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Human immune repertoire in hepatitis B virus infection

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World Journal of Gastroenterology 2021年第25期27卷 3790-3801页

作者： Qiao Zhan jing-hang xu Yan-Yan Yu Emily Lo KK Felicianna Hani El-Nezami Zheng Zeng Department of Infectious Diseases Peking University First HospitalBeijing 100034China School of Biological Sciences University of Hong KongHong KongChina Institute of Public Health and Clinical Nutrition School of MedicineUniversity of Eastern FinlandKuopio FI-70211Finland

Hepatitis B virus(HBV)infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis,liver failure,and hepatocellular *** HBV antigen-induced adaptive immune response plays an important role in HBV *** repertoire sequencing(IRS)has been used to investigate the molecular mechanisms behind the immune system,find novel ways to treat HBV infection,and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV *** review summarizes the human immune repertoire analysis methodology,and the application of the IRS in the prediction of HBV infection progression,treatment,and vaccination.

关键词： Immune repertoire T-cell receptor B-cell receptor Hepatitis B virus Chronic viral infection High-throughput sequencing

Machine Learning for Signal Demodulation in Underwater Wireless Optical Communications

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China Communications 2024年第5期21卷 297-313页

作者： Ma Shuai Yang Lei Ding Wanying Li hang Zhang Zhongdan xu jing Li Zongyan xu Gang Li Shiyin Department of Strategic and Advanced Interdisciplinary Research Peng Cheng LaboratoryShenzhen 518055China School of Information and Control Engineering China University of Mining and TechnologyXuzhou 221116China Data-driven Intelligent Information System Laboratory Shenzhen Research Institute of Big DataShenzhen 518172China Ocean College Zhejiang UniversityZhoushan 316021China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

The underwater wireless optical communication(UWOC)system has gradually become essential to underwater wireless communication *** other existing works on UWOC systems,this paper evaluates the proposed machine learningbased signal demodulation methods through the selfbuilt experimental *** on such a platform,we first construct a real signal dataset with ten modulation ***,we propose a deep belief network(DBN)-based demodulator for feature extraction and multi-class feature *** also design an adaptive boosting(Ada Boost)demodulator as an alternative scheme without feature filtering for multiple modulated ***,it is demonstrated by extensive experimental results that the Ada Boost demodulator significantly outperforms the other *** also reveals that the demodulator accuracy decreases as the modulation order increases for a fixed received optical power.A higher-order modulation may achieve a higher effective transmission rate when the signal-to-noise ratio(SNR)is higher.

关键词： AdaBoost DBN machine learning signal demodulation

Chinese guidelines on the management of liver cirrhosis(abbreviated version)

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World Journal of Gastroenterology 2020年第45期26卷 7088-7103页

作者： Xiao-Yuan xu Hui-Guo Ding Wen-Gang Li jing-hang xu Ying Han Ji-Dong Jia Lai Wei Zhong-Ping Duan En-Qiang Ling-Hu Hui Zhuang Department of Infectious Diseases Peking University First HospitalBeijing 100034China Hepatology and Digestion Center Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Liver Oncology Cancer Radiation Therapy CenterFifth Medical CenterPLA General HospitalBeijing 100039China Department of Immunology and Liver Diseases Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Hepatology Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Internal Medicine of Hepatopancreatobiliary Beijing Tsinghua Changgung HospitalBeijing 102218China Artificial Liver Center Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Gastroenterology First Medical CenterPLA General HospitalBeijing 100853China Department of Pathogenic Biology Peking University Health Science CenterBeijing 100191China

Based on reviews of the literature and experts’consensus,the Chinese Society of Hepatology developed guidelines for the diagnosis and treatment of liver cirrhosis,in order to improve clinical *** addition to what has been covered in previously published guidelines on the management of cirrhosis complications,these guidelines add new sections and provide *** guidelines emphasize the early diagnosis of the cause and assessment of *** treatments including etiological treatment and complication management should be initiated *** addition,regular monitoring,especially surveillance of hepatocellular carcinoma,is crucial for managing patients.

