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Stark splitting of intense red emission for Er^(3+)in O_(h) symmetry sites realizing optical temperature sensing in biological applications

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Rare Metals 2024年第3期43卷 1263-1274页

作者： Yue Guo Lin-Jun Qin jing Xu Xiao-ping Jiang Xiao-Yu Yue Yi Hou Hao Shi Li-Xi Wang Qi-Tu Zhang Collage of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing211816China

Optical temperature sensing based on the fluorescence intensity ratio(FIR)of red emission for lanthanide ions holds significant relevance in non-contact temperature measurement for biological *** this study,the perovskite-structured KZnF_(3)is utilized as a host material for Er^(3+)to achieve a high-purity upconversion(UC)red *** observed Stark splitting of the red emission peak provides evidence of the energy level splitting of Er^(3+).Group theory is employed to decompose the spectral branching of Er^(3+)under the point group symmetry of KZnF_(3),allowing for the derivation of Stark splitting energy levels induced by the crystal field *** optical temperature-sensing behavior of the red UC luminescence was investigated,specifically examining the FIR of the splitting sub-peaks,which exhibited an exponential relationship with *** KZnF_(3):Yb^(3+),Er^(3+)demonstrated a relative sensitivity(S_(r))of 0.00182%·K^(-1)at 298 K,highlighting its excellent response to *** vivo bio-thermometry experiments conducted on chicken breast validated the material's ability to penetrate biological tissues and showed its significant sensitivity of the FIR to *** results establish KZnF_(3):Yb^(3+),Er^(3+)as a promising material for optical thermometry in various biological applications.

关键词： KZnF_(3) Er^(3+) Upconversion luminescence Stark splitting Temperature sensing

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Observation of therapeutic effect of lamp irradiation combined with purple gromwell oil gauze on alleviating intestinal colic in patients

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1749-1755页

作者： Bi-Zhi Cen Yin-Song Chen Li-ping Li jing-Wen Wu Yan-Fen Xie Department of Tumor Center Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina

BACKGROUND Intestinal colic is a common complication in patients who have undergone radical surgery for colorectal *** Chinese medicine has advantages,including safety and stability,for the treatment of intestinal *** irra-diation for abdominal ironing has been applied in the treatment of many gas-trointestinal *** gromwell oil has the effects of clearing heat,cooling blood,reducing swelling,and relieving *** The general effective rate in the observation group was 95.00%,which was significantly higher than that in the control group(86.67%,Pduration of symptoms between the groups(P>0.05).After 1,2,3,and 4 d of treatment,the duration of symptoms in both groups were decreased,and the duration in the observation group was significantly lower than that in the control group(96.54±9.57 vs 110.45±11.23,87.26±12.07 vs 104.44±11.68,80.45±16.21 vs 99.44±14.95,73.18±15.58 vs 92.17±14.20;P0.05).CONCLUSION The use of lamp irradiation combined with purple gromwell oil gauze in patients with intestinal colic after radical surgery for colorectal cancer can reduce symptom duration,alleviate intestinal colic,and improve treatment efficacy,and this approach is *** is worth promoting the use of this treatment in clinical practice.

关键词： Lamp irradiation Purple gromwell oil gauze Intestinal colic Radical surgery for colorectal cancer Therapeutic effect

Design of dual-functional protic porous ionic liquids for boosting selective extractive desulfurization

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Petroleum Science 2024年第4期21卷 2817-2829页

作者： Jin-Rui Zhang Jie Yin jing He Hong-Shun Ran Wei Jiang Hong-ping Li Wen-Shuai Zhu Hua-Ming Li Ming Zhang School of the Environment and Safety Engineering & Institute for Energy Research Jiangsu University School of Chemistry and Chemical Engineering Jiangsu University

Porous ionic liquids have demonstrated excellent performance in the field of separation, attributed to their high specific surface area and efficient mass transfer. Herein, task-specific protic porous ionic liquids(PPILs) were prepared by employing a novel one-step coupling neutralization reaction strategy for extractive desulfurization. The single-extraction efficiency of PPILs reached 75.0% for ***, adding aromatic hydrocarbon interferents resulted in a slight decrease in the extraction efficiency of PPILs(from 45.2% to 37.3%, 37.9%, and 33.5%), indicating the excellent extraction selectivity of PPILs. The experimental measurements and density functional theory calculations reveal that the surface channels of porous structures can selectively capture dibenzothiophene by the stronger electrophilicity(Eint(HS surface channel/DBT)=-39.8 kcal mol-1), and the multiple extraction sites of ion pairs can effectively enrich and transport dibenzothiophene from the oil phase into PPILs through π...π, C-H...π and hydrogen bonds interactions. Furthermore, this straightforward synthetic strategy can be employed in preparing porous liquids, offering new possibilities for synthesizing PPILs with tailored functionalities.

