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Risk factors for long-term prognosis of hepatocellular carcinoma patients after anatomic hepatectomy

World Journal of Clinical Cases 2020年第4期8卷 713-722页

作者： Ya-Li Tian jing-jing Ji Lu-Ning Chen Xin-Long Cui shi-Teng Liu Liang Mao Yu-Dong Qiu Bing-Bing Li Department of Anesthesiology Drum Tower Hospital Affiliated with the Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina Department of Surgery Division of Hepatobiliary and Pancreatic SurgeryDrum Tower Hospital Affiliated with the Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

BACKGROUND The risk factors for patients with major postoperative complications immediately after liver resection have been identified;however,the intermediate and longterm prognoses for these patients have yet to be *** To evaluate the factors responsible for the long-term recurrence-free survival rate in patients with hepatocellular carcinoma(HCC)following anatomic *** We performed a retrospective analysis of 74 patients with HCC who underwent precise anatomic hepatectomy at our institution from January 2013 to December *** observational endpoints for this study were the tumor recurrence or death of the HCC *** overall follow-up duration was three *** recurrence-free survival curves were plotted by the Kaplan-Meier method and were analyzed by the log-rank *** value of each variable for predicting prognosis was assessed via multivariate Cox proportional hazards regression *** The 1-year and 3-year recurrence-free survival rates of HCC patients were 68.92%and 55.41%,respectively,following anatomic liver *** results showed that the 3-year recurrence-free survival rate in HCC patients was closely related to preoperative cirrhosis,jaundice level,tumor stage,maximal tumor diameter,complications of diabetes mellitus,frequency of intraoperative hypotensive episodes,estimated blood loss(EBL),blood transfusion,fluid infusion,and postoperative infection(P<0.1).Based on multivariate analysis,preoperative cirrhosis,tumor stage,intraoperative hypotension,and EBL were identified to be predictors of 3-year recurrence-free survival in HCC patients undergoing anatomic hepatectomy(P<0.05).CONCLUSION Tumor stage and preoperative cirrhosis adversely affect the recurrence-free survival rate in HCC patients following anatomic *** long-term recurrence-free survival rate of patients with HCC is closely related to intraoperative hypotension and EBL.

关键词： Hepatocellular carcinoma Hepatectomy Risk factors Prognosis

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Co-MOFs衍生的钴基化合物催化氧化典型VOCs研究进展

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常州大学学报（自然科学版） 2024年第1期36卷 39-48页

作者：李晶张春乐史宇亮李钰莹吴楠桦常州大学环境科学与工程学院江苏常州213164 常州大学石油化工学院江苏常州213164

基于催化氧化技术在挥发性有机化合物(VOCs)末端治理方面有极高的效率,以及近年来金属有机骨架(MOFs)衍生的钴基化合物在催化氧化VOCs中的优异表现,文章总结了4种典型的钴基MOFs(ZIF-67,ZSA-1,Co-MOF-71和Co-MOF-74)及其衍生的钴基催化... 详细信息

基于催化氧化技术在挥发性有机化合物(VOCs)末端治理方面有极高的效率,以及近年来金属有机骨架(MOFs)衍生的钴基化合物在催化氧化VOCs中的优异表现,文章总结了4种典型的钴基MOFs(ZIF-67,ZSA-1,Co-MOF-71和Co-MOF-74)及其衍生的钴基催化剂的组成与制备方法,并综述了其衍生物催化氧化几种典型VOCs(甲苯、邻二甲苯、甲醛和丙酮)的研究进展。最后归纳了反应过程中空速和湿度等因素对钴基化合物催化氧化VOCs的影响,探讨了MOFs衍生的钴基催化剂的反应机理,并对MOFs衍生的钴基催化剂在VOCs氧化中的研究进行了展望。

关键词： MOFs衍生物钴基化合物 VOCs降解催化氧化

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Overexpression of ACL 1 （abaxially curled leaf 1） Increased Bulliform Cells and Induced Abaxial Curling of Leaf Blades in Rice

