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rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner

Cellular & Molecular Immunology 2014年第2期11卷 206-214页

作者： jing Hao chao zhang jing Song Guihua Hou Key Laboratory for Experimental Teratology of the Ministry of Education and Institute of Experimental Nuclear Medicine Shandong University MedicalSchool Jinan 250012 China

AIIorejection remains an obstacle for successful organ transplantation. Although different types of immunosuppressive agents are effective for controlling rejection and prolonging graft survival, drug treatment is limited because of side effects and toxicity. Therefore, it is necessary and urgent to identify new candidate drugs for inducing allotolerance. Recently, it has been reported that bacterial flagellin induces the immunosuppressive activity of regulatory T cells （Tregs） in humans in vitro. In the present study, we analyzed the effects of recombinant flagellin （rFliC） on allograft survival and explored the underlying mechanisms associated with the activation of recipient Tregs in a murine skin allotransplantation model. The results showed that rFliC administration （3 mg/kg, once per day for 3 days, i.p.） prolonged allograft survival （mean survival time： 18.4--.1.1 days） compared to the control group （10___0.7 days, P〈O.01）. Additionally, higher positive expression of Toll-like receptor 5 （TLR5） was detected within the allograft administered with rFliC. The frequency of CD4＋CD25＋Foxp3＋ Tregs; the expression of Treg-related factors TLR5, Foxp3, TGF-I^I and IL-IO; and the proliferation and suppression of Tregs were increased following rFliC administration compared to the control. Moreover, the increased expression of tolerance-related molecules and the proliferation of Tregs induced by rFliC were attenuated by an anti-TLR5 blocking antibody both in vivo and in vitro. In conclusion, rFliC administration prolongs the survival of allografts, which is associated with the activation of recipient Tregs in a TLR5-dependent manner, rFliC may be a new candidate for anti-allorejection therapy.

关键词： allotransplantation flagellin regulatory T cells TLR5

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Synthesis of a Novel Core-shell Type Acrylic-polyurethane Hybrid Emulsion Containing Siloxane and Fluorine as well as Water and the Oil Resistances of Cured Film

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Chinese Chemical Letters 2006年第8期17卷 1121-1124页

作者： jing chao Xing Yuan zhang Jia Bing DAI Zhen GE Lin Lin FENG Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026

Siliconated polyurethane （Si-PU） was synthesized using isophorone diisocyanate （IPDI）, hydroxybutyl-terminated polydimethylsiloxane （PDMS）, polytetramethylene ether glycol （PTMG）, polypropylene glycol （PPG）, 1,6-hexanediol （HDO）, dimethylol propionic acid （DMPA） and triethylamine （TEA）. Based on butyl acrylate （BA）, 2, 2, 2-trifluoroethylmethacrylate （TFEMA） and Si-PU as a seed emulsion, a novel core-shell type acrylic-polyurethane hybrid emulsion, containing siloxane and fluorine （F-Si-PU）, was prepared by seeded emulsion polymerization. The contents of siloxane and fluorine were determined according to the feed ratio. Fourier transform infrared spectroscopy （FTIR） was used to identify the chain structures of Si-PU and F-Si-PU. Investigation of transmission electron microscopy （TEM） confirmed the core-shell structure of F-Si-PU emulsion. Measurement results of water contact angle and the swelling ratio in water and n-octane for cured film showed that the water and the oil resistances for F-Si-PU had been significantly improved at a suitable content of fluorine and siloxane.

关键词： Core-shell siloxane fluorine acrylic-polyurethane water and oil resistance.