关键词： Protic porous ionic liquids Extractive desulfurization Selectivity Density functional theory

FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis

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Molecular Plant 2024年第5期17卷 772-787页

作者： Baiyan Lu Shengnan Wang Hanqian Feng jing Wang Kaixing Zhang Yilin Li ping Wu Minmin Zhang Yanshu Xia Chao Peng Chao Li School of Life Sciences East China Normal UniversityShanghai 200241China National Facilty for Protein Science Shanghai Zhangjang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The phytohormone auxin plays a pivotal role in governing plant growth and *** the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX(TIR1/AFB)receptors function in both the nucleus and cytoplasm,the mechanism governing the distribution of TIR1/AFBs between these cellular compartments remains *** this study,we demonstrate that auxin-mediated oxidation of TIR1/AFB2 is essential for their targeting to the *** showed that small active molecules,reactive oxygen species(ROS)and nitric oxide(NO),are indispensable for the nucleo-cytoplasmic distribution of TIR1/AFB2 in trichoblasts and root *** studies revealed that this process is regulated by the FERONIA receptor kinase–NADPH oxidase signaling ***,ROS and NO initiate oxidative modifications in TIR1C140/516 and AFB2C135/511,facilitating their subsequent nuclear *** oxidized forms of TIR1C140/516 and AFB2C135/511 play a crucial role in enhancing the function of TIR1 and AFB2 in transcriptional auxin ***,our study reveals a novel mechanism by which auxin stimulates the transport of TIR1/AFB2 from the cytoplasm to the nucleus,orchestrated by the FERONIA–ROS signaling pathway.

关键词： FERONIA TIR1/AFBs oxidative modification nucleo-cytoplasmic distribution root hair development

Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B:A meta-analysis

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World Journal of Hepatology 2024年第3期16卷 465-476页

作者： Shi-Yi Liu Dian Wang jing Liu Lu-ping Yang Gong-Ying Chen Department of Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Medicine Hangzhou Normal UniversityHangzhou 310011Zhejiang ProvinceChina Department of Infectious and Hepatology Diseases Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

BACKGROUND Although hepatitis B virus infection is the leading cause of chronic liver injury globally,nonalcoholic fatty liver disease(NAFLD)is gradually gaining attention as another major chronic liver *** number of patients having chronic hepatitis B(CHB)with concomitant hepatic steatosis has *** To analyze the effect of NAFLD on the response to antiviral treatment in patients with *** Relevant English studies were systematically searched across PubMed,EMBASE,Web of Science,and Cochrane Library until October *** in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were *** Of the 2502 retrieved studies,11 articles were finally *** response until 48 wk(OR=0.87,95%CI:0.50–1.53,P=0.000)and 96 wk(OR=0.35,95%CI:0.24–0.53,P=0.24)and virological response until 96 wk(OR=0.80,95%CI:0.43–1.49,P=0.097)were lower in patients with hepatic steatosis than in patients with CHB *** Hepatic steatosis lowers the biochemical response to antiviral treatment in patients with CHB.

关键词： Nonalcoholic fatty liver disease Hepatitis B virus Antiviral treatment effect Meta-analysis

Latest insights into the global epidemiological features,screening,early diagnosis and prognosis prediction of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第20期30卷 2638-2656页

作者： Yi-Xin Zhao He-ping Zhao Meng-Yao Zhao Yan Yu Xi Qi Ji-Han Wang jing Lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072Shaanxi ProvinceChina

As a highly invasive carcinoma,esophageal cancer(EC)was the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide in *** squamous cell carcinoma(ESCC)is the major histological subtype of EC,and its incidence and mortality rates are decreasing *** to the lack of specific early symptoms,ESCC patients are usually diagnosed with advanced-stage disease with a poor prognosis,and the incidence and mortality rates are still high in many countries,especially in ***,enormous challenges still exist in the management of ESCC,and novel strategies are urgently needed to further decrease the incidence and mortality rates of *** the key molecular mechanisms underlying ESCC pathogenesis have not been fully elucidated,certain promising biomarkers are being investigated to facilitate clinical *** the advent and advancement of highthroughput technologies,such as genomics,proteomics and metabolomics,valuable biomarkers with high sensitivity,specificity and stability could be identified for ***,we aimed to determine the epidemiological features of ESCC in different regions of the world,especially in China,and focused on novel molecular biomarkers associated with ESCC screening,early diagnosis and prognosis prediction.

关键词： Esophageal squamous cell carcinoma Epidemiology Diagnosis Genomics Proteomics Metabolomics

Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa

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Journal of Integrative Plant Biology 2024年第6期66卷 1158-1169页

