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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Controlling Flow Instability in Straight Spur Gear Forging Using Numerical Simulation and Response Surface Method

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Acta Metallurgica Sinica(English Letters) 2018年第1期31卷 82-96页

作者： Zhao-Yang Jin nan-nan Li Kai Yan jing-Xin Chen Dong-Lai Wei Zhen-Shan cui School of Mechanical Engineering Yangzhou University School of Mechanical Engineering Shanghai Dianji University National Die and Mold CAD Engineering Research Center Shanghai Jiao Tong University

Workability domain without the onset of flow instability was developed by numerical simulation and response surface method （RSM） for complex-shaped straight spur gear forging. The processing map of AZ31B alloys was calculated from flow stress curves and then integrated with the finite element model to simulate the distribution of flow instability in the straight spur gear undergoing isothermal forging process. Occurrence of flow instability depends on forging temperature, punch velocity and billet reduction. Taking forging temperature and punch velocity as design variables, while billet reduction as response variable, RSM of workability domain was established. Analysis of variance indicates that forging temperature is the most significant factor determining the appearance of flow instability in the forged gear. Flow instability is easier to take place at lower temperatures of 250 and 300 ℃ in the early stage of forging but at higher temperatures of 350 and 400 ℃ in the later stage of forging, which is attributed to different deformation mechanisms and dynamic recrystallization behaviors at different temperatures or deformation levels. Meanwhile, increasing punch velocity further reduces the workability of the forged gear. Four different processing paths were chosen to carry out the gear forging trials. Visual observations and metallographic examinations demonstrate that the developed workability domain contributes to optimization of forging parameters.

关键词： Processing map Finite element method Response surface method Straight spur gear Magnesium alloy

Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules

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Science China Chemistry 2025年第1期68卷 264-272页

作者： Xueqing Ma Yingying Cheng Yuqiang Liu Xinming Zheng Guangliu Ran Hongxiang Li Xinyue cui Andong Zhang Wenkai Zhang Pei Cheng Wenchao Huang Zhishan Bo Beijing Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal University College of Textiles and Clothing State Key Laboratory of Bio-fibers and Eco-textiles Qingdao University Key State Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of Technology Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University

Understanding the effect of intermolecular interaction on the growth dynamic of active layers is critical for advancing organic solar cells(OSCs). However, the diverse structure of donors and acceptors makes the research challenging. Additives with customizable structures and properties could simplify this complexity. Herein, we meticulously tailor two additives of 3,4-ethylenedioxythiophene(EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene(DBEDOT), possessing distinct intermolecular interaction features to elaborate the inherent relationship. It is found that varied interaction strengths can alter film formation processes. The enhanced intermolecular interaction between the DBEDOT and non-fullerene acceptor BTP-e C9-4F results in pre-aggregation and longer crystallization duration of BTP-e C9-4F, facilitating the formation of films with compact molecular packing and decent phase separation. Thus, exciton dissociation and charge transport become more efficient. Finally, devices processed with DBEDOT exhibit a remarkable power conversion efficiency of 19.35% in small-area OSCs and 14.11% in bladecoated 5 cm × 5 cm organic solar mini-modules. Especially, OSCs can maintain 80% of their initial efficiency after continuous annealing at 85 °C for over 2,100 h.

关键词： organic solar cell non-fullerene acceptor film growth molecular packing intermolecular interaction

Contrast in vulnerability to freezing-induced xylem embolism contributes to divergence in spring phenology between diffuse-and ring-porous temperate trees

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Forest Ecosystems 2022年第6期9卷 734-744页

作者： Ai-Ying Wang Han-Xiao cui Xue-Wei Gong jing-jing Guo nan Wu Guang-You Hao School of Life Sciences and Engineering Shenyang UniversityShenyang110044LiaoningChina Liaoning Key Laboratory of Urban Integrated Pest Management and Ecological Security College of Life Science and BioengineeringShenyang UniversityShenyang110044LiaoningChina CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang110016China University of Chinese Academy of Sciences Beijing100049China Tree Laboratory Shenyang Academy of Landscape-gardeningShenyang110016LiaoningChina