关键词： Liver cirrhosis Diagnosis Therapy Guidelines Hypertension portal Recompensated stage

Automatic Requirement Dependency Extraction Based on Integrated Active Learning Strategies

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Machine Intelligence Research 2024年第5期21卷 993-1010页

作者： Hui Guan Guorong Cai hang xu Department of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Industrial Intelligence Technology on Chemical Process Shenyang110142China

Since requirement dependency extraction is a cognitively challenging and error-prone task,this paper proposes an automatic requirement dependency extraction method based on integrated active learning *** this paper,the coefficient of variation method was used to determine the corresponding weight of the impact factors from three different angles:uncertainty probability,text similarity difference degree and active learning variant prediction divergence *** combining the three factors with the proposed calculation formula to measure the information value of dependency pairs,the top K dependency pairs with the highest comprehensive evaluation value are selected as the optimal *** the optimal samples are continuously added into the initial training set,the performance of the active learning model using different dependency features for requirement dependency extraction is rapidly ***,compared with other active learning strategies,a higher evaluation measure of requirement dependency extraction can be achieved by using the same number of ***,the proposed method using the PV-DM dependency feature improves the weight-F1 by 2.71%,the weight-recall by 2.45%,and the weight-precision by 2.64%in comparison with other strategies,saving approximately 46%of the labelled data compared with the machine learning approach.

关键词： Requirement dependency dependency extraction dependency features integrated active learning strategies coefficient of variation

A Coordinate-Free Approach to the Design of Generalized Griffis-Duffy Platforms

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 95-103页

作者： Chengwei Shen xu Pei Lubin hang jingjun Yu College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China

Architectural singularity belongs to the Type II singularity,in which a parallel manipulator(PM)gains one or more degrees of freedom and becomes *** remaining permanently in a singularity are beneficial for linearto-rotary motion ***-Duffy(GD)platform is a mobile structure admitting a Bricard *** this paper,we present a coordinate-free approach to the design of generalized GD platforms,which consists in determining the shape and attachment of both the moving platform and the fixed *** generalized GD platform is treated as a combination of six coaxial single-loop mechanisms under the same *** to the inversion,hidden in the geometric structure of these single-loop mechanisms,the mapping from a line to a circle establishes the geometric transformation between the fixed base and the moving platform based on the center of inversion,and describes the shape and attachment of the generalized GD ***,the center of inversion not only identifies the location of rotation axis,but also affects the shape of the platform mechanism.A graphical construction of generalized GD platforms using inversion,proposed in the paper,provides geometrically feasible solutions of the manipulator design for the requirement of the location of rotation axis.

关键词： Generalized Griffis-Duffy platforms Self-motion Inversion Coordinate-free determination Manipulator design

Effect of solidification mode on microstructure evolution and properties of magnesium alloy with long-period stacking ordered phase

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Journal of Iron and Steel Research International 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei Chen xu Zhang Qian-hao Zang jing Zhang Di Feng Yan-xin Qiao Yu-hang Guo School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina School of Metallurgy and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employed to prepare Mg–6Gd–3Y–xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy microstructures and the changes in properties were analyzed for different Zn *** has been observed that in alloys without electromagnetic stirring,as the Zn content increases,the alloy structure gradually *** primary second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloys subjected to electromagnetic stirring,there is a relatively higher content of the second phase,primarily consisting of LPSO *** applying electromagnetic stirring,the quantity and the type of LPSO phase in the alloy *** alloy structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloys with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property

Challenges and prospects for room temperature solid-state sodiumsulfur batteries

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Nano Research 2024年第3期17卷 1402-1426页

作者： Yashuang Qiu jing xu Research Center of Grid Energy Storage and Battery Application School of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China

Room temperature sodium-sulfur(Na-S)batteries,known for their high energy density and low cost,are one of the most promising next-generation energy storage ***,the polysulfide shuttling and uncontrollable Na dendrite growth as well as safety issues caused by the use of organic liquid electrolytes in Na-S cells,have severely hindered their ***-state electrolytes instead of liquid electrolytes are considered to be the most direct and effective solution to solve the above ***,its practical application is still greatly challenged due to the poor interfacial compatibility between the all-solid-state electrolytes and the anode/cathode,ionic conductivity,and the shuttle effect caused by the presence of liquid phase in the quasi-solid-state *** paper presents a comprehensive review of solid-state Na-S batteries from the perspective of regulating interfacial compatibility and improving ionic conductivity as well as suppressing polysulfide *** to different components,solid-state electrolytes were divided into five categories:solid inorganic electrolytes,solid polymer electrolytes,polymer/inorganic solid hybrid electrolytes,gel polymer electrolytes,and liquid–solid inorganic hybrid ***,the prospect of developing high performance solid-state electrolytes to improve the cycling stability of room temperature Na-S cells is envisaged.