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High-voltage LiCoO_(2) cathodes for high-energy-density lithiumion battery

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Rare Metals 2022年第12期41卷 3946-3956页

作者： jing-chao zhang Zhe-Dong Liu Cui-Hua Zeng Jia-Wei Luo Yi-Da Deng Xiao-Ya Cui Ya-Nan Chen School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Beijing Frontier Research Center for Biological Structures Tsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China

As the earliest commercial cathode material for lithium-ion batteries,lithium cobalt oxide(LiCoO_(2)) shows various advantages,including high theoretical capacity,excellent rate capability,compressed electrode density,*** now,it still plays an important role in the lithium-ion battery *** to these advantages,further increasing the charging cutoff voltage of LiCoO_(2)to guarantee higher energy density is an irresistible development trend of LiCoO_(2)cathode materials in the ***,using high charging cutoff voltage may induce a lot of negative effects,especially the rapid decay of cycle *** are mainly caused by rapid destruction of crystal structure and aggravation of interface side reaction at high voltage during the ***,how to maintain a stable crystal structure of LiCoO_(2)to ensure the excellent long cycle performance at high voltage is a hot research issue in the further application of LiCoO_(2).In this review,we summarized the failure causes and extensive solutions of LiCoO_(2)at high voltage and promoted some new modification ***,the development trend of solving the failure problem of high-voltage LiCoO_(2)in the future such as defect engineering and high-temperature shock technique is also discussed.

关键词： Lithium-ion battery Lithium cobalt oxide(LiCoO_(2))cathode High voltage Cycle performance Crystal structure

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Shear bond strengths between alumina-toughened zirconia cores and veneering ceramics and their susceptibility to aging

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 402-405页

作者： Yong-Qi Zhao Li Jiang jing-chao zhang Yun-Mao Liao Jun-Jun Lu Wei Li State Key Laboratory of Oral Diseases Sichuan University Hainan Stomatological Hospital

Objective:To evaluate the shear bond strength(SBS) between alumina-toughened zirconia (ATZ) cores and veneering ceramics,investigate the effect of aging in artificial saliva on SBS and compare it with that of yttria-stabilized tetragonal zirconia polycrystals(Y-TZP).Methods:Bars of ATZ and Y-TZP were layered with veneering ceramics in accordance to the recommendation of the *** of each group(n = 10) was aged at 134℃.(under 2 bar pressure) in an autoclave for 48 ***,all specimens were subjected to shear force in a universal testing *** interface and fractured surface of the specimens were evaluated using scanning electron microscopy and X-ray energy dispersive ***:The initial mean SBS values in MPa±SD were 28.9±8.0 for ATZ and 26.2±7.6 for *** aging,the mean SBS values for ATZ and Y-TZP were 22.9±4.9 MPa and 22.8±6.9 MPa,*** the differences between the SBS values of the ATZ and Y-TZP groups nor the influence of aging on all groups were statistically ***:The SBS between the ATZ core and the veneering ceramics was not affected by *** SBS of ATZ to veneering ceramics was not significantly different compared with that of Y-TZP.

关键词： Shear bond strength Zirconia Alumina Veneering ceramics Aging

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Perfusion of gastrodin in abdominal aorta for alleviating spinal cord ischemia reperfusion injury

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 678-683页

作者： Hua Fang jing-chao zhang Miao Yang Hua-Feng Li Jian-Ping zhang Fang-Xiang zhang Quan-Yun Wang Ru-Rong Wang Jin Liu Department of Anesthesiology Guizhou Provincial People's Hospital Department of Anesthesiology Affiliated People's Hospital of Guizhou Medical University Department of Anesthesiology West China Second University Hospital Department of Anesthesiology West China HospitalSichuan University

