检索结果-南通市图书馆

Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis

World Journal of Clinical Cases 2024年第5期12卷 875-879页

作者： Yan-Miao Liu jing Zhang jing-jing wu Wei-Wei Guo Fu-Shan Tang The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Respiratory Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung injury.This condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few days.While lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant drawbacks.The optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains controversial.Despite this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage PF.Additionally,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender factors.Genetic mutations may also impact therapeutic efficacy.Enhancing research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related PF.These measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life.

关键词： COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration Timing Dosage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives

引用

Acta Pharmaceutica Sinica B 2022年第3期12卷 1068-1099页

作者： Qiang Jin jing jing wu Yue wu Hongxin Li Moshe Finel Dandan Wang Guangbo Ge Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044China Division of Pharmaceutical Chemistry and Technology Faculty of PharmacyUniversity of HelsinkiHelsinki 00014Finland

Drug-metabolizing enzymes(DMEs),a diverse group of enzymes responsible for the metabolic elimination of drugs and other xenobiotics,have been recognized as the critical determinants to drug safety and efficacy.Deciphering and understanding the key roles of individual DMEs in drug metabolism and toxicity,as well as characterizing the interactions of central DMEs with xenobiotics require reliable,practical and highly specific tools for sensing the activities of these enzymes in biological systems.In the last few decades,the scientists have developed a variety of optical substrates for sensing human DMEs,parts of them have been successfully used for studying target enzyme(s)in tissue preparations and living systems.Herein,molecular design principals and recent advances in the development and applications of optical substrates for human DMEs have been reviewed systematically.Furthermore,the challenges and future perspectives in this field are also highlighted.The presented information offers a group of practical approaches and imaging tools for sensing DMEs activities in complex biological systems,which strongly facilitates high-throughput screening the modulators of target DMEs and studies on drug/herb-drug interactions,as well as promotes the fundamental researches for exploring the relevance of DMEs to human diseases and drug treatment outcomes.

关键词： Optical substrates Drug-metabolizing enzymes(DMEs) Fluorescence-based assay High-throughput screening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transcatheter Arterial Embolization Combined with Anti-vascular Agent Combretastatin A4 Phosphate Inhibits Growth and Vascularization of Liver Tumor in an Animal Model

引用

Current Medical Science 2022年第6期42卷 1240-1247页

作者： Hui ZHAO Zhen-zhong wu Quan REN jing-jing wu Ying WANG Jun-wei FENG Min RAO Qing DENG Hong-yao HU Department of Interventional Radiology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Ultrasound Renmin Hospital of Wuhan UniversityWuhan430060China

Objective This study aimed to investigate the effect of combretastatin A4 phosphate(CA4P)on proliferation,migration,and capillary tube formation of human umbilical vein endothelial cells(HUVECs)and the efficacy of transcatheter arterial embolization combined with CA4P in the treatment of rabbit VX2 liver tumor.Methods The effects of different concentrations of CA4P on proliferation,migration and capillary tube formation of HUVECs were investigated by cell proliferation assay,wound healing assay and capillary tube formation assay,respectively.Thirty-two rabbits implanted with liver VX2 tumors were randomly divided into 4 groups.After catheterization of the left hepatic artery,the infusion was performed using normal saline(group A),CA4P aqueous solution(group B),lipiodol and polyvinyl alcohol particles(group C),and CA4P lipiodol emulsion and polyvinyl alcohol particles(group D),respectively.Half of the animals in each group were euthanized for immunohistochemical analysis to evaluate microvessel density(MVD)at 3 days post-treatment.The other half were examined by MRI and histology to evaluate tumor growth and necrosis at 7 days post-treatment.Results CA4P could inhibit the proliferation,migration,and tube formation of HUVECs in cell experiments.After interventional treatment,the level of MVD in group D was lower than that in group C(P<0.01).The tumor volume in group C or D was lower than that in group A or B(P<0.01).The tumor necrosis rate was higher in group D than in the other groups.Conclusion The study suggests that CA4P could inhibit the proliferation,migration,and capillary tube formation of HUVECs,and transcatheter arterial embolization combined with CA4P could inhibit the growth of VX2 tumor and obviously induce tumor necrosis.

关键词： embolization,therapeutic vascular disrupting agents combretastatin A4 phosphate liver cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual versus single antiplatelet therapy for patients with long-term oral anticoagulation undergoing coronary intervention： a systematic review and meta-analysis

引用

Journal of Geriatric Cardiology 2017年第12期14卷 725-736页

作者： jing-jing wu Chan ZOU Wen-Yu LIU Guo-Ping YANG Center of Clinical Pharmacology the Third Xiangya Hospital Central South University Changsha Hunan China College of Pharmacy Central South University Changsha Hunan China