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Molecular Plant 2010年第5期3卷 807-817页

作者： Ling Li Zhen-Ying shi Lin Li Ge-Zhi Shen Xin-Qi Wang Lin-Sheng An jing-Liu Zhang National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China Graduate School of the Chinese Academy of Sciences 19 Yuquan Road Beijing 100039 China The Plant Breeding and Cultivation Research Institute Shanghai Academy of Agriculture Sciences 2900 Beidi Road Shanghai 201106 China

Understanding the genetic mechanism underlying rice leaf-shape development is crucial for optimizing rice configuration and achieving high yields; however, little is known about leaf abaxial curling. We isolated a rice transferred DNA （T-DNA） insertion mutant, BY240, which exhibited an abaxial leaf curling phenotype that co-segregated with the inserted T-DNA. The T-DNA was inserted in the promoter of a novel gene, ACL1 （Abaxially Curled Leaf 1）, and led to overexpression of this gene in BY240. Overexpression of ACL1 in wild-type rice also resulted in abaxial leaf curling. ACL1 encodes a protein of 116 amino acids with no known conserved functional domains. Overexpression of ACL2, the only homolog of ACL1 in rice, also induced abaxial leaf curling. RT-PCR analysis revealed high expressions of ACLs in leaf sheaths and leaf blades, suggesting a role for these genes in leaf development. In situ hybridization revealed non-tissue-specific expression of the ACLs in the shoot apical meristem, leaf primordium, and young leaf. Histological analysis showed increased number and exaggeration of bulliform cells and expansion of epidermal cells in the leaves of BY240, which caused developmental discoordination of the abaxial and adaxial sides, resulting in abaxially curled leaves. These results revealed an important mechanism in rice leaf development and provided the genetic basis for agricultural improvement.

关键词： Cell expansion leaf/vegetative development rice ACL1 ACL2 LRI T-DNA bulliform cells.

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The effects of coloring therapy on patients with generalized anxiety disorder

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Animal Models and Experimental Medicine 2022年第6期5卷 502-512页

作者： Bosomtwe Samuel Hongmei Wang Chengdong shi Yongliang Pan Yuzi Yu Weiyu Zhu Zhou jing School of Medicine Huzhou UniversityZhejiangChina Department of Nursing Gregory Catholic HospitalBuduburamCentral RegionGhana Department of Nursing West China Hospital of Sichuan UniversitySichuanChina Department of Nursing Shenzhen Baoan Maternal and Child Health HospitalGuangdongChina Department of Psychosomatic Diseases Huzhou Third People's HospitalZhejiangChina School of Teacher Education Huzhou UniversityZhejiangChina

Generalized anxiety disorder(GAD)has harmful effects on physical and mental health and quality of *** therapy has been reported to have a positive effect on improving patient anxiety and *** there are no reported clinical trials examining their effectiveness as a treatment for *** study was planned to evaluate the effectiveness of coloring therapy combined with conventional therapy in improving anxiety,depression,and positive and negative emotions with *** randomized controlled study comprising 88 GAD patients was selected for intervention in different *** control group(n=45)was given conventional antianxiety medication and physical therapy,and the experimental group(n=43)received coloring therapy combined with conventional *** Self-Rating Depression Scale,Self-Rating Anxiety Scale(SAS),Hamilton Depression Scale,Hamilton Anxiety Scale(HAMA),and Positive and Negative Affect Scale were assessed in both groups before and 3 weeks after the *** the intervention,there were statistical differences in intra-and inter-group comparisons of anxiety,depression,and positive and negative mood scales in the experimental and control groups(p.05).For GAD patients,adding coloring therapy based on conventional drug therapy and physical therapy can not only reduce depression and negative emotions but also have better effects on reducing anxiety and improving po

关键词： anxiety coloring therapy depression generalized anxiety disorder

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种鸽饲粮中添加不同水平的铜对鸽蛋品质、乳鸽组织中铜含量和血清抗氧化指标的影响

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动物营养学报 2024年第5期36卷 3049-3060页

