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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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碳配额所有权解释进路下的碳排放权研究

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河北大学学报（哲学社会科学版） 2025年第1期50卷 135-149页

作者：胡静董宜君中国政法大学民商经济法学院北京100088

我国对碳排放权概念的使用经历了从经济学语境拓展到法学语境的过程。碳排放权的本来面目是经济学上的产权。若将其代入法学语境,碳排放权的性质应为法律权利的客体,地位相当于碳配额。目前法学上将碳排放权作为一项法律权利进行诠释可... 详细信息

我国对碳排放权概念的使用经历了从经济学语境拓展到法学语境的过程。碳排放权的本来面目是经济学上的产权。若将其代入法学语境,碳排放权的性质应为法律权利的客体,地位相当于碳配额。目前法学上将碳排放权作为一项法律权利进行诠释可能会造成该概念理解上的混乱和实际应用上的困难。基于我国碳交易制度的实践,以碳配额作为权利客体,以权利人对碳配额的占有(持有)、使用(排放)、处分(转让、设立担保)等为权利内容的碳配额所有权对制度更有解释力和指引力。若将碳排放权视为排放碳的权利,则行使碳排放权实质上就是运用碳配额所有权的使用权能。碳配额所有权具有广义的政策性,以“行政本质、民法路径”为特点,以减排目标的实现为根本遵循,是以实行公法义务为目的的工具性权利,区别于作为目的性权利的传统民事权利。碳配额所有权的成立以配额的界定为前提,碳配额、核证自愿减排量的界定依赖碳排放量和减排量的检测和认定,基于此,行政机关应对数据质量进行严格监管。

关键词：碳排放权交易碳排放权碳配额所有权配额核证自愿减排量

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Studies on the Electrochemical Behavior of Bleomycin at a Co/GC Ion Implantation Modified Electrode and Its Application

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Chemical Research in Chinese Universities 2001年第4期17卷 362-367页

作者： hu jing-bo LI Qi-long Department of Chemistry Beijing Normal UniversityBeijing 100875P.R.China

In a 0. 10 mol/L HAc-NaAc buffer solution (pH = 4. 59), a sensitive reduction peak of bleomycin was observed by linear sweep voltammetry at a Co/GC ion implantation modified electrode. The peak potential was-0. 73 V(iw. SCE). The peak current was proportional to the concentration of bleomycin over the range of 5.0 × 10-8-1.0× 10-6 and 1.0× 10-6-1. 0 × 10-5 mol/L with a detection limit of 2.0 × 10-8 mol/L. The electrochemical behavior of the reduction peak of bleomycin at the Co/GC modified electrode was studied by linear sweep and cyclic voltammetry and applied to the determination of bleomycin in urine. This method is simple, rapid and reliable. The reduction process is quasi-reversible. The experiments of AES and XPS showed that Co was surely implanted into the surface of GCE and the depth distribution of Co was in good agreement with Gooses normal distribution; the implanted Co at GCE improved the electrocatalytic activity.

关键词： Co/GC ion implantation modified electrode Electrochemical behavior Linear sweep voltammetry Bleomycin

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Densities and surface tensions of ionic liquids/sulfuric acid binary mixtures

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1513-1521页

作者： Tao Zhang jing hu Shengwei Tang Multi-phase Mass Transfer and Reaction Engineering Lab School of Chemical Engineering Sichuan University

The densities and surface tensions of [Bmim][TFO]/H2SO4, [Hmim][TFO]/H2SO4 and [Omim][TFO]/H2SO4 binary mixtures were measured by pycnometer and Wilhelmy plate method respectively. The results show that densities and surface tensions of the mixtures decreased monotonously with increasing temperatures and increasing ionic liquid （IL） molar fraction. IL with longer alkyl side-chain length brings a lower density and a smaller surface tension to the ILs/H2SO4 binary mixtures. The densities and surface tensions of the mixtures are fitted well by Jouyban-Acree （JAM） model and LWW model respectively. Redlich-Kister （R-K）equation and modified Redlich-Kister （R-K） equation describe the excess molar volumes and excess surface tensions of the mixtures well respectively. Adding a small amount of ILs （XIL 〈 0.1 ） into sulfuric acid brings an obvious decrease to the density and the surface tension. The results imply that the densities and surface tensions of IL5/H2SO4 binary mixtures can be modulated by changing the IL dosage or tailoring the IL structure.

