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Activating transcription factor 5 regulates lipid metabolism in adipocytes

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Science Bulletin 2016年第23期61卷 1802-1809页

作者： jing-hui jiang Yue Zhao Liu-Ling Xiao Cui-Song Zhu Shu-Fen Li Xi Li Key Laboratory of Metabolic Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Basic Medical SchoolShanghai 200032 China jiangsu Key Laboratory of Molecular Medicine School of Medicine Nanjing University Nanjing 210093 China Chongqing Medical University Chongqing 400016 China

Activating transcription factor 5(ATF5) is a member of the activating transcription factor/cA MP response element binding protein(ATF/CREB) family, and is highly expressed in liver and adipose tissue. Previous reports have shown that ATF5 promoted 3T3-L1 preadipocytes differentiation. In this study, we found that ATF5 was highly expressed in mature adipocytes, suggesting a potential role of ATF5 in mature adipocytes, which has not been reported previously. To understand the function of ATF5 in mature adipocytes, we knocked down the expression of ATF5 in 3T3-L1 mature adipocytes and observed decreased lipid droplets. Consistent with the in vitro experiment, the knockdown of ATF5 in white adipose tissue led to less adipose tissue and smaller adipocytes size. Further research revealed that the inhibition of ATF5 diminished the adipocytes size via the inhibition of fatty acid synthetase, stearyl coenzyme A desaturation enzyme 1, and the induction of carnitine palmitoyl transferase 1, one key enzyme of lipid metabolism. In addition, ATF5 knockdown in inguinal white adipose tissue improved whole body insulin *** work provides a new understanding of ATF5 function in mature adipocytes and a potential therapeutic target of diabetes.

关键词： Activating tra scription factor 5 Adipocytes Lipid metabolism.

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-Lin jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang jing Qu Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

冠状动脉靶血管内注射尼可地尔对急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗术中无复流现象的预防效果研究

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中国全科医学 2017年第23期20卷 2832-2837,2847页

作者：齐琪陈涛牛竞辉姜志安河北医科大学第三医院心血管二科河北省石家庄市050051 河北医科大学第三医院关节一科河北省石家庄市050051

目的观察无复流现象(NRP)发生前冠状动脉靶血管内注射尼可地尔对急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)术中NRP的预防效果。方法选择2015年1月—2016年9月河北医科大学第三医院收治的需行急诊PCI术的急性STEM... 详细信息

目的观察无复流现象(NRP)发生前冠状动脉靶血管内注射尼可地尔对急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)术中NRP的预防效果。方法选择2015年1月—2016年9月河北医科大学第三医院收治的需行急诊PCI术的急性STEMI患者105例,采用随机数字表法分为尼可地尔组、硝普钠组和对照组,每组各35例。尼可地尔组采用球囊扩张及加压泵于靶血管向靶病变远端2 mm处预先注射尼可地尔2 mg、硝普钠组注射硝普钠200μg、对照组注射0.9%氯化钠溶液。观察PCI术前及结束时梗死相关血管心肌梗死溶栓试验(TIMI)血流分级、校正TIMI血流帧数(c TFC)、TIMI心肌灌注分级(TMPG)、术中NRP发生率及术后90 min ST段回落率(STR),PCI术前及术后1周时检测N末端脑钠肽前体(NT-pro BNP);PCI术前及术后每4 h检测肌酸激酶同工酶(CK-MB)及肌钙蛋白I(c Tn I),记录其峰值水平。PCI术前及术后1周时采用心脏彩超计算室壁运动积分指数(WMSI)及左心室射血分数(LVEF)。观察PCI术中低血压发生情况及术后预后情况。结果 3组患者术前TIMI血流分级、达到TMPG 3级的比例、NT-pro BNP、CK-MB、c Tn I、WMSI及LVEF比较,差异均无统计学意义(P>0.05)。硝普钠组和尼可地尔组患者术后c TFC及NRP发生率较对照组降低,术后达到TMPG 3级的比例及STR≥50%的比例较对照组升高(P0.05)。对照组、硝普钠组及尼可地尔组术中分别有3例(9.1%)、8例(24.2%)及0例发生低血压,需多巴胺处理,3组低血压发生率比较,差异有统计学意义(χ2=10.236,P=0.006);其中硝普钠组低血压发生率较尼可地尔组升高(P<0.01)。3组PCI术后3个月主要心脏不良事件(MACEs)发生率分别为:15.2%(5/33)、6.1%(2/33)及5.9%(2/34),差异无统计学意义(χ2=2.276,P=0.320)。结论 NRP发生前冠状动脉靶血管内注射尼可地尔可安全、有效地预防急性STEMI患者急诊PCI术中NRP发生,并改善心肌灌注水平和心功能。