作者：刘文丽邵玉新秦士贞张博李晶孙鸿索琰瑞赵东栋申莉李昊轩史兆国王铮甘肃农业大学动物科学技术学院兰州730070 北京市农林科学院畜牧兽医研究所北京100097 北京优帝鸽业有限公司北京101309

本试验旨在研究饲粮中添加不同水平的铜对乳鸽组织及鸽乳中铜含量、鸽蛋品质、乳鸽血清抗氧化指标等的影响。选择120对银羽王父母代种鸽,随机配对分为5组,包括1个对照组(基础饲粮中不添加铜)和4个试验组(基础饲粮中分别添加4、8、12、16... 详细信息

本试验旨在研究饲粮中添加不同水平的铜对乳鸽组织及鸽乳中铜含量、鸽蛋品质、乳鸽血清抗氧化指标等的影响。选择120对银羽王父母代种鸽,随机配对分为5组,包括1个对照组(基础饲粮中不添加铜)和4个试验组(基础饲粮中分别添加4、8、12、16 mg/kg铜),每组8个重复,每个重复3对种鸽。以CuSO_(4)·5H_(2)O(铜含量24.57%)作为铜源,各组铜含量的实测值分别为5.66、8.67、11.46、15.22、20.09 mg/kg。试验期46 d。结果表明:随着饲粮中铜添加水平的增加,鸽乳中铜含量及1~28日龄种鸽平均日采食量(ADFI)呈显著线性增加(P0.05)。以乳鸽血清CP活性及母鸽血清CAT活性作为评价种鸽饲粮铜需要量的敏感指标,进行最佳二次曲线模型评价,初步获得饲粮中铜的适宜添加水平分别为3.96及7.96 mg/kg。由此可见,在种鸽饲粮中添加适宜水平的铜可提升鸽蛋品质及母鸽、乳鸽抗氧化能力。

关键词：鸽子铜蛋品质抗氧化性能

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3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota

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World Journal of Gastroenterology 2022年第46期28卷 6522-6536页

作者： Qiong-Zi He Peng Wei Jun-Zhi Zhang Tong-Tong Liu Kun-Qun shi Huan-Huan Liu jing-Wei Zhang shi-Jia Liu Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina College of The First Clinical Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198Jiangsu ProvinceChina

BACKGROUND 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid(BT2)is a benzothiophene carboxylate derivative that can suppress the catabolism of branched-chain amino acid(BCAA)-associated mammalian target of rapamycin complex 1(mTORC1)*** studies have demonstrated the therapeutic effects of BT2 on arthritis,liver cancer,and kidney ***,the effects of BT2 on ulcerative colitis(UC)are *** To investigate the anti-UC effects of BT2 and the underlying *** Mouse UC models were created through the administration of 3.5%dextran sodium sulfate(DSS)for 7 *** mice in the treated groups were administered salazosulfapyridine(300 mg/kg)or BT2(20 mg/kg)orally from day 1 to day *** the end of the study,all of the mice were sacrificed,and colon tissues were removed for hematoxylin and eosin staining,immunoblot analyses,and immunohistochemical *** levels were measured by flow *** contents of BCAAs including valine,leucine,and isoleucine,in mouse serum were detected by liquid chromatography-tandem mass spectrometry,and the abundance of intestinal flora was analyzed by 16S ribosomal DNA *** Our results revealed that BT2 significantly ameliorated the inflammatory symptoms and pathological damage induced by DSS in ***2 also reduced the production of the proinflammatory cytokines interleukin 6(IL-6),IL-9,and IL-2 and increased the anti-inflammatory cytokine IL-10 *** addition,BT2 notably improved BCAA catabolism and suppressed mTORC1 activation and cyclooxygenase-2 expression in the colon tissues of UC ***,highthroughput sequencing revealed that BT2 restored the gut microbial abundance and diversity in mice with *** with the DSS group,BT2 treatment increased the ratio of Firmicutes to Bacteroidetes and decreased the abundance of Enterobacteriaceae and *** Our results indicated that BT2 significantly ameliorated DSS-induced UC and that the late

