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Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan Cao Zhiqun He Chunjun liang Mingxing Chen jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

冬虫夏草及其伪制品——戴氏虫草加工品的性状和显微鉴定研究

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中国药学杂志 2020年第14期55卷 1189-1194页

作者：杨莎康帅齐景梁高必兴郑玉光四川省食品药品检验检测院成都611731 中国食品药品检定研究院北京100050 河北中医学院药学院石家庄050200

目的对冬虫夏草及其伪制品——戴氏虫草加工品进行鉴别研究。方法以冬虫夏草和4种伪制品实物标本为研究对象,应用照相机和体式显微镜观察记录子座与虫体结合方式、虫体色泽和腹足等性状特征,应用透射光显微镜及CCD数码成像系统观察记录... 详细信息

目的对冬虫夏草及其伪制品——戴氏虫草加工品进行鉴别研究。方法以冬虫夏草和4种伪制品实物标本为研究对象,应用照相机和体式显微镜观察记录子座与虫体结合方式、虫体色泽和腹足等性状特征,应用透射光显微镜及CCD数码成像系统观察记录子座横切面、虫体体壁和腹足趾部等显微鉴别特征,并通过图像列表对观察结果进行比较。结果冬虫夏草与其4种伪制品在性状和显微特征上存在较为明显的差异。结论冬虫夏草与其伪制品——戴氏虫草加工品可通过性状和显微特征上的差异进行鉴别。

关键词：冬虫夏草伪制品戴氏虫草性状鉴定显微

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多基原兔耳草HPLC指纹图谱对比研究

中草药 2020年第15期51卷 4019-4024页

作者：高必兴苟琰齐景梁蒋桂华耿昭周娟成都中医药大学药学院四川成都610072 四川省食品药品检验检测院/国家药品监督管理局中成药质量评价重点实验室四川成都611731

目的建立现有国家药品标准收载的兔耳草基原全缘兔耳草Lagotis integra(药材名为兔耳草)及短管兔耳草***(药材名为洪连)的HPLC指纹图谱方法,并通过所建立的方法对市场上其他3种较为常见的兔耳草(圆穗兔耳草***、革叶兔耳草***及短穗兔耳... 详细信息

目的建立现有国家药品标准收载的兔耳草基原全缘兔耳草Lagotis integra(药材名为兔耳草)及短管兔耳草***(药材名为洪连)的HPLC指纹图谱方法,并通过所建立的方法对市场上其他3种较为常见的兔耳草(圆穗兔耳草***、革叶兔耳草***及短穗兔耳草***)进行对比研究。方法全缘兔耳草与短管兔耳草的HPLC指纹图谱相似度低,故分别建立二者HPLC指纹图谱方法;采用Waters X-Bridge C18(250 mm×4.6 mm,5μm);流动相为乙腈-0.2%甲酸水溶液,梯度洗脱;体积流量1.0 mL/min;检测波长328 nm;柱温35℃(全缘兔耳草)及25℃(短管兔耳草)。结果建立的全缘兔耳草HPLC对照指纹图谱指认了14个共有峰,并标定了大车前苷、鞭打绣球苷B、10-O-trans-p-methoxycinnamoyl-catalpol及10-O-[(E)-3,4-dimethoxycinnamoyl]catalpol峰;所建立的短管兔耳草HPLC对照指纹图谱存在13个共有峰,并标定松果菊苷、大车前苷及毛蕊花糖苷峰;建立的全缘兔耳草HPLC对照指纹图谱与所有批次全缘兔耳草及革叶兔耳草的相似度均大于0.9,与其他3种兔耳草相似度低;建立的短管兔耳草HPLC对照指纹图谱与所有批次短管兔耳草及圆穗兔耳草的相似度均大于0.9,与其他3种兔耳草相似度低。结论已建立的方法能有效地对各基原兔耳草进行鉴别,建议革叶兔耳草与全缘兔耳草同时收载于《卫生部药品标准(藏药第一册)》,圆穗兔耳草可作为《中国药典》2015年版一部收载的"洪连"的新基原。

关键词：全缘兔耳草短管兔耳草圆穗兔耳草革叶兔耳草短穗兔耳草 HPLC指纹图谱

QuEChERS法结合气相色谱-串联质谱法测定贝母类中药中53种农药残留

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中草药 2020年第20期51卷 5337-5347页

作者：耿昭李小红苟琰高必兴齐景梁钟恋郭力成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地四川成都611137 四川省食品药品检验检测院国家药品监督管理局中成药质量评价重点实验室四川成都611731