Objective:To observe the effects of perfusion of the gastrodin in abdominal aorta for alleviating the spinal cord ischemia reperfusion injury(SCIRI).Methods:A total of 36 New Zealand white rabbits were divided randomly into sham-operated group(group S),control group(group C) and gastrodin group(group G),12 rabbits for each *** abdominalis infrarenalis blocking method was applied to establish the SCIRI *** changes of motor evoked potentials(MEPs) before the ischemia and on 30 min,60 min,6 h,12 h and 24 h of reperfusion of the gastrodin were respectively recorded,and the neurologic function score before the ischemia,on the 6 h,12 h and 24 h of the reperfusion of the gastrodin were *** the changes of the concentration of serum neuron specific enolase(NSE),interleukin(IL)-l β and IL-8 were measured before the ischemia,after 45 min of ischemia,and on 30 min,60 min,6 h,12 h and 24 h of reperfusion of *** the levels of spinal cord nerve cells mitochondrial superoxide dismutase(SOD),reactive oxygen species(ROS),glutathione peroxidase(GSH-PX),malondialdehyde(MDA),total antioxidant capacity(T-AOC) and mitochondrial swelling degree(MSD) were tested and the histopathologic changes in spinal cord tissues were ***:The levels of the NSE,IL-lfter the ischemβ,IL-8,ROS,MDA and MSD of group C were all significantly elevated aia(P<0.01);the levels of the spinal nerve cell mitochondria SOD,GSH-PX and T-AOC were all significantly reduced(P<0.01),MEPs and spinal cord tissue pathology were damaged significantly(P<0.01).The rate of motor neuron abnormalities and the damages of spinal cord tissue pathology of group G were significantly milder than those of group C(P<0.01);the levels of NSE,IL-lROS,MDA and MSD were significantly lower than those of group C(P< 0.01),but tβ,IL-8,he levels of SOD,GSH-PX and T-AOC were all significantly higher than those of group C(P<0.01),and the recovery of neurologic function score during the reperfusion of gastro

关键词： Gastrodin Spinal cord ischemia reperfusion injury Mitochondria Motor evoked potential

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Co-free/Co-poor high-Ni cathode for high energy,stable and low-cost lithium-ion batteries

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Rare Metals 2023年第7期42卷 2214-2225页

作者： Zhe-Dong Liu Chun-Ying Wang jing-chao zhang Jia-Wei Luo Cui-Hua Zeng Wei-Di Liu Rui Liu Ya-Nan Chen School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Tianjin UniversityTianjin300072China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD4072Australia

Advanced cathode materials have been considered as the key to significantly improve the energy density of lithium-ion batteries(LIBs).High-Ni layer-structured cathodes,especially with Ni atomic content above 0.9(LiN1_(x)M_(1-x)O_(2),x≥0.9),exhibit high capacity to be commercially available in electric vehicles(EVs).However,the intrinsic structure instability of high-Ni materials and the negative impacts severely restrict their further applic *** addition,Co has various effective efforts to stabilize the layered ***,due to the high cost of Co,it is required to be ***,modification methods on increasing the stability of high-Ni cathode with the reduction of Co content have been widely *** this review,we summarized various effective research progresses and several potential modification strategies of Cofree/Co-poor layered c athodes with Ni content over *** challenges and development opportunities of high-Ni,Cofree/Co-poor cathodes are further overviewed to meet the future commercial energy demands.

关键词： Lithium-ion batteries(LIBs) Co-free/poor High-Ni Cathode materials

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Self-Assembly of Bacteria in Alternating-Current Electric Fields

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Chinese Physics Letters 2024年第10期41卷 137-143页

作者： Yan-Ran Li Yi-Wu Zong Hong zhang jing-chao zhang Chun-Ying Feng Jian-Jun Qiao Hao Song Kun Zhao Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Petrochemical Research Institute of Petrochina Co. Ltd.Beijing 102206China Center for Medical Genetics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Jiangsu Key Laboratory of Sericultural and Animal Biotechnology School of BiotechnologyJiangsu University of Science and TechnologyZhenjiang 212100China Key Laboratory of Silkworm and Mulberry Genetic Improvement Ministry of Agriculture and Rural AffairsSericultural Scientific Research CenterChinese Academy of Agricultural SciencesZhenjiang 212100China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China The Sichuan Provincial Key Laboratory for Human Disease Gene Study and The Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

Self-assembly of bacteria in electric fields is a promising route to fabricate biomaterials with reversible and specific ***,due to relatively less studies,our understanding of the self-assembly of bacteria in electric fields is still ***,how different bacterial species behave differently in their fieldmediated self-assembly behavior remains to be *** this study,we choose four bacterial species,including Shewanella oneidensis,Pseudomonas aeruginosa,Bacillus subtilis and Lactococcus lactis as model systems,and investigate their self-assembly behavior in alternating-current(AC)electric fields for both diluted and concentrated *** phase diagrams in the plane of applied field strength vs frequency are *** results show that in diluted suspensions,a transition sequence of isotropic–paranematic–string–columnar phases is observed in all strains as the field strength *** of the assembled structures are quantitatively differentiated among different *** concentrated suspensions,besides the isotropic and paranematic phases,a higher ordered phase with interdigitating rectangular crystal domains(OIR)and an ordered phase with smectic A liquid crystal domains are observed for *** and ***,*** findings shed new light on fabricating potential biomaterials by assembling cells of appropriately chosen bacterial species that have desired surface properties under AC electric fields.