作者： Yin Chen Jian-ping Huang Yong-Jiang Wang Meng-Ling Tu Junheng Li Bingyan Xu Guoqing Peng jing Yang Sheng-Xiong Huang State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor *** that two C-10 modified camptothecin derivatives,topotecan and irinotecan,have been approved as potent anticancer agents,there is a critical need for methods to access other aromatic ringfunctionalized congeners(e.g.,C-9,C-10,etc.).However,contemporary methods for chemical oxidation are generally harsh and low-yielding when applied to the camptothecin scaffold,thereby limiting the development of modified *** herein,we have identified four tailoring enzymes responsible for C-9 modifications of camptothecin from Nothapodytes tomentosa,via metabolomic and transcriptomic *** consist of a cytochrome P450(Nt CPT9H)which catalyzes the regioselective oxidation of camptothecin to 9-hydroxycamptothecin,as well as two methyltransferases(Nt OMT1/2,converting 9-hydroxycamptothecin to 9-methoxycamptothecin),and a uridine diphosphate-glycosyltransferase(Nt UGT5,decorating 9-hydroxycamptothecin to9-β-D-glucosyloxycamptothecin).Importantly,the critical residues that contribute to the specific catalytic activity of Nt CPT9H have been elucidated through molecular docking and mutagenesis *** work provides a genetic basis for producing camptothecin derivatives through metabolic *** will hasten the discovery of novel C-9 modified camptothecin derivatives,with profound implications for pharmaceutical manufacture.

关键词： camptothecin biosynthesis enzymatic assay Nothapodytes tomentosa tailoring enzyme transcriptomic analysis

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Salivary metabolites are promising noninvasive biomarkers of druginduced liver injury

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World Journal of Gastroenterology 2024年第18期30卷 2454-2466页

作者： Si-Miao Yu Hao-Cheng Zheng Si-Ci Wang Wen-Ya Rong ping Li jing jing Ting-Ting He Jia-Hui Li Xia Ding Rui-Lin Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology of Traditional Chinese Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China The First Clinical Medical College Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Drug-induced liver injury(DILI)is one of the most common adverse events of medication use,and its incidence is ***,early detection of DILI is a crucial challenge due to a lack of biomarkers and noninvasive *** To identify salivary metabolic biomarkers of DILI for the future development of noninvasive diagnostic *** Saliva samples from 31 DILI patients and 35 healthy controls(HCs)were subjected to untargeted metabolomics using ultrahigh-pressure liquid chromatography coupled with tandem mass *** analyses,including partial least squares-discriminant analysis modeling,t tests and weighted metabolite coexpression network analysis(WMCNA),were conducted to identify key differentially expressed metabolites(DEMs)and metabolite *** we utilized least absolute shrinkage and selection operato and random fores analyses for biomarker *** use of each metabolite and metabolite set to detect DILI was evaluated with area under the receiver operating characteristic *** We found 247 differentially expressed salivary metabolites between the DILI group and the HC *** WMCNA,we identified a set of 8 DEMs closely related to liver injury for further prediction ***,the distinct separation of DILI patients and HCs was achieved with five metabolites,namely,12-hydroxydodecanoic acid,3-hydroxydecanoic acid,tetradecanedioic acid,hypoxanthine,and inosine(area under the curve:0.733-1).CONCLUSION Salivary metabolomics revealed previously unreported metabolic alterations and diagnostic biomarkers in the saliva of DILI *** study may provide a potentially feasible and noninvasive diagnostic method for DILI,but further validation is needed.

关键词： Drug-Induced liver injury Salivary Metabolomics Biomarker Weighted metabolite Coexpression network analysis Machine learning Noninvasive Diagnostic method Metabolites

Postoperative body weight change and its influencing factors in patients with gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2242-2254页

作者： Yan Li Li-Hua Huang Hui-Di Zhu ping He Bei-Bei Li Li-jing Wen Department of Gastrointestinal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Nursing The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The high incidence and mortality of gastric cancer(GC)pose a significant threat to human life and health,and it has become an important public health challenge in *** weight loss is a common complication after surgical treatment in patients with GC and is associated with poor prognosis and GC ***,current attention to postoperative weight change in GC patients remains insufficient,and the descriptions of postoperative weight change and its influencing factors are also *** To investigate body weight changes in patients with GC within 6 mo after gastrectomy and identify factors that influence dynamic body weight *** We conducted a prospective longitudinal study of 121 patients with GC and collected data before(T0)and 1(T1),3(T2),and 6(T3)mo after gastrectomy using a general data questionnaire,psychological distress thermometer,and body weight *** general estimation equation(GEE)was used to analyze the dynamic trends of body weight changes and factors that influence body weight changes in patients with GC within 6 mo of *** The median weight loss at T1,T2,and T3 was 7.29%(2.84%,9.40%),11.11%(7.64%,14.91%),and 14.75%(8.80%,19.84%),*** GEE results showed that preoperative body mass index(BMI),significant psychological distress,religious beliefs,and sex were risk factors for weight loss in patients with GC within 6 mo after gastrectomy(P<0.05).Compared with preoperative low-weight patients,preoperative obese patients were more likely to have weight loss(β=14.685,P<0.001).Furthermore,patients with significant psychological distress were more likely to lose weight than those without(β=2.490,P<0.001),and religious patients were less likely to lose weight 6 mo after gastrectomy than those without religious beliefs(β=-6.844,P=0.001).Compared to female patients,male patients were more likely to experience weight loss 6 mo after gastrectomy(β=4.262,P=0.038).CONCLUSION Male patients wi

关键词： Gastric cancer Gastrectomy Weight loss Influencing factors Body mass index