关键词： 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid Ulcerative colitis Mechanistic target of rapamycin complex 1 Intestinal flora Dextran sodium sulfate Cyclooxygenase-2

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Rational construction of high-active CO_(3)O_(4) electrocatalysts for oxygen evolution reaction

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Nano Research 2023年第1期16卷 624-633页

作者： Tianyun Zhang shichao Zhao Chuanming Zhu jing shi Chao Su Jiawen Yang Meng Wang Jun Li Junhui Li Pingle Liu Conghui Wang College of Chemical Engineering Xiangtan UniversityXiangtan 411105China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Analytical Instrumentation center Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China

Rational construction of high-efficiency electrocatalysts for oxygen evolution reaction(OER)is critical for renewable-energy technologies,but it is highly challenging to rationally regulate their surface structures to improve the OER ***,we proposed a“model-etching”strategy to investigate chemical etching of CO_(3)O_(4).The cubic CO_(3)O_(4)nanocrystals enclosed by well-defined facets are synthesized as model crystals,whose uniform surface structures allow us to study the etching mechanism at atomic *** kinetics study together with DFT calculations discloses that{111}facets,the highly active facets for OER,serve as etch-stop facets in the etching reaction and H_(2)SO_(4)molecules play a special role in creating surface Co2^(+),the active center of *** results direct us to rationally optimize the surface structures of CO_(3)O_(4) to develop highly active OER *** favorable performance of overpotential(η)and the Tafel slope decrease even to 268 mV@10 mA·cm−2 and 74 mV·dec−1,*** general,our study shows that chemical etching of model crystals could help us rationally construct high-efficiency electrocatalysts.

关键词： cobalt oxide chemical etching high active facets oxygen evolution reaction surface structure

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山东省14~18岁寄宿高中生生活质量及其影响因素分析

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中国健康教育 2024年第2期40卷 125-131页

作者：江靖雯张嘉文罗晓蕾李改云丁明峰李懿伦韩雪梅兰州大学公共卫生学院甘肃兰州730000

目的了解山东省寄宿高中生生活质量及其影响因素,为提高寄宿高中生生活质量提供支持。方法资料来源于中国青少年健康现状及健康相关行为开放数据集(DYH)2020—2021学年的调查数据,获取6922名14~18岁高中生的相关信息,利用儿童青少年... 详细信息

目的了解山东省寄宿高中生生活质量及其影响因素,为提高寄宿高中生生活质量提供支持。方法资料来源于中国青少年健康现状及健康相关行为开放数据集(DYH)2020—2021学年的调查数据,获取6922名14~18岁高中生的相关信息,利用儿童青少年生活质量量表(QLSCA)评价寄宿高中生生活质量情况。应用多元线性回归模型分析影响高中生生活质量的相关因素。结果 6922名高中生中,寄宿生4920人(71.08%),非寄宿生2002人(28.92%)。寄宿高中生同伴关系、师生关系、学习能力与态度、自我概念、负性情绪、作业态度、生活机会性、活动机会性、运动能力、自我满意度和生活质量总分低于非寄宿生,差异具有统计学意义(P<0.05)。多元线性回归分析显示,社会心理功能影响程度前3位的因素为:睡眠时长(β=0.18)、父母关系(β=0.15)和家庭经济条件(β=0.08);生理心理健康功能影响程度前3位的因素为睡眠时长(β=0.15)、父母关系(β=0.11)和是否独生(β=-0.02);生活环境功能影响程度前3位的因素为父母关系(β=0.19)、家庭经济条件(β=-0.12)、睡眠时长(β=0.11)和性别(β=0.11);生活质量满意度影响程度前3位的因素为父母关系(β=0.27)、睡眠时长(β=0.17)、家庭经济条件(β=0.08)和性别(β=-0.08);生活质量总分影响程度前3位的因素为父母关系(β=0.22)、睡眠时长(β=0.21)和家庭经济条件(β=0.08)。结论性别、居住地、是否为独生子女、父母受教育水平、家庭经济条件、睡眠时长、父母关系是影响寄宿高中生生活质量的主要因素。山东省寄宿高中生生活质量较低,应采取措施进行改善。