Background:The spring phenology and growth strategy of temperate tree species can be strongly linked to their sensitivity to frosts,which deserve more profound investigations under the background of climate warming particularly considering the advancement of spring phenology as well as the increase in frequency and intensity of spring cold ***:Spring phenologies,stem radial growth characteristics,frost sensitivity of leaves and stem hydraulic systems were studied in five diffuse-porous and five ring-porous temperate tree species under a common garden ***:The results showed that the spring leaf phenology of the diffuse-porous species was one to two weeks earlier than that of the ring-porous *** ring-porous species had significantly higher stem hydraulic conductivity than the diffuse-porous species(1.81 and 0.95 kg·m^(-1)·s^(-1)·MPa^(-1),P<0.05)but were more vulnerable to freeze-thaw induced xylem embolism than the *** a simulated freeze-thaw event,the average percentage loss of hydraulic conductivity in the current year shoots increased from 26.0%(native embolism)to 86.7%in the ring-porous species,while it only increased from 21.3%to 38.3%in the diffuse-porous *** spring phenology was clearly correlated with vulnerability to freeze-thaw induced embolism,with the more vulnerable ring-porous species exhibited substantially delayed phenology to reduce risks of catastrophic hydraulic dysfunction during spring ***,ring-porous species can offset the postponed onset of growth and gained even higher annual growth due to significantly higher hydraulic efficiency and leaf gas exchange ***:Contrasts between ring-porous and diffuse-porous species in resistance to freeze-thaw induced embolism suggest that they face different selective pressures from early spring frosts,which may at least be partially responsible for their divergence in spring phenology and growth strategy and can potentially lead to di

关键词： Diffuse-porous trees Freeze-thaw cycle Frost damage Ring-porous trees Spring phenology Xylem embolism

Translation of steel surface defect detection algorithm with fusion of multiple attention detection heads

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Optoelectronics Letters 2025年

作者： SHI Tao cui Jie LI Song Tianjin University of Technology， School of Electrical Engineering and Automation North China University of Science and Technology， School of Electrical Engineering

This paper proposes an end-to-end defect detection algorithm model called YOLOv5-CJ to address the issues of missed detections and low accuracy in visual steel surface defect detection. By incorporating the C3＿MSBlock module， which is designed based on Res2Net and contains multi-scale information， into the backbone network， the model can represent multi-scale features at a finer granularity level and increase the network's receptive field. In the detection head， the DyHead attention mechanism is introduced， which integrates scale awareness， spatial awareness， and task awareness， to help the model better cope with complex industrial scenes with large background interference， significant defect scale variations， and easily confused defect categories. Soft NMS is employed to enhance the recognition capability in overlapping regions. Experimental results demonstrate that the proposed YOLOv5-CJ model outperforms YOLOv5s，achieving an average precision (mAP0.5 and mAP0.5:0.95) improvement of 1.9% and 7.2% on the NEU-DET dataset， and 5.3% and 4.3% on the GC10-DET dataset， respectively， validating the feasibility and effectiveness of the proposed model.

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CEO自恋对高管团队成员工作幸福感的影响:CEO谦卑与领导关系认同的作用

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管理工程学报 2025年第2期39卷 206-220页

作者：尹奎赵景宋萌崔国东董念念北京科技大学经济管理学院北京100083 中国人民大学劳动人事学院北京100872 北京工业大学经济管理学院北京100124 山东大学山东省人才发展战略研究院山东济南250100

自恋的CEO在企业中比比皆是,会对员工与组织产生深远影响,而CEO谦卑特质是重要的情境因素。高管团队成员直面CEO并担负着组织内部重要的领导职责,对CEO自恋特质的感知和反应更深刻,其工作幸福感可能也更容易受到影响。基于关系认同理论... 详细信息

自恋的CEO在企业中比比皆是,会对员工与组织产生深远影响,而CEO谦卑特质是重要的情境因素。高管团队成员直面CEO并担负着组织内部重要的领导职责,对CEO自恋特质的感知和反应更深刻,其工作幸福感可能也更容易受到影响。基于关系认同理论,本文构建了一个有中介的调节效应模型,对56位CEO与319位TMT成员的配对数据进行分析,结果表明:CEO自恋对TMT成员工作幸福感产生负向影响;CEO谦卑能够弱化CEO自恋对TMT成员有关领导关系认同的消极影响;TMT成员对领导关系的认同积极影响工作幸福感,中介了CEO谦卑对CEO自恋与TMT成员工作幸福感关系的调节作用。研究拓展了领导自恋影响员工工作幸福感的研究层次与边界情境,揭示了领导关系认同在CEO谦卑弱化CEO自恋消极影响效应中的内在机制,验证了不同领导组合相对于单一领导对领导关系认同与工作幸福感的增强更具有效性,因而丰富了工作幸福感影响因素研究的主体,对CEO的遴选与培训具有潜在的指导意义。

