动幸福:一个批判性的哲学审视

思想理论教育 2019年第6期 19-24页

作者：毛勒堂韩涛上海师范大学哲学与法政学院

劳动是纷繁复杂的社会生活之基础,是波澜壮阔的人类历史之底色。谋求劳动幸福既是人类劳动得以持久展开的深层动因,也是人类社会心向往之的高远价值目标。在迄今为止的人类社会历史中,劳动更多的是与劳动者的劳累、艰辛乃至痛苦联系在... 详细信息

劳动是纷繁复杂的社会生活之基础,是波澜壮阔的人类历史之底色。谋求劳动幸福既是人类劳动得以持久展开的深层动因,也是人类社会心向往之的高远价值目标。在迄今为止的人类社会历史中,劳动更多的是与劳动者的劳累、艰辛乃至痛苦联系在一起的。尽管如此,劳动在根本上构成人类幸福的基础与源泉,对于人类幸福的生成、创造和实现具有深刻的本体论地位。而劳动幸福,作为一种在劳动中生发的自由自觉的生命存在样式和情感体验,是劳动意志的自觉实现和人之本质力量的自由彰显,其实现有赖于劳动者的胜任能力、人性化的劳动环境、正义的劳动分配以及崇尚劳动的文化氛围。

关键词：劳动幸福劳动幸福哲学批判

Clinical outcomes of adult medulloblastoma:A retrospective analysis at a single institute

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Translational Neuroscience and Clinics 2015年第1期1卷 17-24页

作者： tao Jiang Jin Zhu jing Dong Junmei Wang Jiang Du Chunde Li Yuqi Zhang Department of Neurosurgery Beijing TianT an Hospital Capital Medical University Department of Neurosurgery Tsinghua University Yuquan Hospital Medical Center Tsinghua University Beijing Neurosurgical Institute Capital Medical University

Objectives: Adult medulloblastoma is a rare tumor, and few retrospective studies on medulloblastoma have been published to date. A standard treatment regimen has not yet been established. Accordingly, this study was designed to determine the treatment outcomes and prognostic factors for patients with adult ***: We retrospectively reviewed all cases of adult medulloblastoma at the Beijing Tiantan Hospital between 2004 and 2007. There were 33 patients in total. Tumor removal followed by radiotherapy was performed in all patients. Five patients received maintenance chemotherapy after radiotherapy. Statistical analysis was performed using the log‐rank test, Kaplan–Meier method, and Cox regression analysis. Results: The median follow‐up period was 73 months. The 5‐year progression‐free survival(PFS) and overall survival(OS) rates were 45.5% ± 8.7% and 51.5% ± 8.7%,respectively. Recurrence or progression was observed in 21 patients, and 14 patients were still alive. Tumor location at the midline with infiltration to the floor of the fourth ventricle was associated with the worst PFS and OS(P = 0.032). Hemispheric desmoplastic/nodular medulloblastomas(DNMBs) were associated with a better outcome than midline DNMB. The average‐risk group tended to have a better 5‐year PFS rate than the high‐risk group(P = 0.065). Conclusions: Tumor location is an important prognostic marker for adulthood *** propose a molecular and clinical staging system should be established for adulthood MB. Further prospective clinical trials should be performed to draw a conclusion.

关键词： medulloblastoma(MB) risk factors survival adult

Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART:a longterm observation in treatment-naïve patients

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Infectious Diseases of Poverty 2020年第3期9卷 144-145页

作者： Shuai Chen Yang han Xiao-jing Song Yan-ling Li Ting Zhu Hong-Zhou Lu Xiao-Ping Tang Tong Zhang Min Zhao Yun He Sheng-Hua He Min Wang Yong-Zhen Li Shao-Biao Huang Yong Li jing Liu Wei Cao Tai-Sheng Li Department of Infectious Diseases Peking Union Medical College HospitalChinese Academy of Medical SciencesNo.1 ShuaifuyuanWangfujing StreetBeijing 100730China 不详

Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological *** aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of ***:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to December *** HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based *** patients had baseline HIV-RNA levels over 500 copies/ml,good adherence,and were followed for at least 24 *** suppression was defined as the first HIV-RNA<50 copies/*** failure was defined as any of incomplete viral suppression(HIV-RNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-RNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load ***:A total of 758 treatment-naïve HIV patients in China were *** follow-up time(IQR)was 144(108–276)*** week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOR]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOR=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-RNA were related with delayed efficacy of NNRTI-based ART and increased risk of treatment failure.

关键词： HIV Viral load Baseline RNA Antiretroviral therapy Treatment outcome Virologic response

Carbon Emission Cycle and Literature Measurement of Carbon Fiber Vehicles

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Meteorological and Environmental Research 2020年第6期11卷 60-67,72页

作者： Junpeng CHEN Dongri LIAO tao YUAN Jize WANG jing TANG Xinyuan HE jingjun JIANG School of Mechanical and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China Xiaoxiang College Hunan University of Science and TechnologyXiangtan 411201China School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Information and Intelligent Engineering Zhejiang Wanli UniversityNingbo 315000China

Carbon fiber is a kind of high-temperature fiber with high modulus and strength *** fiber material is made of carbon fiber braid with carbon content>90%.Among them,resin-based carbon fiber reinforced composite material is often used as automotive structural *** with the A36 steel commonly used in automobiles,the T300/5208 carbon fiber reinforced epoxy resin composite commonly used in automobiles has a higher tensile strength of 2500-3300 MPa and a lower density of 6.25 g/cm 3,showing great performance *** this paper,by analyzing the trend of automobile lightweight,and exploring the development prospects of carbon fiber in the field of automobile lightweight,the literature in the Elsevier database is analyzed by scientific measurement analysis method,and the research hotspot in the field is *** relationship between the development of fiber materials and the promotion of policies is analyzed by comparing the number of carbon fiber automobile literature publications and key event *** paper proposes a keyword-based influence calculation *** drawing analysis tools of information visualization scientific knowledge map and scientific measurement methods of keyword,it proposes the scientific measurement analysis literature of on-board carbon fiber,explores and discusses some frontier directions of automotive carbon fiber *** research provides reference for studying automobile lightweight carbon fiber material.