关键词： Ionic liquid Sulfuric acid Density Surface tension Excess property

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A study on fatigue damage different compaction using characteristics of asphalt mixture under 3D-microstructural

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Frontiers of Structural and Civil Engineering 2017年第3期11卷 329-337页

作者： jing hu Pengfei LIU Bernhard STEINAUER Institute of Highway Engineering RWTH Aachen University D52074 Aachen Germany

The aim of this paper is investigating the microstructural characteristics of asphalt mixture under different compaction powers. In order to achieve this aim, a test track was built to provide asphalt mixture specimens and X-ray computed tomography （XCT） device was used to scan the internal structure. The aggregate particles and air-voids were extracted using Digital Image Processing （DIP）, so the relationship between compaction and air-voids was determined at first, and then, the effect of aggregate particles on the morphology of air-voids can be evaluated, finally, fatigue properties of asphalt mixture with different air-void ratio were measured by indirect tensile fatigue test as well. The research results release the distribution ofmicrostructures in asphalt pavement. 3D fractal dimension is an effective indicator to quantize the complexity of aggregate particles and air-voids; suffering the same compaction power, aggregates cause different constitutions of air-voids in asphalt mixture; investigation in this paper can present the essential relationship between microstructures and fatigue properties.

关键词： asphalt mixture microstructure morphology digital image processing fatigue damage

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Multifunctional aggregates for precise cellular analysis

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Science China Chemistry 2021年第11期64卷 1938-1945页

作者： jing-jing hu Xiaoqi Dong Wenlian Jiang Fan Xia Xiaoding Lou State Key Laboratory of Biogeology and Environmental Geology Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430074China

Precisely analyzing the target materials in living cells can reveal the essence and mystery of life at a deeper level,which will provide reliable theoretical basis for the occurrence,development,treatment and prognosis of major ***,because living cells are in the dynamic process of metabolism,there are several challenges existed in accurate analysis,including subcellular compartment heterogeneity,plasma membrane interface barrier,and cell cycle *** this regard,our group has designed and synthesized a series of multifunctional aggregates by mainly integrating the peptide elements,nucleic acid elements and aggregation elements to overcome the *** article summarizes the latest developments of multifunctional aggregates for precise cell analysis by our group,and systematically introduces them according to different design concepts and targeting dimensions,such as space,efficiency as well as *** hope this work could contribute to analyzing the biomarkers in cells through constructing the multifunctional aggregates,understanding the operation mechanism of cells,finally inspiring technology breakthroughs in biomedical fields.

关键词： precise cellular analysis aggregation induced emission peptide nucleic acid aggregate

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Incorporating two coupling noises into a nonlinear competitive system with saturation effect

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International Journal of Biomathematics 2020年第2期13卷 75-101页

作者： jing hu Zhijun Liu Department of Mathematics Hubei Minzu University 445000EnshiHubeiP.R.China

In this paper,a novel stochastic two-species competitive system with saturation effect is formulated,in which there exist two noise resources and their coupling mode is relatively complex and every noise source has elfect on the intrinsic growth rates of both *** the help of some suitable Lyapunov functions,sufficient conditions for stochastic permanence are established as exponential extinction,extinction,permanence in time average and asymptotic pathwise estimation of *** effect of coupling noise on the asymptotic behaviors of the populations is shown.