关键词： sodium-sulfur batteries solid-state electrolytes ionic conductivity polysulfide shuttling interfacial compatibility

A stable staggered-grid finite-difference scheme for acoustic modeling beyond conventional stability limit

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Petroleum Science 2024年第1期21卷 182-194页

作者： jing-Yi xu Yang Liu National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China China University of Petroleum(Beijing) Karamay CampusKaramay 834000XinjiangChina

Staggered-grid finite-difference(SGFD)schemes have been widely used in acoustic wave modeling for geophysical *** improved methods are proposed to enhance the accuracy of numerical ***,these methods are inevitably limited by the maximum Courant-Friedrichs-Lewy(CFL)numbers,making them unstable when modeling with large time sampling intervals or small grid *** solve this problem,we extend a stable SGFD scheme by controlling SGFD dispersion relations and maximizing the maximum CFL ***,to improve modeling stability,we minimize the error between the FD dispersion relation and the exact relation in the given wave-number region,and make the FD dispersion approach a given function outside the given wave-number area,thus breaking the conventional limits of the maximum CFL ***,to obtain high modeling accuracy,we use the SGFD scheme based on the Remez algorithm to compute the FD *** addition,the hybrid absorbing boundary condition is adopted to suppress boundary reflections and we find a suitable weighting coefficient for the proposed *** derivation and numerical modeling demonstrate that the proposed scheme can maintain high accuracy in the modeling process and the value of the maximum CFL number of the proposed scheme can exceed that of the conventional SGFD scheme when adopting a small maximum effective wavenumber,indicating that the proposed scheme improves stability during the modeling.

关键词： Acoustic wave Staggered-grid finite-difference(SGFD) modeling Courant-friedrichs-lewy(CFL)number Stability

Single transition-metal atoms anchored on a novel Diracdispersiveπ-πconjugated holey graphitic carbon nitride substrate:computational screening toward efficient bifunctional OER/ORR electrocatalysts

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Rare Metals 2024年第8期43卷 3819-3832页

作者： Chun-Yao Fang Xi-hang Zhang Qiang Zhang Di Liu Xiao-Meng Cui jing-Cheng xu Cheng-Long Shi Meng-Yu Yang College of Science University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Nonprecious-metal-group single-metal-atom catalysts with bifunctional catalytic capabilities toward the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)are highly sought after in energy-conversion and storage ***,producing renewable and sustainable energy sources remains ***,single-transition metal atoms anchored onπ-πconjugated two-dimensional(2D)graphitic carbon nitride substrates formπ-d conjugated conductive channels that enhance the overall electrocatalytic ***,firstprinciples calculations were carried out to design and demonstrate a novel macropore graphitic carbon nitride(gC_(10)N_(3))as a promising 2D electrocatalyst substrate to support single-transition metal(TM,from Sc to Au).The"donation-acceptance"charge interaction in the TM-N_(2)moiety effectively balances the adsorption strength of oxygenated intermediates in Ni@g-C_(10)N_(3)and Rh@gC_(10)N_3,making them effective bifunctional OER/ORR electrocatalysts with IrO_(2)/Pt-beyond overpotentials being as low as 0.39/0.38 V and 0.54/0.44 V,***,they possess high stability and conductivity and are less susceptible to oxidation and corrosion under working *** guarantees high activity under ambient ***,the origin of the OER/ORR activity of TM@g-C_(10)N_(3) is explained using multilevel descriptors:intrinsic(p,Bader charge,integral crystal orbital Hamilton population(ICOHP),bond length,and d-band center(εd).In particular,for optimal Ni@g-C_(10)N_(3),the clear hybridization between the Ni-d orbital and surface O-p orbital causes the paired electrons to occupy the bonding *** enables OH~*to be adsorbed on the Ni@g-C_(10)N_(3),thereby achieving the highest catalytic performance.

关键词： First-principles calculation Oxygen evolution reaction Oxygen reduction reaction Bifunctional electrocatalysts Single-metal-atom electrocatalysts