关键词： Carbon emission Carbon fiber Mechanical properties Light weight Visualization technology

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考布他汀A_4类肿瘤血管破坏剂的研究进展

中国药理学与毒理学杂志 2013年第4期27卷 739-744页

作者：韩福国戚欣李静中国海洋大学医药学院海洋药物教育部重点实验室山东青岛266003

肿瘤血管破坏剂(VDA)是一类靶向肿瘤血管的抗肿瘤药物,能够快速、有选择地引发肿瘤组织内部既成血管的塌陷,阻断血液供应,从而引发肿瘤组织缺血性坏死。因此,VDA在治疗实体瘤方面具有很大的应用前景。其中,考布他汀A4(CA4)疗效较好,但... 详细信息

肿瘤血管破坏剂(VDA)是一类靶向肿瘤血管的抗肿瘤药物,能够快速、有选择地引发肿瘤组织内部既成血管的塌陷,阻断血液供应,从而引发肿瘤组织缺血性坏死。因此,VDA在治疗实体瘤方面具有很大的应用前景。其中,考布他汀A4(CA4)疗效较好,但同时毒性较大。在寻找更特异性的VDA过程中,研究者合成了一系列CA4的类似物。本文分析了这些CA4类似物的结构,指出二芳基桥链的顺式构型为其特点,而且这些化合物与微管蛋白上的秋水仙碱作用位点结合,抑制微管蛋白的聚合。与传统抗肿瘤药物不同的是,CA4类VDA的抗肿瘤作用主要是通过选择性破坏肿瘤组织的血管系统实现的。同时,本文介绍了CA4类VDA的典型药物、影响CA4类VDA药效的肿瘤因素和宿主因素,以及为增强疗效和降低毒性作用而进行的联合用药情况。虽然CA4类VDA具有很大的应用前景,但目前还存在一些缺点,因而有必要继续寻找高效低毒的VDA,同时寻找可靠的生物标志物来指导VDA的临床用药也很有必要。

关键词：肿瘤血管破坏剂考布他汀A4

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化学修饰的水溶性碳纳米管

南京工业大学学报（自然科学版） 2010年第3期32卷 99-104页

作者：张弢李含南京大学材料科学与工程系江苏南京210093

碳纳米管因其独特的结构和性质受到广泛注意,但它不溶、不熔的特性也限制了它的应用.因此,如何制备可溶解碳纳米管,尤其是在水中可溶解的碳纳米管成为许多领域,特别是与生物医学相关的领域的高度重视,而化学修饰则是获得这一特性的重要... 详细信息

碳纳米管因其独特的结构和性质受到广泛注意,但它不溶、不熔的特性也限制了它的应用.因此,如何制备可溶解碳纳米管,尤其是在水中可溶解的碳纳米管成为许多领域,特别是与生物医学相关的领域的高度重视,而化学修饰则是获得这一特性的重要手段.从碳纳米管修饰物的化学结构角度出发,综述了不同化合物对碳纳米管的水溶性修饰改性.

关键词：碳纳米管化学修饰水溶性

Application of cDNA array for studying the gene expression profile of mature appressoria of Magnaporthe grisea

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第2期8卷 88-97页

作者： JIN Qing-chao DONG Hai-tao PENG You-liang CHEN Bao-shan SHAO jing DENG Ye DAI Cheng-en FANG Yong-qi LOU Yi-chun LI You-zhi LI De-bao Bioinformatics and Gene Network Research Group School of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Key Laboratory of Molecular Plant Pathology Ministry of Agriculture China Agricultural University Beijing 100094 China Laboratory of Subtropical Bioresource Conservation and Utilization Guangxi University Nanning 530004 China

Appressorium is an infection structure of the phytopathogenic fungus Magnaporthe grisea. Analysis of gene expression profiles ofappressorium development provides insight into the molecular basis of pathogenicity and control of this fungal plant disease. A cDNA array representing 2927 unique genes based on a large EST （expressed sequence tag） database ofM. grisea strain Y34 was constructed and used to profile the gene expression patterns at mycelium and appressorium maturation stages. Compared with mycelia, 55 up-regulated and 22 down-regulated genes were identified in mature appressoria. Among 77 genes, 16 genes showed no similarity to the genome sequences of M. grisea. A novel homologue of peptidyl-prolyl cis-trans isomerase was found to be expressed at low-level in mature appressoria of M. grisea. The results indicated that the genes such as pyruvate carboxylase, phospholipid metabolism-related protein and glyceraldehyde 3-phosphate dehydrogenase involved in gluconeogenesis, lipid metabolism and glycolysis, showed differential expression in mature appressoria. Furthermore, genes such as PTHll, beta subunit of G protein and SGTI involved in cell signalling, were expressed differentially in mature appressoria. Northern blot analysis was used to confirm the cDNA array results.

关键词： Magnaporthe grisea Mature appressoria cDNA array Gene expression profile