关键词： Randomized competitive model white noise coupling stochastic permanence→extinction asymptotic pathwise estimation

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V2I Physical Layer Security Beamforming with Antenna Hardware Impairments under RIS Assistance

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Computers, Materials & Continua 2024年第10期81卷 1835-1854页

作者： Zerong Tang Tiecheng Song jing hu School of Information Science and Engineering Southeast UniversityNanjing210096China

The Internet of Vehicles(IoV)will carry a large amount of security and privacy-related data,which makes the secure communication between the IoV terminals increasingly *** paper studies the joint beamforming for physical-layer security transmission in the coexistence of Vehicle-to-Infrastructure(V2I)and Vehicle-toVehicle(V2V)communication with Reconfigurable Intelligent Surface(RIS)assistance,taking into account hardware impairments.A communication model for physical-layer security transmission is established when the eavesdropping user is present and the base station antenna has hardware impairments assisted by *** on this model,we propose to maximize the V2I physical-layer security transmission *** solve the coupled non-convex optimization problem,an alternating optimization algorithm based on second-order cone programming and semidefinite relaxation is proposed to obtain the optimal V2I base station transmit precoding and RIS reflect phase shift ***,simulation results are presented to verify the convergence and superiority of our proposed algorithm while analyzing the impact of system parameters on the V2I physical-layer security transmission *** simulation results further demonstrate that the proposed robust beamforming algorithm considering hardware impairments will achieve an average performance improvement of 0.7 dB over a non-robustly designed ***,increasing the number of RIS reflective units from 10 to 50 results in an almost 2 dB enhancement in secure transmission rate.

关键词： Internet of vehicle reconfigurable intelligent surface physical-layer security transmission antenna hardware impairments

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Trees with Non-regular Fractal Boundary

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Acta Mathematica Sinica,English Series 2008年第8期24卷 1345-1350页

作者： jing hu YU Yi Ming DING Department of Mathematics School of Sciences Wuhan University of Technology Wuhan 430070 P. R. China Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 P. R. China

For any given 0 〈α 〈 β 〈 ∞, we construct a tree such that under tree metric, the Hausdorff dimension of the corresponding boundary is α, but both the Packing dimension and the boxing dimension are β. Applying the connection between tree and iterated functions system, non- regular fractal sets on real line are constructed. Moreover, the method adopted in our paper is different from those which have been used before for constructing non-regular fractal set in general metric space.

关键词： tree boundary fractal dimensions non-regularity recursive structures

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Quantifying Dynamical Predictability:the Pseudo-Ensemble Approach

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 569-588页

作者： Jianbo GAO Wenwen TUNG jing hu PMB Intelligence LLC PO Box 2077 West Lafayette IN 47996 USA. Purdue Climate Change Research Center Department of Earth and Atmospheric Sciences Purdue University 550 Stadium Mall Dr. West Lafayette IN 47907-2051 USA. PMB Intelligence LLC PO Box 2077 West Lafayette IN 47996 USA Affymetrix Inc. 3380 Central Expressway Santa Clara CA 95051 USA.

The ensemble technique has been widely used in numerical weather prediction and extended-range *** approaches to evaluate the predictability using the ensemble technique can be divided into two major *** is dynamical,including generating Lyapunov vectors,bred vectors,and singular vectors,sampling the fastest error-growing directions of the phase space,and examining the dependence of prediction efficiency on ensemble *** other is statistical,including distributional analysis and quantifying prediction utility by the Shannon entropy and the relative ***,with simple models,one could choose as many ensembles as possible,with each ensemble containing a large number of *** the forecast models become increasingly complicated,however,one would only be able to afford a small number of ensembles,each with limited number of members,thus sacrificing estimation accuracy of the forecast *** uncover connections between different information theoretic approaches and between dynamical and statistical approaches,we propose an (∈;T)-entropy and scale-dependent Lyapunov exponent——based general theoretical framework to quantify information loss in ensemble *** importantly,to tremendously expedite computations,reduce data storage,and improve forecasting accuracy,we propose a technique for constructing a large number of "pseudo" ensembles from one single solution or scalar *** pseudo-ensemble technique appears to be applicable under rather general conditions,one important situation being that observational data are available but the exact dynamical model is unknown.

关键词： Dynamical predictability Ensemble forecasting Relative entropy Kolmogorov entropy Scale-dependent Lyapunov exponent

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