关键词： suspensions diluted biomaterials

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In vitro corrosion resistance of layer-by-layer assembled polyacrylic acid multilayers induced Ca–P coating on magnesium alloy AZ31

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Bioactive Materials 2020年第1期5卷 153-163页

作者： Lan-Yue Cui Shen-Cong Cheng Lu-Xian Liang jing-chao zhang Shuo-Qi Li Zhen-Lin Wang Rong-Chang Zeng College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China College of Materials Science and Engineering Chongqing University of TechnologyChongqing400065China

Biodegradable magnesium(Mg)-based alloys have aroused great concern owing to their promising characteristics as temporary implants for orthopedic *** their undesirably rapid corrosion rate under physiological conditions has limited the actual clinical *** study reports the use of a novel biomimetic polyelectrolyte multilayer template,based on polyvinylpyrrolidone(PVP)and polyacrylic acid(PAA)via layerby-layer(LbL)assembly,to improve the corrosion resistance of the *** characterization techniques(field-emission scanning electron microscopy,Fourier transform infrared(FTIR)spectrophotometer and X-ray diffractometer)confirmed the formation of biomineralized Ca–P coating on AZ31 *** hydrogen evolution and electrochemical corrosion tests demonstrated that the corrosion protection of the polyelectrolyte-induced Ca–P coating on AZ31 *** formation mechanism of biomineralized Ca–P coating was proposed.

关键词： Magnesium alloy Layer-by-layer assembly Biomineralization Calcium phosphate Coating Corrosion

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In vitro corrosion resistance,antibacterial activity and cytocompatibility of a layer-by-layer assembled DNA coating on magnesium alloy

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Journal of Magnesium and Alloys 2021年第1期9卷 266-280页

作者： Lan-Yue Cui Ling Gao jing-chao zhang Zhe Tang Xiao-Li Fan Jia-Cheng Liu Dong-Chu Chen Rong-Chang Zeng Shuo-Qi Li Ke-Qian Zhi College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266555China Key Lab of Oral Clinical Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266555China School of Materials Science and Energy Engineering Foshan UniversityFoshan 528000China

A chitosan/deoxyribonucleic acid(CHI/DNA)_(5)coating was constructed by layer-by-layer(LbL)assembly dip coating method with Mg(OH)_(2)coating as an inner protective layer on AZ31 alloy.X-ray diffractometry,X-ray photoelectron spectrometry,Fourier transform infrared spectroscopy and field-emission scanning electron microscopy were utilized to represent the chemical compositions and surface morphologies of the *** tests and hydrogen evolution measurements were implemented to confirm the good corrosion resistance of the composite coating in artificial body *** activity of the composite coatings was tested via the plate-counting method,and the cytotoxicity of the samples was appraised by MTT assay and Live/dead staining.A double action was put into effect for the composite coating,which the inner Mg(OH)2 coating plays the part of physical barrier,and the outer(CHI/DNA)5 coating is employed as an inducer to fabricate a biocompatible Ca-P corrosion product coating during immersion,making up for its thin ***,the composite coating is also beneficial for the growth of bone,resulting from the biomineralization effect of the outer polyelectrolyte *** good antibacterial property of the(CHI/DNA)5/Mg(OH)2 coating is ascribed to the contact-killing strength of ***,the obtained(CHI/DNA)5/Mg(OH)2 coating has a wide application prospect in the field of Mg-based bone implantation.

关键词： Magnesium alloys Coatings Layer-by-layer assembly Biomaterials Antibacterial properties Corrosion

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing zhang jing Yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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