这元分析的 ObjectiveThe 主要目的为在冠的 intervention.MethodsPubMed 以后拿 OAC 的病人是为在最佳的政体仍然是的冠的 intervention.BackgroundThe 以后拿口头的 anticoagulation ( OAC )的病人比较双对单个的 antiplatelet 治疗的功效和安全争论的， Embase 和 Cochrane 控制试用的中央收款机为病人 requ 包括三倍的治疗( TT )对 OAC 正单个 antiplatelet 治疗的数据被在找合格研究主要结果是主要不利心脏、脑血管的事件(MACCE ) 。安全结果是与 32,825 个病人一起的主要 bleeding.ResultsFourteen 研究被包括。在未来的研究之中，有 TT 的病人向主要流血的更高的风险有一个趋势[机会比率(或) ：1.56， 95% 信心间隔(CI ) ：0.98-2.49， P = 0.06 ] 并且所有原因死亡的显著地更高的风险(或；2.11， 95% CI：1.10-4.06 P = 0.02 ) 与 OAC 正 clopidogrel 相比。同时， TT 与 MACCE 的减少的风险被联系(或：0.63， 95% CI：051-0.77 P < 0.0001 ) ，所有原因死亡(或：0.45， 95% CI：0.20-0.97， P = 0.04 ) ，并且 stroke/transient ischemic 攻击(TIA )/peripheral 栓塞(PE )( 或：0.29， 95% CI：0.09-0.96， P = 0.04 ) 与在冠的干预以后要求 OAC 的 OAC 正 aspirin.ConclusionsFor 病人相比， OAC 正 clopidogrel 可以比 TT 带更临床的网利益，而 OAC 正阿司匹林应该是最后选择。更大尺寸的使随机化的控制试用被需要证实这些调查结果。

关键词：治疗评论系统 PubMed OAC 阿司匹林调查结果 CI

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nephrotic syndrome in syngeneic hematopoietic stem cell transplantation recipients: A case report

引用

World Journal of Clinical Cases 2021年第3期9卷 614-622页

作者： Ming-Chuan Bai jing-jing wu Kou-Rong Miao jing-Feng Zhu Hui-Juan Mao Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hematopoietic stem cell transplantation(HSCT)is widely used in the treatment of hematological diseases.However,complications after transplantation,such as acute and chronic graft-vs-host disease(GVHD),still seriously affect the quality of life and even threaten the lives of patients.There is evidence that glomerular diseases can manifest as GVHD.However,GVHD should not occur as a result of syngeneic HSCT.CASE SUMMARY A 20-year-old male diagnosed with T lymphoblastic lymphoma(stage IIIA,aaIPI 1)in September 2013 was treated with six cycles of hyper-CVAD and achieved complete remission.He underwent syngeneic HSCT in June 2014,and had no kidney disease history before the transplant.However,nephrotic syndrome occurred 24 mo later in the patient after syngeneic HSCT.Renal biopsy was performed,which led to a diagnosis of atypical membranous nephropathy.After treatment with glucocorticoids combined with cyclophosphamide and cyclosporine,the nephrotic syndrome was completely relieved.CONCLUSION We report a case of delayed nephrotic syndrome after syngeneic HSCT.Antibodymediated autoimmune glomerular disease may be the underlying mechanism.After treatment with immunosuppressive agents,the nephrotic syndrome was completely relieved but further long-term follow-up is still needed.

关键词： Syngeneic hematopoietic stem cell transplantation Nephrotic syndrome Graft vs host disease Cyclosporine Autoimmune glomerular disease Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study

引用

Neural Regeneration Research 2022年第12期17卷 2743-2749页

作者： Xiao-Jun Guan Tao Guo Cheng Zhou Ting Gao jing-jing wu Victor Han Steven Cao Hong-Jiang Wei Yu-Yao Zhang Min Xuan Quan-Quan Gu Pei-Yu Huang Chun-Lei Liu Jia-Li Pu Bao-Rong Zhang Feng Cui Xiao-Jun Xu Min-Ming Zhang Department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Neurology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCAUSA Institute for Medical Imaging Technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Information Science and Technology ShanghaiTech UniversityShanghaiChina Helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA Department of Radiology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang ProvinceChina

Brain radiomics can reflect the characteristics of brain pathophysiology.However,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous studies.In this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August 2019.According to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation dataset.We extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training dataset.The informative features so identified were then used to construct a diagnostic model for PD.The constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training dataset.On the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,respectively.The accuracies for predicting tremor-dominant and non-tremor-dominant PD were 79.8±6.9%and 79.1±6.5%,respectively.In concl

关键词： diagnosis imaging biomarker iron magnetic resonance imaging neuroimaging Parkinson’s disease quantitative susceptibility mapping R2*mapping radiomics T1-weighted imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Grafting Branch Length and Density Dependent Performance of Zwitterionic Polymer Decorated Polypropylene Membrane

引用

Chinese Journal of Polymer Science 2018年第4期36卷 528-535页

作者： jing-jing wu Jin Zhou jing-Qiu Rong Yao Lu Hui Dong Hai-Yin Yu Jia-Shan Gu College of Chemistry and Materials Science Anhui Normal University Department of Material and Chemical Engineering Chizhou University

Branch length and density have critical effects on membrane performances; however, it is regarded to be traditionally difficult to investigate the relationship due to the uncontrolled membrane modification methods. In this study, zwitterionic polymer with controlled grafting branch chain length（degree of polymerization） and grafting density（grafting chains per membrane area） was tethered to the microporous polypropylene membrane surface based on the combination of reversible addition-fragmentation chain transfer（RAFT） polymerization technique with click reaction. The modified membranes were tested by filtrating protein dispersion to highlight the correlations of branch chain length and grafting density with the membrane permeation performances. The pure water flux, the flux recovery ratio are positively and significantly, and the irreversible fouling negatively and significantly correlated with grafting density. These results demonstrate that the larger the coverage of the membrane with poly{[2-（methacryloyloxy）ethyl]-dimethyl-（3-sulfopropyl） ammonium hydroxide}（PMEDSAH）, the higher the pure water flux and the higher the flux recover ratio, and the lower the irreversible fouling, which shows that high grafting density is favorable to fouling reducing.