目的建立基于QuEChERS法结合气相色谱-串联质谱法(GC-MS/MS)对贝母类中药中53种农药残留量的快速检测方法,并应用于193批样品筛查。方法根据调研选择禁限用及常用农药作为检测指标。采用QuEChERS法对样品进行前处理,在气相色谱-串联质... 详细信息

目的建立基于QuEChERS法结合气相色谱-串联质谱法(GC-MS/MS)对贝母类中药中53种农药残留量的快速检测方法,并应用于193批样品筛查。方法根据调研选择禁限用及常用农药作为检测指标。采用QuEChERS法对样品进行前处理,在气相色谱-串联质谱多反应监测(MRM)模式下进行测定,以3个添加水平测定样品的回收率和RSD。结果53种农药在一定含量范围内线性关系良好,r均大于0.9978;在1倍LOD(Limit of Detection)、2倍LOD、10倍LOD 3个添加浓度水平进行回收率试验中,86.8%的农药在60%~140%,RSD均小于15%;各农药检出限均小于0.01 mg/kg。193批贝母类中药种共检出14种农药,91批样品有检出,检出率为47.2%,仅有1批超出即将执行的《中国药典》2020年版限度规定。结论该方法检测指标具有一定针对性,且操作简便快速、灵敏可靠,适用于贝母类中药中农药残留的筛查测定。对于贝母类中药的生产种植和流通监管具有一定的参考意义。

关键词：贝母类中药农药残留 QuEChERS法气相色谱-串联质谱法多反应监测

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大黄种子内源抑制物质活性研究

时珍国医国药 2013年第9期24卷 2258-2259页

作者：李敏敬勇刘薇林秋霞夏琴齐景梁成都中医药大学药学院四川成都611137 四川省食品药品检验所四川成都610097

目的对大黄种子内源抑制物进行初步研究。方法用甲醇和蒸馏水分别制备大黄种子的浸提液,并测定白菜种子的发芽率和根长来测定其抑制活性。结果大黄种子含有一定的内源抑制物质,对发芽率无明显抑制作用,但对胚根的生长却具有明显的抑制作... 详细信息

目的对大黄种子内源抑制物进行初步研究。方法用甲醇和蒸馏水分别制备大黄种子的浸提液,并测定白菜种子的发芽率和根长来测定其抑制活性。结果大黄种子含有一定的内源抑制物质,对发芽率无明显抑制作用,但对胚根的生长却具有明显的抑制作用,并且水浸提液对胚根的抑制作用大于醇浸提液。结论大黄播种前用水浸泡种子,可降低其抑制物质对胚根的抑制作用,提高出苗率。

关键词：大黄种子内源抑制物质

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv liang Wang jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： jing Yao Yuan Li Xi Liu Wenping liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Smad蛋白抑制剂SIS3对细粒棘球蚴原头节的作用研究

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中国病原生物学杂志 2017年第5期12卷 389-393页

作者：张静曾静李亮齐海成王超林仁勇李静新疆医科大学基础医学院新疆乌鲁木齐830011 新疆医科大学第一附属医院/临床医学研究院新疆包虫病基础医学重点实验室

目的研究Smad蛋白抑制剂SIS3对体外细粒棘球蚴原头节的影响。方法建立体外细粒棘球蚴培养体系,以不同浓度(12.5、25、50和100μmol/L)、不同作用时间(24、48、72和96h)对原头节进行药物(Smad蛋白抑制剂SIS3)干预试验,伊红染色和扫描及... 详细信息

目的研究Smad蛋白抑制剂SIS3对体外细粒棘球蚴原头节的影响。方法建立体外细粒棘球蚴培养体系,以不同浓度(12.5、25、50和100μmol/L)、不同作用时间(24、48、72和96h)对原头节进行药物(Smad蛋白抑制剂SIS3)干预试验,伊红染色和扫描及透射电镜观察不同浓度药物干预过程中原头节活力及虫体超微结构的变化。结果SIS3干预48h,50和100μmol/L SIS3组与空白对照组原头节活力显著下降;作用96h,50和100μmol/L SIS3组原头节活力分别下降(10.06±2.79)%和(19.49±2.63)%。随着药物浓度的增加,扫描电镜观察原头节体表绒毛排列紊乱,吸盘结构变形,顶突小钩脱落;透射电镜观察药物组原头节表层微毛减少或消失,合胞体带变薄,胞浆空泡化,虫体内部出现脂滴等。结论 Smad信号通路抑制剂SIS3对体外细粒棘球蚴有抑制作用,为治疗细粒棘球蚴病提供了理论基础。

关键词：细粒棘球蚴 Smad信号通路抑制剂SIS3 体外培养