关键词：青少年寄宿生活质量影响因素回归分析

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湖泊水体中溶解氧和高锰酸盐指数多时间尺度相关性的分形测量

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中国沼气 2024年第2期42卷 47-54页

作者：邓国海庞仁燕张惠李静都鸿菲史凯四川省生态环境监测总站四川成都610074 西华师范大学环境科学与工程学院嘉陵江流域生态环境保护与污染防治南充市重点实验室四川南充637009

深入理解水质指标之间的相关性演化,有助于阐明水华发生及演化机理。为探究湖泊水体中溶解氧(DO)和高锰酸盐指数(I Mn)水质指标的多时间尺度非线性相关性特征及演化规律,应用集合经验模态分解法(EEMD)和多重分形去趋势互相关分析法(MFDC... 详细信息

深入理解水质指标之间的相关性演化,有助于阐明水华发生及演化机理。为探究湖泊水体中溶解氧(DO)和高锰酸盐指数(I Mn)水质指标的多时间尺度非线性相关性特征及演化规律,应用集合经验模态分解法(EEMD)和多重分形去趋势互相关分析法(MFDCCA),对泸沽湖和邛海湖2022年2月1日~2023年8月31日DO和I Mn之间相关性的长期持续性及多重分形特征进行研究。结果表明:1)泸沽湖和邛海湖DO演化主要受到不同时间尺度上气象条件的影响。前8个模态叠加后构成DO的高频成分模态,可以更好地反映藻类生长对DO的影响,而减少气候季节变化对DO的影响。2)在研究时间尺度内,DO高频分量和I Mn指标相关作用的强度随时间以幂函数形式缓慢衰减,其相关性在一定时高的U形变化。气象条件变化是导致Δh值和藻密度具有互相关关系的主要原因。研究湖泊水体中DO和I Mn之间相关性的多重分形变化模式,可为完善湖泊水体中藻类演化动态及水华预测预警模型提供新的动力参数。

关键词： DO 高锰酸盐指数集合经验模态分解多重分形

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Investigation of regulating rheological properties of water-based drilling fluids by ultrasound

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Petroleum Science 2021年第6期18卷 1698-1708页

作者： Wei-An Huang jing-Wen Wang Ming Lei Gong-Rang Li Zhi-Feng Duan Zhi-Jun Li shi-Fu Yu School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Sinopec Shengli Petroleum Engineering Co. Ltd.Drilling Technology Research InstituteDongying257017ShandongChina Oil and Gas Technology Research Institute of Changqing Oilfield Branch Xi'an710018ShaanxiChina Key Laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Qingdao266580ShandongChina sPetroChina Daqing Oilfield Co. Ltd.Research Institute of Oil Production EngineeringDaqing163000HeilongjiangChina

Regulating rheological properties of water-based drilling fluids has always been a hot *** paper proposed a new method for regulating rheological properties of water-based drilling fluids by ultrasonic *** experimental results showed that the ultrasound increased the viscosity and yield point of bentonite suspension by reducing the particle size of clay,destroying the network structure between clay particles,increasing the mud yield and the cation exchange capacity of bentonite,and promoting the hydration dispersion of *** change of rheological property showed a memory effect at room temperature and high ***,the ultrasonic energy affected the network structure between clays and polymer chains,thus regulating the rheological properties of the bentonite-polymer *** two types of drilling fluids investigated,the rheology of the poly-sulfonate drilling fluid was regulated by damaging the grid structure between additives and clays by low-power ultrasound and reducing the clay particle size by high-power ultrasound,while the rheology of the deep-water drilling fluid was mainly regulated by disentangling the spatial grid structure between ***,ultrasound showed no effect on the lubricity,inhibition and stability of drilling fluids,which proved the feasibility of ultrasound to regulate rheological properties of water-based drilling fluids.

关键词： Ultrasound Suspension Water-based drilling fluid Rheological property

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