关键词： Grafting branch length Grafting density Polypropylene membrane Protein fouling Zwitterionic polymer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids

引用

Chinese Chemical Letters 2015年第11期26卷 1381-1384页

作者： Jie-Xiong Wang jing-jing wu Heng Chen Shao-wu Zhang Fan-Hong wu School of Chemical and Environmental Engineering Shanghai Institute of Technology Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

A convenient and efficient approach for difluoroalkyl-containing γ-hutyrolactones via the radical addition reaction of iododifluoromethyl ketones with 4-pentenoic acids initiated by AIBN in CH3CN at 60 ℃ was reporte... 详细信息

关键词： γ-ButyrolactonesDifluoromethyleneFluorine-containing lactoneRadical reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients

引用

World Journal of Gastroenterology 2017年第15期23卷 2802-2810页

作者： Jin-Lin Cheng Xiao-Ling Wang Shi-Gui Yang Hong Zhao jing-jing wu Lan-Juan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious DiseasesFirst Affiliated HospitalSchool of MedicineZhejiang University Department of Pathology First Affiliated HospitalSchool of MedicineZhejiang University Department of Infectious Diseases First Affiliated HospitalSchool of MedicineZhejiang University

AIM To determine incidence and clinical biomarkers of marked necroinflammation and fibrosis characteristics among chronic hepatitis B(CHB) patients with persistently normal alanine aminotransferase(PNALT).METHODS Liver biopsy was performed on 115 CHB patients with PNALT. Necroinflammation and fibrosis were graded by the Knodell histologic activity index and the Ishak fibrosis score, respectively. Correlations between the available clinical parameters and necroinflammation and fibrosis were analysed.RESULTS Marked necroinflammation(Knodell activity index ≥ 7) and fibrosis(Ishak fibrosis score ≥ 3) were found in 36.5% and 15.5% of CHB patients with PNALT, respectively. Following a univariate logistic regression analysis, multiple logistic regression analysis indicated that aspartate transaminase(AST)(AUROC = 0.852, cut-off value = 22.5 U/L) serves as an independent predictor of notable liver inflammation, while platelet(PLT) count(AUROC = 0.905, cut-off value = 171.5 ×109/m L) and gamma-glutamyl transpeptidase(GGT)(AUROC = 0.909, cut-off value = 21.5 U/L) level serve as independent predictors of notable liver fibrosis.CONCLUSION A considerable proportion of marked histological abnormalities existed in our cohort, who will benefit from optimal therapeutic strategies administered according to predictive indication by AST, PLT and GGT levels.

关键词：长期的肝炎 B 肝活体检视正常丙氨酸 aminotransferase Necroinflammation 肝的纤维变性

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation of the mechanism of action of Sanwu Huangqin Tang in the treatment of restless leg syndrome based on network pharmacology,molecular docking technology and molecular dynamics simulation

引用

TMR Modern Herbal Medicine 2023年第4期6卷 11-28页

作者： Man Wen Yan-Xin Wang Yan-Yan Chen jing-jing wu Zheng Yu Department of Encephalopathy The First Affiliated Hospital of Anhui University of Traditional Chineses MedicineHefei 230031China

Background:Through the use of network pharmacology and molecular docking approaches,this study will examine the pharmacological effects of Sanwu Huangqin Tang on restless legs syndrome in order to better understand the mechanism of action of Traditional Chinese medicine(TCM)on RLS.Method:Utilise the TCMSP database to collect and select the drug components of Sanwu Huangqin Tang,and the Uniprot database to identify pertinent targets;RLS-related disease targets were obtained from GeneCards,DrugBank,and OMIM databases;and STRING and Cytoscape 3.9.1 software were used to generate an interaction network.KEGG pathway analysis and GO enrichment analysis were performed utilizing the DAVID database.Use Autodock for analyzing the relationships between targets and core components.Result:By using a network pharmacology approach,83 active ingredients and 50 drug-disease intersecting targets were derived for Sanwu Huangqin Tang.The molecular docking results showed that the drug components had strong affinity with the average target targets.Conclusions:This study provides new insights into the mechanism through which Traditional Chinese Medicine(TCM)treats Restless Legs Syndrome(RLS).Furthermore,it lays the foundation for additional research into the mechanism of treatment for RLS through the intervention that addresses various targets and pathways using the active ingredients identified by Sanwu Huangqin Tang.

关键词： Sanwu Huangqin Tang restless legs syndrome network pharmacology inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：