关键词： CEO自恋 CEO谦卑工作幸福感领导关系认同

High-voltage LiCoO_(2) cathodes for high-energy-density lithiumion battery

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Rare Metals 2022年第12期41卷 3946-3956页

作者： jing-Chao Zhang Zhe-Dong Liu cui-Hua Zeng Jia-Wei Luo Yi-Da Deng Xiao-Ya cui Ya-nan Chen School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Beijing Frontier Research Center for Biological Structures Tsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China

As the earliest commercial cathode material for lithium-ion batteries,lithium cobalt oxide(LiCoO_(2)) shows various advantages,including high theoretical capacity,excellent rate capability,compressed electrode density,*** now,it still plays an important role in the lithium-ion battery *** to these advantages,further increasing the charging cutoff voltage of LiCoO_(2)to guarantee higher energy density is an irresistible development trend of LiCoO_(2)cathode materials in the ***,using high charging cutoff voltage may induce a lot of negative effects,especially the rapid decay of cycle *** are mainly caused by rapid destruction of crystal structure and aggravation of interface side reaction at high voltage during the ***,how to maintain a stable crystal structure of LiCoO_(2)to ensure the excellent long cycle performance at high voltage is a hot research issue in the further application of LiCoO_(2).In this review,we summarized the failure causes and extensive solutions of LiCoO_(2)at high voltage and promoted some new modification ***,the development trend of solving the failure problem of high-voltage LiCoO_(2)in the future such as defect engineering and high-temperature shock technique is also discussed.

关键词： Lithium-ion battery Lithium cobalt oxide(LiCoO_(2))cathode High voltage Cycle performance Crystal structure

Review of Market Power Assessment and Mitigation in Reshaping of Power Systems

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1067-1084页

作者： nan Shang Yi Ding Wenqi cui Energy Development Research Institute.China Southern Power Grid GuangzhouChina College of Electrical Engineering Zhejiang UniversityHangzhouChina Department of Electrical and Computer Engineering University of WashingtonSeattleUSA

The deregulation of the power industry requires avoiding market power abuse to maintain the market competitiveness. To this end, a sequence of assessment measurements or mitigation mechanisms is required. Meanwhile, the increasing renewable energy resources(RESs) and flexible demand response resources(DRSs) are changing the behaviors of market participants and creating new cases of market power *** new circumstances bring the new evaluation and control methods of market power to the forefront. This paper provides a comprehensive review of market power in the reshaping of power systems due to the increasing RES and the development of DRS. The market power at the supply side, demand side,and in the multi-energy system is categorized and reviewed. In addition, the applications of market power supervision measures in the US, the Nordics, UK, and China are ***, the unsolved issues, possible key technologies,and potential research topics on market power are discussed.

关键词： Market power renewable energy source(RES) flexible demand response source(DRS) assessment mitigation

A review on numerical studies of airflow dynamics and particle deposition in human respiratory system Author links open overlay panel

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Particuology 2024年第8期91卷 351-377页

作者： Hao jing Xinguang cui School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan430074China

Accurate assessment and prediction of airflow dynamics and particle deposition in the human respiratory tract are essential for human health,involving inhaled drugs for treating various diseases and toxic particles that can cause *** intricate process involves complex multiphase flow with distinct respiratory *** fluid dynamics(CFD)acts as a bridge,overcoming the limitations of in vivo and in vitro experiments and providing a means to fully comprehend and reveal the fundamental mechanisms of respiratory flow and particle behavior on a microscopic *** paper provides a comprehensive overview and concise summary of recent advancements in the numerical simulation of airflow and particle deposition in the human respiratory ***,it summarizes the transition of respiratory tract models from segmented models to emerging physiological characteristic models and whole-lung airway models,and the latest developments on the effects of key factors such as geometric variations,respiratory patterns,and particle physical/chemical properties on respiratory flow and particle deposition.A notable focus of this review is on emerging physiological characteristics models and their associated complex airflow and particle dynamics inside *** paper concludes with recommendations for future research to further advance the development of this field.

关键词： Airflow dynamics Particle deposition Human respiratory system Numerical modeling