关键词：心肌梗死血管成形术,气囊,冠状动脉无复流现象尼可地尔

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao jing-Wen Li hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Down-regulation of β1,4-galactosyltransferase 5 activates BMPsignaling pathway and promotes adipocyte commitment through BMPRIA

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Down-regulation of β1,4-galactosyltransferase 5 activates B...

Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

中国生物化学与分子生物学会第十一次会员代表大会暨201...

作者： Shu-Fen Li Liu-Ling Xiao Shu-Wen Qian Zhi-Chun Zhang Yue Zhao jing-hui jiang Qi-Qun Tang Xi Li Key Laboratory of Molecular Medicine the Ministry of Education

Glycosylation of proteins is one of the most important post-translational *** of glycosyltransferases and aberrant glycosylation have been implicated inmany different diseases due to changes associated with protein location and *** show here thatβ1,4-galactosyltransferase 5(B4GalT5)expression is positivelycorrelated with obesity in *** pluripotent mesenchymal C3H10T1/2 cells,downregulationof B4GalT5 induces cells commitment to the adipocyte lineage without BMP2/4treatment which is essential for adipocyte *** silencing of Smad4and p38MAPK suggested that both Smad and p38 MAPK pathways are involved in this ***,B4GalT5knockdown decreases BMPRIA glycosylation,boost endocytosis ofBMPRIA,thus provokes redistribution of BMPRIA and promotes the BMP signaling ***,disruption of B4GalT5 expression in adipose tissue by adenovirusshRNA in high fat diet mouse model increases adipocyte ratio of total tissue cells,improves insulin sensitivity and reduces *** results demonstrate B4GalT5downregulation activate BMP signaling pathway and thus promote adipocytic commitmentthrough modifying BMPRIA and regulating its cellular location.

关键词： β1 4-galactosyltransferase 5 BMP signaling pathway adipocyte commitmentB MPRIA

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-hui jiang Wei-Dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

盐酸胺碘酮-羟丙基-β-环糊精包合物的制备与表征

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华西药学杂志 2014年第5期29卷 500-502页

作者：景姜辉任丽莉陈国广南京工业大学药学院江苏南京211816

目的制备并鉴定盐酸胺碘酮羟丙基-β-环糊精包合物(Ami-HP-β-CD)。方法运用溶液搅拌法制备AmiHP-β-CD包合物,考察溶剂极性对包合物溶解度的影响及介质的稳定性,利用UV、DSC、FT-IR、1HNMR等方法鉴定包合物的结构。结果低极性溶剂的加... 详细信息

目的制备并鉴定盐酸胺碘酮羟丙基-β-环糊精包合物(Ami-HP-β-CD)。方法运用溶液搅拌法制备AmiHP-β-CD包合物,考察溶剂极性对包合物溶解度的影响及介质的稳定性,利用UV、DSC、FT-IR、1HNMR等方法鉴定包合物的结构。结果低极性溶剂的加入使包合物的溶解度增加,包合前后物质的波谱图存在显著差异。结论 HP-β-CD能显著提高Ami的溶解度及溶出速率,低极性溶剂有利于包合物的溶解。波谱方法显示新的物象特征,表明了包合物的形成。

关键词：盐酸胺碘酮羟丙基-β-环糊精包合技术

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia jing Wen Xue-Lin Cheng Yan Han Ming-hui Peng jing Zhou Yao Liu Sun-Fang jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years